LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZG5_LEIIN
TriTrypDb:
LINF_210025700
Length:
135

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HZG5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZG5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 47 51 PF00656 0.670
CLV_NRD_NRD_1 102 104 PF00675 0.556
CLV_NRD_NRD_1 7 9 PF00675 0.491
CLV_PCSK_KEX2_1 104 106 PF00082 0.618
CLV_PCSK_KEX2_1 7 9 PF00082 0.491
CLV_PCSK_PC1ET2_1 104 106 PF00082 0.664
CLV_PCSK_SKI1_1 8 12 PF00082 0.545
DEG_SPOP_SBC_1 42 46 PF00917 0.451
LIG_14-3-3_CanoR_1 15 20 PF00244 0.583
LIG_BIR_II_1 1 5 PF00653 0.639
LIG_BRCT_BRCA1_1 109 113 PF00533 0.604
LIG_DLG_GKlike_1 15 22 PF00625 0.578
LIG_FHA_1 116 122 PF00498 0.626
LIG_FHA_1 34 40 PF00498 0.496
LIG_FHA_2 114 120 PF00498 0.586
LIG_FHA_2 9 15 PF00498 0.603
LIG_NRBOX 21 27 PF00104 0.431
LIG_SH3_3 114 120 PF00018 0.586
LIG_SUMO_SIM_anti_2 18 24 PF11976 0.557
LIG_TRAF2_1 11 14 PF00917 0.600
LIG_TRAF2_1 73 76 PF00917 0.410
LIG_WRC_WIRS_1 27 32 PF05994 0.423
MOD_CK2_1 8 14 PF00069 0.658
MOD_CK2_1 84 90 PF00069 0.363
MOD_GlcNHglycan 1 4 PF01048 0.651
MOD_GSK3_1 107 114 PF00069 0.593
MOD_GSK3_1 41 48 PF00069 0.594
MOD_GSK3_1 84 91 PF00069 0.384
MOD_NEK2_1 1 6 PF00069 0.639
MOD_NEK2_1 111 116 PF00069 0.546
MOD_NEK2_1 25 30 PF00069 0.452
MOD_NEK2_1 88 93 PF00069 0.445
MOD_NEK2_2 98 103 PF00069 0.537
MOD_PIKK_1 1 7 PF00454 0.607
MOD_PKA_2 78 84 PF00069 0.674
MOD_PKA_2 98 104 PF00069 0.386
MOD_Plk_1 107 113 PF00069 0.576
MOD_Plk_1 53 59 PF00069 0.552
TRG_ER_diArg_1 102 105 PF00400 0.543
TRG_ER_diArg_1 57 60 PF00400 0.439
TRG_ER_diArg_1 7 9 PF00400 0.491
TRG_NLS_MonoExtC_3 102 108 PF00514 0.573
TRG_Pf-PMV_PEXEL_1 8 13 PF00026 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P421 Leptomonas seymouri 43% 89%
A0A3Q8IE24 Leishmania donovani 97% 100%
A4HC22 Leishmania braziliensis 67% 100%
E9AVF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QC24 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS