Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZE6_LEIIN

TriTrypDb:

LINF_210023500

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.622
CLV_C14_Caspase3-7	317	321	PF00656	0.741
CLV_C14_Caspase3-7	342	346	PF00656	0.818
CLV_C14_Caspase3-7	567	571	PF00656	0.860
CLV_NRD_NRD_1	137	139	PF00675	0.742
CLV_NRD_NRD_1	180	182	PF00675	0.655
CLV_NRD_NRD_1	22	24	PF00675	0.684
CLV_NRD_NRD_1	310	312	PF00675	0.752
CLV_PCSK_FUR_1	135	139	PF00082	0.737
CLV_PCSK_KEX2_1	137	139	PF00082	0.746
CLV_PCSK_KEX2_1	180	182	PF00082	0.660
CLV_PCSK_KEX2_1	22	24	PF00082	0.686
CLV_PCSK_SKI1_1	137	141	PF00082	0.701
CLV_PCSK_SKI1_1	155	159	PF00082	0.647
CLV_PCSK_SKI1_1	183	187	PF00082	0.812
CLV_PCSK_SKI1_1	265	269	PF00082	0.839
CLV_PCSK_SKI1_1	272	276	PF00082	0.732
CLV_PCSK_SKI1_1	403	407	PF00082	0.618
CLV_PCSK_SKI1_1	640	644	PF00082	0.710
DEG_APCC_DBOX_1	154	162	PF00400	0.801
DEG_APCC_DBOX_1	271	279	PF00400	0.633
DEG_Nend_UBRbox_3	1	3	PF02207	0.841
DEG_SPOP_SBC_1	321	325	PF00917	0.766
DEG_SPOP_SBC_1	40	44	PF00917	0.814
DEG_SPOP_SBC_1	474	478	PF00917	0.721
DEG_SPOP_SBC_1	650	654	PF00917	0.755
DOC_ANK_TNKS_1	381	388	PF00023	0.778
DOC_CYCLIN_RxL_1	132	145	PF00134	0.671
DOC_MAPK_DCC_7	155	163	PF00069	0.798
DOC_MAPK_gen_1	29	37	PF00069	0.582
DOC_MAPK_MEF2A_6	155	163	PF00069	0.798
DOC_MAPK_MEF2A_6	257	266	PF00069	0.628
DOC_MAPK_MEF2A_6	31	39	PF00069	0.621
DOC_PP1_RVXF_1	135	142	PF00149	0.681
DOC_PP2B_LxvP_1	582	585	PF13499	0.687
DOC_PP2B_LxvP_1	603	606	PF13499	0.846
DOC_PP2B_LxvP_1	95	98	PF13499	0.751
DOC_PP4_FxxP_1	114	117	PF00568	0.720
DOC_USP7_MATH_1	127	131	PF00917	0.815
DOC_USP7_MATH_1	227	231	PF00917	0.741
DOC_USP7_MATH_1	258	262	PF00917	0.687
DOC_USP7_MATH_1	267	271	PF00917	0.694
DOC_USP7_MATH_1	310	314	PF00917	0.702
DOC_USP7_MATH_1	321	325	PF00917	0.729
DOC_USP7_MATH_1	440	444	PF00917	0.751
DOC_USP7_MATH_1	472	476	PF00917	0.741
DOC_USP7_MATH_1	520	524	PF00917	0.636
DOC_USP7_MATH_1	555	559	PF00917	0.756
DOC_USP7_MATH_1	650	654	PF00917	0.755
DOC_USP7_MATH_1	8	12	PF00917	0.809
DOC_WW_Pin1_4	104	109	PF00397	0.628
DOC_WW_Pin1_4	142	147	PF00397	0.611
DOC_WW_Pin1_4	233	238	PF00397	0.786
DOC_WW_Pin1_4	30	35	PF00397	0.789
DOC_WW_Pin1_4	328	333	PF00397	0.757
DOC_WW_Pin1_4	501	506	PF00397	0.810
DOC_WW_Pin1_4	532	537	PF00397	0.853
DOC_WW_Pin1_4	545	550	PF00397	0.642
DOC_WW_Pin1_4	557	562	PF00397	0.789
DOC_WW_Pin1_4	57	62	PF00397	0.732
DOC_WW_Pin1_4	580	585	PF00397	0.698
LIG_14-3-3_CanoR_1	137	142	PF00244	0.744
LIG_14-3-3_CanoR_1	187	197	PF00244	0.843
LIG_14-3-3_CanoR_1	257	263	PF00244	0.646
LIG_14-3-3_CanoR_1	394	400	PF00244	0.555
LIG_14-3-3_CanoR_1	413	418	PF00244	0.458
LIG_14-3-3_CanoR_1	486	493	PF00244	0.554
LIG_14-3-3_CanoR_1	532	536	PF00244	0.777
LIG_14-3-3_CanoR_1	6	14	PF00244	0.737
LIG_14-3-3_CanoR_1	610	619	PF00244	0.843
LIG_14-3-3_CanoR_1	81	85	PF00244	0.648
LIG_deltaCOP1_diTrp_1	393	400	PF00928	0.639
LIG_DLG_GKlike_1	413	420	PF00625	0.664
LIG_FHA_1	404	410	PF00498	0.660
LIG_FHA_1	53	59	PF00498	0.705
LIG_FHA_2	251	257	PF00498	0.661
LIG_FHA_2	293	299	PF00498	0.800
LIG_LIR_Apic_2	442	448	PF02991	0.835
LIG_MYND_1	99	103	PF01753	0.821
LIG_SH2_PTP2	509	512	PF00017	0.814
LIG_SH2_SRC	445	448	PF00017	0.802
LIG_SH2_STAT3	359	362	PF00017	0.706
LIG_SH2_STAT5	436	439	PF00017	0.740
LIG_SH2_STAT5	509	512	PF00017	0.814
LIG_SH3_2	24	29	PF14604	0.658
LIG_SH3_3	115	121	PF00018	0.640
LIG_SH3_3	156	162	PF00018	0.794
LIG_SH3_3	21	27	PF00018	0.665
LIG_SH3_3	273	279	PF00018	0.790
LIG_SH3_3	280	286	PF00018	0.775
LIG_SH3_3	298	304	PF00018	0.723
LIG_SH3_3	329	335	PF00018	0.645
LIG_SH3_3	351	357	PF00018	0.635
LIG_SH3_3	375	381	PF00018	0.538
LIG_SH3_3	533	539	PF00018	0.687
LIG_SH3_3	543	549	PF00018	0.713
LIG_SH3_3	558	564	PF00018	0.861
LIG_SH3_3	583	589	PF00018	0.726
LIG_SH3_3	590	596	PF00018	0.761
LIG_SH3_3	598	604	PF00018	0.681
LIG_SUMO_SIM_par_1	122	131	PF11976	0.741
LIG_SUMO_SIM_par_1	207	212	PF11976	0.793
LIG_SUMO_SIM_par_1	510	515	PF11976	0.814
LIG_TRAF2_1	313	316	PF00917	0.774
LIG_WW_3	97	101	PF00397	0.829
MOD_CDC14_SPxK_1	535	538	PF00782	0.848
MOD_CDC14_SPxK_1	60	63	PF00782	0.724
MOD_CDK_SPK_2	557	562	PF00069	0.692
MOD_CDK_SPxK_1	532	538	PF00069	0.853
MOD_CDK_SPxK_1	57	63	PF00069	0.730
MOD_CK1_1	150	156	PF00069	0.785
MOD_CK1_1	198	204	PF00069	0.763
MOD_CK1_1	290	296	PF00069	0.759
MOD_CK1_1	324	330	PF00069	0.860
MOD_CK1_1	42	48	PF00069	0.658
MOD_CK1_1	475	481	PF00069	0.764
MOD_CK1_1	498	504	PF00069	0.591
MOD_CK1_1	523	529	PF00069	0.803
MOD_CK1_1	548	554	PF00069	0.857
MOD_CK1_1	608	614	PF00069	0.850
MOD_CK1_1	652	658	PF00069	0.809
MOD_CK2_1	196	202	PF00069	0.636
MOD_CK2_1	228	234	PF00069	0.743
MOD_CK2_1	250	256	PF00069	0.660
MOD_CK2_1	290	296	PF00069	0.815
MOD_CK2_1	310	316	PF00069	0.773
MOD_CK2_1	395	401	PF00069	0.644
MOD_DYRK1A_RPxSP_1	532	536	PF00069	0.777
MOD_GlcNHglycan	152	155	PF01048	0.817
MOD_GlcNHglycan	211	214	PF01048	0.722
MOD_GlcNHglycan	230	233	PF01048	0.778
MOD_GlcNHglycan	240	243	PF01048	0.726
MOD_GlcNHglycan	289	292	PF01048	0.869
MOD_GlcNHglycan	326	329	PF01048	0.769
MOD_GlcNHglycan	44	47	PF01048	0.777
MOD_GlcNHglycan	478	481	PF01048	0.782
MOD_GlcNHglycan	518	521	PF01048	0.778
MOD_GlcNHglycan	526	529	PF01048	0.773
MOD_GlcNHglycan	553	556	PF01048	0.767
MOD_GlcNHglycan	566	569	PF01048	0.704
