LeishMANIAdb
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Palmitoyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Palmitoyltransferase
Gene product:
palmitoyl acyltransferase 3 - putative
Species:
Leishmania infantum
UniProt:
A4HZD7_LEIIN
TriTrypDb:
LINF_210022400
Length:
596

Annotations

LeishMANIAdb annotations

Palmitoyltransferase. Leishmaniids have +2 extra TM segments at the N-terminus while all other Kinetoplastids typically only have the 4 core ones.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0031090 organelle membrane 3 1

Expansion

Sequence features

A4HZD7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZD7

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 2
GO:0006605 protein targeting 5 2
GO:0006612 protein targeting to membrane 5 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0006810 transport 3 2
GO:0006886 intracellular protein transport 4 2
GO:0006897 endocytosis 5 2
GO:0008104 protein localization 4 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0015031 protein transport 4 2
GO:0016192 vesicle-mediated transport 4 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018198 peptidyl-cysteine modification 6 2
GO:0018230 peptidyl-L-cysteine S-palmitoylation 7 2
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 7 2
GO:0018345 protein palmitoylation 6 2
GO:0019538 protein metabolic process 3 2
GO:0033036 macromolecule localization 2 2
GO:0036211 protein modification process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 2
GO:0043543 protein acylation 5 2
GO:0044238 primary metabolic process 2 2
GO:0045184 establishment of protein localization 3 2
GO:0046907 intracellular transport 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
GO:0051668 localization within membrane 3 2
GO:0070727 cellular macromolecule localization 3 2
GO:0071702 organic substance transport 4 2
GO:0071704 organic substance metabolic process 2 2
GO:0071705 nitrogen compound transport 4 2
GO:0072657 protein localization to membrane 4 2
GO:0090150 establishment of protein localization to membrane 4 2
GO:1901564 organonitrogen compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016409 palmitoyltransferase activity 5 7
GO:0016417 S-acyltransferase activity 5 7
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 7
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 7
GO:0019707 protein-cysteine S-acyltransferase activity 3 7
GO:0140096 catalytic activity, acting on a protein 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.740
CLV_C14_Caspase3-7 186 190 PF00656 0.762
CLV_C14_Caspase3-7 229 233 PF00656 0.805
CLV_NRD_NRD_1 13 15 PF00675 0.504
CLV_NRD_NRD_1 173 175 PF00675 0.494
CLV_NRD_NRD_1 251 253 PF00675 0.546
CLV_NRD_NRD_1 323 325 PF00675 0.438
CLV_NRD_NRD_1 330 332 PF00675 0.355
CLV_NRD_NRD_1 399 401 PF00675 0.630
CLV_NRD_NRD_1 402 404 PF00675 0.594
