LeishMANIAdb
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LETM1 domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
LETM1 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZF7_LEIIN
TriTrypDb:
LINF_210024400
Length:
395

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0016020 membrane 2 9
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 9

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZF7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZF7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 334 338 PF00656 0.457
CLV_NRD_NRD_1 188 190 PF00675 0.561
CLV_NRD_NRD_1 211 213 PF00675 0.505
CLV_NRD_NRD_1 273 275 PF00675 0.461
CLV_NRD_NRD_1 354 356 PF00675 0.574
CLV_PCSK_KEX2_1 188 190 PF00082 0.561
CLV_PCSK_KEX2_1 211 213 PF00082 0.505
CLV_PCSK_KEX2_1 273 275 PF00082 0.461
CLV_PCSK_KEX2_1 354 356 PF00082 0.574
CLV_PCSK_KEX2_1 61 63 PF00082 0.330
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.330
CLV_PCSK_SKI1_1 27 31 PF00082 0.363
CLV_PCSK_SKI1_1 273 277 PF00082 0.472
CLV_PCSK_SKI1_1 349 353 PF00082 0.568
DEG_APCC_DBOX_1 211 219 PF00400 0.288
DEG_Nend_UBRbox_3 1 3 PF02207 0.590
DOC_CDC14_PxL_1 13 21 PF14671 0.544
DOC_CKS1_1 54 59 PF01111 0.666
DOC_CYCLIN_RxL_1 349 359 PF00134 0.374
DOC_CYCLIN_yClb1_LxF_4 10 16 PF00134 0.538
DOC_MAPK_gen_1 9 15 PF00069 0.574
DOC_MAPK_MEF2A_6 97 106 PF00069 0.550
DOC_PP1_RVXF_1 352 359 PF00149 0.374
DOC_PP4_FxxP_1 275 278 PF00568 0.272
DOC_PP4_FxxP_1 298 301 PF00568 0.290
DOC_USP7_MATH_1 23 27 PF00917 0.561
DOC_WW_Pin1_4 53 58 PF00397 0.546
LIG_14-3-3_CanoR_1 148 153 PF00244 0.343
LIG_14-3-3_CanoR_1 211 216 PF00244 0.297
LIG_14-3-3_CanoR_1 232 242 PF00244 0.347
LIG_14-3-3_CanoR_1 260 267 PF00244 0.201
LIG_14-3-3_CanoR_1 62 71 PF00244 0.518
LIG_BRCT_BRCA1_1 121 125 PF00533 0.370
LIG_deltaCOP1_diTrp_1 158 165 PF00928 0.297
LIG_deltaCOP1_diTrp_1 175 182 PF00928 0.313
LIG_deltaCOP1_diTrp_1 241 247 PF00928 0.266
LIG_deltaCOP1_diTrp_1 269 275 PF00928 0.273
LIG_DLG_GKlike_1 211 218 PF00625 0.302
LIG_FHA_1 2 8 PF00498 0.579
LIG_FHA_1 224 230 PF00498 0.454
LIG_FHA_1 253 259 PF00498 0.289
LIG_FHA_1 314 320 PF00498 0.277
LIG_FHA_1 369 375 PF00498 0.375
LIG_FHA_2 131 137 PF00498 0.322
LIG_LIR_Apic_2 297 301 PF02991 0.294
LIG_LIR_Gen_1 175 182 PF02991 0.313
LIG_LIR_Gen_1 202 210 PF02991 0.303
LIG_LIR_Gen_1 249 258 PF02991 0.280
LIG_LIR_Gen_1 294 303 PF02991 0.293
LIG_LIR_Gen_1 32 41 PF02991 0.515
LIG_LIR_Gen_1 340 347 PF02991 0.381
LIG_LIR_Gen_1 4 13 PF02991 0.575
LIG_LIR_Nem_3 159 165 PF02991 0.304
LIG_LIR_Nem_3 175 181 PF02991 0.300
LIG_LIR_Nem_3 199 204 PF02991 0.319
LIG_LIR_Nem_3 226 230 PF02991 0.359
LIG_LIR_Nem_3 241 245 PF02991 0.272
LIG_LIR_Nem_3 249 254 PF02991 0.260
LIG_LIR_Nem_3 269 275 PF02991 0.254
LIG_LIR_Nem_3 294 298 PF02991 0.284
LIG_LIR_Nem_3 32 36 PF02991 0.496
LIG_LIR_Nem_3 4 8 PF02991 0.514
LIG_PCNA_yPIPBox_3 82 92 PF02747 0.498
LIG_PDZ_Class_2 390 395 PF00595 0.518
LIG_Pex14_1 161 165 PF04695 0.308
LIG_Pex14_1 178 182 PF04695 0.310
