Vitamin B6 photo-protection and homoeostasis-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis - putative

Species:

Leishmania infantum

UniProt:

A4HZF0_LEIIN

TriTrypDb:

LINF_210023900

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HZF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.732
CLV_C14_Caspase3-7	583	587	PF00656	0.726
CLV_C14_Caspase3-7	627	631	PF00656	0.813
CLV_NRD_NRD_1	309	311	PF00675	0.508
CLV_NRD_NRD_1	360	362	PF00675	0.435
CLV_NRD_NRD_1	391	393	PF00675	0.438
CLV_NRD_NRD_1	465	467	PF00675	0.562
CLV_NRD_NRD_1	495	497	PF00675	0.499
CLV_NRD_NRD_1	542	544	PF00675	0.528
CLV_NRD_NRD_1	566	568	PF00675	0.380
CLV_NRD_NRD_1	614	616	PF00675	0.508
CLV_NRD_NRD_1	62	64	PF00675	0.341
CLV_NRD_NRD_1	622	624	PF00675	0.540
CLV_PCSK_FUR_1	540	544	PF00082	0.522
CLV_PCSK_KEX2_1	360	362	PF00082	0.435
CLV_PCSK_KEX2_1	391	393	PF00082	0.428
CLV_PCSK_KEX2_1	441	443	PF00082	0.461
CLV_PCSK_KEX2_1	495	497	PF00082	0.513
CLV_PCSK_KEX2_1	542	544	PF00082	0.528
CLV_PCSK_KEX2_1	566	568	PF00082	0.424
CLV_PCSK_KEX2_1	61	63	PF00082	0.341
CLV_PCSK_KEX2_1	614	616	PF00082	0.538
CLV_PCSK_KEX2_1	622	624	PF00082	0.525
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.461
CLV_PCSK_PC7_1	58	64	PF00082	0.410
CLV_PCSK_SKI1_1	108	112	PF00082	0.305
CLV_PCSK_SKI1_1	188	192	PF00082	0.410
CLV_PCSK_SKI1_1	228	232	PF00082	0.314
CLV_PCSK_SKI1_1	511	515	PF00082	0.452
CLV_PCSK_SKI1_1	551	555	PF00082	0.563
CLV_PCSK_SKI1_1	63	67	PF00082	0.401
CLV_PCSK_SKI1_1	70	74	PF00082	0.320
CLV_PCSK_SKI1_1	99	103	PF00082	0.372
DEG_APCC_DBOX_1	107	115	PF00400	0.542
DEG_COP1_1	426	436	PF00400	0.605
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DEG_SCF_TRCP1_1	205	211	PF00400	0.476
DEG_SCF_TRCP1_1	312	317	PF00400	0.750
DOC_CDC14_PxL_1	335	343	PF14671	0.651
DOC_CKS1_1	45	50	PF01111	0.814
DOC_CYCLIN_RxL_1	331	340	PF00134	0.702
DOC_CYCLIN_RxL_1	67	75	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.542
DOC_MAPK_gen_1	310	318	PF00069	0.743
DOC_MAPK_gen_1	506	514	PF00069	0.681
DOC_MAPK_MEF2A_6	108	116	PF00069	0.542
DOC_MAPK_RevD_3	428	442	PF00069	0.740
DOC_PP1_RVXF_1	288	294	PF00149	0.542
DOC_PP1_RVXF_1	369	375	PF00149	0.553
DOC_PP1_RVXF_1	509	515	PF00149	0.654
DOC_PP2B_LxvP_1	175	178	PF13499	0.531
DOC_PP2B_LxvP_1	286	289	PF13499	0.542
DOC_PP2B_LxvP_1	336	339	PF13499	0.649
DOC_USP7_MATH_1	230	234	PF00917	0.580
DOC_USP7_MATH_1	252	256	PF00917	0.410
DOC_USP7_MATH_1	264	268	PF00917	0.309
DOC_USP7_MATH_1	347	351	PF00917	0.675
DOC_USP7_MATH_1	403	407	PF00917	0.641
DOC_USP7_MATH_1	582	586	PF00917	0.781
DOC_USP7_MATH_1	633	637	PF00917	0.790
DOC_WW_Pin1_4	322	327	PF00397	0.671
DOC_WW_Pin1_4	41	46	PF00397	0.763
DOC_WW_Pin1_4	47	52	PF00397	0.765
DOC_WW_Pin1_4	472	477	PF00397	0.793
DOC_WW_Pin1_4	590	595	PF00397	0.725
DOC_WW_Pin1_4	599	604	PF00397	0.618
LIG_14-3-3_CanoR_1	155	160	PF00244	0.542
LIG_14-3-3_CanoR_1	209	213	PF00244	0.542
LIG_14-3-3_CanoR_1	232	236	PF00244	0.572
LIG_14-3-3_CanoR_1	62	72	PF00244	0.610
LIG_BRCT_BRCA1_1	140	144	PF00533	0.542
LIG_BRCT_BRCA1_1	347	351	PF00533	0.721
LIG_CSL_BTD_1	178	181	PF09270	0.610
LIG_CSL_BTD_1	436	439	PF09270	0.609
LIG_FHA_1	100	106	PF00498	0.380
LIG_FHA_1	134	140	PF00498	0.531
LIG_FHA_1	156	162	PF00498	0.610
LIG_FHA_1	164	170	PF00498	0.518
LIG_FHA_1	23	29	PF00498	0.721
LIG_FHA_1	365	371	PF00498	0.653
LIG_FHA_1	417	423	PF00498	0.666
LIG_FHA_1	548	554	PF00498	0.615
LIG_FHA_1	605	611	PF00498	0.775
LIG_FHA_1	667	673	PF00498	0.694
LIG_FHA_1	80	86	PF00498	0.542
LIG_FHA_2	447	453	PF00498	0.677
LIG_FHA_2	64	70	PF00498	0.610
LIG_FHA_2	652	658	PF00498	0.672
LIG_GBD_Chelix_1	64	72	PF00786	0.372
LIG_LIR_Gen_1	141	152	PF02991	0.515
LIG_LIR_Gen_1	158	165	PF02991	0.595
LIG_LIR_Gen_1	296	306	PF02991	0.604
LIG_LIR_Gen_1	350	359	PF02991	0.708
LIG_LIR_Gen_1	419	428	PF02991	0.618
LIG_LIR_Gen_1	666	675	PF02991	0.699
LIG_LIR_Nem_3	141	147	PF02991	0.542
LIG_LIR_Nem_3	158	162	PF02991	0.542
LIG_LIR_Nem_3	185	190	PF02991	0.534
LIG_LIR_Nem_3	237	241	PF02991	0.449
LIG_LIR_Nem_3	267	272	PF02991	0.379
LIG_LIR_Nem_3	296	301	PF02991	0.580
LIG_LIR_Nem_3	350	355	PF02991	0.655
LIG_LIR_Nem_3	377	382	PF02991	0.612
LIG_LIR_Nem_3	417	423	PF02991	0.597
LIG_LIR_Nem_3	426	430	PF02991	0.631
LIG_LIR_Nem_3	435	440	PF02991	0.556
LIG_LIR_Nem_3	666	671	PF02991	0.683
LIG_MAD2	70	78	PF02301	0.572
LIG_NRBOX	657	663	PF00104	0.629
LIG_Pex14_1	527	531	PF04695	0.569
LIG_Pex14_2	212	216	PF04695	0.542
LIG_Pex14_2	374	378	PF04695	0.548
LIG_PTB_Apo_2	662	669	PF02174	0.667
LIG_PTB_Phospho_1	662	668	PF10480	0.662
LIG_REV1ctd_RIR_1	376	384	PF16727	0.564
LIG_RPA_C_Fungi	56	68	PF08784	0.314
LIG_SH2_CRK	249	253	PF00017	0.314
LIG_SH2_CRK	275	279	PF00017	0.406
LIG_SH2_CRK	352	356	PF00017	0.634
LIG_SH2_CRK	362	366	PF00017	0.657
LIG_SH2_CRK	536	540	PF00017	0.599
LIG_SH2_CRK	668	672	PF00017	0.612
LIG_SH2_NCK_1	249	253	PF00017	0.314
LIG_SH2_NCK_1	352	356	PF00017	0.499
LIG_SH2_PTP2	421	424	PF00017	0.576
LIG_SH2_STAP1	352	356	PF00017	0.499
LIG_SH2_STAP1	668	672	PF00017	0.573
LIG_SH2_STAT3	440	443	PF00017	0.528
LIG_SH2_STAT5	362	365	PF00017	0.575
LIG_SH2_STAT5	421	424	PF00017	0.512
LIG_SH2_STAT5	427	430	PF00017	0.548
LIG_SH2_STAT5	5	8	PF00017	0.693
LIG_SH2_STAT5	529	532	PF00017	0.450
LIG_SH2_STAT5	668	671	PF00017	0.612
LIG_SH3_3	175	181	PF00018	0.406
LIG_SH3_3	341	347	PF00018	0.602
LIG_SH3_3	39	45	PF00018	0.800
LIG_SH3_3	419	425	PF00018	0.428
LIG_SH3_3	48	54	PF00018	0.648
LIG_SH3_3	509	515	PF00018	0.602
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.464
LIG_SUMO_SIM_anti_2	333	340	PF11976	0.549
LIG_SUMO_SIM_par_1	24	30	PF11976	0.464
LIG_SUMO_SIM_par_1	320	325	PF11976	0.514
LIG_SUMO_SIM_par_1	333	340	PF11976	0.540
LIG_TYR_ITIM	521	526	PF00017	0.469
LIG_WRC_WIRS_1	235	240	PF05994	0.449
MOD_CDK_SPK_2	322	327	PF00069	0.587
MOD_CK1_1	126	132	PF00069	0.361
MOD_CK1_1	234	240	PF00069	0.422
MOD_CK1_1	325	331	PF00069	0.570
MOD_CK1_1	44	50	PF00069	0.769
MOD_CK1_1	585	591	PF00069	0.787
MOD_CK1_1	602	608	PF00069	0.592
MOD_CK1_1	79	85	PF00069	0.503
MOD_CK2_1	446	452	PF00069	0.596
MOD_CK2_1	63	69	PF00069	0.503
MOD_CK2_1	651	657	PF00069	0.569
MOD_CK2_1	77	83	PF00069	0.276
MOD_Cter_Amidation	493	496	PF01082	0.653
MOD_GlcNHglycan	194	197	PF01048	0.400
MOD_GlcNHglycan	205	208	PF01048	0.269
MOD_GlcNHglycan	266	269	PF01048	0.368
MOD_GlcNHglycan	312	315	PF01048	0.699
MOD_GlcNHglycan	327	330	PF01048	0.322
MOD_GlcNHglycan	347	350	PF01048	0.363
MOD_GlcNHglycan	401	404	PF01048	0.519
MOD_GlcNHglycan	457	460	PF01048	0.578
MOD_GlcNHglycan	476	479	PF01048	0.652
MOD_GlcNHglycan	55	58	PF01048	0.736
MOD_GSK3_1	122	129	PF00069	0.406
MOD_GSK3_1	230	237	PF00069	0.385
MOD_GSK3_1	247	254	PF00069	0.331
MOD_GSK3_1	306	313	PF00069	0.650
MOD_GSK3_1	347	354	PF00069	0.669
MOD_GSK3_1	399	406	PF00069	0.553
MOD_GSK3_1	40	47	PF00069	0.717
MOD_GSK3_1	470	477	PF00069	0.717
MOD_GSK3_1	49	56	PF00069	0.688
MOD_GSK3_1	598	605	PF00069	0.512
MOD_GSK3_1	629	636	PF00069	0.739
MOD_GSK3_1	99	106	PF00069	0.419
MOD_N-GLC_1	559	564	PF02516	0.752
MOD_N-GLC_1	99	104	PF02516	0.503
MOD_NEK2_1	123	128	PF00069	0.375
MOD_NEK2_1	138	143	PF00069	0.461
MOD_NEK2_1	306	311	PF00069	0.624
MOD_NEK2_1	351	356	PF00069	0.642
MOD_NEK2_1	374	379	PF00069	0.425
MOD_NEK2_1	547	552	PF00069	0.556
MOD_NEK2_1	651	656	PF00069	0.581
MOD_NEK2_2	182	187	PF00069	0.394
MOD_NEK2_2	347	352	PF00069	0.682
MOD_NEK2_2	366	371	PF00069	0.376
MOD_PKA_1	310	316	PF00069	0.689
MOD_PKA_2	208	214	PF00069	0.392
MOD_PKA_2	231	237	PF00069	0.449
MOD_PKA_2	455	461	PF00069	0.666
MOD_PKA_2	651	657	PF00069	0.569
MOD_PKB_1	61	69	PF00069	0.449
MOD_Plk_1	416	422	PF00069	0.447
MOD_Plk_1	559	565	PF00069	0.749
MOD_Plk_2-3	426	432	PF00069	0.552
MOD_Plk_4	126	132	PF00069	0.406
MOD_Plk_4	138	144	PF00069	0.406
MOD_Plk_4	182	188	PF00069	0.433
MOD_Plk_4	234	240	PF00069	0.392
MOD_Plk_4	296	302	PF00069	0.514
MOD_Plk_4	314	320	PF00069	0.440
MOD_Plk_4	347	353	PF00069	0.671
MOD_Plk_4	374	380	PF00069	0.507
MOD_Plk_4	416	422	PF00069	0.494
MOD_Plk_4	667	673	PF00069	0.620
MOD_ProDKin_1	322	328	PF00069	0.583
MOD_ProDKin_1	41	47	PF00069	0.719
MOD_ProDKin_1	472	478	PF00069	0.759
MOD_ProDKin_1	590	596	PF00069	0.660
MOD_ProDKin_1	599	605	PF00069	0.511
TRG_DiLeu_BaEn_1	37	42	PF01217	0.778
TRG_DiLeu_BaEn_1	657	662	PF01217	0.531
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.516
TRG_ENDOCYTIC_2	275	278	PF00928	0.406
TRG_ENDOCYTIC_2	298	301	PF00928	0.553
TRG_ENDOCYTIC_2	352	355	PF00928	0.564
TRG_ENDOCYTIC_2	356	359	PF00928	0.526
TRG_ENDOCYTIC_2	420	423	PF00928	0.471
TRG_ENDOCYTIC_2	427	430	PF00928	0.573
TRG_ENDOCYTIC_2	523	526	PF00928	0.405
TRG_ENDOCYTIC_2	531	534	PF00928	0.367
TRG_ENDOCYTIC_2	536	539	PF00928	0.265
TRG_ENDOCYTIC_2	668	671	PF00928	0.612
TRG_ER_diArg_1	359	361	PF00400	0.520
TRG_ER_diArg_1	539	542	PF00400	0.570
TRG_ER_diArg_1	566	568	PF00400	0.460
TRG_ER_diArg_1	61	63	PF00400	0.411
TRG_ER_diArg_1	614	616	PF00400	0.673
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W6	Leptomonas seymouri	53%	98%
A0A3S7WWW0	Leishmania donovani	100%	100%
E9AVD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QC42	Leishmania major	88%	100%