Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZD9_LEIIN

TriTrypDb:

LINF_210022700

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HZD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.570
CLV_NRD_NRD_1	229	231	PF00675	0.444
CLV_NRD_NRD_1	254	256	PF00675	0.646
CLV_NRD_NRD_1	52	54	PF00675	0.589
CLV_NRD_NRD_1	82	84	PF00675	0.530
CLV_PCSK_FUR_1	252	256	PF00082	0.635
CLV_PCSK_KEX2_1	228	230	PF00082	0.441
CLV_PCSK_KEX2_1	254	256	PF00082	0.596
CLV_PCSK_KEX2_1	52	54	PF00082	0.478
CLV_PCSK_KEX2_1	82	84	PF00082	0.530
CLV_PCSK_PC7_1	224	230	PF00082	0.529
CLV_PCSK_SKI1_1	143	147	PF00082	0.661
CLV_PCSK_SKI1_1	18	22	PF00082	0.529
CLV_PCSK_SKI1_1	199	203	PF00082	0.482
CLV_PCSK_SKI1_1	35	39	PF00082	0.453
CLV_PCSK_SKI1_1	82	86	PF00082	0.552
DEG_SPOP_SBC_1	89	93	PF00917	0.590
DOC_AGCK_PIF_1	42	47	PF00069	0.504
DOC_CYCLIN_RxL_1	15	24	PF00134	0.496
DOC_PP1_RVXF_1	65	71	PF00149	0.519
DOC_PP1_RVXF_1	80	87	PF00149	0.544
DOC_PP2B_LxvP_1	108	111	PF13499	0.600
DOC_USP7_MATH_1	157	161	PF00917	0.663
DOC_USP7_MATH_1	90	94	PF00917	0.649
DOC_USP7_MATH_1	97	101	PF00917	0.653
LIG_14-3-3_CanoR_1	155	164	PF00244	0.565
LIG_14-3-3_CanoR_1	172	181	PF00244	0.603
LIG_14-3-3_CanoR_1	259	266	PF00244	0.667
LIG_14-3-3_CanoR_1	40	45	PF00244	0.464
LIG_14-3-3_CanoR_1	96	106	PF00244	0.620
LIG_APCC_ABBA_1	193	198	PF00400	0.529
LIG_APCC_ABBAyCdc20_2	192	198	PF00400	0.529
LIG_CaM_IQ_9	27	42	PF13499	0.454
LIG_Clathr_ClatBox_1	116	120	PF01394	0.479
LIG_Clathr_ClatBox_1	20	24	PF01394	0.396
LIG_CtBP_PxDLS_1	111	115	PF00389	0.529
LIG_deltaCOP1_diTrp_1	253	258	PF00928	0.622
LIG_FHA_1	200	206	PF00498	0.422
LIG_FHA_2	142	148	PF00498	0.560
LIG_LIR_Gen_1	184	195	PF02991	0.443
LIG_LIR_Gen_1	39	50	PF02991	0.466
LIG_LIR_Gen_1	7	17	PF02991	0.590
LIG_LIR_Nem_3	204	209	PF02991	0.538
LIG_LIR_Nem_3	39	45	PF02991	0.446
LIG_LIR_Nem_3	46	50	PF02991	0.495
LIG_LIR_Nem_3	7	12	PF02991	0.553
LIG_Pex14_1	221	225	PF04695	0.563
LIG_Pex14_2	44	48	PF04695	0.534
LIG_PTB_Apo_2	216	223	PF02174	0.491
LIG_REV1ctd_RIR_1	83	89	PF16727	0.612
LIG_SH2_CRK	210	214	PF00017	0.482
LIG_SH2_CRK	9	13	PF00017	0.523
LIG_SH2_STAT5	187	190	PF00017	0.521
LIG_SH2_STAT5	210	213	PF00017	0.522
LIG_SH2_STAT5	225	228	PF00017	0.379
LIG_SH2_STAT5	36	39	PF00017	0.410
LIG_SH2_STAT5	69	72	PF00017	0.533
LIG_SUMO_SIM_anti_2	112	120	PF11976	0.515
LIG_SUMO_SIM_par_1	112	120	PF11976	0.489
LIG_WRC_WIRS_1	44	49	PF05994	0.511
MOD_CK1_1	128	134	PF00069	0.561
MOD_CK1_1	160	166	PF00069	0.622
MOD_CK1_1	167	173	PF00069	0.610
MOD_CK1_1	262	268	PF00069	0.595
MOD_CK1_1	43	49	PF00069	0.487
MOD_CK1_1	72	78	PF00069	0.465
MOD_CK1_1	92	98	PF00069	0.404
MOD_CK2_1	141	147	PF00069	0.664
MOD_CK2_1	172	178	PF00069	0.460
MOD_GlcNHglycan	159	162	PF01048	0.667
MOD_GlcNHglycan	174	177	PF01048	0.460
MOD_GlcNHglycan	92	95	PF01048	0.674
MOD_GlcNHglycan	99	102	PF01048	0.680
MOD_GSK3_1	121	128	PF00069	0.505
MOD_GSK3_1	156	163	PF00069	0.636
MOD_GSK3_1	164	171	PF00069	0.533
MOD_GSK3_1	172	179	PF00069	0.649
MOD_GSK3_1	181	188	PF00069	0.553
MOD_GSK3_1	229	236	PF00069	0.494
MOD_GSK3_1	88	95	PF00069	0.667
MOD_N-GLC_1	185	190	PF02516	0.577
MOD_N-GLC_1	40	45	PF02516	0.449
MOD_NEK2_1	146	151	PF00069	0.576
MOD_NEK2_1	181	186	PF00069	0.522
MOD_NEK2_1	201	206	PF00069	0.250
MOD_NEK2_1	4	9	PF00069	0.566
MOD_PIKK_1	121	127	PF00454	0.592
MOD_PKA_1	229	235	PF00069	0.482
MOD_PKA_2	229	235	PF00069	0.482
MOD_PKA_2	4	10	PF00069	0.580
MOD_PKA_2	95	101	PF00069	0.613
MOD_Plk_1	141	147	PF00069	0.606
MOD_Plk_1	185	191	PF00069	0.522
MOD_Plk_1	40	46	PF00069	0.452
MOD_Plk_2-3	141	147	PF00069	0.627
MOD_Plk_4	125	131	PF00069	0.499
MOD_Plk_4	229	235	PF00069	0.399
TRG_DiLeu_BaEn_1	112	117	PF01217	0.565
TRG_DiLeu_BaEn_2	177	183	PF01217	0.547
TRG_ENDOCYTIC_2	187	190	PF00928	0.454
TRG_ENDOCYTIC_2	210	213	PF00928	0.470
TRG_ENDOCYTIC_2	9	12	PF00928	0.522
TRG_ER_diArg_1	228	230	PF00400	0.414
TRG_ER_diArg_1	254	256	PF00400	0.605
TRG_ER_diArg_1	33	36	PF00400	0.525
TRG_ER_diArg_1	65	68	PF00400	0.612
TRG_ER_diArg_1	81	83	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V9	Leptomonas seymouri	60%	98%
A0A0S4IH77	Bodo saltans	30%	100%
A0A1X0NHE8	Trypanosomatidae	42%	100%
A0A3S7WWT7	Leishmania donovani	100%	100%
A4HBY9	Leishmania braziliensis	80%	100%
D0A146	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QC53	Leishmania major	93%	100%
V5B1U8	Trypanosoma cruzi	39%	100%