Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function - DUF607 - putative

Species:

Leishmania infantum

UniProt:

A4HZH5_LEIIN

TriTrypDb:

LINF_210026700

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HZH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZH5

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	12
GO:0006874	intracellular calcium ion homeostasis	7	12
GO:0006875	obsolete intracellular metal ion homeostasis	6	12
GO:0009987	cellular process	1	12
GO:0019725	cellular homeostasis	2	12
GO:0030003	intracellular monoatomic cation homeostasis	5	12
GO:0042592	homeostatic process	3	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0051560	mitochondrial calcium ion homeostasis	8	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055074	calcium ion homeostasis	8	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0055082	intracellular chemical homeostasis	3	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	12
GO:0072507	obsolete divalent inorganic cation homeostasis	7	12
GO:0098771	inorganic ion homeostasis	6	12
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006851	mitochondrial calcium ion transmembrane transport	4	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0070588	calcium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005261	monoatomic cation channel activity	5	12
GO:0005262	calcium channel activity	6	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015085	calcium ion transmembrane transporter activity	6	12
GO:0015267	channel activity	4	12
GO:0015291	secondary active transmembrane transporter activity	4	12
GO:0015292	uniporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0046873	metal ion transmembrane transporter activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.258
CLV_NRD_NRD_1	7	9	PF00675	0.382
CLV_PCSK_KEX2_1	125	127	PF00082	0.263
CLV_PCSK_KEX2_1	59	61	PF00082	0.377
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.377
CLV_PCSK_SKI1_1	214	218	PF00082	0.392
CLV_PCSK_SKI1_1	22	26	PF00082	0.326
CLV_PCSK_SKI1_1	27	31	PF00082	0.247
CLV_PCSK_SKI1_1	59	63	PF00082	0.352
CLV_PCSK_SKI1_1	8	12	PF00082	0.366
DOC_MAPK_gen_1	59	67	PF00069	0.532
DOC_MAPK_MEF2A_6	59	67	PF00069	0.562
DOC_USP7_MATH_1	135	139	PF00917	0.337
DOC_USP7_MATH_1	170	174	PF00917	0.449
DOC_USP7_MATH_1	182	186	PF00917	0.489
DOC_USP7_MATH_1	224	228	PF00917	0.622
DOC_USP7_MATH_1	92	96	PF00917	0.533
DOC_USP7_UBL2_3	23	27	PF12436	0.628
DOC_WW_Pin1_4	37	42	PF00397	0.612
LIG_14-3-3_CanoR_1	114	118	PF00244	0.564
LIG_Actin_WH2_2	71	87	PF00022	0.573
LIG_BRCT_BRCA1_1	94	98	PF00533	0.581
LIG_deltaCOP1_diTrp_1	129	133	PF00928	0.581
LIG_FHA_1	138	144	PF00498	0.461
LIG_FHA_1	147	153	PF00498	0.342
LIG_FHA_1	160	166	PF00498	0.399
LIG_FHA_2	45	51	PF00498	0.561
LIG_HCF-1_HBM_1	183	186	PF13415	0.562
LIG_LIR_Gen_1	173	182	PF02991	0.395
LIG_LIR_Gen_1	183	194	PF02991	0.345
LIG_LIR_Gen_1	28	34	PF02991	0.532
LIG_LIR_Gen_1	69	79	PF02991	0.502
LIG_LIR_Gen_1	95	105	PF02991	0.566
LIG_LIR_Nem_3	129	133	PF02991	0.526
LIG_LIR_Nem_3	149	153	PF02991	0.282
LIG_LIR_Nem_3	173	179	PF02991	0.383
LIG_LIR_Nem_3	183	189	PF02991	0.345
LIG_LIR_Nem_3	28	33	PF02991	0.535
LIG_LIR_Nem_3	69	75	PF02991	0.502
LIG_LIR_Nem_3	95	101	PF02991	0.577
LIG_PCNA_PIPBox_1	141	150	PF02747	0.344
LIG_SH2_CRK	102	106	PF00017	0.562
LIG_SH2_NCK_1	186	190	PF00017	0.537
LIG_SH2_STAP1	174	178	PF00017	0.363
LIG_SH2_STAT5	147	150	PF00017	0.326
LIG_SH2_STAT5	176	179	PF00017	0.475
LIG_SH2_STAT5	54	57	PF00017	0.517
LIG_SH2_STAT5	70	73	PF00017	0.451
LIG_SH3_3	154	160	PF00018	0.276
LIG_SH3_3	86	92	PF00018	0.581
LIG_SUMO_SIM_par_1	63	69	PF11976	0.536
LIG_TRAF2_1	218	221	PF00917	0.650
LIG_WRC_WIRS_1	147	152	PF05994	0.328
MOD_CK1_1	185	191	PF00069	0.562
MOD_CK2_1	44	50	PF00069	0.553
MOD_Cter_Amidation	20	23	PF01082	0.403
MOD_GlcNHglycan	137	140	PF01048	0.329
MOD_GlcNHglycan	246	249	PF01048	0.440
MOD_GlcNHglycan	85	88	PF01048	0.380
MOD_GSK3_1	131	138	PF00069	0.415
MOD_GSK3_1	159	166	PF00069	0.306
MOD_GSK3_1	185	192	PF00069	0.525
MOD_GSK3_1	244	251	PF00069	0.659
MOD_NEK2_1	105	110	PF00069	0.568
MOD_NEK2_1	163	168	PF00069	0.348
MOD_NEK2_2	54	59	PF00069	0.582
MOD_PIKK_1	137	143	PF00454	0.398
MOD_PIKK_1	32	38	PF00454	0.653
MOD_PIKK_1	39	45	PF00454	0.519
MOD_PKA_1	242	248	PF00069	0.698
MOD_PKA_2	113	119	PF00069	0.576
MOD_PKA_2	231	237	PF00069	0.689
MOD_Plk_1	182	188	PF00069	0.480
MOD_Plk_1	189	195	PF00069	0.470
MOD_Plk_4	159	165	PF00069	0.311
MOD_Plk_4	189	195	PF00069	0.532
MOD_Plk_4	2	8	PF00069	0.652
MOD_ProDKin_1	37	43	PF00069	0.614
MOD_SUMO_rev_2	210	219	PF00179	0.592
MOD_SUMO_rev_2	68	78	PF00179	0.581
TRG_ENDOCYTIC_2	102	105	PF00928	0.561
TRG_ENDOCYTIC_2	147	150	PF00928	0.326
TRG_ENDOCYTIC_2	174	177	PF00928	0.359
TRG_ENDOCYTIC_2	186	189	PF00928	0.505
TRG_ENDOCYTIC_2	72	75	PF00928	0.500
TRG_ER_diArg_1	124	126	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P418	Leptomonas seymouri	60%	89%
A0A0S4IYH5	Bodo saltans	35%	100%
A0A1X0NHK2	Trypanosomatidae	42%	93%
A0A3Q8IFA5	Leishmania donovani	100%	100%
A0A422N8V4	Trypanosoma rangeli	35%	96%
A4HC33	Leishmania braziliensis	83%	100%
D0A0Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AVG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QC14	Leishmania major	95%	100%
V5DIC7	Trypanosoma cruzi	42%	84%