LIG_Pex14_1 247 251 PF04695 0.257
LIG_Pex14_1 33 37 PF04695 0.495
LIG_PTB_Apo_2 35 42 PF02174 0.582
LIG_PTB_Phospho_1 35 41 PF10480 0.578
LIG_SH2_CRK 111 115 PF00017 0.296
LIG_SH2_CRK 251 255 PF00017 0.284
LIG_SH2_GRB2like 242 245 PF00017 0.257
LIG_SH2_GRB2like 322 325 PF00017 0.278
LIG_SH2_NCK_1 111 115 PF00017 0.355
LIG_SH2_NCK_1 323 327 PF00017 0.307
LIG_SH2_NCK_1 49 53 PF00017 0.634
LIG_SH2_STAP1 279 283 PF00017 0.309
LIG_SH2_STAT5 155 158 PF00017 0.282
LIG_SH2_STAT5 162 165 PF00017 0.306
LIG_SH2_STAT5 318 321 PF00017 0.261
LIG_SH2_STAT5 328 331 PF00017 0.315
LIG_SH2_STAT5 55 58 PF00017 0.664
LIG_SH3_3 222 228 PF00018 0.312
LIG_SH3_3 51 57 PF00018 0.642
LIG_SUMO_SIM_par_1 311 316 PF11976 0.268
LIG_TRAF2_1 133 136 PF00917 0.345
LIG_TRAF2_1 172 175 PF00917 0.383
LIG_TRAF2_1 382 385 PF00917 0.347
LIG_TRFH_1 111 115 PF08558 0.418
MOD_CK1_1 121 127 PF00069 0.364
MOD_CK1_1 151 157 PF00069 0.287
MOD_CK2_1 130 136 PF00069 0.308
MOD_CK2_1 281 287 PF00069 0.354
MOD_CK2_1 78 84 PF00069 0.499
MOD_GlcNHglycan 150 153 PF01048 0.573
MOD_GlcNHglycan 331 336 PF01048 0.665
MOD_GSK3_1 121 128 PF00069 0.277
MOD_GSK3_1 230 237 PF00069 0.414
MOD_GSK3_1 74 81 PF00069 0.513
MOD_N-GLC_1 170 175 PF02516 0.539
MOD_N-GLC_1 281 286 PF02516 0.536
MOD_N-GLC_1 74 79 PF02516 0.423
MOD_NEK2_1 1 6 PF00069 0.562
MOD_NEK2_1 21 26 PF00069 0.567
MOD_NEK2_1 218 223 PF00069 0.277
MOD_NEK2_1 230 235 PF00069 0.318
MOD_NEK2_1 252 257 PF00069 0.289
MOD_PIKK_1 170 176 PF00454 0.340
MOD_PIKK_1 21 27 PF00454 0.518
MOD_PIKK_1 252 258 PF00454 0.296
MOD_PIKK_1 368 374 PF00454 0.377
MOD_PIKK_1 62 68 PF00454 0.524
MOD_PIKK_1 78 84 PF00454 0.510
MOD_PKA_1 211 217 PF00069 0.294
MOD_PKA_2 211 217 PF00069 0.294
MOD_Plk_1 331 337 PF00069 0.469
MOD_Plk_4 151 157 PF00069 0.275
MOD_Plk_4 29 35 PF00069 0.561
MOD_ProDKin_1 53 59 PF00069 0.556
MOD_SUMO_rev_2 134 139 PF00179 0.356
MOD_SUMO_rev_2 305 310 PF00179 0.387
TRG_AP2beta_CARGO_1 202 211 PF09066 0.312
TRG_DiLeu_BaEn_1 84 89 PF01217 0.477
TRG_DiLeu_BaLyEn_6 225 230 PF01217 0.455
TRG_ENDOCYTIC_2 111 114 PF00928 0.412
TRG_ENDOCYTIC_2 162 165 PF00928 0.350
TRG_ENDOCYTIC_2 201 204 PF00928 0.316
TRG_ENDOCYTIC_2 242 245 PF00928 0.265
TRG_ENDOCYTIC_2 251 254 PF00928 0.264
TRG_ENDOCYTIC_2 295 298 PF00928 0.284
TRG_ER_diArg_1 187 189 PF00400 0.361
TRG_ER_diArg_1 210 212 PF00400 0.309
TRG_ER_diArg_1 272 274 PF00400 0.261
TRG_ER_diArg_1 353 355 PF00400 0.374
TRG_Pf-PMV_PEXEL_1 354 359 PF00026 0.579

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIK3 Leptomonas seymouri 83% 100%
A0A0S4J380 Bodo saltans 64% 100%
A0A1X0NI33 Trypanosomatidae 73% 100%
A0A3R7KN89 Trypanosoma rangeli 73% 100%
A0A3S7WWT0 Leishmania donovani 99% 100%
A4HC05 Leishmania braziliensis 92% 100%
D0A125 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 100%
E9AVE2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QC37 Leishmania major 98% 100%
V5DIA8 Trypanosoma cruzi 70% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS