LeishMANIAdb
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GST_C_6 domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GST_C_6 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZF6_LEIIN
TriTrypDb:
LINF_210024500 *
Length:
451

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 19 (POMP19) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZF6

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 1
GO:0006626 protein targeting to mitochondrion 5 1
GO:0006810 transport 3 1
GO:0006839 mitochondrial transport 4 1
GO:0006886 intracellular protein transport 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070585 protein localization to mitochondrion 6 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072655 establishment of protein localization to mitochondrion 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.376
CLV_C14_Caspase3-7 302 306 PF00656 0.539
CLV_NRD_NRD_1 161 163 PF00675 0.447
CLV_NRD_NRD_1 211 213 PF00675 0.368
CLV_NRD_NRD_1 279 281 PF00675 0.410
CLV_NRD_NRD_1 332 334 PF00675 0.397
CLV_NRD_NRD_1 349 351 PF00675 0.339
CLV_PCSK_KEX2_1 161 163 PF00082 0.554
CLV_PCSK_KEX2_1 211 213 PF00082 0.384
CLV_PCSK_KEX2_1 332 334 PF00082 0.397
CLV_PCSK_KEX2_1 349 351 PF00082 0.339
CLV_PCSK_SKI1_1 217 221 PF00082 0.291
CLV_PCSK_SKI1_1 281 285 PF00082 0.427
CLV_PCSK_SKI1_1 350 354 PF00082 0.433
CLV_Separin_Metazoa 248 252 PF03568 0.584
DEG_APCC_DBOX_1 31 39 PF00400 0.377
DEG_SPOP_SBC_1 138 142 PF00917 0.458
DOC_CKS1_1 31 36 PF01111 0.380
DOC_MAPK_MEF2A_6 119 127 PF00069 0.316
DOC_MAPK_MEF2A_6 40 49 PF00069 0.392
DOC_PP2B_LxvP_1 90 93 PF13499 0.297
DOC_USP7_MATH_1 129 133 PF00917 0.401
DOC_USP7_MATH_1 138 142 PF00917 0.445
DOC_USP7_MATH_1 171 175 PF00917 0.409
DOC_USP7_MATH_1 310 314 PF00917 0.456
DOC_WW_Pin1_4 125 130 PF00397 0.391
DOC_WW_Pin1_4 30 35 PF00397 0.404
DOC_WW_Pin1_4 442 447 PF00397 0.482
DOC_WW_Pin1_4 58 63 PF00397 0.373
DOC_WW_Pin1_4 71 76 PF00397 0.324
LIG_14-3-3_CanoR_1 211 215 PF00244 0.604
LIG_14-3-3_CanoR_1 22 31 PF00244 0.381
LIG_14-3-3_CanoR_1 251 257 PF00244 0.570
LIG_14-3-3_CanoR_1 280 288 PF00244 0.657
LIG_14-3-3_CanoR_1 50 56 PF00244 0.350
LIG_AP_GAE_1 166 172 PF02883 0.347
LIG_BIR_III_2 170 174 PF00653 0.357
LIG_BIR_III_2 336 340 PF00653 0.591
LIG_BRCT_BRCA1_1 3 7 PF00533 0.325
LIG_BRCT_BRCA1_1 400 404 PF00533 0.448
LIG_BRCT_BRCA1_1 51 55 PF00533 0.375
LIG_EH_1 236 240 PF12763 0.599
LIG_FHA_1 357 363 PF00498 0.668
LIG_FHA_2 112 118 PF00498 0.376
LIG_FHA_2 197 203 PF00498 0.368
LIG_FHA_2 218 224 PF00498 0.462
LIG_FHA_2 300 306 PF00498 0.550
LIG_IRF3_LxIS_1 123 128 PF10401 0.349
LIG_LIR_Gen_1 166 177 PF02991 0.405
LIG_LIR_Gen_1 220 229 PF02991 0.499
LIG_LIR_Gen_1 270 279 PF02991 0.569
LIG_LIR_Gen_1 396 407 PF02991 0.293
LIG_LIR_Gen_1 61 67 PF02991 0.352
LIG_LIR_Nem_3 166 172 PF02991 0.404
LIG_LIR_Nem_3 270 276 PF02991 0.567
LIG_LIR_Nem_3 392 398 PF02991 0.316
LIG_LIR_Nem_3 401 407 PF02991 0.226
LIG_LIR_Nem_3 61 66 PF02991 0.501
LIG_LIR_Nem_3 81 86 PF02991 0.309
LIG_MLH1_MIPbox_1 400 404 PF16413 0.448
LIG_NRBOX 411 417 PF00104 0.525
LIG_Pex14_1 395 399 PF04695 0.364
LIG_Pex14_2 197 201 PF04695 0.404
LIG_PTB_Apo_2 234 241 PF02174 0.604
LIG_Rb_LxCxE_1 103 122 PF01857 0.257
LIG_SH2_NCK_1 113 117 PF00017 0.374
LIG_SH2_NCK_1 309 313 PF00017 0.464
LIG_SH2_SRC 303 306 PF00017 0.533
