Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZG3_LEIIN

TriTrypDb:

LINF_210024600

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.678
CLV_NRD_NRD_1	222	224	PF00675	0.641
CLV_PCSK_KEX2_1	185	187	PF00082	0.685
CLV_PCSK_KEX2_1	222	224	PF00082	0.641
CLV_PCSK_KEX2_1	277	279	PF00082	0.655
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.644
CLV_PCSK_SKI1_1	2	6	PF00082	0.643
CLV_PCSK_SKI1_1	244	248	PF00082	0.452
DEG_Nend_UBRbox_1	1	4	PF02207	0.654
DEG_SCF_FBW7_2	4	11	PF00400	0.631
DEG_SPOP_SBC_1	16	20	PF00917	0.669
DEG_SPOP_SBC_1	214	218	PF00917	0.653
DEG_SPOP_SBC_1	24	28	PF00917	0.594
DOC_ANK_TNKS_1	178	185	PF00023	0.635
DOC_CKS1_1	198	203	PF01111	0.605
DOC_CYCLIN_RxL_1	244	255	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.470
DOC_MAPK_gen_1	244	253	PF00069	0.449
DOC_MAPK_MEF2A_6	244	253	PF00069	0.449
DOC_PP4_FxxP_1	306	309	PF00568	0.708
DOC_SPAK_OSR1_1	321	325	PF12202	0.524
DOC_USP7_MATH_1	174	178	PF00917	0.608
DOC_USP7_MATH_1	192	196	PF00917	0.678
DOC_USP7_MATH_1	23	27	PF00917	0.758
DOC_USP7_MATH_1	287	291	PF00917	0.655
DOC_USP7_MATH_1	297	301	PF00917	0.608
DOC_USP7_MATH_1	317	321	PF00917	0.682
DOC_USP7_MATH_1	387	391	PF00917	0.641
DOC_USP7_MATH_1	41	45	PF00917	0.496
DOC_USP7_MATH_1	62	66	PF00917	0.634
DOC_USP7_UBL2_3	2	6	PF12436	0.643
DOC_WW_Pin1_4	170	175	PF00397	0.551
DOC_WW_Pin1_4	197	202	PF00397	0.593
DOC_WW_Pin1_4	208	213	PF00397	0.637
DOC_WW_Pin1_4	215	220	PF00397	0.638
DOC_WW_Pin1_4	272	277	PF00397	0.616
DOC_WW_Pin1_4	283	288	PF00397	0.632
DOC_WW_Pin1_4	311	316	PF00397	0.614
DOC_WW_Pin1_4	350	355	PF00397	0.662
DOC_WW_Pin1_4	4	9	PF00397	0.640
DOC_WW_Pin1_4	408	413	PF00397	0.598
DOC_WW_Pin1_4	89	94	PF00397	0.585
LIG_14-3-3_CanoR_1	278	287	PF00244	0.796
LIG_14-3-3_CanoR_1	321	330	PF00244	0.489
LIG_14-3-3_CanoR_1	405	413	PF00244	0.678
LIG_14-3-3_CanoR_1	416	420	PF00244	0.523
LIG_14-3-3_CanoR_1	46	50	PF00244	0.613
LIG_Actin_WH2_2	68	85	PF00022	0.620
LIG_APCC_ABBA_1	74	79	PF00400	0.619
LIG_BIR_III_2	273	277	PF00653	0.647
LIG_BRCT_BRCA1_1	302	306	PF00533	0.677
LIG_CSL_BTD_1	198	201	PF09270	0.597
LIG_FHA_1	127	133	PF00498	0.420
LIG_FHA_1	152	158	PF00498	0.477
LIG_FHA_2	323	329	PF00498	0.494
LIG_FHA_2	338	344	PF00498	0.623
LIG_HCF-1_HBM_1	123	126	PF13415	0.475
LIG_LIR_Apic_2	303	309	PF02991	0.678
LIG_LIR_Gen_1	103	114	PF02991	0.511
LIG_LIR_Gen_1	255	264	PF02991	0.452
LIG_LIR_Nem_3	103	109	PF02991	0.523
LIG_LIR_Nem_3	255	261	PF02991	0.426
LIG_NRBOX	144	150	PF00104	0.435
LIG_NRBOX	423	429	PF00104	0.495
LIG_SH2_CRK	106	110	PF00017	0.481
LIG_SH2_STAT3	131	134	PF00017	0.435
LIG_SH2_STAT3	426	429	PF00017	0.489
LIG_SH2_STAT5	106	109	PF00017	0.507
LIG_SH2_STAT5	131	134	PF00017	0.414
LIG_SH2_STAT5	426	429	PF00017	0.489
LIG_SH3_3	177	183	PF00018	0.657
LIG_SH3_3	195	201	PF00018	0.594
LIG_SH3_3	265	271	PF00018	0.551
LIG_SH3_3	302	308	PF00018	0.642
LIG_SH3_3	91	97	PF00018	0.631
LIG_TRFH_1	72	76	PF08558	0.631
MOD_CDC14_SPxK_1	275	278	PF00782	0.625
MOD_CDK_SPK_2	272	277	PF00069	0.616
MOD_CDK_SPK_2	4	9	PF00069	0.640
MOD_CDK_SPxK_1	272	278	PF00069	0.619
MOD_CDK_SPxxK_3	215	222	PF00069	0.710
MOD_CK1_1	28	34	PF00069	0.626
MOD_CK1_1	280	286	PF00069	0.730
MOD_CK1_1	300	306	PF00069	0.639
MOD_CK1_1	320	326	PF00069	0.539
MOD_CK1_1	368	374	PF00069	0.682
MOD_CK1_1	380	386	PF00069	0.565
MOD_CK1_1	44	50	PF00069	0.544
MOD_CK1_1	63	69	PF00069	0.476
MOD_CK1_1	92	98	PF00069	0.695
MOD_CK1_1	99	105	PF00069	0.480
MOD_CK2_1	320	326	PF00069	0.527
MOD_Cter_Amidation	183	186	PF01082	0.685
MOD_GlcNHglycan	174	177	PF01048	0.752
MOD_GlcNHglycan	194	197	PF01048	0.614
MOD_GlcNHglycan	206	209	PF01048	0.644
MOD_GlcNHglycan	282	285	PF01048	0.714
MOD_GlcNHglycan	289	292	PF01048	0.652
MOD_GlcNHglycan	299	302	PF01048	0.578
MOD_GlcNHglycan	374	377	PF01048	0.627
MOD_GlcNHglycan	379	382	PF01048	0.601
MOD_GlcNHglycan	401	404	PF01048	0.683
MOD_GlcNHglycan	406	409	PF01048	0.732
MOD_GlcNHglycan	62	65	PF01048	0.628
MOD_GlcNHglycan	89	92	PF01048	0.599
MOD_GSK3_1	11	18	PF00069	0.665
MOD_GSK3_1	140	147	PF00069	0.459
MOD_GSK3_1	170	177	PF00069	0.574
MOD_GSK3_1	204	211	PF00069	0.628
MOD_GSK3_1	213	220	PF00069	0.773
MOD_GSK3_1	24	31	PF00069	0.569
MOD_GSK3_1	283	290	PF00069	0.668
MOD_GSK3_1	368	375	PF00069	0.653
MOD_GSK3_1	399	406	PF00069	0.689
MOD_GSK3_1	41	48	PF00069	0.773
MOD_GSK3_1	58	65	PF00069	0.557
MOD_GSK3_1	85	92	PF00069	0.653
MOD_GSK3_1	96	103	PF00069	0.591
MOD_N-GLC_1	126	131	PF02516	0.441
MOD_N-GLC_1	192	197	PF02516	0.749
MOD_N-GLC_1	214	219	PF02516	0.636
MOD_N-GLC_1	24	29	PF02516	0.635
MOD_N-GLC_1	251	256	PF02516	0.529
MOD_NEK2_1	204	209	PF00069	0.631
MOD_NEK2_1	251	256	PF00069	0.529
MOD_NEK2_1	372	377	PF00069	0.648
MOD_NEK2_1	427	432	PF00069	0.485
MOD_NEK2_2	126	131	PF00069	0.441
MOD_PIKK_1	300	306	PF00454	0.686
MOD_PIKK_1	387	393	PF00454	0.640
MOD_PIKK_1	41	47	PF00454	0.588
MOD_PIKK_1	92	98	PF00454	0.597
MOD_PKA_1	185	191	PF00069	0.684
MOD_PKA_1	277	283	PF00069	0.768
MOD_PKA_2	185	191	PF00069	0.758
MOD_PKA_2	204	210	PF00069	0.503
MOD_PKA_2	277	283	PF00069	0.833
MOD_PKA_2	320	326	PF00069	0.511
MOD_PKA_2	372	378	PF00069	0.644
MOD_PKA_2	404	410	PF00069	0.686
MOD_PKA_2	415	421	PF00069	0.523
MOD_PKA_2	45	51	PF00069	0.655
MOD_Plk_1	126	132	PF00069	0.436
MOD_Plk_1	387	393	PF00069	0.640
MOD_Plk_1	53	59	PF00069	0.564
MOD_Plk_2-3	420	426	PF00069	0.520
MOD_Plk_4	104	110	PF00069	0.487
MOD_Plk_4	11	17	PF00069	0.606
MOD_Plk_4	140	146	PF00069	0.458
MOD_Plk_4	152	158	PF00069	0.522
MOD_Plk_4	308	314	PF00069	0.695
MOD_ProDKin_1	170	176	PF00069	0.558
MOD_ProDKin_1	197	203	PF00069	0.599
MOD_ProDKin_1	208	214	PF00069	0.637
MOD_ProDKin_1	215	221	PF00069	0.710
MOD_ProDKin_1	272	278	PF00069	0.619
MOD_ProDKin_1	283	289	PF00069	0.632
MOD_ProDKin_1	311	317	PF00069	0.612
MOD_ProDKin_1	350	356	PF00069	0.661
MOD_ProDKin_1	4	10	PF00069	0.641
MOD_ProDKin_1	408	414	PF00069	0.598
MOD_ProDKin_1	89	95	PF00069	0.584
MOD_SUMO_for_1	8	11	PF00179	0.552
TRG_DiLeu_BaEn_1	11	16	PF01217	0.610
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.597
TRG_ENDOCYTIC_2	106	109	PF00928	0.483
TRG_ENDOCYTIC_2	258	261	PF00928	0.415
TRG_ER_diArg_1	160	163	PF00400	0.477
TRG_ER_diArg_1	222	225	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K6	Leptomonas seymouri	57%	100%
A0A3S7WWV7	Leishmania donovani	100%	100%
A4HC07	Leishmania braziliensis	83%	100%
E9AVE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	97%
Q4QC35	Leishmania major	95%	100%