DUF5745 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZE5_LEIIN

TriTrypDb:

LINF_210023400

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	7
GO:0005813	centrosome	3	7
GO:0005815	microtubule organizing center	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HZE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.521
CLV_C14_Caspase3-7	56	60	PF00656	0.558
CLV_C14_Caspase3-7	594	598	PF00656	0.685
CLV_C14_Caspase3-7	610	614	PF00656	0.424
CLV_NRD_NRD_1	155	157	PF00675	0.718
CLV_NRD_NRD_1	303	305	PF00675	0.435
CLV_NRD_NRD_1	544	546	PF00675	0.702
CLV_NRD_NRD_1	582	584	PF00675	0.787
CLV_NRD_NRD_1	603	605	PF00675	0.676
CLV_NRD_NRD_1	617	619	PF00675	0.584
CLV_NRD_NRD_1	648	650	PF00675	0.670
CLV_NRD_NRD_1	770	772	PF00675	0.469
CLV_NRD_NRD_1	800	802	PF00675	0.434
CLV_NRD_NRD_1	862	864	PF00675	0.439
CLV_PCSK_FUR_1	133	137	PF00082	0.577
CLV_PCSK_FUR_1	646	650	PF00082	0.647
CLV_PCSK_FUR_1	768	772	PF00082	0.457
CLV_PCSK_KEX2_1	135	137	PF00082	0.625
CLV_PCSK_KEX2_1	154	156	PF00082	0.702
CLV_PCSK_KEX2_1	302	304	PF00082	0.433
CLV_PCSK_KEX2_1	544	546	PF00082	0.702
CLV_PCSK_KEX2_1	582	584	PF00082	0.699
CLV_PCSK_KEX2_1	603	605	PF00082	0.676
CLV_PCSK_KEX2_1	617	619	PF00082	0.569
CLV_PCSK_KEX2_1	648	650	PF00082	0.670
CLV_PCSK_KEX2_1	673	675	PF00082	0.709
CLV_PCSK_KEX2_1	770	772	PF00082	0.474
CLV_PCSK_KEX2_1	800	802	PF00082	0.443
CLV_PCSK_KEX2_1	857	859	PF00082	0.423
CLV_PCSK_KEX2_1	862	864	PF00082	0.445
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.625
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.571
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.433
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.696
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.407
CLV_PCSK_PC7_1	766	772	PF00082	0.453
CLV_PCSK_PC7_1	858	864	PF00082	0.408
CLV_PCSK_SKI1_1	64	68	PF00082	0.675
CLV_PCSK_SKI1_1	674	678	PF00082	0.657
CLV_PCSK_SKI1_1	729	733	PF00082	0.603
CLV_PCSK_SKI1_1	789	793	PF00082	0.420
CLV_Separin_Metazoa	867	871	PF03568	0.519
DEG_SPOP_SBC_1	105	109	PF00917	0.685
DEG_SPOP_SBC_1	116	120	PF00917	0.599
DEG_SPOP_SBC_1	184	188	PF00917	0.487
DEG_SPOP_SBC_1	368	372	PF00917	0.491
DEG_SPOP_SBC_1	399	403	PF00917	0.594
DEG_SPOP_SBC_1	48	52	PF00917	0.557
DOC_ANK_TNKS_1	581	588	PF00023	0.571
DOC_CKS1_1	111	116	PF01111	0.620
DOC_CKS1_1	711	716	PF01111	0.623
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.625
DOC_MAPK_gen_1	302	311	PF00069	0.406
DOC_MAPK_gen_1	789	798	PF00069	0.446
DOC_MAPK_MEF2A_6	302	311	PF00069	0.406
DOC_MAPK_MEF2A_6	339	347	PF00069	0.367
DOC_MAPK_MEF2A_6	64	72	PF00069	0.557
DOC_MAPK_RevD_3	139	155	PF00069	0.563
DOC_PP4_FxxP_1	34	37	PF00568	0.550
DOC_PP4_FxxP_1	437	440	PF00568	0.647
DOC_PP4_MxPP_1	417	420	PF00568	0.584
DOC_USP7_MATH_1	105	109	PF00917	0.709
DOC_USP7_MATH_1	131	135	PF00917	0.799
DOC_USP7_MATH_1	144	148	PF00917	0.545
DOC_USP7_MATH_1	150	154	PF00917	0.596
DOC_USP7_MATH_1	161	165	PF00917	0.564
DOC_USP7_MATH_1	173	177	PF00917	0.492
DOC_USP7_MATH_1	185	189	PF00917	0.592
DOC_USP7_MATH_1	213	217	PF00917	0.603
DOC_USP7_MATH_1	369	373	PF00917	0.507
DOC_USP7_MATH_1	40	44	PF00917	0.582
DOC_USP7_MATH_1	48	52	PF00917	0.532
DOC_USP7_MATH_1	556	560	PF00917	0.698
DOC_USP7_MATH_1	642	646	PF00917	0.647
DOC_USP7_MATH_1	775	779	PF00917	0.380
DOC_WW_Pin1_4	107	112	PF00397	0.613
DOC_WW_Pin1_4	215	220	PF00397	0.690
DOC_WW_Pin1_4	293	298	PF00397	0.438
DOC_WW_Pin1_4	483	488	PF00397	0.670
DOC_WW_Pin1_4	562	567	PF00397	0.631
DOC_WW_Pin1_4	575	580	PF00397	0.692
DOC_WW_Pin1_4	581	586	PF00397	0.563
DOC_WW_Pin1_4	626	631	PF00397	0.649
DOC_WW_Pin1_4	667	672	PF00397	0.643
DOC_WW_Pin1_4	710	715	PF00397	0.646
LIG_14-3-3_CanoR_1	103	112	PF00244	0.596
LIG_14-3-3_CanoR_1	271	281	PF00244	0.348
LIG_14-3-3_CanoR_1	33	37	PF00244	0.515
LIG_14-3-3_CanoR_1	64	69	PF00244	0.541
LIG_14-3-3_CanoR_1	648	653	PF00244	0.606
LIG_14-3-3_CanoR_1	717	722	PF00244	0.556
LIG_14-3-3_CanoR_1	751	758	PF00244	0.535
LIG_14-3-3_CanoR_1	833	837	PF00244	0.442
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BIR_III_4	145	149	PF00653	0.562
LIG_BIR_III_4	426	430	PF00653	0.601
LIG_BRCT_BRCA1_1	274	278	PF00533	0.343
LIG_CaM_IQ_9	758	773	PF13499	0.447
LIG_FHA_1	499	505	PF00498	0.520
LIG_FHA_1	65	71	PF00498	0.542
LIG_FHA_1	833	839	PF00498	0.435
LIG_FHA_2	1	7	PF00498	0.524
LIG_FHA_2	184	190	PF00498	0.534
LIG_FHA_2	234	240	PF00498	0.611
LIG_FHA_2	592	598	PF00498	0.598
LIG_FHA_2	723	729	PF00498	0.513
LIG_FHA_2	788	794	PF00498	0.475
LIG_FHA_2	813	819	PF00498	0.417
LIG_LIR_Apic_2	383	388	PF02991	0.531
LIG_LIR_Gen_1	258	267	PF02991	0.400
LIG_LIR_Gen_1	275	286	PF02991	0.340
LIG_LIR_Nem_3	21	25	PF02991	0.555
LIG_LIR_Nem_3	258	262	PF02991	0.382
LIG_LIR_Nem_3	274	280	PF02991	0.339
LIG_LIR_Nem_3	403	409	PF02991	0.638
LIG_LIR_Nem_3	506	512	PF02991	0.495
LIG_LYPXL_yS_3	22	25	PF13949	0.542
LIG_MLH1_MIPbox_1	274	278	PF16413	0.343
LIG_PDZ_Class_2	879	884	PF00595	0.416
LIG_PROFILIN_1	223	229	PF00235	0.506
LIG_PTB_Apo_2	508	515	PF02174	0.482
LIG_PTB_Phospho_1	508	514	PF10480	0.476
LIG_REV1ctd_RIR_1	729	735	PF16727	0.554
LIG_SH2_CRK	282	286	PF00017	0.352
LIG_SH2_CRK	406	410	PF00017	0.636
LIG_SH2_CRK	509	513	PF00017	0.493
LIG_SH2_CRK	699	703	PF00017	0.631
LIG_SH2_CRK	813	817	PF00017	0.438
LIG_SH2_NCK_1	406	410	PF00017	0.580
LIG_SH2_NCK_1	699	703	PF00017	0.631
LIG_SH2_SRC	406	409	PF00017	0.636
LIG_SH2_SRC	493	496	PF00017	0.612
LIG_SH2_STAP1	773	777	PF00017	0.450
LIG_SH2_STAP1	813	817	PF00017	0.438
LIG_SH2_STAP1	842	846	PF00017	0.410
LIG_SH2_STAP1	871	875	PF00017	0.417
LIG_SH2_STAT3	435	438	PF00017	0.541
LIG_SH2_STAT3	71	74	PF00017	0.689
LIG_SH2_STAT3	773	776	PF00017	0.459
LIG_SH2_STAT5	493	496	PF00017	0.612
LIG_SH2_STAT5	730	733	PF00017	0.604
LIG_SH2_STAT5	757	760	PF00017	0.441
LIG_SH3_1	708	714	PF00018	0.570
LIG_SH3_3	108	114	PF00018	0.622
LIG_SH3_3	138	144	PF00018	0.654
LIG_SH3_3	196	202	PF00018	0.626
LIG_SH3_3	218	224	PF00018	0.687
LIG_SH3_3	413	419	PF00018	0.638
LIG_SH3_3	445	451	PF00018	0.571
LIG_SH3_3	510	516	PF00018	0.600
LIG_SH3_3	650	656	PF00018	0.693
LIG_SH3_3	708	714	PF00018	0.640
LIG_SH3_3	716	722	PF00018	0.717
LIG_SH3_3	81	87	PF00018	0.639
LIG_SUMO_SIM_par_1	307	312	PF11976	0.397
LIG_TRAF2_1	236	239	PF00917	0.591
LIG_TRAF2_1	520	523	PF00917	0.675
LIG_TRAF2_1	685	688	PF00917	0.671
LIG_TRAF2_1	725	728	PF00917	0.511
LIG_TYR_ITIM	280	285	PF00017	0.342
LIG_WRC_WIRS_1	256	261	PF05994	0.373
LIG_WW_3	709	713	PF00397	0.581
MOD_CDK_SPxK_1	667	673	PF00069	0.637
MOD_CDK_SPxxK_3	575	582	PF00069	0.699
MOD_CDK_SPxxK_3	667	674	PF00069	0.636
MOD_CDK_SPxxK_3	710	717	PF00069	0.585
MOD_CK1_1	106	112	PF00069	0.625
MOD_CK1_1	115	121	PF00069	0.638
MOD_CK1_1	296	302	PF00069	0.439
MOD_CK1_1	43	49	PF00069	0.595
MOD_CK1_1	486	492	PF00069	0.593
MOD_CK1_1	50	56	PF00069	0.530
MOD_CK1_1	559	565	PF00069	0.611
MOD_CK1_1	787	793	PF00069	0.402
MOD_CK1_1	832	838	PF00069	0.438
MOD_CK1_1	9	15	PF00069	0.579
MOD_CK2_1	117	123	PF00069	0.636
MOD_CK2_1	183	189	PF00069	0.541
MOD_CK2_1	233	239	PF00069	0.621
MOD_CK2_1	575	581	PF00069	0.696
MOD_CK2_1	633	639	PF00069	0.666
MOD_CK2_1	672	678	PF00069	0.641
MOD_CK2_1	722	728	PF00069	0.515
MOD_CK2_1	744	750	PF00069	0.500
MOD_CK2_1	780	786	PF00069	0.455
MOD_CK2_1	787	793	PF00069	0.445
MOD_CK2_1	812	818	PF00069	0.417
MOD_GlcNHglycan	119	122	PF01048	0.636
MOD_GlcNHglycan	12	15	PF01048	0.590
MOD_GlcNHglycan	145	149	PF01048	0.662
MOD_GlcNHglycan	156	159	PF01048	0.753
MOD_GlcNHglycan	16	19	PF01048	0.546
MOD_GlcNHglycan	163	166	PF01048	0.534
MOD_GlcNHglycan	191	194	PF01048	0.638
MOD_GlcNHglycan	215	218	PF01048	0.623
MOD_GlcNHglycan	371	374	PF01048	0.464
MOD_GlcNHglycan	402	405	PF01048	0.585
MOD_GlcNHglycan	431	434	PF01048	0.645
MOD_GlcNHglycan	457	460	PF01048	0.625
MOD_GlcNHglycan	475	478	PF01048	0.564
MOD_GlcNHglycan	52	55	PF01048	0.555
MOD_GlcNHglycan	527	530	PF01048	0.666
MOD_GlcNHglycan	562	565	PF01048	0.610
MOD_GlcNHglycan	575	578	PF01048	0.645
MOD_GlcNHglycan	656	659	PF01048	0.668
MOD_GlcNHglycan	674	677	PF01048	0.563
MOD_GlcNHglycan	753	756	PF01048	0.536
MOD_GlcNHglycan	777	780	PF01048	0.447
MOD_GlcNHglycan	8	11	PF01048	0.668
MOD_GlcNHglycan	873	878	PF01048	0.408
MOD_GSK3_1	103	110	PF00069	0.660
MOD_GSK3_1	112	119	PF00069	0.700
MOD_GSK3_1	150	157	PF00069	0.776
MOD_GSK3_1	183	190	PF00069	0.623
MOD_GSK3_1	215	222	PF00069	0.668
MOD_GSK3_1	230	237	PF00069	0.536
MOD_GSK3_1	262	269	PF00069	0.490
MOD_GSK3_1	40	47	PF00069	0.581
MOD_GSK3_1	49	56	PF00069	0.528
MOD_GSK3_1	494	501	PF00069	0.578
MOD_GSK3_1	5	12	PF00069	0.558
MOD_GSK3_1	521	528	PF00069	0.662
MOD_GSK3_1	556	563	PF00069	0.614
MOD_GSK3_1	60	67	PF00069	0.476
MOD_GSK3_1	780	787	PF00069	0.426
MOD_N-GLC_1	213	218	PF02516	0.565
MOD_N-GLC_1	378	383	PF02516	0.480
MOD_N-GLC_1	38	43	PF02516	0.527
MOD_N-GLC_2	443	445	PF02516	0.540
MOD_NEK2_1	117	122	PF00069	0.636
MOD_NEK2_1	286	291	PF00069	0.411
MOD_NEK2_1	367	372	PF00069	0.588
MOD_NEK2_1	4	9	PF00069	0.575
MOD_NEK2_1	494	499	PF00069	0.592
MOD_NEK2_1	560	565	PF00069	0.619
MOD_NEK2_1	72	77	PF00069	0.622
MOD_NEK2_1	780	785	PF00069	0.456
MOD_NEK2_1	846	851	PF00069	0.411
MOD_NEK2_2	175	180	PF00069	0.608
MOD_NEK2_2	273	278	PF00069	0.341
MOD_NEK2_2	533	538	PF00069	0.680
MOD_PIKK_1	539	545	PF00454	0.702
MOD_PIKK_1	591	597	PF00454	0.573
MOD_PIKK_1	690	696	PF00454	0.742
MOD_PIKK_1	697	703	PF00454	0.638
MOD_PIKK_1	72	78	PF00454	0.604
MOD_PK_1	266	272	PF00069	0.386
MOD_PKA_1	154	160	PF00069	0.563
MOD_PKA_1	648	654	PF00069	0.605
MOD_PKA_2	14	20	PF00069	0.580
MOD_PKA_2	154	160	PF00069	0.722
MOD_PKA_2	265	271	PF00069	0.478
MOD_PKA_2	32	38	PF00069	0.485
MOD_PKA_2	642	648	PF00069	0.621
MOD_PKA_2	744	750	PF00069	0.500
MOD_PKA_2	780	786	PF00069	0.455
MOD_PKA_2	832	838	PF00069	0.438
MOD_PKB_1	646	654	PF00069	0.583
MOD_Plk_1	286	292	PF00069	0.408
MOD_Plk_1	494	500	PF00069	0.584
MOD_Plk_1	873	879	PF00069	0.408
MOD_Plk_4	195	201	PF00069	0.646
MOD_Plk_4	273	279	PF00069	0.370
MOD_Plk_4	494	500	PF00069	0.615
MOD_Plk_4	812	818	PF00069	0.417
MOD_Plk_4	846	852	PF00069	0.417
MOD_ProDKin_1	107	113	PF00069	0.615
MOD_ProDKin_1	215	221	PF00069	0.688
MOD_ProDKin_1	293	299	PF00069	0.437
MOD_ProDKin_1	483	489	PF00069	0.670
MOD_ProDKin_1	562	568	PF00069	0.632
MOD_ProDKin_1	575	581	PF00069	0.695
MOD_ProDKin_1	626	632	PF00069	0.650
MOD_ProDKin_1	667	673	PF00069	0.643
MOD_ProDKin_1	710	716	PF00069	0.646
MOD_SUMO_for_1	856	859	PF00179	0.432
MOD_SUMO_rev_2	741	749	PF00179	0.480
MOD_SUMO_rev_2	787	796	PF00179	0.464
TRG_DiLeu_BaEn_4	327	333	PF01217	0.397
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.349
TRG_ENDOCYTIC_2	22	25	PF00928	0.542
TRG_ENDOCYTIC_2	282	285	PF00928	0.354
TRG_ENDOCYTIC_2	406	409	PF00928	0.556
TRG_ENDOCYTIC_2	509	512	PF00928	0.491
TRG_ENDOCYTIC_2	813	816	PF00928	0.440
TRG_ER_diArg_1	602	604	PF00400	0.648
TRG_ER_diArg_1	617	620	PF00400	0.588
TRG_ER_diArg_1	646	649	PF00400	0.651
TRG_ER_diArg_1	765	768	PF00400	0.450
TRG_ER_diArg_1	769	771	PF00400	0.461
TRG_ER_diArg_1	799	801	PF00400	0.446
TRG_NES_CRM1_1	335	350	PF08389	0.396
TRG_Pf-PMV_PEXEL_1	756	760	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC22	Leptomonas seymouri	53%	94%
A0A3Q8IB84	Leishmania donovani	99%	100%
A4HBZ6	Leishmania braziliensis	75%	99%
E9AVD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QC47	Leishmania major	90%	100%