CLV_NRD_NRD_1 528 530 PF00675 0.553
CLV_NRD_NRD_1 551 553 PF00675 0.500
CLV_PCSK_FUR_1 400 404 PF00082 0.464
CLV_PCSK_KEX2_1 13 15 PF00082 0.504
CLV_PCSK_KEX2_1 173 175 PF00082 0.494
CLV_PCSK_KEX2_1 251 253 PF00082 0.546
CLV_PCSK_KEX2_1 323 325 PF00082 0.438
CLV_PCSK_KEX2_1 330 332 PF00082 0.355
CLV_PCSK_KEX2_1 399 401 PF00082 0.606
CLV_PCSK_KEX2_1 402 404 PF00082 0.622
CLV_PCSK_KEX2_1 462 464 PF00082 0.400
CLV_PCSK_KEX2_1 480 482 PF00082 0.356
CLV_PCSK_KEX2_1 528 530 PF00082 0.512
CLV_PCSK_KEX2_1 551 553 PF00082 0.500
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.380
CLV_PCSK_PC1ET2_1 480 482 PF00082 0.376
CLV_PCSK_SKI1_1 256 260 PF00082 0.545
CLV_PCSK_SKI1_1 330 334 PF00082 0.438
CLV_PCSK_SKI1_1 367 371 PF00082 0.285
CLV_PCSK_SKI1_1 463 467 PF00082 0.358
CLV_PCSK_SKI1_1 517 521 PF00082 0.427
CLV_PCSK_SKI1_1 528 532 PF00082 0.468
CLV_PCSK_SKI1_1 8 12 PF00082 0.504
DEG_APCC_DBOX_1 13 21 PF00400 0.709
DEG_APCC_DBOX_1 366 374 PF00400 0.530
DEG_APCC_DBOX_1 511 519 PF00400 0.604
DEG_Nend_UBRbox_2 1 3 PF02207 0.726
DOC_CKS1_1 67 72 PF01111 0.500
DOC_CYCLIN_RxL_1 459 470 PF00134 0.398
DOC_CYCLIN_RxL_1 497 506 PF00134 0.694
DOC_CYCLIN_yCln2_LP_2 424 430 PF00134 0.438
DOC_MAPK_gen_1 13 20 PF00069 0.645
DOC_MAPK_gen_1 312 321 PF00069 0.713
DOC_MAPK_gen_1 551 559 PF00069 0.652
DOC_MAPK_HePTP_8 549 561 PF00069 0.524
DOC_MAPK_MEF2A_6 13 22 PF00069 0.639
DOC_MAPK_MEF2A_6 308 315 PF00069 0.668
DOC_MAPK_MEF2A_6 552 561 PF00069 0.685
DOC_MAPK_RevD_3 237 252 PF00069 0.738
DOC_PP1_RVXF_1 36 43 PF00149 0.595
DOC_PP1_RVXF_1 498 505 PF00149 0.692
DOC_PP2B_LxvP_1 319 322 PF13499 0.763
DOC_PP2B_LxvP_1 332 335 PF13499 0.522
DOC_PP2B_LxvP_1 424 427 PF13499 0.438
DOC_PP4_FxxP_1 169 172 PF00568 0.810
DOC_USP7_MATH_1 471 475 PF00917 0.552
DOC_USP7_UBL2_3 517 521 PF12436 0.656
DOC_WW_Pin1_4 142 147 PF00397 0.821
DOC_WW_Pin1_4 168 173 PF00397 0.796
DOC_WW_Pin1_4 189 194 PF00397 0.869
DOC_WW_Pin1_4 408 413 PF00397 0.438
DOC_WW_Pin1_4 66 71 PF00397 0.505
LIG_14-3-3_CanoR_1 264 273 PF00244 0.727
LIG_14-3-3_CanoR_1 286 291 PF00244 0.633
LIG_14-3-3_CanoR_1 528 535 PF00244 0.652
LIG_AP2alpha_1 504 508 PF02296 0.675
LIG_BRCT_BRCA1_1 269 273 PF00533 0.749
LIG_BRCT_BRCA1_1 486 490 PF00533 0.744
LIG_BRCT_BRCA1_1 95 99 PF00533 0.530
LIG_CaM_NSCaTE_8 377 384 PF13499 0.473
LIG_Clathr_ClatBox_1 296 300 PF01394 0.737
LIG_deltaCOP1_diTrp_1 540 546 PF00928 0.683
LIG_DLG_GKlike_1 251 258 PF00625 0.661
LIG_EH1_1 443 451 PF00400 0.443
LIG_eIF4E_1 459 465 PF01652 0.534
LIG_eIF4E_1 579 585 PF01652 0.723
LIG_FHA_1 150 156 PF00498 0.718
LIG_FHA_1 199 205 PF00498 0.816
LIG_FHA_1 212 218 PF00498 0.666
LIG_FHA_1 236 242 PF00498 0.796
LIG_FHA_1 35 41 PF00498 0.604
LIG_FHA_1 382 388 PF00498 0.473
LIG_FHA_1 434 440 PF00498 0.406
LIG_FHA_1 441 447 PF00498 0.348
LIG_FHA_1 467 473 PF00498 0.558
LIG_FHA_1 51 57 PF00498 0.315
LIG_FHA_1 579 585 PF00498 0.723
LIG_FHA_2 184 190 PF00498 0.824
LIG_FHA_2 293 299 PF00498 0.717
LIG_FHA_2 346 352 PF00498 0.595
LIG_FHA_2 468 474 PF00498 0.639
LIG_FHA_2 508 514 PF00498 0.660
LIG_HP1_1 74 78 PF01393 0.321
LIG_IBAR_NPY_1 494 496 PF08397 0.565
LIG_Integrin_RGD_1 226 228 PF01839 0.601
LIG_LIR_Apic_2 109 115 PF02991 0.788
LIG_LIR_Apic_2 491 495 PF02991 0.607
LIG_LIR_Gen_1 455 465 PF02991 0.534
LIG_LIR_Gen_1 53 60 PF02991 0.534
LIG_LIR_Gen_1 581 590 PF02991 0.741
LIG_LIR_Gen_1 72 83 PF02991 0.211
LIG_LIR_Nem_3 213 219 PF02991 0.835
LIG_LIR_Nem_3 384 389 PF02991 0.380
LIG_LIR_Nem_3 455 460 PF02991 0.534
LIG_LIR_Nem_3 53 57 PF02991 0.534
LIG_LIR_Nem_3 564 569 PF02991 0.700
LIG_LIR_Nem_3 581 585 PF02991 0.572
LIG_LIR_Nem_3 72 78 PF02991 0.211
LIG_LIR_Nem_3 86 90 PF02991 0.300
LIG_LYPXL_SIV_4 427 435 PF13949 0.438
LIG_NRBOX 292 298 PF00104 0.622
LIG_NRBOX 77 83 PF00104 0.473
LIG_Pex14_1 562 566 PF04695 0.681
LIG_Pex14_2 29 33 PF04695 0.707
LIG_Pex14_2 504 508 PF04695 0.675
LIG_SH2_CRK 112 116 PF00017 0.753
LIG_SH2_CRK 389 393 PF00017 0.534
LIG_SH2_CRK 492 496 PF00017 0.591
LIG_SH2_GRB2like 125 128 PF00017 0.679
LIG_SH2_GRB2like 459 462 PF00017 0.534
LIG_SH2_GRB2like 90 93 PF00017 0.534
LIG_SH2_PTP2 75 78 PF00017 0.473
LIG_SH2_SRC 125 128 PF00017 0.788
LIG_SH2_STAP1 116 120 PF00017 0.746
LIG_SH2_STAT3 9 12 PF00017 0.656
LIG_SH2_STAT5 110 113 PF00017 0.553
LIG_SH2_STAT5 116 119 PF00017 0.703
LIG_SH2_STAT5 16 19 PF00017 0.705
LIG_SH2_STAT5 325 328 PF00017 0.522
LIG_SH2_STAT5 368 371 PF00017 0.534
LIG_SH2_STAT5 391 394 PF00017 0.438
LIG_SH2_STAT5 438 441 PF00017 0.473
LIG_SH2_STAT5 459 462 PF00017 0.534
LIG_SH2_STAT5 476 479 PF00017 0.512
LIG_SH2_STAT5 75 78 PF00017 0.489
LIG_SH2_STAT5 90 93 PF00017 0.329
LIG_SH3_3 176 182 PF00018 0.831
LIG_SH3_3 190 196 PF00018 0.733
LIG_SH3_3 203 209 PF00018 0.709
LIG_SH3_3 281 287 PF00018 0.764
LIG_SH3_3 424 430 PF00018 0.438
LIG_SH3_3 574 580 PF00018 0.759
LIG_SUMO_SIM_par_1 294 300 PF11976 0.736
LIG_TYR_ITIM 387 392 PF00017 0.353
LIG_TYR_ITIM 73 78 PF00017 0.534
LIG_WRC_WIRS_1 30 35 PF05994 0.638
LIG_WRC_WIRS_1 51 56 PF05994 0.534
LIG_WRC_WIRS_1 566 571 PF05994 0.658
LIG_WRC_WIRS_1 579 584 PF05994 0.487
LIG_WRC_WIRS_1 84 89 PF05994 0.534
LIG_WW_1 107 110 PF00397 0.675
LIG_WW_2 209 212 PF00397 0.808
LIG_WW_3 309 313 PF00397 0.640
MOD_CDC14_SPxK_1 171 174 PF00782 0.820
MOD_CDC14_SPxK_1 411 414 PF00782 0.534
MOD_CDK_SPK_2 142 147 PF00069 0.627
MOD_CDK_SPK_2 168 173 PF00069 0.630
MOD_CDK_SPK_2 189 194 PF00069 0.708
MOD_CDK_SPxK_1 168 174 PF00069 0.815
MOD_CDK_SPxK_1 408 414 PF00069 0.534
MOD_CK1_1 128 134 PF00069 0.854
MOD_CK1_1 254 260 PF00069 0.743
MOD_CK1_1 292 298 PF00069 0.492
MOD_CK1_1 437 443 PF00069 0.443
MOD_CK2_1 292 298 PF00069 0.620
MOD_CK2_1 467 473 PF00069 0.534
MOD_CMANNOS 374 377 PF00535 0.534
MOD_GlcNHglycan 132 136 PF01048 0.652
MOD_GlcNHglycan 189 192 PF01048 0.554
MOD_GlcNHglycan 228 232 PF01048 0.793
MOD_GlcNHglycan 267 270 PF01048 0.657
MOD_GlcNHglycan 586 589 PF01048 0.752
MOD_GSK3_1 127 134 PF00069 0.753
MOD_GSK3_1 149 156 PF00069 0.710
MOD_GSK3_1 183 190 PF00069 0.781
MOD_GSK3_1 263 270 PF00069 0.597
MOD_GSK3_1 29 36 PF00069 0.635
MOD_GSK3_1 377 384 PF00069 0.534
MOD_GSK3_1 433 440 PF00069 0.473
MOD_GSK3_1 467 474 PF00069 0.400
MOD_GSK3_1 484 491 PF00069 0.460
MOD_GSK3_1 561 568 PF00069 0.607
MOD_GSK3_1 65 72 PF00069 0.561
MOD_GSK3_1 93 100 PF00069 0.541
MOD_N-GLC_1 187 192 PF02516 0.769
MOD_N-GLC_1 33 38 PF02516 0.587
MOD_N-GLC_1 467 472 PF02516 0.401
MOD_N-GLC_1 488 493 PF02516 0.459
MOD_N-GLC_2 344 346 PF02516 0.460
MOD_N-GLC_2 358 360 PF02516 0.375
MOD_NEK2_1 183 188 PF00069 0.821
MOD_NEK2_1 265 270 PF00069 0.521
MOD_NEK2_1 29 34 PF00069 0.592
MOD_NEK2_1 381 386 PF00069 0.375
MOD_NEK2_1 434 439 PF00069 0.456
MOD_NEK2_1 444 449 PF00069 0.316
MOD_NEK2_1 452 457 PF00069 0.473
MOD_NEK2_1 466 471 PF00069 0.357
MOD_NEK2_1 507 512 PF00069 0.553
MOD_NEK2_1 94 99 PF00069 0.600
MOD_NEK2_2 471 476 PF00069 0.473
MOD_PIKK_1 149 155 PF00454 0.796
MOD_PIKK_1 204 210 PF00454 0.763
MOD_PKA_1 251 257 PF00069 0.598
MOD_PKA_1 528 534 PF00069 0.688
MOD_PKA_2 251 257 PF00069 0.720
MOD_PKA_2 263 269 PF00069 0.508
MOD_PKA_2 392 398 PF00069 0.443
MOD_PKA_2 528 534 PF00069 0.627
MOD_Plk_1 108 114 PF00069 0.651
MOD_Plk_1 153 159 PF00069 0.673
MOD_Plk_1 183 189 PF00069 0.854
MOD_Plk_1 467 473 PF00069 0.534
MOD_Plk_1 488 494 PF00069 0.511
MOD_Plk_4 292 298 PF00069 0.503
MOD_Plk_4 377 383 PF00069 0.532
MOD_Plk_4 434 440 PF00069 0.374
MOD_Plk_4 444 450 PF00069 0.441
MOD_Plk_4 452 458 PF00069 0.464
MOD_Plk_4 471 477 PF00069 0.219
MOD_ProDKin_1 142 148 PF00069 0.788
MOD_ProDKin_1 168 174 PF00069 0.758
MOD_ProDKin_1 189 195 PF00069 0.857
MOD_ProDKin_1 408 414 PF00069 0.534
MOD_ProDKin_1 66 72 PF00069 0.620
MOD_SUMO_for_1 520 523 PF00179 0.554
TRG_DiLeu_BaLyEn_6 314 319 PF01217 0.443
TRG_DiLeu_LyEn_5 589 594 PF01217 0.723
TRG_ENDOCYTIC_2 368 371 PF00928 0.534
TRG_ENDOCYTIC_2 389 392 PF00928 0.370
TRG_ENDOCYTIC_2 579 582 PF00928 0.688
TRG_ENDOCYTIC_2 75 78 PF00928 0.534
TRG_ER_diArg_1 172 174 PF00400 0.611
TRG_ER_diArg_1 311 314 PF00400 0.644
TRG_ER_diArg_1 322 324 PF00400 0.288
TRG_ER_diArg_1 330 332 PF00400 0.400
TRG_ER_diArg_1 399 401 PF00400 0.501
TRG_ER_diArg_1 402 404 PF00400 0.505
TRG_ER_diArg_1 551 553 PF00400 0.566
TRG_NES_CRM1_1 154 166 PF08389 0.740
TRG_Pf-PMV_PEXEL_1 101 105 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 402 407 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 551 555 PF00026 0.622

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IAF5 Leishmania donovani 100% 84%
A4HC51 Leishmania braziliensis 69% 100%
E9AVC4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QC55 Leishmania major 92% 100%
Q4QC56 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS