Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZG0_LEIIN

TriTrypDb:

LINF_210024200

Length:

544

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HZG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	408	414	PF00089	0.483
CLV_NRD_NRD_1	142	144	PF00675	0.361
CLV_NRD_NRD_1	320	322	PF00675	0.500
CLV_NRD_NRD_1	337	339	PF00675	0.528
CLV_NRD_NRD_1	513	515	PF00675	0.475
CLV_NRD_NRD_1	79	81	PF00675	0.657
CLV_PCSK_KEX2_1	235	237	PF00082	0.467
CLV_PCSK_KEX2_1	336	338	PF00082	0.562
CLV_PCSK_KEX2_1	513	515	PF00082	0.475
CLV_PCSK_KEX2_1	79	81	PF00082	0.657
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.430
CLV_PCSK_SKI1_1	102	106	PF00082	0.492
CLV_PCSK_SKI1_1	170	174	PF00082	0.611
CLV_PCSK_SKI1_1	232	236	PF00082	0.405
CLV_PCSK_SKI1_1	380	384	PF00082	0.503
CLV_PCSK_SKI1_1	80	84	PF00082	0.678
DEG_APCC_DBOX_1	432	440	PF00400	0.685
DEG_SPOP_SBC_1	330	334	PF00917	0.787
DOC_CKS1_1	14	19	PF01111	0.660
DOC_CKS1_1	355	360	PF01111	0.652
DOC_CKS1_1	381	386	PF01111	0.702
DOC_CYCLIN_yClb1_LxF_4	123	128	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.438
DOC_MAPK_gen_1	223	231	PF00069	0.601
DOC_MAPK_MEF2A_6	223	231	PF00069	0.634
DOC_PP1_RVXF_1	123	129	PF00149	0.542
DOC_PP2B_LxvP_1	347	350	PF13499	0.728
DOC_PP2B_LxvP_1	525	528	PF13499	0.712
DOC_PP2B_LxvP_1	64	67	PF13499	0.448
DOC_USP7_MATH_1	181	185	PF00917	0.423
DOC_USP7_MATH_1	259	263	PF00917	0.725
DOC_USP7_MATH_1	330	334	PF00917	0.787
DOC_USP7_MATH_1	376	380	PF00917	0.710
DOC_USP7_MATH_1	46	50	PF00917	0.359
DOC_USP7_MATH_1	507	511	PF00917	0.765
DOC_USP7_MATH_1	517	521	PF00917	0.733
DOC_WW_Pin1_4	13	18	PF00397	0.676
DOC_WW_Pin1_4	281	286	PF00397	0.712
DOC_WW_Pin1_4	354	359	PF00397	0.686
DOC_WW_Pin1_4	380	385	PF00397	0.703
DOC_WW_Pin1_4	499	504	PF00397	0.699
DOC_WW_Pin1_4	526	531	PF00397	0.706
LIG_14-3-3_CanoR_1	183	190	PF00244	0.377
LIG_14-3-3_CanoR_1	24	29	PF00244	0.576
LIG_14-3-3_CanoR_1	279	284	PF00244	0.734
LIG_14-3-3_CanoR_1	327	335	PF00244	0.688
LIG_14-3-3_CanoR_1	336	345	PF00244	0.746
LIG_Actin_WH2_2	448	463	PF00022	0.681
LIG_APCC_ABBA_1	193	198	PF00400	0.365
LIG_BRCT_BRCA1_1	185	189	PF00533	0.510
LIG_BRCT_BRCA1_1	52	56	PF00533	0.389
LIG_deltaCOP1_diTrp_1	19	28	PF00928	0.634
LIG_EVH1_2	352	356	PF00568	0.689
LIG_FHA_1	121	127	PF00498	0.442
LIG_FHA_1	130	136	PF00498	0.542
LIG_FHA_1	147	153	PF00498	0.335
LIG_FHA_1	160	166	PF00498	0.257
LIG_FHA_1	171	177	PF00498	0.366
LIG_FHA_1	195	201	PF00498	0.292
LIG_FHA_1	25	31	PF00498	0.576
LIG_FHA_1	381	387	PF00498	0.702
LIG_FHA_1	490	496	PF00498	0.710
LIG_FHA_1	56	62	PF00498	0.407
LIG_FHA_2	14	20	PF00498	0.575
LIG_FHA_2	146	152	PF00498	0.335
LIG_FHA_2	383	389	PF00498	0.661
LIG_FHA_2	535	541	PF00498	0.716
LIG_GBD_Chelix_1	30	38	PF00786	0.335
LIG_LIR_Gen_1	134	142	PF02991	0.581
LIG_LIR_Gen_1	148	157	PF02991	0.335
LIG_LIR_Gen_1	27	35	PF02991	0.367
LIG_LIR_Gen_1	388	398	PF02991	0.789
LIG_LIR_Gen_1	466	473	PF02991	0.707
LIG_LIR_Nem_3	134	140	PF02991	0.583
LIG_LIR_Nem_3	148	153	PF02991	0.335
LIG_LIR_Nem_3	246	251	PF02991	0.603
LIG_LIR_Nem_3	27	31	PF02991	0.376
LIG_LIR_Nem_3	388	393	PF02991	0.788
LIG_LIR_Nem_3	466	470	PF02991	0.706
LIG_PCNA_yPIPBox_3	169	183	PF02747	0.420
LIG_PDZ_Class_2	539	544	PF00595	0.754
LIG_PTB_Apo_2	103	110	PF02174	0.183
LIG_PTB_Apo_2	210	217	PF02174	0.335
LIG_PTB_Apo_2	51	58	PF02174	0.356
LIG_PTB_Apo_2	83	90	PF02174	0.370
LIG_PTB_Phospho_1	103	109	PF10480	0.236
LIG_PTB_Phospho_1	83	89	PF10480	0.411
LIG_SH2_CRK	137	141	PF00017	0.584
LIG_SH2_CRK	190	194	PF00017	0.402
LIG_SH2_CRK	467	471	PF00017	0.708
LIG_SH2_NCK_1	190	194	PF00017	0.441
LIG_SH2_NCK_1	390	394	PF00017	0.790
LIG_SH2_NCK_1	467	471	PF00017	0.708
LIG_SH2_SRC	109	112	PF00017	0.437
LIG_SH2_SRC	203	206	PF00017	0.389
LIG_SH2_STAP1	196	200	PF00017	0.292
LIG_SH2_STAT5	109	112	PF00017	0.335
LIG_SH2_STAT5	175	178	PF00017	0.362
LIG_SH2_STAT5	196	199	PF00017	0.334
LIG_SH2_STAT5	203	206	PF00017	0.335
LIG_SH2_STAT5	68	71	PF00017	0.348
LIG_SH2_STAT5	98	101	PF00017	0.342
LIG_SH3_2	358	363	PF14604	0.664
LIG_SH3_3	347	353	PF00018	0.769
LIG_SH3_3	355	361	PF00018	0.808
LIG_SH3_3	375	381	PF00018	0.751
LIG_SH3_3	390	396	PF00018	0.706
LIG_SH3_3	500	506	PF00018	0.714
LIG_SH3_3	524	530	PF00018	0.708
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.453
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.453
LIG_SUMO_SIM_par_1	151	158	PF11976	0.389
LIG_SUMO_SIM_par_1	202	208	PF11976	0.342
LIG_TYR_ITIM	135	140	PF00017	0.586
LIG_WRC_WIRS_1	156	161	PF05994	0.333
MOD_CDK_SPxxK_3	13	20	PF00069	0.667
MOD_CK1_1	254	260	PF00069	0.620
MOD_CK1_1	329	335	PF00069	0.670
MOD_CK1_1	428	434	PF00069	0.699
MOD_CK1_1	488	494	PF00069	0.703
MOD_CK1_1	55	61	PF00069	0.365
MOD_CK2_1	13	19	PF00069	0.584
MOD_CK2_1	145	151	PF00069	0.492
MOD_CK2_1	336	342	PF00069	0.797
MOD_CK2_1	382	388	PF00069	0.662
MOD_CK2_1	483	489	PF00069	0.736
MOD_DYRK1A_RPxSP_1	380	384	PF00069	0.703
MOD_GlcNHglycan	120	123	PF01048	0.374
MOD_GlcNHglycan	185	188	PF01048	0.664
MOD_GlcNHglycan	207	210	PF01048	0.278
MOD_GlcNHglycan	328	331	PF01048	0.459
MOD_GlcNHglycan	430	433	PF01048	0.499
MOD_GlcNHglycan	485	488	PF01048	0.516
MOD_GlcNHglycan	509	512	PF01048	0.515
MOD_GSK3_1	155	162	PF00069	0.338
MOD_GSK3_1	170	177	PF00069	0.349
MOD_GSK3_1	199	206	PF00069	0.292
MOD_GSK3_1	20	27	PF00069	0.634
MOD_GSK3_1	251	258	PF00069	0.716
MOD_GSK3_1	326	333	PF00069	0.732
MOD_GSK3_1	376	383	PF00069	0.707
MOD_GSK3_1	46	53	PF00069	0.351
MOD_GSK3_1	485	492	PF00069	0.698
MOD_GSK3_1	534	541	PF00069	0.716
MOD_N-GLC_1	181	186	PF02516	0.568
MOD_N-GLC_1	219	224	PF02516	0.382
MOD_N-GLC_1	456	461	PF02516	0.436
MOD_N-GLC_1	75	80	PF02516	0.552
MOD_NEK2_1	155	160	PF00069	0.331
MOD_NEK2_1	189	194	PF00069	0.449
MOD_NEK2_1	199	204	PF00069	0.280
MOD_NEK2_1	52	57	PF00069	0.350
MOD_PIKK_1	259	265	PF00454	0.661
MOD_PIKK_1	266	272	PF00454	0.662
MOD_PKA_1	336	342	PF00069	0.797
MOD_PKA_2	182	188	PF00069	0.377
MOD_PKA_2	278	284	PF00069	0.678
MOD_PKA_2	326	332	PF00069	0.733
MOD_PKA_2	336	342	PF00069	0.751
MOD_PKB_1	336	344	PF00069	0.797
MOD_PKB_1	481	489	PF00069	0.760
MOD_Plk_1	456	462	PF00069	0.702
MOD_Plk_1	538	544	PF00069	0.717
MOD_Plk_4	155	161	PF00069	0.389
MOD_Plk_4	199	205	PF00069	0.395
MOD_Plk_4	207	213	PF00069	0.471
MOD_Plk_4	24	30	PF00069	0.576
MOD_Plk_4	36	42	PF00069	0.395
MOD_Plk_4	465	471	PF00069	0.705
MOD_Plk_4	52	58	PF00069	0.300
MOD_ProDKin_1	13	19	PF00069	0.669
MOD_ProDKin_1	281	287	PF00069	0.711
MOD_ProDKin_1	354	360	PF00069	0.684
MOD_ProDKin_1	380	386	PF00069	0.703
MOD_ProDKin_1	499	505	PF00069	0.694
MOD_ProDKin_1	526	532	PF00069	0.708
MOD_SUMO_rev_2	339	347	PF00179	0.754
MOD_SUMO_rev_2	452	458	PF00179	0.681
TRG_ENDOCYTIC_2	137	140	PF00928	0.588
TRG_ENDOCYTIC_2	190	193	PF00928	0.391
TRG_ENDOCYTIC_2	196	199	PF00928	0.334
TRG_ENDOCYTIC_2	248	251	PF00928	0.622
TRG_ENDOCYTIC_2	390	393	PF00928	0.790
TRG_ENDOCYTIC_2	467	470	PF00928	0.707
TRG_ER_diArg_1	335	338	PF00400	0.701
TRG_ER_diArg_1	480	483	PF00400	0.765
TRG_NES_CRM1_1	151	167	PF08389	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA63	Leptomonas seymouri	52%	94%
A0A3S5H7A1	Leishmania donovani	99%	100%
A4HC03	Leishmania braziliensis	67%	94%
E9AVE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QC39	Leishmania major	88%	97%