Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquitin-2 like Rad60 SUMO-like - putative

Species:

Leishmania infantum

UniProt:

A4HZG6_LEIIN

TriTrypDb:

LINF_210025800

Length:

161

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	131	133	PF00082	0.395
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.395
CLV_PCSK_SKI1_1	67	71	PF00082	0.387
CLV_PCSK_SKI1_1	7	11	PF00082	0.380
CLV_PCSK_SKI1_1	83	87	PF00082	0.373
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DOC_MAPK_MEF2A_6	110	117	PF00069	0.345
DOC_USP7_MATH_1	127	131	PF00917	0.408
DOC_USP7_MATH_1	13	17	PF00917	0.585
DOC_WW_Pin1_4	137	142	PF00397	0.724
LIG_14-3-3_CanoR_1	60	68	PF00244	0.478
LIG_Actin_WH2_2	54	72	PF00022	0.327
LIG_FHA_1	80	86	PF00498	0.417
LIG_FHA_2	102	108	PF00498	0.265
LIG_FHA_2	35	41	PF00498	0.455
LIG_FHA_2	84	90	PF00498	0.397
LIG_LIR_Gen_1	25	32	PF02991	0.494
LIG_LIR_Nem_3	25	29	PF02991	0.473
LIG_Pex14_2	46	50	PF04695	0.436
LIG_SH2_STAT5	8	11	PF00017	0.500
MOD_CAAXbox	158	161	PF01239	0.562
MOD_CK1_1	16	22	PF00069	0.590
MOD_CK1_1	96	102	PF00069	0.385
MOD_CK2_1	101	107	PF00069	0.345
MOD_CK2_1	127	133	PF00069	0.447
MOD_CK2_1	136	142	PF00069	0.512
MOD_CK2_1	34	40	PF00069	0.381
MOD_CK2_1	83	89	PF00069	0.345
MOD_GlcNHglycan	145	148	PF01048	0.648
MOD_GlcNHglycan	18	21	PF01048	0.443
MOD_GlcNHglycan	63	66	PF01048	0.426
MOD_GlcNHglycan	95	98	PF01048	0.360
MOD_GSK3_1	79	86	PF00069	0.339
MOD_N-GLC_2	33	35	PF02516	0.528
MOD_PKA_1	153	159	PF00069	0.649
MOD_PKA_2	59	65	PF00069	0.385
MOD_Plk_1	35	41	PF00069	0.381
MOD_Plk_4	109	115	PF00069	0.371
MOD_ProDKin_1	137	143	PF00069	0.724
MOD_SUMO_rev_2	48	57	PF00179	0.362
MOD_SUMO_rev_2	96	101	PF00179	0.371
TRG_ER_diArg_1	3	6	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H2	Leptomonas seymouri	54%	100%
A0A0S4JTL1	Bodo saltans	34%	100%
A0A1X0NHK7	Trypanosomatidae	38%	100%
A0A3Q8IB92	Leishmania donovani	99%	100%
A0A3R7RFJ8	Trypanosoma rangeli	31%	100%
A4HC23	Leishmania braziliensis	63%	100%
D0A109	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AVF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QC23	Leishmania major	91%	99%