Mitochondrial RNA binding complex 1 subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit - putative

Species:

Leishmania infantum

UniProt:

A4HZG7_LEIIN

TriTrypDb:

LINF_210025900

Length:

340

Annotations

Annotations by Jardim et al.

Nucleic acid binding, mitochondrial RNA binding complex 1 subunit Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZG7

PDB structure(s): 7aih_Am , 7am2_Am , 7ane_Am

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.480
CLV_NRD_NRD_1	21	23	PF00675	0.398
CLV_NRD_NRD_1	299	301	PF00675	0.472
CLV_NRD_NRD_1	3	5	PF00675	0.641
CLV_NRD_NRD_1	336	338	PF00675	0.439
CLV_NRD_NRD_1	50	52	PF00675	0.416
CLV_PCSK_FUR_1	19	23	PF00082	0.497
CLV_PCSK_KEX2_1	138	140	PF00082	0.414
CLV_PCSK_KEX2_1	204	206	PF00082	0.560
CLV_PCSK_KEX2_1	21	23	PF00082	0.398
CLV_PCSK_KEX2_1	299	301	PF00082	0.472
CLV_PCSK_KEX2_1	3	5	PF00082	0.641
CLV_PCSK_KEX2_1	50	52	PF00082	0.416
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.414
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.560
CLV_PCSK_PC7_1	134	140	PF00082	0.399
CLV_PCSK_SKI1_1	205	209	PF00082	0.566
CLV_PCSK_SKI1_1	288	292	PF00082	0.414
DEG_APCC_KENBOX_2	122	126	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SIAH_1	42	50	PF03145	0.556
DOC_MAPK_gen_1	3	9	PF00069	0.655
DOC_MAPK_MEF2A_6	37	46	PF00069	0.550
DOC_PP1_RVXF_1	23	30	PF00149	0.478
DOC_PP1_RVXF_1	69	76	PF00149	0.398
DOC_USP7_MATH_1	196	200	PF00917	0.532
DOC_USP7_MATH_1	211	215	PF00917	0.460
DOC_USP7_UBL2_3	204	208	PF12436	0.505
DOC_WW_Pin1_4	82	87	PF00397	0.398
LIG_14-3-3_CanoR_1	3	9	PF00244	0.602
LIG_14-3-3_CanoR_1	30	38	PF00244	0.439
LIG_14-3-3_CanoR_1	320	326	PF00244	0.469
LIG_deltaCOP1_diTrp_1	255	262	PF00928	0.422
LIG_FHA_1	161	167	PF00498	0.516
LIG_FHA_1	170	176	PF00498	0.503
LIG_FHA_1	289	295	PF00498	0.478
LIG_FHA_2	322	328	PF00498	0.411
LIG_LIR_Apic_2	313	317	PF02991	0.432
LIG_LIR_Apic_2	318	322	PF02991	0.484
LIG_LIR_Gen_1	181	189	PF02991	0.355
LIG_LIR_Gen_1	238	249	PF02991	0.498
LIG_LIR_Gen_1	58	66	PF02991	0.411
LIG_LIR_Nem_3	131	136	PF02991	0.474
LIG_LIR_Nem_3	238	244	PF02991	0.489
LIG_LIR_Nem_3	39	44	PF02991	0.453
LIG_LIR_Nem_3	58	64	PF02991	0.385
LIG_LIR_Nem_3	87	93	PF02991	0.401
LIG_LIR_Nem_3	99	105	PF02991	0.387
LIG_SH2_CRK	147	151	PF00017	0.341
LIG_SH2_CRK	314	318	PF00017	0.488
LIG_SH2_CRK	319	323	PF00017	0.515
LIG_SH2_GRB2like	182	185	PF00017	0.354
LIG_SH2_GRB2like	331	334	PF00017	0.634
LIG_SH2_SRC	93	96	PF00017	0.506
LIG_SH2_STAP1	331	335	PF00017	0.679
LIG_SH2_STAT5	136	139	PF00017	0.427
LIG_SH2_STAT5	145	148	PF00017	0.331
LIG_SH2_STAT5	182	185	PF00017	0.354
LIG_SH2_STAT5	202	205	PF00017	0.442
LIG_SH2_STAT5	241	244	PF00017	0.459
LIG_SH2_STAT5	295	298	PF00017	0.578
LIG_SH2_STAT5	331	334	PF00017	0.673
LIG_SH2_STAT5	66	69	PF00017	0.405
LIG_SH2_STAT5	93	96	PF00017	0.420
LIG_SH3_3	323	329	PF00018	0.606
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.495
LIG_UBA3_1	111	120	PF00899	0.415
LIG_WRC_WIRS_1	232	237	PF05994	0.398
MOD_CK2_1	240	246	PF00069	0.491
MOD_CK2_1	283	289	PF00069	0.512
MOD_CMANNOS	257	260	PF00535	0.417
MOD_Cter_Amidation	335	338	PF01082	0.433
MOD_GlcNHglycan	238	241	PF01048	0.539
MOD_GlcNHglycan	285	288	PF01048	0.493
MOD_GSK3_1	231	238	PF00069	0.445
MOD_GSK3_1	264	271	PF00069	0.506
MOD_NEK2_1	235	240	PF00069	0.551
MOD_NEK2_1	290	295	PF00069	0.490
MOD_NEK2_1	64	69	PF00069	0.436
MOD_PIKK_1	36	42	PF00454	0.501
MOD_PKA_2	2	8	PF00069	0.581
MOD_PKB_1	281	289	PF00069	0.562
MOD_Plk_1	107	113	PF00069	0.462
MOD_Plk_4	107	113	PF00069	0.453
MOD_Plk_4	178	184	PF00069	0.376
MOD_Plk_4	211	217	PF00069	0.540
MOD_Plk_4	290	296	PF00069	0.452
MOD_ProDKin_1	82	88	PF00069	0.395
MOD_SUMO_rev_2	265	270	PF00179	0.437
MOD_SUMO_rev_2	34	39	PF00179	0.499
TRG_ENDOCYTIC_2	147	150	PF00928	0.342
TRG_ENDOCYTIC_2	182	185	PF00928	0.354
TRG_ENDOCYTIC_2	241	244	PF00928	0.459
TRG_ER_diArg_1	19	22	PF00400	0.448
TRG_ER_diArg_1	2	4	PF00400	0.620
TRG_ER_diArg_1	280	283	PF00400	0.534
TRG_ER_diArg_1	49	51	PF00400	0.437
TRG_NES_CRM1_1	164	176	PF08389	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F9	Leptomonas seymouri	83%	100%
A0A0S4J3G5	Bodo saltans	46%	86%
A0A1X0NHG3	Trypanosomatidae	70%	99%
A0A3Q8IL95	Leishmania donovani	100%	100%
A0A3R7N7R7	Trypanosoma rangeli	67%	99%
A4HC24	Leishmania braziliensis	92%	100%
D0A108	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9AVF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QC22	Leishmania major	98%	100%
V5BHD8	Trypanosoma cruzi	71%	100%