Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peroxidase - putative

Species:

Leishmania infantum

UniProt:

A4HZF3_LEIIN

TriTrypDb:

LINF_210025100

Length:

341

Annotations

Annotations by Jardim et al.

Redox homeostasis, peroxidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HZF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZF3

PDB structure(s): 5via_A

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	17
GO:0006979	response to oxidative stress	3	17
GO:0009987	cellular process	1	17
GO:0033554	cellular response to stress	3	17
GO:0034599	cellular response to oxidative stress	4	17
GO:0042221	response to chemical	2	17
GO:0050896	response to stimulus	1	17
GO:0051716	cellular response to stimulus	2	17
GO:0062197	cellular response to chemical stress	4	17
GO:0070887	cellular response to chemical stimulus	3	17
GO:0000302	response to reactive oxygen species	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0010941	regulation of cell death	4	1
GO:0030322	stabilization of membrane potential	4	1
GO:0042391	regulation of membrane potential	3	1
GO:0042592	homeostatic process	3	1
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0042981	regulation of apoptotic process	6	1
GO:0043066	negative regulation of apoptotic process	7	1
GO:0043067	regulation of programmed cell death	5	1
GO:0043069	negative regulation of programmed cell death	6	1
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048878	chemical homeostasis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0060548	negative regulation of cell death	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0072593	reactive oxygen species metabolic process	3	2
GO:0098771	inorganic ion homeostasis	6	1
GO:1901700	response to oxygen-containing compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004601	peroxidase activity	2	17
GO:0005488	binding	1	17
GO:0016209	antioxidant activity	1	17
GO:0016491	oxidoreductase activity	2	17
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	17
GO:0020037	heme binding	4	17
GO:0046906	tetrapyrrole binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:1901363	heterocyclic compound binding	2	17
GO:0004129	cytochrome-c oxidase activity	4	1
GO:0004447	iodide peroxidase activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008447	L-ascorbate oxidase activity	5	1
GO:0009055	electron transfer activity	3	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3	1
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	1
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	4	1
GO:0016688	L-ascorbate peroxidase activity	3	3
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0140905	haloperoxidase activity	3	1
GO:0140906	halogenase activity	4	1
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.470
CLV_NRD_NRD_1	94	96	PF00675	0.445
CLV_PCSK_KEX2_1	170	172	PF00082	0.496
CLV_PCSK_KEX2_1	226	228	PF00082	0.489
CLV_PCSK_KEX2_1	281	283	PF00082	0.412
CLV_PCSK_KEX2_1	330	332	PF00082	0.516
CLV_PCSK_KEX2_1	94	96	PF00082	0.452
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.504
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.474
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.412
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.516
CLV_PCSK_SKI1_1	227	231	PF00082	0.423
CLV_PCSK_SKI1_1	86	90	PF00082	0.432
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DEG_SPOP_SBC_1	128	132	PF00917	0.197
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.313
DOC_PP4_FxxP_1	182	185	PF00568	0.197
DOC_PP4_FxxP_1	2	5	PF00568	0.615
DOC_USP7_MATH_1	128	132	PF00917	0.337
DOC_USP7_MATH_1	20	24	PF00917	0.582
DOC_USP7_MATH_1	204	208	PF00917	0.225
DOC_USP7_MATH_1	81	85	PF00917	0.281
DOC_USP7_UBL2_3	274	278	PF12436	0.229
DOC_USP7_UBL2_3	56	60	PF12436	0.356
