GBBH-like_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF971) - putative

Species:

Leishmania infantum

UniProt:

A4HZD8_LEIIN

TriTrypDb:

LINF_210022600

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZD8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.779
CLV_NRD_NRD_1	181	183	PF00675	0.686
CLV_NRD_NRD_1	219	221	PF00675	0.598
CLV_NRD_NRD_1	383	385	PF00675	0.430
CLV_NRD_NRD_1	441	443	PF00675	0.665
CLV_PCSK_FUR_1	154	158	PF00082	0.651
CLV_PCSK_FUR_1	438	442	PF00082	0.667
CLV_PCSK_KEX2_1	154	156	PF00082	0.785
CLV_PCSK_KEX2_1	181	183	PF00082	0.686
CLV_PCSK_KEX2_1	219	221	PF00082	0.598
CLV_PCSK_KEX2_1	383	385	PF00082	0.430
CLV_PCSK_KEX2_1	440	442	PF00082	0.667
CLV_PCSK_KEX2_1	448	450	PF00082	0.583
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.658
CLV_PCSK_PC7_1	444	450	PF00082	0.681
CLV_PCSK_SKI1_1	182	186	PF00082	0.748
CLV_PCSK_SKI1_1	213	217	PF00082	0.587
CLV_PCSK_SKI1_1	298	302	PF00082	0.744
CLV_PCSK_SKI1_1	30	34	PF00082	0.476
CLV_PCSK_SKI1_1	384	388	PF00082	0.307
CLV_PCSK_SKI1_1	400	404	PF00082	0.369
CLV_Separin_Metazoa	270	274	PF03568	0.589
CLV_Separin_Metazoa	286	290	PF03568	0.570
DEG_Nend_UBRbox_3	1	3	PF02207	0.489
DEG_SPOP_SBC_1	159	163	PF00917	0.653
DEG_SPOP_SBC_1	183	187	PF00917	0.654
DEG_SPOP_SBC_1	288	292	PF00917	0.795
DEG_SPOP_SBC_1	305	309	PF00917	0.526
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.467
DOC_MAPK_gen_1	255	262	PF00069	0.609
DOC_MAPK_MEF2A_6	117	126	PF00069	0.541
DOC_MAPK_MEF2A_6	43	51	PF00069	0.471
DOC_MAPK_MEF2A_6	52	60	PF00069	0.429
DOC_PP2B_LxvP_1	47	50	PF13499	0.505
DOC_PP4_FxxP_1	262	265	PF00568	0.586
DOC_PP4_FxxP_1	51	54	PF00568	0.527
DOC_USP7_MATH_1	101	105	PF00917	0.503
DOC_USP7_MATH_1	115	119	PF00917	0.553
DOC_USP7_MATH_1	159	163	PF00917	0.702
DOC_USP7_MATH_1	174	178	PF00917	0.578
DOC_USP7_MATH_1	183	187	PF00917	0.588
DOC_USP7_MATH_1	228	232	PF00917	0.699
DOC_USP7_MATH_1	279	283	PF00917	0.759
DOC_USP7_MATH_1	288	292	PF00917	0.685
DOC_USP7_MATH_1	304	308	PF00917	0.565
DOC_USP7_MATH_1	312	316	PF00917	0.542
DOC_USP7_MATH_1	322	326	PF00917	0.738
DOC_USP7_MATH_1	393	397	PF00917	0.496
DOC_WW_Pin1_4	11	16	PF00397	0.470
DOC_WW_Pin1_4	110	115	PF00397	0.710
DOC_WW_Pin1_4	135	140	PF00397	0.553
DOC_WW_Pin1_4	160	165	PF00397	0.786
DOC_WW_Pin1_4	166	171	PF00397	0.695
DOC_WW_Pin1_4	341	346	PF00397	0.746
DOC_WW_Pin1_4	363	368	PF00397	0.630
DOC_WW_Pin1_4	419	424	PF00397	0.504
DOC_WW_Pin1_4	52	57	PF00397	0.493
DOC_WW_Pin1_4	58	63	PF00397	0.531
LIG_14-3-3_CanoR_1	154	164	PF00244	0.627
LIG_14-3-3_CanoR_1	181	189	PF00244	0.584
LIG_14-3-3_CanoR_1	226	236	PF00244	0.563
LIG_14-3-3_CanoR_1	273	278	PF00244	0.756
LIG_14-3-3_CanoR_1	298	303	PF00244	0.742
LIG_14-3-3_CanoR_1	306	312	PF00244	0.628
LIG_14-3-3_CanoR_1	321	330	PF00244	0.800
LIG_14-3-3_CanoR_1	336	340	PF00244	0.478
LIG_14-3-3_CanoR_1	35	40	PF00244	0.502
LIG_14-3-3_CanoR_1	431	439	PF00244	0.354
LIG_14-3-3_CanoR_1	68	72	PF00244	0.575
LIG_Actin_WH2_2	385	402	PF00022	0.630
LIG_BH_BH3_1	181	197	PF00452	0.702
LIG_BIR_III_4	87	91	PF00653	0.480
LIG_BRCT_BRCA1_1	162	166	PF00533	0.656
LIG_BRCT_BRCA1_1	194	198	PF00533	0.380
LIG_EVH1_1	12	16	PF00568	0.466
LIG_EVH1_1	53	57	PF00568	0.430
LIG_EVH1_2	16	20	PF00568	0.457
LIG_FHA_1	183	189	PF00498	0.584
LIG_FHA_1	353	359	PF00498	0.468
LIG_FHA_1	387	393	PF00498	0.573
LIG_FHA_2	128	134	PF00498	0.554
LIG_FHA_2	261	267	PF00498	0.466
LIG_FHA_2	36	42	PF00498	0.509
LIG_LIR_Apic_2	261	265	PF02991	0.587
LIG_LIR_Apic_2	76	81	PF02991	0.444
LIG_LIR_Gen_1	19	27	PF02991	0.428
LIG_LIR_Gen_1	256	265	PF02991	0.610
LIG_LIR_Gen_1	413	420	PF02991	0.630
LIG_LIR_Gen_1	452	463	PF02991	0.514
LIG_LIR_Nem_3	19	25	PF02991	0.437
LIG_LIR_Nem_3	256	262	PF02991	0.620
LIG_LIR_Nem_3	338	342	PF02991	0.516
LIG_LIR_Nem_3	413	419	PF02991	0.630
LIG_SH2_CRK	22	26	PF00017	0.417
LIG_SH2_CRK	414	418	PF00017	0.534
LIG_SH2_CRK	78	82	PF00017	0.468
LIG_SH2_NCK_1	78	82	PF00017	0.468
LIG_SH2_STAP1	22	26	PF00017	0.417
LIG_SH2_STAP1	397	401	PF00017	0.630
LIG_SH2_STAP1	412	416	PF00017	0.457
LIG_SH2_STAP1	455	459	PF00017	0.641
LIG_SH2_STAT5	152	155	PF00017	0.644
LIG_SH2_STAT5	259	262	PF00017	0.596
LIG_SH2_STAT5	361	364	PF00017	0.630
LIG_SH2_STAT5	365	368	PF00017	0.515
LIG_SH2_STAT5	416	419	PF00017	0.615
LIG_SH2_STAT5	433	436	PF00017	0.327
LIG_SH2_STAT5	78	81	PF00017	0.507
LIG_SH3_2	284	289	PF14604	0.708
LIG_SH3_3	10	16	PF00018	0.474
LIG_SH3_3	212	218	PF00018	0.703
LIG_SH3_3	278	284	PF00018	0.758
LIG_SH3_3	342	348	PF00018	0.741
LIG_SH3_3	51	57	PF00018	0.499
LIG_SUMO_SIM_anti_2	266	273	PF11976	0.549
LIG_SUMO_SIM_par_1	55	61	PF11976	0.516
LIG_TRFH_1	166	170	PF08558	0.713
LIG_WW_3	286	290	PF00397	0.710
MOD_CDK_SPK_2	166	171	PF00069	0.525
MOD_CDK_SPxxK_3	110	117	PF00069	0.707
MOD_CDK_SPxxK_3	135	142	PF00069	0.559
MOD_CDK_SPxxK_3	419	426	PF00069	0.500
MOD_CK1_1	109	115	PF00069	0.733
MOD_CK1_1	11	17	PF00069	0.469
MOD_CK1_1	187	193	PF00069	0.569
MOD_CK1_1	282	288	PF00069	0.841
MOD_CK1_1	292	298	PF00069	0.655
MOD_CK1_1	422	428	PF00069	0.533
MOD_CK1_1	462	468	PF00069	0.385
MOD_CK1_1	70	76	PF00069	0.549
MOD_CK2_1	127	133	PF00069	0.499
MOD_CK2_1	228	234	PF00069	0.693
MOD_CK2_1	260	266	PF00069	0.457
MOD_CK2_1	70	76	PF00069	0.558
MOD_Cter_Amidation	381	384	PF01082	0.523
MOD_DYRK1A_RPxSP_1	363	367	PF00069	0.523
MOD_GlcNHglycan	135	138	PF01048	0.554
MOD_GlcNHglycan	176	179	PF01048	0.662
MOD_GlcNHglycan	291	294	PF01048	0.721
MOD_GlcNHglycan	308	311	PF01048	0.595
MOD_GlcNHglycan	324	327	PF01048	0.589
MOD_GlcNHglycan	348	351	PF01048	0.648
MOD_GlcNHglycan	407	410	PF01048	0.390
MOD_GlcNHglycan	461	464	PF01048	0.424
MOD_GSK3_1	106	113	PF00069	0.531
MOD_GSK3_1	155	162	PF00069	0.631
MOD_GSK3_1	183	190	PF00069	0.637
MOD_GSK3_1	288	295	PF00069	0.805
MOD_GSK3_1	401	408	PF00069	0.322
MOD_GSK3_1	418	425	PF00069	0.439
MOD_GSK3_1	66	73	PF00069	0.579
MOD_N-GLC_1	228	233	PF02516	0.696
MOD_NEK2_1	127	132	PF00069	0.590
MOD_NEK2_1	184	189	PF00069	0.717
MOD_NEK2_1	192	197	PF00069	0.521
MOD_NEK2_1	198	203	PF00069	0.385
MOD_NEK2_1	64	69	PF00069	0.547
MOD_PIKK_1	198	204	PF00454	0.518
MOD_PIKK_1	76	82	PF00454	0.510
MOD_PK_1	449	455	PF00069	0.551
MOD_PKA_1	155	161	PF00069	0.789
MOD_PKA_1	440	446	PF00069	0.657
MOD_PKA_2	155	161	PF00069	0.633
MOD_PKA_2	288	294	PF00069	0.714
MOD_PKA_2	305	311	PF00069	0.514
MOD_PKA_2	335	341	PF00069	0.510
MOD_PKA_2	440	446	PF00069	0.657
MOD_PKA_2	67	73	PF00069	0.573
MOD_PKB_1	438	446	PF00069	0.660
MOD_Plk_1	228	234	PF00069	0.563
MOD_Plk_1	260	266	PF00069	0.570
MOD_Plk_4	148	154	PF00069	0.631
MOD_Plk_4	184	190	PF00069	0.579
MOD_Plk_4	43	49	PF00069	0.557
MOD_ProDKin_1	11	17	PF00069	0.469
MOD_ProDKin_1	110	116	PF00069	0.709
MOD_ProDKin_1	135	141	PF00069	0.556
MOD_ProDKin_1	160	166	PF00069	0.789
MOD_ProDKin_1	341	347	PF00069	0.741
MOD_ProDKin_1	363	369	PF00069	0.523
MOD_ProDKin_1	419	425	PF00069	0.502
MOD_ProDKin_1	52	58	PF00069	0.494
MOD_SUMO_rev_2	205	215	PF00179	0.721
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.511
TRG_ENDOCYTIC_2	22	25	PF00928	0.424
TRG_ENDOCYTIC_2	259	262	PF00928	0.596
TRG_ENDOCYTIC_2	414	417	PF00928	0.523
TRG_ENDOCYTIC_2	427	430	PF00928	0.599
TRG_ENDOCYTIC_2	455	458	PF00928	0.509
TRG_ER_diArg_1	153	156	PF00400	0.782
TRG_ER_diArg_1	181	183	PF00400	0.686
TRG_ER_diArg_1	218	220	PF00400	0.597
TRG_ER_diArg_1	242	245	PF00400	0.694
TRG_ER_diArg_1	353	356	PF00400	0.620
TRG_ER_diArg_1	437	440	PF00400	0.638
TRG_ER_diArg_1	441	444	PF00400	0.597
TRG_NES_CRM1_1	267	280	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAY8	Leishmania donovani	99%	100%
A4HBZ0	Leishmania braziliensis	67%	96%
E9AVC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QC54	Leishmania major	88%	100%