HMG box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HZE9_LEIIN

TriTrypDb:

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.538
CLV_NRD_NRD_1	236	238	PF00675	0.566
CLV_NRD_NRD_1	75	77	PF00675	0.479
CLV_NRD_NRD_1	81	83	PF00675	0.435
CLV_PCSK_KEX2_1	148	150	PF00082	0.512
CLV_PCSK_KEX2_1	236	238	PF00082	0.566
CLV_PCSK_KEX2_1	266	268	PF00082	0.497
CLV_PCSK_KEX2_1	27	29	PF00082	0.748
CLV_PCSK_KEX2_1	77	79	PF00082	0.480
CLV_PCSK_KEX2_1	81	83	PF00082	0.447
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.512
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.497
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.564
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.460
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DOC_PP2B_LxvP_1	276	279	PF13499	0.533
DOC_USP7_MATH_1	107	111	PF00917	0.648
DOC_USP7_MATH_1	188	192	PF00917	0.674
DOC_USP7_MATH_1	207	211	PF00917	0.594
DOC_USP7_MATH_1	262	266	PF00917	0.543
DOC_USP7_MATH_1	59	63	PF00917	0.690
DOC_USP7_UBL2_3	234	238	PF12436	0.568
DOC_WW_Pin1_4	141	146	PF00397	0.540
DOC_WW_Pin1_4	210	215	PF00397	0.717
LIG_14-3-3_CanoR_1	221	227	PF00244	0.470
LIG_14-3-3_CanoR_1	249	258	PF00244	0.423
LIG_14-3-3_CanoR_1	51	60	PF00244	0.595
LIG_14-3-3_CanoR_1	81	91	PF00244	0.408
LIG_BIR_III_2	187	191	PF00653	0.662
LIG_FHA_2	110	116	PF00498	0.542
LIG_FHA_2	142	148	PF00498	0.466
LIG_LIR_Gen_1	139	146	PF02991	0.517
LIG_LIR_Gen_1	224	233	PF02991	0.422
LIG_LIR_Nem_3	224	229	PF02991	0.424
LIG_LIR_Nem_3	85	90	PF02991	0.430
LIG_SH2_NCK_1	259	263	PF00017	0.448
LIG_SH2_STAP1	151	155	PF00017	0.430
LIG_SH2_STAP1	259	263	PF00017	0.448
LIG_SH2_STAP1	87	91	PF00017	0.582
LIG_SH2_STAT5	90	93	PF00017	0.459
LIG_SH3_1	77	83	PF00018	0.446
LIG_SH3_3	189	195	PF00018	0.681
LIG_SH3_3	77	83	PF00018	0.426
LIG_TRAF2_1	252	255	PF00917	0.519
MOD_CDK_SPxxK_3	141	148	PF00069	0.468
MOD_CK1_1	157	163	PF00069	0.528
MOD_CK1_1	180	186	PF00069	0.515
MOD_CK1_1	210	216	PF00069	0.614
MOD_CK1_1	222	228	PF00069	0.391
MOD_CK1_1	265	271	PF00069	0.499
MOD_CK1_1	45	51	PF00069	0.631
MOD_CK1_1	62	68	PF00069	0.625
MOD_CK1_1	69	75	PF00069	0.548
MOD_CK2_1	141	147	PF00069	0.472
MOD_CK2_1	249	255	PF00069	0.427
MOD_CK2_1	51	57	PF00069	0.563
MOD_CK2_1	82	88	PF00069	0.458
MOD_Cter_Amidation	234	237	PF01082	0.567
MOD_Cter_Amidation	25	28	PF01082	0.584
MOD_GlcNHglycan	170	173	PF01048	0.592
MOD_GlcNHglycan	180	183	PF01048	0.754
MOD_GlcNHglycan	251	254	PF01048	0.446
MOD_GlcNHglycan	276	279	PF01048	0.724
MOD_GlcNHglycan	53	56	PF01048	0.568
MOD_GlcNHglycan	61	64	PF01048	0.652
MOD_GlcNHglycan	84	87	PF01048	0.398
MOD_GSK3_1	164	171	PF00069	0.552
MOD_GSK3_1	176	183	PF00069	0.538
MOD_GSK3_1	270	277	PF00069	0.528
MOD_GSK3_1	42	49	PF00069	0.634
MOD_GSK3_1	62	69	PF00069	0.556
MOD_N-GLC_1	249	254	PF02516	0.549
MOD_N-GLC_1	46	51	PF02516	0.724
MOD_NEK2_1	272	277	PF00069	0.483
MOD_NEK2_2	46	51	PF00069	0.602
MOD_PIKK_1	194	200	PF00454	0.567
MOD_PIKK_1	270	276	PF00454	0.590
MOD_PKA_2	208	214	PF00069	0.584
MOD_Plk_1	46	52	PF00069	0.650
MOD_Plk_4	136	142	PF00069	0.520
MOD_ProDKin_1	141	147	PF00069	0.541
MOD_ProDKin_1	210	216	PF00069	0.717
MOD_SUMO_rev_2	252	258	PF00179	0.520
TRG_ER_diArg_1	75	78	PF00400	0.483
TRG_ER_diArg_1	80	82	PF00400	0.429
TRG_NLS_MonoExtC_3	75	80	PF00514	0.443
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX4	Leptomonas seymouri	32%	94%
A0A3Q8IL79	Leishmania donovani	99%	100%
A4HC00	Leishmania braziliensis	60%	99%
E9AVD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QC43	Leishmania major	88%	100%