LIG_SH2_SRC 344 347 PF00017 0.549
LIG_SH2_STAT5 113 116 PF00017 0.373
LIG_SH2_STAT5 198 201 PF00017 0.547
LIG_SH2_STAT5 303 306 PF00017 0.508
LIG_SH2_STAT5 344 347 PF00017 0.490
LIG_SH2_STAT5 360 363 PF00017 0.566
LIG_SH2_STAT5 403 406 PF00017 0.327
LIG_SH3_3 28 34 PF00018 0.394
LIG_SUMO_SIM_par_1 410 417 PF11976 0.499
LIG_TRAF2_1 419 422 PF00917 0.325
LIG_TRFH_1 360 364 PF08558 0.646
LIG_WRC_WIRS_1 218 223 PF05994 0.582
MOD_CDK_SPxxK_3 33 40 PF00069 0.375
MOD_CK1_1 132 138 PF00069 0.444
MOD_CK1_1 141 147 PF00069 0.438
MOD_CK1_1 255 261 PF00069 0.583
MOD_CK1_1 299 305 PF00069 0.569
MOD_CK1_1 36 42 PF00069 0.331
MOD_CK1_1 441 447 PF00069 0.559
MOD_CK1_1 61 67 PF00069 0.510
MOD_CK1_1 70 76 PF00069 0.433
MOD_CK2_1 217 223 PF00069 0.584
MOD_GlcNHglycan 134 137 PF01048 0.679
MOD_GlcNHglycan 143 146 PF01048 0.696
MOD_GlcNHglycan 166 169 PF01048 0.549
MOD_GlcNHglycan 241 244 PF01048 0.428
MOD_GlcNHglycan 284 287 PF01048 0.397
MOD_GlcNHglycan 3 6 PF01048 0.529
MOD_GlcNHglycan 356 359 PF01048 0.396
MOD_GlcNHglycan 386 389 PF01048 0.472
MOD_GlcNHglycan 447 450 PF01048 0.753
MOD_GlcNHglycan 56 59 PF01048 0.713
MOD_GSK3_1 121 128 PF00069 0.317
MOD_GSK3_1 137 144 PF00069 0.356
MOD_GSK3_1 172 179 PF00069 0.320
MOD_GSK3_1 275 282 PF00069 0.553
MOD_GSK3_1 295 302 PF00069 0.601
MOD_GSK3_1 389 396 PF00069 0.460
MOD_GSK3_1 438 445 PF00069 0.525
MOD_GSK3_1 54 61 PF00069 0.367
MOD_GSK3_1 62 69 PF00069 0.458
MOD_NEK2_1 1 6 PF00069 0.342
MOD_NEK2_1 123 128 PF00069 0.395
MOD_NEK2_1 196 201 PF00069 0.408
MOD_NEK2_1 225 230 PF00069 0.489
MOD_NEK2_1 239 244 PF00069 0.555
MOD_NEK2_1 254 259 PF00069 0.599
MOD_NEK2_1 279 284 PF00069 0.551
MOD_NEK2_1 295 300 PF00069 0.551
MOD_NEK2_1 393 398 PF00069 0.334
MOD_OFUCOSY 153 159 PF10250 0.441
MOD_PIKK_1 438 444 PF00454 0.537
MOD_PKA_2 111 117 PF00069 0.375
MOD_PKA_2 210 216 PF00069 0.603
MOD_PKA_2 225 231 PF00069 0.529
MOD_PKA_2 279 285 PF00069 0.632
MOD_PKA_2 299 305 PF00069 0.586
MOD_PKA_2 39 45 PF00069 0.397
MOD_PKA_2 49 55 PF00069 0.335
MOD_Plk_1 121 127 PF00069 0.412
MOD_Plk_2-3 420 426 PF00069 0.424
MOD_Plk_4 101 107 PF00069 0.339
MOD_Plk_4 217 223 PF00069 0.527
MOD_Plk_4 299 305 PF00069 0.521
MOD_Plk_4 311 317 PF00069 0.434
MOD_Plk_4 389 395 PF00069 0.512
MOD_Plk_4 398 404 PF00069 0.407
MOD_Plk_4 62 68 PF00069 0.513
MOD_Plk_4 78 84 PF00069 0.340
MOD_ProDKin_1 125 131 PF00069 0.396
MOD_ProDKin_1 30 36 PF00069 0.403
MOD_ProDKin_1 442 448 PF00069 0.482
MOD_ProDKin_1 58 64 PF00069 0.374
MOD_ProDKin_1 71 77 PF00069 0.322
MOD_SUMO_for_1 148 151 PF00179 0.414
MOD_SUMO_rev_2 213 219 PF00179 0.559
TRG_AP2beta_CARGO_1 270 280 PF09066 0.598
TRG_ENDOCYTIC_2 198 201 PF00928 0.543
TRG_ENDOCYTIC_2 403 406 PF00928 0.307
TRG_ER_diArg_1 160 162 PF00400 0.246
TRG_ER_diArg_1 210 212 PF00400 0.574
TRG_ER_diArg_1 332 334 PF00400 0.597
TRG_ER_diArg_1 348 350 PF00400 0.530
TRG_Pf-PMV_PEXEL_1 161 166 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2X3 Leptomonas seymouri 53% 100%
A0A1X0NHP3 Trypanosomatidae 38% 100%
A0A3R7N7N1 Trypanosoma rangeli 35% 100%
A0A3S7WWQ5 Leishmania donovani 100% 100%
A4HC06 Leishmania braziliensis 77% 100%
D0A124 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9AVE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QC36 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS