Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZE3_LEIIN

TriTrypDb:

LINF_210023200

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.659
CLV_NRD_NRD_1	219	221	PF00675	0.633
CLV_NRD_NRD_1	251	253	PF00675	0.624
CLV_NRD_NRD_1	278	280	PF00675	0.747
CLV_NRD_NRD_1	330	332	PF00675	0.552
CLV_NRD_NRD_1	365	367	PF00675	0.668
CLV_NRD_NRD_1	442	444	PF00675	0.518
CLV_NRD_NRD_1	493	495	PF00675	0.541
CLV_NRD_NRD_1	501	503	PF00675	0.359
CLV_PCSK_FUR_1	310	314	PF00082	0.409
CLV_PCSK_FUR_1	363	367	PF00082	0.661
CLV_PCSK_KEX2_1	219	221	PF00082	0.633
CLV_PCSK_KEX2_1	251	253	PF00082	0.624
CLV_PCSK_KEX2_1	278	280	PF00082	0.657
CLV_PCSK_KEX2_1	312	314	PF00082	0.444
CLV_PCSK_KEX2_1	330	332	PF00082	0.386
CLV_PCSK_KEX2_1	362	364	PF00082	0.658
CLV_PCSK_KEX2_1	365	367	PF00082	0.645
CLV_PCSK_KEX2_1	408	410	PF00082	0.608
CLV_PCSK_KEX2_1	442	444	PF00082	0.518
CLV_PCSK_KEX2_1	459	461	PF00082	0.529
CLV_PCSK_KEX2_1	493	495	PF00082	0.541
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.411
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.658
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.608
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.529
CLV_PCSK_SKI1_1	266	270	PF00082	0.592
CLV_PCSK_SKI1_1	382	386	PF00082	0.694
CLV_PCSK_SKI1_1	493	497	PF00082	0.522
CLV_PCSK_SKI1_1	503	507	PF00082	0.458
DEG_APCC_DBOX_1	441	449	PF00400	0.480
DEG_APCC_DBOX_1	492	500	PF00400	0.514
DEG_Nend_UBRbox_3	1	3	PF02207	0.524
DEG_SPOP_SBC_1	115	119	PF00917	0.626
DEG_SPOP_SBC_1	132	136	PF00917	0.507
DEG_SPOP_SBC_1	236	240	PF00917	0.672
DEG_SPOP_SBC_1	428	432	PF00917	0.671
DOC_CKS1_1	107	112	PF01111	0.521
DOC_CKS1_1	176	181	PF01111	0.696
DOC_CYCLIN_RxL_1	377	389	PF00134	0.646
DOC_CYCLIN_RxL_1	440	450	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.625
DOC_MAPK_FxFP_2	20	23	PF00069	0.658
DOC_MAPK_gen_1	266	275	PF00069	0.632
DOC_MAPK_JIP1_4	44	50	PF00069	0.549
DOC_PP2B_LxvP_1	112	115	PF13499	0.452
DOC_PP2B_LxvP_1	16	19	PF13499	0.677
DOC_PP2B_LxvP_1	48	51	PF13499	0.560
DOC_PP2B_LxvP_1	64	67	PF13499	0.591
DOC_PP2B_LxvP_1	95	98	PF13499	0.517
DOC_PP4_FxxP_1	20	23	PF00568	0.714
DOC_PP4_FxxP_1	54	57	PF00568	0.584
DOC_USP7_MATH_1	115	119	PF00917	0.648
DOC_USP7_MATH_1	126	130	PF00917	0.584
DOC_USP7_MATH_1	132	136	PF00917	0.514
DOC_USP7_MATH_1	162	166	PF00917	0.692
DOC_USP7_MATH_1	172	176	PF00917	0.559
DOC_USP7_MATH_1	181	185	PF00917	0.517
DOC_USP7_MATH_1	188	192	PF00917	0.635
DOC_USP7_MATH_1	218	222	PF00917	0.644
DOC_USP7_MATH_1	417	421	PF00917	0.670
DOC_USP7_MATH_1	428	432	PF00917	0.649
DOC_USP7_MATH_1	43	47	PF00917	0.571
DOC_USP7_MATH_1	476	480	PF00917	0.639
DOC_USP7_MATH_1	49	53	PF00917	0.560
DOC_USP7_MATH_1	67	71	PF00917	0.744
DOC_WW_Pin1_4	106	111	PF00397	0.653
DOC_WW_Pin1_4	175	180	PF00397	0.693
DOC_WW_Pin1_4	229	234	PF00397	0.640
DOC_WW_Pin1_4	339	344	PF00397	0.577
DOC_WW_Pin1_4	409	414	PF00397	0.718
DOC_WW_Pin1_4	423	428	PF00397	0.561
DOC_WW_Pin1_4	474	479	PF00397	0.643
LIG_14-3-3_CanoR_1	141	146	PF00244	0.706
LIG_14-3-3_CanoR_1	197	206	PF00244	0.571
LIG_14-3-3_CanoR_1	219	223	PF00244	0.632
LIG_14-3-3_CanoR_1	313	322	PF00244	0.404
LIG_14-3-3_CanoR_1	363	369	PF00244	0.660
LIG_14-3-3_CanoR_1	394	400	PF00244	0.639
LIG_AP2alpha_2	488	490	PF02296	0.560
LIG_APCC_ABBA_1	291	296	PF00400	0.620
LIG_BIR_III_4	187	191	PF00653	0.709
LIG_EVH1_1	54	58	PF00568	0.583
LIG_EVH1_1	96	100	PF00568	0.513
LIG_EVH1_2	102	106	PF00568	0.511
LIG_FHA_1	107	113	PF00498	0.571
LIG_FHA_1	270	276	PF00498	0.759
LIG_FHA_1	480	486	PF00498	0.599
LIG_FHA_2	352	358	PF00498	0.686
LIG_FHA_2	482	488	PF00498	0.653
LIG_HCF-1_HBM_1	326	329	PF13415	0.441
LIG_Integrin_RGD_1	185	187	PF01839	0.650
LIG_LIR_Apic_2	40	45	PF02991	0.668
LIG_LIR_Apic_2	52	57	PF02991	0.506
LIG_LIR_Gen_1	334	343	PF02991	0.509
LIG_LIR_Gen_1	449	458	PF02991	0.514
LIG_LIR_Nem_3	326	332	PF02991	0.467
LIG_LIR_Nem_3	334	339	PF02991	0.478
LIG_LIR_Nem_3	449	455	PF02991	0.510
LIG_MYND_1	93	97	PF01753	0.558
LIG_PDZ_Class_1	505	510	PF00595	0.466
LIG_PROFILIN_1	97	103	PF00235	0.581
LIG_PTAP_UEV_1	399	404	PF05743	0.639
LIG_PTB_Apo_2	489	496	PF02174	0.523
LIG_SH2_CRK	107	111	PF00017	0.592
LIG_SH2_CRK	329	333	PF00017	0.454
LIG_SH2_SRC	336	339	PF00017	0.548
LIG_SH2_STAP1	336	340	PF00017	0.475
LIG_SH2_STAP1	5	9	PF00017	0.637
LIG_SH2_STAT5	321	324	PF00017	0.448
LIG_SH3_1	107	113	PF00018	0.530
LIG_SH3_1	96	102	PF00018	0.585
LIG_SH3_3	107	113	PF00018	0.606
LIG_SH3_3	166	172	PF00018	0.713
LIG_SH3_3	173	179	PF00018	0.618
LIG_SH3_3	230	236	PF00018	0.538
LIG_SH3_3	337	343	PF00018	0.540
LIG_SH3_3	397	403	PF00018	0.753
LIG_SH3_3	407	413	PF00018	0.680
LIG_SH3_3	422	428	PF00018	0.555
LIG_SH3_3	467	473	PF00018	0.651
LIG_SH3_3	52	58	PF00018	0.581
LIG_SH3_3	79	85	PF00018	0.695
LIG_SH3_3	94	100	PF00018	0.457
LIG_SUMO_SIM_par_1	177	184	PF11976	0.590
LIG_WRC_WIRS_1	222	227	PF05994	0.593
LIG_WW_2	110	113	PF00397	0.563
MOD_CDC14_SPxK_1	342	345	PF00782	0.601
MOD_CDK_SPK_2	229	234	PF00069	0.583
MOD_CDK_SPxK_1	339	345	PF00069	0.584
MOD_CK1_1	118	124	PF00069	0.627
MOD_CK1_1	125	131	PF00069	0.629
MOD_CK1_1	133	139	PF00069	0.696
MOD_CK1_1	175	181	PF00069	0.634
MOD_CK1_1	198	204	PF00069	0.624
MOD_CK1_1	221	227	PF00069	0.780
MOD_CK1_1	228	234	PF00069	0.815
MOD_CK1_1	235	241	PF00069	0.667
MOD_CK1_1	256	262	PF00069	0.698
MOD_CK1_1	305	311	PF00069	0.504
MOD_CK1_1	35	41	PF00069	0.656
MOD_CK1_1	393	399	PF00069	0.764
MOD_CK1_1	430	436	PF00069	0.684
MOD_CK1_1	437	443	PF00069	0.523
MOD_CK1_1	463	469	PF00069	0.613
MOD_CK1_1	477	483	PF00069	0.725
MOD_CK2_1	313	319	PF00069	0.455
MOD_CK2_1	331	337	PF00069	0.464
MOD_CK2_1	35	41	PF00069	0.622
MOD_CK2_1	351	357	PF00069	0.525
MOD_CK2_1	418	424	PF00069	0.689
MOD_CK2_1	481	487	PF00069	0.653
MOD_CK2_1	69	75	PF00069	0.621
MOD_DYRK1A_RPxSP_1	409	413	PF00069	0.640
MOD_GlcNHglycan	120	124	PF01048	0.697
MOD_GlcNHglycan	138	141	PF01048	0.751
MOD_GlcNHglycan	201	204	PF01048	0.677
MOD_GlcNHglycan	225	228	PF01048	0.757
MOD_GlcNHglycan	256	259	PF01048	0.617
MOD_GlcNHglycan	315	318	PF01048	0.599
MOD_GlcNHglycan	36	40	PF01048	0.682
MOD_GlcNHglycan	415	418	PF01048	0.667
MOD_GlcNHglycan	420	423	PF01048	0.685
MOD_GlcNHglycan	433	436	PF01048	0.561
MOD_GlcNHglycan	462	465	PF01048	0.574
MOD_GlcNHglycan	507	510	PF01048	0.548
MOD_GlcNHglycan	69	72	PF01048	0.739
MOD_GSK3_1	114	121	PF00069	0.631
MOD_GSK3_1	122	129	PF00069	0.606
MOD_GSK3_1	132	139	PF00069	0.769
MOD_GSK3_1	140	147	PF00069	0.675
MOD_GSK3_1	195	202	PF00069	0.683
MOD_GSK3_1	221	228	PF00069	0.691
MOD_GSK3_1	232	239	PF00069	0.676
MOD_GSK3_1	254	261	PF00069	0.573
MOD_GSK3_1	369	376	PF00069	0.790
MOD_GSK3_1	409	416	PF00069	0.699
MOD_GSK3_1	423	430	PF00069	0.577
MOD_GSK3_1	433	440	PF00069	0.529
MOD_GSK3_1	477	484	PF00069	0.687
MOD_N-GLC_1	351	356	PF02516	0.545
MOD_NEK2_1	225	230	PF00069	0.709
MOD_NEK2_1	429	434	PF00069	0.659
MOD_NEK2_1	447	452	PF00069	0.485
MOD_NEK2_1	505	510	PF00069	0.493
MOD_PIKK_1	141	147	PF00454	0.595
MOD_PIKK_1	447	453	PF00454	0.478
MOD_PK_1	195	201	PF00069	0.657
MOD_PKA_2	136	142	PF00069	0.721
MOD_PKA_2	218	224	PF00069	0.633
MOD_PKA_2	277	283	PF00069	0.612
MOD_PKA_2	364	370	PF00069	0.647
MOD_PKA_2	373	379	PF00069	0.649
MOD_PKA_2	393	399	PF00069	0.503
MOD_Plk_1	12	18	PF00069	0.509
MOD_Plk_1	302	308	PF00069	0.461
MOD_ProDKin_1	106	112	PF00069	0.656
MOD_ProDKin_1	175	181	PF00069	0.694
MOD_ProDKin_1	229	235	PF00069	0.643
MOD_ProDKin_1	339	345	PF00069	0.584
MOD_ProDKin_1	409	415	PF00069	0.718
MOD_ProDKin_1	423	429	PF00069	0.563
MOD_ProDKin_1	474	480	PF00069	0.644
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.510
TRG_ENDOCYTIC_2	329	332	PF00928	0.473
TRG_ENDOCYTIC_2	336	339	PF00928	0.483
TRG_ER_diArg_1	251	253	PF00400	0.796
TRG_ER_diArg_1	277	279	PF00400	0.640
TRG_ER_diArg_1	329	331	PF00400	0.461
TRG_ER_diArg_1	332	335	PF00400	0.453
TRG_ER_diArg_1	363	366	PF00400	0.660
TRG_ER_diArg_1	441	443	PF00400	0.653
TRG_ER_diArg_1	493	495	PF00400	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I273	Leptomonas seymouri	31%	69%
A0A3S7WWP6	Leishmania donovani	100%	100%
A4HC17	Leishmania braziliensis	63%	100%
E9AVD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QC49	Leishmania major	86%	100%