MOD_GlcNHglycan	597	600	PF01048	0.870
MOD_GlcNHglycan	634	637	PF01048	0.679
MOD_GlcNHglycan	655	658	PF01048	0.842
MOD_GSK3_1	137	144	PF00069	0.696
MOD_GSK3_1	146	153	PF00069	0.693
MOD_GSK3_1	161	168	PF00069	0.582
MOD_GSK3_1	179	186	PF00069	0.751
MOD_GSK3_1	189	196	PF00069	0.767
MOD_GSK3_1	290	297	PF00069	0.803
MOD_GSK3_1	320	327	PF00069	0.846
MOD_GSK3_1	405	412	PF00069	0.658
MOD_GSK3_1	472	479	PF00069	0.789
MOD_GSK3_1	482	489	PF00069	0.699
MOD_GSK3_1	497	504	PF00069	0.607
MOD_GSK3_1	516	523	PF00069	0.567
MOD_GSK3_1	52	59	PF00069	0.721
MOD_GSK3_1	527	534	PF00069	0.608
MOD_GSK3_1	551	558	PF00069	0.728
MOD_GSK3_1	606	613	PF00069	0.789
MOD_GSK3_1	649	656	PF00069	0.836
MOD_GSK3_1	66	73	PF00069	0.572
MOD_LATS_1	522	528	PF00433	0.613
MOD_N-GLC_2	402	404	PF02516	0.631
MOD_NEK2_1	139	144	PF00069	0.753
MOD_NEK2_1	405	410	PF00069	0.656
MOD_NEK2_1	423	428	PF00069	0.507
MOD_NEK2_1	496	501	PF00069	0.623
MOD_NEK2_1	649	654	PF00069	0.835
MOD_NEK2_1	72	77	PF00069	0.750
MOD_PIKK_1	14	20	PF00454	0.777
MOD_PIKK_1	250	256	PF00454	0.757
MOD_PIKK_1	367	373	PF00454	0.686
MOD_PIKK_1	403	409	PF00454	0.707
MOD_PIKK_1	527	533	PF00454	0.852
MOD_PKA_1	137	143	PF00069	0.661
MOD_PKA_2	137	143	PF00069	0.661
MOD_PKA_2	179	185	PF00069	0.813
MOD_PKA_2	310	316	PF00069	0.739
MOD_PKA_2	440	446	PF00069	0.649
MOD_PKA_2	485	491	PF00069	0.724
MOD_PKA_2	523	529	PF00069	0.832
MOD_PKA_2	531	537	PF00069	0.689
MOD_PKA_2	80	86	PF00069	0.668
MOD_PKB_1	135	143	PF00069	0.658
MOD_Plk_1	268	274	PF00069	0.801
MOD_Plk_1	423	429	PF00069	0.586
MOD_Plk_4	162	168	PF00069	0.656
MOD_Plk_4	395	401	PF00069	0.630
MOD_Plk_4	614	620	PF00069	0.760
MOD_ProDKin_1	104	110	PF00069	0.629
MOD_ProDKin_1	142	148	PF00069	0.610
MOD_ProDKin_1	233	239	PF00069	0.784
MOD_ProDKin_1	30	36	PF00069	0.789
MOD_ProDKin_1	328	334	PF00069	0.757
MOD_ProDKin_1	501	507	PF00069	0.810
MOD_ProDKin_1	532	538	PF00069	0.853
MOD_ProDKin_1	545	551	PF00069	0.641
MOD_ProDKin_1	557	563	PF00069	0.790
MOD_ProDKin_1	57	63	PF00069	0.730
MOD_ProDKin_1	580	586	PF00069	0.697
MOD_SUMO_for_1	217	220	PF00179	0.769
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.797
TRG_ENDOCYTIC_2	509	512	PF00928	0.814
TRG_ER_diArg_1	134	137	PF00400	0.730
TRG_ER_diArg_1	179	181	PF00400	0.823
TRG_ER_diArg_1	22	24	PF00400	0.686
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.772
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.784

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWS0	Leishmania donovani	99%	100%
A4HBZ7	Leishmania braziliensis	56%	99%
E9AVD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QC46	Leishmania major	85%	100%