Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZH3_LEIIN

TriTrypDb:

LINF_210026500

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZH3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.593
CLV_PCSK_KEX2_1	41	43	PF00082	0.460
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.460
CLV_PCSK_PC7_1	37	43	PF00082	0.373
CLV_PCSK_SKI1_1	56	60	PF00082	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.505
DOC_CKS1_1	91	96	PF01111	0.396
DOC_MAPK_gen_1	41	48	PF00069	0.482
DOC_MAPK_HePTP_8	38	50	PF00069	0.461
DOC_MAPK_MEF2A_6	41	50	PF00069	0.473
DOC_PP2B_LxvP_1	52	55	PF13499	0.583
DOC_PP4_FxxP_1	107	110	PF00568	0.446
DOC_USP7_MATH_1	84	88	PF00917	0.622
DOC_USP7_UBL2_3	53	57	PF12436	0.503
DOC_WW_Pin1_4	90	95	PF00397	0.489
LIG_14-3-3_CanoR_1	42	47	PF00244	0.448
LIG_14-3-3_CanoR_1	70	76	PF00244	0.592
LIG_FHA_2	14	20	PF00498	0.445
LIG_FHA_2	57	63	PF00498	0.577
LIG_FHA_2	84	90	PF00498	0.509
LIG_LIR_Gen_1	97	102	PF02991	0.431
LIG_LIR_Nem_3	97	101	PF02991	0.420
LIG_RPA_C_Fungi	26	38	PF08784	0.361
LIG_SH2_CRK	98	102	PF00017	0.430
LIG_SH2_STAT3	138	141	PF00017	0.527
LIG_SH2_STAT5	117	120	PF00017	0.371
LIG_SH2_STAT5	138	141	PF00017	0.527
LIG_SH2_STAT5	98	101	PF00017	0.414
LIG_SH3_3	76	82	PF00018	0.597
LIG_SH3_3	88	94	PF00018	0.404
LIG_SH3_5	94	98	PF00018	0.385
LIG_SUMO_SIM_par_1	8	14	PF11976	0.324
MOD_CK2_1	13	19	PF00069	0.466
MOD_CK2_1	72	78	PF00069	0.598
MOD_GlcNHglycan	118	121	PF01048	0.548
MOD_GlcNHglycan	86	89	PF01048	0.737
MOD_N-GLC_1	84	89	PF02516	0.729
MOD_NEK2_1	100	105	PF00069	0.440
MOD_NEK2_1	13	18	PF00069	0.469
MOD_PKA_1	41	47	PF00069	0.474
MOD_PKA_1	56	62	PF00069	0.431
MOD_PKA_2	41	47	PF00069	0.446
MOD_PKA_2	69	75	PF00069	0.585
MOD_Plk_1	13	19	PF00069	0.311
MOD_Plk_2-3	14	20	PF00069	0.309
MOD_ProDKin_1	90	96	PF00069	0.472
TRG_ENDOCYTIC_2	98	101	PF00928	0.426
TRG_ER_diArg_1	125	128	PF00400	0.399
TRG_ER_diArg_1	35	38	PF00400	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU38	Leptomonas seymouri	36%	98%
A0A3Q8IAH7	Leishmania donovani	99%	100%
A0A422N8B7	Trypanosoma rangeli	31%	100%
A4HC30	Leishmania braziliensis	68%	100%
E9AVG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QC16	Leishmania major	91%	100%