LeishMANIAdb
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N-acetyltransferase domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
N-acetyltransferase domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZE7_LEIIN
TriTrypDb:
LINF_210023600
Length:
544

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZE7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZE7

PDB structure(s): 7aih_Ah , 7am2_Ah , 7ane_Ah

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.345
CLV_C14_Caspase3-7 335 339 PF00656 0.475
CLV_C14_Caspase3-7 349 353 PF00656 0.448
CLV_NRD_NRD_1 187 189 PF00675 0.313
CLV_NRD_NRD_1 400 402 PF00675 0.372
CLV_NRD_NRD_1 445 447 PF00675 0.363
CLV_NRD_NRD_1 471 473 PF00675 0.505
CLV_NRD_NRD_1 499 501 PF00675 0.496
CLV_NRD_NRD_1 514 516 PF00675 0.306
CLV_PCSK_KEX2_1 187 189 PF00082 0.313
CLV_PCSK_KEX2_1 39 41 PF00082 0.440
CLV_PCSK_KEX2_1 400 402 PF00082 0.372
CLV_PCSK_KEX2_1 444 446 PF00082 0.359
CLV_PCSK_KEX2_1 471 473 PF00082 0.486
CLV_PCSK_KEX2_1 499 501 PF00082 0.496
CLV_PCSK_KEX2_1 5 7 PF00082 0.471
CLV_PCSK_KEX2_1 514 516 PF00082 0.306
CLV_PCSK_KEX2_1 524 526 PF00082 0.478
CLV_PCSK_PC1ET2_1 39 41 PF00082 0.485
CLV_PCSK_PC1ET2_1 444 446 PF00082 0.359
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.630
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.552
CLV_PCSK_PC7_1 495 501 PF00082 0.485
CLV_PCSK_SKI1_1 176 180 PF00082 0.313
CLV_PCSK_SKI1_1 289 293 PF00082 0.364
CLV_PCSK_SKI1_1 312 316 PF00082 0.290
CLV_PCSK_SKI1_1 33 37 PF00082 0.525
CLV_PCSK_SKI1_1 368 372 PF00082 0.367
CLV_PCSK_SKI1_1 386 390 PF00082 0.154
CLV_PCSK_SKI1_1 414 418 PF00082 0.422
CLV_PCSK_SKI1_1 427 431 PF00082 0.345
CLV_PCSK_SKI1_1 499 503 PF00082 0.504
CLV_PCSK_SKI1_1 525 529 PF00082 0.456
CLV_PCSK_SKI1_1 6 10 PF00082 0.472
DEG_APCC_DBOX_1 175 183 PF00400 0.290
DEG_Nend_Nbox_1 1 3 PF02207 0.447
DEG_ODPH_VHL_1 306 317 PF01847 0.390
DOC_ANK_TNKS_1 200 207 PF00023 0.336
DOC_CKS1_1 381 386 PF01111 0.353
DOC_CKS1_1 99 104 PF01111 0.299
DOC_CYCLIN_RxL_1 184 194 PF00134 0.384
DOC_MAPK_gen_1 134 144 PF00069 0.314
DOC_MAPK_gen_1 184 193 PF00069 0.321
DOC_MAPK_gen_1 5 11 PF00069 0.571
DOC_MIT_MIM_1 81 90 PF04212 0.444
DOC_PP1_RVXF_1 91 97 PF00149 0.300
DOC_PP4_FxxP_1 14 17 PF00568 0.380
DOC_PP4_FxxP_1 253 256 PF00568 0.329
DOC_PP4_FxxP_1 265 268 PF00568 0.384
DOC_PP4_FxxP_1 99 102 PF00568 0.290
DOC_USP7_MATH_1 280 284 PF00917 0.447
DOC_USP7_MATH_1 42 46 PF00917 0.501
DOC_USP7_MATH_1 453 457 PF00917 0.550
DOC_USP7_MATH_2 17 23 PF00917 0.471
DOC_USP7_UBL2_3 519 523 PF12436 0.579
DOC_USP7_UBL2_3 93 97 PF12436 0.367
DOC_WW_Pin1_4 264 269 PF00397 0.454
DOC_WW_Pin1_4 294 299 PF00397 0.406
DOC_WW_Pin1_4 380 385 PF00397 0.340
DOC_WW_Pin1_4 98 103 PF00397 0.306
LIG_14-3-3_CanoR_1 151 155 PF00244 0.448
LIG_14-3-3_CanoR_1 361 367 PF00244 0.345
LIG_14-3-3_CanoR_1 400 408 PF00244 0.367
LIG_14-3-3_CanoR_1 82 86 PF00244 0.429
LIG_Actin_WH2_2 280 296 PF00022 0.386
LIG_Actin_WH2_2 385 402 PF00022 0.362
LIG_APCC_ABBA_1 107 112 PF00400 0.298
LIG_APCC_ABBA_1 285 290 PF00400 0.376
LIG_BRCT_BRCA1_1 83 87 PF00533 0.350
LIG_Clathr_ClatBox_1 179 183 PF01394 0.287
LIG_deltaCOP1_diTrp_1 200 207 PF00928 0.301
LIG_FHA_1 387 393 PF00498 0.268
LIG_FHA_1 479 485 PF00498 0.671
LIG_FHA_1 90 96 PF00498 0.281
LIG_FHA_1 99 105 PF00498 0.281
LIG_FHA_2 231 237 PF00498 0.345
LIG_FHA_2 273 279 PF00498 0.382
LIG_FHA_2 415 421 PF00498 0.360
LIG_FHA_2 480 486 PF00498 0.537
LIG_IBAR_NPY_1 222 224 PF08397 0.364
LIG_LIR_Apic_2 252 256 PF02991 0.361
LIG_LIR_Apic_2 262 268 PF02991 0.358
LIG_LIR_Gen_1 258 268 PF02991 0.466
LIG_LIR_Gen_1 27 35 PF02991 0.393
LIG_LIR_Gen_1 332 340 PF02991 0.355
LIG_LIR_Gen_1 526 536 PF02991 0.458
LIG_LIR_Nem_3 136 142 PF02991 0.385
LIG_LIR_Nem_3 200 205 PF02991 0.324
LIG_LIR_Nem_3 248 253 PF02991 0.344
LIG_LIR_Nem_3 258 264 PF02991 0.354
LIG_LIR_Nem_3 27 31 PF02991 0.391
LIG_LIR_Nem_3 332 336 PF02991 0.327
LIG_LIR_Nem_3 428 433 PF02991 0.313
LIG_LIR_Nem_3 526 531 PF02991 0.448
LIG_LIR_Nem_3 84 90 PF02991 0.335
LIG_NRBOX 461 467 PF00104 0.440
LIG_Pex14_1 448 452 PF04695 0.383
LIG_Pex14_1 65 69 PF04695 0.399
LIG_Pex14_2 261 265 PF04695 0.364
LIG_PTB_Apo_2 535 542 PF02174 0.482
LIG_PTB_Phospho_1 535 541 PF10480 0.478
LIG_REV1ctd_RIR_1 368 378 PF16727 0.442
LIG_SH2_CRK 28 32 PF00017 0.410
LIG_SH2_PTP2 224 227 PF00017 0.394
LIG_SH2_SRC 224 227 PF00017 0.375
LIG_SH2_STAT3 69 72 PF00017 0.442
LIG_SH2_STAT5 132 135 PF00017 0.422
LIG_SH2_STAT5 197 200 PF00017 0.289
LIG_SH2_STAT5 215 218 PF00017 0.343
LIG_SH2_STAT5 224 227 PF00017 0.338
LIG_SH2_STAT5 316 319 PF00017 0.273
LIG_SH2_STAT5 382 385 PF00017 0.337
LIG_SH2_STAT5 395 398 PF00017 0.284
LIG_SH2_STAT5 46 49 PF00017 0.540
LIG_SH2_STAT5 464 467 PF00017 0.469
LIG_SUMO_SIM_anti_2 233 239 PF11976 0.490
LIG_TRAF2_1 260 263 PF00917 0.494
LIG_TRAF2_1 332 335 PF00917 0.380
LIG_TRAF2_1 456 459 PF00917 0.442
LIG_TRFH_1 28 32 PF08558 0.487
LIG_TYR_ITIM 431 436 PF00017 0.328
LIG_WRPW_2 66 69 PF00400 0.470
MOD_CDK_SPxK_1 380 386 PF00069 0.371
MOD_CK1_1 269 275 PF00069 0.444
MOD_CK1_1 55 61 PF00069 0.445
MOD_CK2_1 329 335 PF00069 0.416
MOD_CK2_1 414 420 PF00069 0.368
MOD_CK2_1 453 459 PF00069 0.542
MOD_CK2_1 479 485 PF00069 0.549
MOD_CMANNOS 199 202 PF00535 0.308
MOD_Cter_Amidation 37 40 PF01082 0.456
MOD_Cter_Amidation 469 472 PF01082 0.473
MOD_GlcNHglycan 2 5 PF01048 0.578
MOD_GlcNHglycan 317 320 PF01048 0.293
MOD_GlcNHglycan 362 365 PF01048 0.359
MOD_GSK3_1 165 172 PF00069 0.341
MOD_GSK3_1 453 460 PF00069 0.590
MOD_GSK3_1 519 526 PF00069 0.511
MOD_N-GLC_1 49 54 PF02516 0.488
MOD_NEK2_1 169 174 PF00069 0.337
MOD_NEK2_1 315 320 PF00069 0.354
MOD_NEK2_1 357 362 PF00069 0.323
MOD_PIKK_1 169 175 PF00454 0.342
MOD_PK_1 523 529 PF00069 0.532
MOD_PKA_1 33 39 PF00069 0.451
MOD_PKA_1 523 529 PF00069 0.532
MOD_PKA_2 133 139 PF00069 0.388
MOD_PKA_2 150 156 PF00069 0.442
MOD_PKA_2 360 366 PF00069 0.345
MOD_PKA_2 513 519 PF00069 0.554
MOD_PKA_2 81 87 PF00069 0.429
MOD_Plk_1 110 116 PF00069 0.313
MOD_Plk_1 149 155 PF00069 0.356
MOD_Plk_1 457 463 PF00069 0.440
MOD_Plk_1 55 61 PF00069 0.459
MOD_Plk_2-3 458 464 PF00069 0.440
MOD_Plk_4 165 171 PF00069 0.353
MOD_Plk_4 280 286 PF00069 0.403
MOD_ProDKin_1 264 270 PF00069 0.451
MOD_ProDKin_1 294 300 PF00069 0.415
MOD_ProDKin_1 380 386 PF00069 0.338
MOD_ProDKin_1 98 104 PF00069 0.305
TRG_DiLeu_BaLyEn_6 352 357 PF01217 0.434
TRG_ENDOCYTIC_2 250 253 PF00928 0.337
TRG_ENDOCYTIC_2 28 31 PF00928 0.431
TRG_ENDOCYTIC_2 288 291 PF00928 0.347
TRG_ENDOCYTIC_2 433 436 PF00928 0.328
TRG_ER_diArg_1 186 188 PF00400 0.295
TRG_ER_diArg_1 399 401 PF00400 0.371
TRG_ER_diArg_1 445 447 PF00400 0.366
TRG_ER_diArg_1 499 501 PF00400 0.496
TRG_ER_diArg_1 513 515 PF00400 0.451
TRG_NLS_MonoExtN_4 443 448 PF00514 0.444
TRG_Pf-PMV_PEXEL_1 434 438 PF00026 0.336
TRG_Pf-PMV_PEXEL_1 500 505 PF00026 0.485

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3W4 Leptomonas seymouri 84% 100%
A0A0S4JTY1 Bodo saltans 56% 99%
A0A1X0NHH6 Trypanosomatidae 64% 98%
A0A3R7KIX4 Trypanosoma rangeli 71% 100%
A0A3S7WWP5 Leishmania donovani 100% 100%
A4HBZ8 Leishmania braziliensis 94% 100%
D0A135 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
E9AVD4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QC45 Leishmania major 96% 100%
V5B1V1 Trypanosoma cruzi 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS