Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZH2_LEIIN

TriTrypDb:

LINF_210026400

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	26	28	PF00082	0.443
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.443
CLV_PCSK_SKI1_1	339	343	PF00082	0.463
CLV_PCSK_SKI1_1	357	361	PF00082	0.253
CLV_PCSK_SKI1_1	397	401	PF00082	0.433
CLV_PCSK_SKI1_1	85	89	PF00082	0.421
CLV_Separin_Metazoa	221	225	PF03568	0.304
DEG_APCC_DBOX_1	356	364	PF00400	0.418
DEG_MDM2_SWIB_1	169	177	PF02201	0.374
DEG_Nend_UBRbox_2	1	3	PF02207	0.421
DEG_ODPH_VHL_1	89	101	PF01847	0.259
DOC_CKS1_1	31	36	PF01111	0.480
DOC_CYCLIN_RxL_1	394	405	PF00134	0.382
DOC_MAPK_MEF2A_6	316	324	PF00069	0.423
DOC_MAPK_MEF2A_6	7	15	PF00069	0.357
DOC_PP2B_LxvP_1	88	91	PF13499	0.503
DOC_PP4_FxxP_1	135	138	PF00568	0.361
DOC_PP4_FxxP_1	77	80	PF00568	0.427
DOC_USP7_MATH_1	110	114	PF00917	0.523
DOC_USP7_MATH_1	126	130	PF00917	0.341
DOC_USP7_MATH_1	157	161	PF00917	0.511
DOC_USP7_MATH_1	19	23	PF00917	0.505
DOC_USP7_MATH_1	210	214	PF00917	0.456
DOC_USP7_MATH_1	256	260	PF00917	0.462
DOC_USP7_MATH_1	395	399	PF00917	0.526
DOC_USP7_MATH_1	431	435	PF00917	0.578
DOC_WW_Pin1_4	30	35	PF00397	0.453
DOC_WW_Pin1_4	309	314	PF00397	0.442
DOC_WW_Pin1_4	326	331	PF00397	0.231
DOC_WW_Pin1_4	348	353	PF00397	0.485
LIG_14-3-3_CanoR_1	216	221	PF00244	0.397
LIG_14-3-3_CanoR_1	307	313	PF00244	0.392
LIG_14-3-3_CanoR_1	316	321	PF00244	0.341
LIG_14-3-3_CanoR_1	409	414	PF00244	0.466
LIG_Actin_WH2_2	301	318	PF00022	0.421
LIG_BRCT_BRCA1_1	228	232	PF00533	0.356
LIG_deltaCOP1_diTrp_1	171	179	PF00928	0.383
LIG_FHA_1	172	178	PF00498	0.351
LIG_FHA_1	206	212	PF00498	0.414
LIG_FHA_1	217	223	PF00498	0.388
LIG_FHA_1	23	29	PF00498	0.504
LIG_FHA_1	273	279	PF00498	0.519
LIG_FHA_1	294	300	PF00498	0.508
LIG_FHA_1	301	307	PF00498	0.510
LIG_FHA_1	317	323	PF00498	0.258
LIG_FHA_1	336	342	PF00498	0.244
LIG_FHA_1	45	51	PF00498	0.419
LIG_FHA_2	348	354	PF00498	0.411
LIG_FHA_2	400	406	PF00498	0.505
LIG_FHA_2	410	416	PF00498	0.495
LIG_LIR_Apic_2	74	80	PF02991	0.418
LIG_LIR_Gen_1	171	181	PF02991	0.449
LIG_LIR_Gen_1	229	238	PF02991	0.356
LIG_LIR_Gen_1	276	286	PF02991	0.336
LIG_LIR_Gen_1	64	73	PF02991	0.336
LIG_LIR_Nem_3	118	123	PF02991	0.383
LIG_LIR_Nem_3	171	176	PF02991	0.459
LIG_LIR_Nem_3	229	235	PF02991	0.328
LIG_LIR_Nem_3	276	282	PF02991	0.345
LIG_LIR_Nem_3	64	69	PF02991	0.374
LIG_NRBOX	27	33	PF00104	0.480
LIG_PCNA_yPIPBox_3	62	71	PF02747	0.343
LIG_Pex14_2	169	173	PF04695	0.386
LIG_Pex14_2	95	99	PF04695	0.432
LIG_Rb_pABgroove_1	147	155	PF01858	0.323
LIG_REV1ctd_RIR_1	334	343	PF16727	0.469
LIG_SH2_CRK	120	124	PF00017	0.280
LIG_SH2_NCK_1	198	202	PF00017	0.313
LIG_SH2_STAT5	198	201	PF00017	0.312
LIG_SH2_STAT5	234	237	PF00017	0.370
LIG_SH3_3	206	212	PF00018	0.403
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.432
LIG_SUMO_SIM_anti_2	434	441	PF11976	0.593
LIG_SUMO_SIM_par_1	207	213	PF11976	0.426
LIG_TYR_ITSM	116	123	PF00017	0.283
MOD_CDK_SPxxK_3	309	316	PF00069	0.367
MOD_CK1_1	113	119	PF00069	0.387
MOD_CK1_1	22	28	PF00069	0.457
MOD_CK1_1	284	290	PF00069	0.447
MOD_CK1_1	309	315	PF00069	0.447
MOD_CK1_1	325	331	PF00069	0.263
MOD_CK1_1	335	341	PF00069	0.317
MOD_CK1_1	383	389	PF00069	0.459
MOD_CK1_1	435	441	PF00069	0.623
MOD_CK1_1	81	87	PF00069	0.514
MOD_CK2_1	399	405	PF00069	0.476
MOD_CK2_1	409	415	PF00069	0.500
MOD_GlcNHglycan	102	105	PF01048	0.435
MOD_GlcNHglycan	159	162	PF01048	0.460
MOD_GlcNHglycan	201	204	PF01048	0.327
MOD_GlcNHglycan	212	215	PF01048	0.386
MOD_GlcNHglycan	283	286	PF01048	0.479
MOD_GlcNHglycan	386	389	PF01048	0.534
MOD_GlcNHglycan	43	47	PF01048	0.406
MOD_GlcNHglycan	434	437	PF01048	0.588
MOD_GSK3_1	106	113	PF00069	0.432
MOD_GSK3_1	18	25	PF00069	0.429
MOD_GSK3_1	281	288	PF00069	0.383
MOD_GSK3_1	307	314	PF00069	0.518
MOD_GSK3_1	322	329	PF00069	0.274
MOD_GSK3_1	380	387	PF00069	0.355
MOD_GSK3_1	395	402	PF00069	0.377
MOD_GSK3_1	431	438	PF00069	0.588
MOD_N-GLC_1	11	16	PF02516	0.435
MOD_N-GLC_1	162	167	PF02516	0.548
MOD_N-GLC_1	196	201	PF02516	0.497
MOD_N-GLC_1	332	337	PF02516	0.354
MOD_NEK2_1	115	120	PF00069	0.339
MOD_NEK2_1	181	186	PF00069	0.318
MOD_NEK2_1	281	286	PF00069	0.500
MOD_NEK2_1	308	313	PF00069	0.435
MOD_NEK2_1	315	320	PF00069	0.335
MOD_NEK2_1	322	327	PF00069	0.277
MOD_NEK2_1	332	337	PF00069	0.265
MOD_NEK2_1	369	374	PF00069	0.417
MOD_NEK2_1	384	389	PF00069	0.285
MOD_NEK2_1	399	404	PF00069	0.399
MOD_NEK2_1	408	413	PF00069	0.486
MOD_NEK2_2	395	400	PF00069	0.366
MOD_PIKK_1	285	291	PF00454	0.385
MOD_PIKK_1	419	425	PF00454	0.473
MOD_PIKK_1	75	81	PF00454	0.425
MOD_PK_1	237	243	PF00069	0.420
MOD_PKA_2	306	312	PF00069	0.459
MOD_PKA_2	315	321	PF00069	0.352
MOD_PKA_2	408	414	PF00069	0.437
MOD_PKA_2	419	425	PF00069	0.361
MOD_PKA_2	81	87	PF00069	0.563
MOD_Plk_1	11	17	PF00069	0.371
MOD_Plk_1	162	168	PF00069	0.548
MOD_Plk_1	181	187	PF00069	0.238
MOD_Plk_1	196	202	PF00069	0.436
MOD_Plk_1	226	232	PF00069	0.488
MOD_Plk_1	332	338	PF00069	0.449
MOD_Plk_4	115	121	PF00069	0.502
MOD_Plk_4	172	178	PF00069	0.358
MOD_Plk_4	257	263	PF00069	0.419
MOD_Plk_4	322	328	PF00069	0.336
MOD_Plk_4	332	338	PF00069	0.323
MOD_Plk_4	380	386	PF00069	0.336
MOD_Plk_4	435	441	PF00069	0.603
MOD_ProDKin_1	30	36	PF00069	0.454
MOD_ProDKin_1	309	315	PF00069	0.435
MOD_ProDKin_1	326	332	PF00069	0.230
MOD_ProDKin_1	348	354	PF00069	0.485
MOD_SUMO_rev_2	156	166	PF00179	0.483
MOD_SUMO_rev_2	81	87	PF00179	0.399
TRG_DiLeu_BaEn_2	130	136	PF01217	0.461
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.301
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.362
TRG_DiLeu_LyEn_5	189	194	PF01217	0.414
TRG_ENDOCYTIC_2	120	123	PF00928	0.276
TRG_ER_diArg_1	215	218	PF00400	0.368
TRG_NES_CRM1_1	4	17	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.221

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III8	Leptomonas seymouri	58%	100%
A0A1X0NJ75	Trypanosomatidae	35%	100%
A0A3Q8IC10	Leishmania donovani	100%	100%
A0A3S5IQQ3	Trypanosoma rangeli	33%	100%
A4HC29	Leishmania braziliensis	82%	100%
D0A102	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AVG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QC17	Leishmania major	94%	100%
V5BRG3	Trypanosoma cruzi	34%	100%