LIG_14-3-3_CanoR_1	333	338	PF00244	0.330
LIG_APCC_ABBA_1	332	337	PF00400	0.385
LIG_deltaCOP1_diTrp_1	156	160	PF00928	0.206
LIG_deltaCOP1_diTrp_1	309	317	PF00928	0.265
LIG_FHA_1	130	136	PF00498	0.273
LIG_FHA_1	28	34	PF00498	0.420
LIG_FHA_1	320	326	PF00498	0.260
LIG_FHA_1	85	91	PF00498	0.334
LIG_FHA_2	100	106	PF00498	0.293
LIG_FHA_2	193	199	PF00498	0.232
LIG_FHA_2	296	302	PF00498	0.298
LIG_IBAR_NPY_1	19	21	PF08397	0.604
LIG_LIR_Gen_1	23	32	PF02991	0.526
LIG_LIR_Gen_1	319	329	PF02991	0.245
LIG_LIR_Nem_3	242	248	PF02991	0.247
LIG_LIR_Nem_3	298	302	PF02991	0.238
LIG_LIR_Nem_3	30	34	PF02991	0.292
LIG_LIR_Nem_3	326	332	PF02991	0.273
LIG_Pex14_1	313	317	PF04695	0.252
LIG_Pex14_2	317	321	PF04695	0.262
LIG_PTB_Apo_2	145	152	PF02174	0.300
LIG_PTB_Apo_2	228	235	PF02174	0.247
LIG_PTB_Phospho_1	145	151	PF10480	0.300
LIG_PTB_Phospho_1	228	234	PF10480	0.233
LIG_SH2_CRK	235	239	PF00017	0.219
LIG_SH2_GRB2like	146	149	PF00017	0.300
LIG_SH2_NCK_1	335	339	PF00017	0.393
LIG_SH2_SRC	146	149	PF00017	0.300
LIG_SH2_STAP1	151	155	PF00017	0.368
LIG_SH2_STAT5	122	125	PF00017	0.313
LIG_SH2_STAT5	146	149	PF00017	0.311
LIG_SH2_STAT5	228	231	PF00017	0.273
LIG_SH2_STAT5	270	273	PF00017	0.276
LIG_SH3_1	171	177	PF00018	0.326
LIG_SH3_3	171	177	PF00018	0.286
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.245
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.272
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.257
LIG_TRAF2_1	308	311	PF00917	0.376
MOD_CK1_1	183	189	PF00069	0.300
MOD_CK1_1	319	325	PF00069	0.248
MOD_CK1_1	84	90	PF00069	0.337
MOD_CK2_1	127	133	PF00069	0.347
MOD_CK2_1	192	198	PF00069	0.232
MOD_CK2_1	204	210	PF00069	0.258
MOD_CK2_1	213	219	PF00069	0.258
MOD_CK2_1	295	301	PF00069	0.346
MOD_CK2_1	99	105	PF00069	0.274
MOD_Cter_Amidation	10	13	PF01082	0.486
MOD_Cter_Amidation	224	227	PF01082	0.513
MOD_GlcNHglycan	213	218	PF01048	0.439
MOD_GlcNHglycan	318	321	PF01048	0.459
MOD_GlcNHglycan	68	71	PF01048	0.558
MOD_GSK3_1	123	130	PF00069	0.289
MOD_GSK3_1	246	253	PF00069	0.364
MOD_GSK3_1	333	340	PF00069	0.331
MOD_GSK3_1	80	87	PF00069	0.381
MOD_GSK3_1	99	106	PF00069	0.223
MOD_N-GLC_1	162	167	PF02516	0.404
MOD_N-GLC_1	27	32	PF02516	0.314
MOD_N-GLC_1	295	300	PF02516	0.429
MOD_NEK2_1	123	128	PF00069	0.331
MOD_NEK2_1	27	32	PF00069	0.489
MOD_NEK2_1	324	329	PF00069	0.271
MOD_NEK2_1	80	85	PF00069	0.288
MOD_NEK2_2	81	86	PF00069	0.269
MOD_PIKK_1	250	256	PF00454	0.317
MOD_PK_1	180	186	PF00069	0.294
MOD_PKA_1	12	18	PF00069	0.637
MOD_PKB_1	331	339	PF00069	0.393
MOD_Plk_1	27	33	PF00069	0.420
MOD_Plk_1	295	301	PF00069	0.244
MOD_Plk_4	183	189	PF00069	0.206
MOD_Plk_4	27	33	PF00069	0.543
MOD_SUMO_rev_2	176	182	PF00179	0.159
MOD_SUMO_rev_2	51	57	PF00179	0.426
TRG_DiLeu_BaEn_1	198	203	PF01217	0.229
TRG_ENDOCYTIC_2	151	154	PF00928	0.311
TRG_ENDOCYTIC_2	234	237	PF00928	0.209
TRG_ER_diArg_1	331	334	PF00400	0.330
TRG_NLS_MonoExtC_3	329	334	PF00514	0.336
TRG_NLS_MonoExtN_4	278	284	PF00514	0.237
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y9	Leptomonas seymouri	80%	84%
A0A0N0P6I0	Leptomonas seymouri	26%	100%
A0A0S4JPM4	Bodo saltans	47%	68%
A0A1X0NHV6	Trypanosomatidae	55%	93%
A0A3S7WWR4	Leishmania donovani	100%	100%
A0A422N895	Trypanosoma rangeli	55%	90%
A4HAD2	Leishmania braziliensis	24%	95%
A4HC12	Leishmania braziliensis	88%	100%
A4I9H5	Leishmania infantum	25%	100%
D0A114	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	91%
E9AVE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B4H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
H6V7N3	Leishmania donovani	25%	100%
Q4Q3K2	Leishmania major	25%	100%
Q4QC30	Leishmania major	94%	100%
Q6CW24	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	99%
Q9FE01	Oryza sativa subsp. japonica	24%	100%
V5BHD3	Trypanosoma cruzi	55%	100%
V5BM56	Trypanosoma cruzi	25%	100%