LeishMANIAdb
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2-oxoisovalerate dehydrogenase subunit alpha

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
2-oxoisovalerate dehydrogenase subunit alpha
Gene product:
2-oxoisovalerate dehydrogenase alpha subunit - putative
Species:
Leishmania infantum
UniProt:
A4HZE0_LEIIN
TriTrypDb:
LINF_210022900
Length:
479

Annotations

Annotations by Jardim et al.

Amino acid metabolism, 2-oxoisovalerate dehydrogenase alpha subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex 4 1
GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0045239 tricarboxylic acid cycle enzyme complex 3 1
GO:0045240 dihydrolipoyl dehydrogenase complex 4 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1
GO:1990204 oxidoreductase complex 3 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZE0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZE0

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0006520 amino acid metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009056 catabolic process 2 11
GO:0009063 amino acid catabolic process 4 11
GO:0009081 branched-chain amino acid metabolic process 4 11
GO:0009083 branched-chain amino acid catabolic process 5 11
GO:0009987 cellular process 1 11
GO:0016054 organic acid catabolic process 4 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0043436 oxoacid metabolic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044248 cellular catabolic process 3 11
GO:0044281 small molecule metabolic process 2 11
GO:0044282 small molecule catabolic process 3 11
GO:0046395 carboxylic acid catabolic process 5 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:1901565 organonitrogen compound catabolic process 4 11
GO:1901575 organic substance catabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 5 11
GO:0016491 oxidoreductase activity 2 11
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 4 11
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.518
CLV_C14_Caspase3-7 335 339 PF00656 0.436
CLV_C14_Caspase3-7 37 41 PF00656 0.389
CLV_C14_Caspase3-7 74 78 PF00656 0.456
CLV_NRD_NRD_1 251 253 PF00675 0.200
CLV_NRD_NRD_1 346 348 PF00675 0.221
CLV_NRD_NRD_1 423 425 PF00675 0.247
CLV_NRD_NRD_1 431 433 PF00675 0.242
CLV_PCSK_FUR_1 421 425 PF00082 0.164
CLV_PCSK_KEX2_1 217 219 PF00082 0.181
CLV_PCSK_KEX2_1 251 253 PF00082 0.200
CLV_PCSK_KEX2_1 423 425 PF00082 0.257
CLV_PCSK_KEX2_1 431 433 PF00082 0.232
CLV_PCSK_PC1ET2_1 217 219 PF00082 0.181
CLV_PCSK_SKI1_1 136 140 PF00082 0.294
CLV_PCSK_SKI1_1 358 362 PF00082 0.271
CLV_PCSK_SKI1_1 424 428 PF00082 0.252
DEG_APCC_DBOX_1 423 431 PF00400 0.336
DEG_Nend_Nbox_1 1 3 PF02207 0.500
DEG_SCF_FBW7_1 307 313 PF00400 0.388
DEG_SCF_FBW7_2 452 457 PF00400 0.371
DEG_SPOP_SBC_1 42 46 PF00917 0.382
DOC_CKS1_1 307 312 PF01111 0.375
DOC_CKS1_1 409 414 PF01111 0.431
DOC_MAPK_gen_1 347 354 PF00069 0.431
DOC_PP1_RVXF_1 144 150 PF00149 0.390
DOC_USP7_MATH_1 310 314 PF00917 0.405
DOC_USP7_MATH_1 380 384 PF00917 0.471
DOC_USP7_MATH_1 412 416 PF00917 0.431
DOC_USP7_MATH_1 469 473 PF00917 0.555
DOC_USP7_MATH_1 83 87 PF00917 0.719
DOC_WW_Pin1_4 223 228 PF00397 0.416
DOC_WW_Pin1_4 306 311 PF00397 0.375
DOC_WW_Pin1_4 392 397 PF00397 0.388
DOC_WW_Pin1_4 408 413 PF00397 0.356
DOC_WW_Pin1_4 450 455 PF00397 0.325
DOC_WW_Pin1_4 81 86 PF00397 0.530
LIG_14-3-3_CanoR_1 146 150 PF00244 0.375
LIG_14-3-3_CanoR_1 20 30 PF00244 0.395
LIG_14-3-3_CanoR_1 266 272 PF00244 0.471
LIG_APCC_ABBA_1 151 156 PF00400 0.471
LIG_APCC_Cbox_1 401 407 PF00515 0.351
LIG_CSL_BTD_1 409 412 PF09270 0.406
LIG_FHA_1 111 117 PF00498 0.499
LIG_FHA_1 253 259 PF00498 0.346
LIG_FHA_1 364 370 PF00498 0.493
LIG_FHA_1 414 420 PF00498 0.412
LIG_FHA_1 43 49 PF00498 0.414
LIG_FHA_1 451 457 PF00498 0.406
LIG_FHA_2 187 193 PF00498 0.406
LIG_FHA_2 259 265 PF00498 0.509
LIG_FHA_2 372 378 PF00498 0.421
LIG_FHA_2 420 426 PF00498 0.461
LIG_FHA_2 441 447 PF00498 0.370
LIG_FHA_2 47 53 PF00498 0.371
LIG_FHA_2 85 91 PF00498 0.526
LIG_GBD_Chelix_1 361 369 PF00786 0.219
LIG_LIR_Apic_2 406 412 PF02991 0.427
LIG_LIR_Gen_1 148 158 PF02991 0.471
LIG_LIR_Gen_1 398 405 PF02991 0.446
LIG_LIR_Gen_1 446 456 PF02991 0.476
LIG_LIR_Nem_3 171 177 PF02991 0.407
LIG_LIR_Nem_3 184 188 PF02991 0.443
LIG_LIR_Nem_3 392 397 PF02991 0.383
LIG_LIR_Nem_3 398 403 PF02991 0.387
LIG_LIR_Nem_3 446 452 PF02991 0.478
LIG_PDZ_Class_3 474 479 PF00595 0.527
LIG_Pex14_1 34 38 PF04695 0.336
LIG_Pex14_2 390 394 PF04695 0.388
LIG_PTB_Apo_2 299 306 PF02174 0.390
LIG_PTB_Apo_2 32 39 PF02174 0.362
LIG_PTB_Phospho_1 299 305 PF10480 0.390
LIG_REV1ctd_RIR_1 296 305 PF16727 0.471
LIG_SH2_CRK 327 331 PF00017 0.388
LIG_SH2_CRK 343 347 PF00017 0.388
LIG_SH2_NCK_1 188 192 PF00017 0.471
LIG_SH2_SRC 305 308 PF00017 0.406
LIG_SH2_STAP1 240 244 PF00017 0.388
LIG_SH2_STAT5 188 191 PF00017 0.420
LIG_SH3_3 221 227 PF00018 0.415
LIG_SH3_3 434 440 PF00018 0.364
LIG_SH3_3 53 59 PF00018 0.399
LIG_SUMO_SIM_par_1 358 363 PF11976 0.399
MOD_CDK_SPxxK_3 392 399 PF00069 0.391
MOD_CK1_1 114 120 PF00069 0.506
MOD_CK1_1 308 314 PF00069 0.384
MOD_CK1_1 370 376 PF00069 0.378
MOD_CK1_1 46 52 PF00069 0.379
MOD_CK2_1 166 172 PF00069 0.445
MOD_CK2_1 186 192 PF00069 0.431
MOD_CK2_1 258 264 PF00069 0.419
MOD_CK2_1 380 386 PF00069 0.406
MOD_CK2_1 392 398 PF00069 0.406
MOD_CK2_1 419 425 PF00069 0.461
MOD_CK2_1 84 90 PF00069 0.528
MOD_GlcNHglycan 125 128 PF01048 0.394
MOD_GlcNHglycan 77 80 PF01048 0.663
MOD_GlcNHglycan 97 100 PF01048 0.462
MOD_GSK3_1 110 117 PF00069 0.434
MOD_GSK3_1 123 130 PF00069 0.285
MOD_GSK3_1 145 152 PF00069 0.404
MOD_GSK3_1 223 230 PF00069 0.397
MOD_GSK3_1 254 261 PF00069 0.482
MOD_GSK3_1 287 294 PF00069 0.405
MOD_GSK3_1 306 313 PF00069 0.304
MOD_GSK3_1 363 370 PF00069 0.471
MOD_GSK3_1 371 378 PF00069 0.383
MOD_GSK3_1 408 415 PF00069 0.406
MOD_GSK3_1 42 49 PF00069 0.366
MOD_GSK3_1 91 98 PF00069 0.644
MOD_LATS_1 108 114 PF00433 0.294
MOD_NEK2_1 149 154 PF00069 0.409
MOD_NEK2_1 2 7 PF00069 0.479
MOD_NEK2_1 258 263 PF00069 0.489
MOD_NEK2_1 288 293 PF00069 0.403
MOD_NEK2_1 390 395 PF00069 0.471
MOD_NEK2_2 145 150 PF00069 0.375
MOD_NEK2_2 293 298 PF00069 0.388
MOD_NEK2_2 469 474 PF00069 0.510
MOD_PIKK_1 227 233 PF00454 0.398
MOD_PIKK_1 310 316 PF00454 0.405
MOD_PKA_2 145 151 PF00069 0.375
MOD_PKA_2 19 25 PF00069 0.427
MOD_PKA_2 367 373 PF00069 0.388
MOD_Plk_1 110 116 PF00069 0.459
MOD_Plk_1 376 382 PF00069 0.391
MOD_Plk_4 111 117 PF00069 0.382
MOD_Plk_4 149 155 PF00069 0.417
MOD_Plk_4 254 260 PF00069 0.419
MOD_Plk_4 267 273 PF00069 0.471
MOD_Plk_4 293 299 PF00069 0.375
MOD_ProDKin_1 223 229 PF00069 0.416
MOD_ProDKin_1 306 312 PF00069 0.375
MOD_ProDKin_1 392 398 PF00069 0.388
MOD_ProDKin_1 408 414 PF00069 0.356
MOD_ProDKin_1 450 456 PF00069 0.318
MOD_ProDKin_1 81 87 PF00069 0.531
MOD_SUMO_for_1 109 112 PF00179 0.355
TRG_AP2beta_CARGO_1 398 407 PF09066 0.389
TRG_ENDOCYTIC_2 150 153 PF00928 0.471
TRG_ENDOCYTIC_2 343 346 PF00928 0.431
TRG_ER_diArg_1 251 253 PF00400 0.398
TRG_ER_diArg_1 381 384 PF00400 0.420
TRG_ER_diArg_1 421 424 PF00400 0.459
TRG_ER_diArg_1 430 432 PF00400 0.432
TRG_Pf-PMV_PEXEL_1 471 475 PF00026 0.466

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKY9 Leptomonas seymouri 26% 100%
A0A0N1P9U6 Leptomonas seymouri 76% 100%
A0A1X0NHX6 Trypanosomatidae 53% 100%
A0A3Q8IB83 Leishmania donovani 26% 100%
A0A3R7KFA1 Trypanosoma rangeli 26% 100%
A0A3S7WWV0 Leishmania donovani 100% 100%
A0A422NSQ8 Trypanosoma rangeli 52% 100%
A4H9P1 Leishmania braziliensis 28% 100%
A4HC14 Leishmania braziliensis 85% 100%
A4HY08 Leishmania infantum 26% 100%
A5A6H9 Pan troglodytes 43% 100%
A7MB35 Bos taurus 26% 100%
D0A145 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9ARS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AVC7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O24457 Arabidopsis thaliana 23% 100%
O31404 Bacillus subtilis (strain 168) 28% 100%
O45924 Caenorhabditis elegans 47% 100%
P09060 Pseudomonas putida 31% 100%
P11178 Bos taurus 43% 100%
P11960 Rattus norvegicus 44% 100%
P12694 Homo sapiens 44% 100%
P21873 Geobacillus stearothermophilus 29% 100%
P21881 Bacillus subtilis (strain 168) 31% 100%
P26267 Ascaris suum 25% 100%
P26268 Ascaris suum 25% 100%
P29804 Sus scrofa 26% 100%
P35485 Acholeplasma laidlawii 28% 100%
P47516 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 28% 100%
P50136 Mus musculus 43% 100%
P51267 Porphyra purpurea 27% 100%
P52900 Sminthopsis macroura 24% 100%
P60089 Staphylococcus aureus (strain Mu50 / ATCC 700699) 29% 100%
P60090 Staphylococcus aureus (strain MW2) 29% 100%
P75390 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 28% 100%
P9WIS2 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 35% 100%
P9WIS3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 35% 100%
Q06437 Rattus norvegicus 23% 100%
Q4MTG0 Bacillus cereus 30% 100%
Q4QC52 Leishmania major 94% 100%
Q4QDQ1 Leishmania major 26% 100%
Q54M22 Dictyostelium discoideum 45% 100%
Q5HGZ1 Staphylococcus aureus (strain COL) 29% 100%
Q5HQ76 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 30% 100%
Q5SLR4 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 35% 100%
Q654V6 Oryza sativa subsp. japonica 25% 100%
Q6GAC1 Staphylococcus aureus (strain MSSA476) 29% 100%
Q6GHZ2 Staphylococcus aureus (strain MRSA252) 29% 100%
Q72GU1 Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) 35% 100%
Q7XTJ3 Oryza sativa subsp. japonica 26% 100%
Q820A6 Staphylococcus aureus (strain N315) 29% 100%
Q84JL2 Arabidopsis thaliana 43% 100%
Q8CPN3 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 30% 100%
Q8HXY4 Macaca fascicularis 43% 100%
Q9I1M2 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 35% 100%
Q9LPL5 Arabidopsis thaliana 45% 100%
V5AZ52 Trypanosoma cruzi 26% 100%
V5DIA0 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS