Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytochrome b5-like Heme/Steroid binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZE1_LEIIN

TriTrypDb:

LINF_210023000

Length:

221

Annotations

Annotations by Jardim et al.

Mitochondrial protein, cytochrome b5-like Heme/Steroid binding domain

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.475
CLV_NRD_NRD_1	125	127	PF00675	0.345
CLV_PCSK_FUR_1	123	127	PF00082	0.436
CLV_PCSK_KEX2_1	125	127	PF00082	0.407
CLV_Separin_Metazoa	150	154	PF03568	0.363
DOC_USP7_MATH_1	119	123	PF00917	0.432
DOC_USP7_MATH_1	19	23	PF00917	0.263
DOC_USP7_UBL2_3	38	42	PF12436	0.403
DOC_WW_Pin1_4	28	33	PF00397	0.301
LIG_14-3-3_CanoR_1	128	134	PF00244	0.349
LIG_14-3-3_CanoR_1	164	169	PF00244	0.432
LIG_14-3-3_CanoR_1	3	10	PF00244	0.407
LIG_BIR_II_1	1	5	PF00653	0.436
LIG_FHA_1	122	128	PF00498	0.322
LIG_FHA_1	137	143	PF00498	0.306
LIG_FHA_1	29	35	PF00498	0.284
LIG_FHA_1	45	51	PF00498	0.372
LIG_FHA_2	132	138	PF00498	0.410
LIG_FHA_2	145	151	PF00498	0.233
LIG_FHA_2	181	187	PF00498	0.336
LIG_FHA_2	4	10	PF00498	0.290
LIG_LIR_Apic_2	102	108	PF02991	0.330
LIG_LIR_Apic_2	204	208	PF02991	0.326
LIG_LIR_Apic_2	81	85	PF02991	0.343
LIG_LIR_Gen_1	154	163	PF02991	0.383
LIG_LIR_Gen_1	165	175	PF02991	0.358
LIG_LIR_Gen_1	17	28	PF02991	0.327
LIG_LIR_Gen_1	194	203	PF02991	0.343
LIG_LIR_Nem_3	154	159	PF02991	0.324
LIG_LIR_Nem_3	165	171	PF02991	0.291
LIG_LIR_Nem_3	17	23	PF02991	0.324
LIG_LIR_Nem_3	194	199	PF02991	0.347
LIG_NRBOX	147	153	PF00104	0.425
LIG_PDZ_Class_1	216	221	PF00595	0.435
LIG_SH2_CRK	82	86	PF00017	0.360
LIG_SH2_GRB2like	213	216	PF00017	0.419
LIG_SH2_PTP2	20	23	PF00017	0.342
LIG_SH2_SRC	115	118	PF00017	0.279
LIG_SH2_SRC	206	209	PF00017	0.281
LIG_SH2_STAT5	115	118	PF00017	0.311
LIG_SH2_STAT5	156	159	PF00017	0.311
LIG_SH2_STAT5	166	169	PF00017	0.289
LIG_SH2_STAT5	20	23	PF00017	0.307
LIG_SH2_STAT5	206	209	PF00017	0.281
LIG_SH2_STAT5	5	8	PF00017	0.356
LIG_SH3_3	87	93	PF00018	0.364
LIG_SH3_4	48	55	PF00018	0.422
LIG_SUMO_SIM_par_1	26	31	PF11976	0.286
LIG_TRAF2_1	147	150	PF00917	0.362
MOD_CK2_1	131	137	PF00069	0.398
MOD_CK2_1	144	150	PF00069	0.286
MOD_CK2_1	3	9	PF00069	0.299
MOD_GlcNHglycan	76	79	PF01048	0.488
MOD_GSK3_1	131	138	PF00069	0.433
MOD_GSK3_1	74	81	PF00069	0.363
MOD_LATS_1	162	168	PF00433	0.435
MOD_NEK2_1	178	183	PF00069	0.428
MOD_PK_1	155	161	PF00069	0.392
MOD_PKB_1	153	161	PF00069	0.379
MOD_Plk_1	135	141	PF00069	0.357
MOD_Plk_1	144	150	PF00069	0.328
MOD_Plk_1	56	62	PF00069	0.311
MOD_Plk_2-3	136	142	PF00069	0.387
MOD_Plk_2-3	192	198	PF00069	0.474
MOD_Plk_4	164	170	PF00069	0.353
MOD_Plk_4	91	97	PF00069	0.353
MOD_ProDKin_1	28	34	PF00069	0.299
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.302
TRG_ENDOCYTIC_2	156	159	PF00928	0.354
TRG_ENDOCYTIC_2	166	169	PF00928	0.332
TRG_ENDOCYTIC_2	20	23	PF00928	0.342
TRG_ENDOCYTIC_2	37	40	PF00928	0.387
TRG_ER_diArg_1	123	126	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G7	Leptomonas seymouri	84%	100%
A0A0S4IWY2	Bodo saltans	60%	100%
A0A1X0NJA6	Trypanosomatidae	66%	99%
A0A3R7MUY6	Trypanosoma rangeli	64%	100%
A0A3S7WWT8	Leishmania donovani	100%	100%
A4HC15	Leishmania braziliensis	94%	100%
D0A144	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AVC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q0IHR1	Xenopus tropicalis	47%	100%
Q4QC51	Leishmania major	98%	100%
Q567I9	Danio rerio	47%	100%
Q5NCY3	Mus musculus	46%	97%
Q5PPR6	Xenopus laevis	48%	100%
Q5R4Q5	Pongo abelii	45%	97%
Q6P9G0	Homo sapiens	45%	97%