G_PROTEIN_RECEP_F1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZD6_LEIIN

TriTrypDb:

LINF_210022200

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HZD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.477
CLV_NRD_NRD_1	172	174	PF00675	0.437
CLV_NRD_NRD_1	180	182	PF00675	0.393
CLV_PCSK_KEX2_1	104	106	PF00082	0.477
CLV_PCSK_KEX2_1	172	174	PF00082	0.436
DEG_APCC_DBOX_1	256	264	PF00400	0.687
DEG_APCC_DBOX_1	56	64	PF00400	0.252
DEG_APCC_DBOX_1	88	96	PF00400	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DOC_CDC14_PxL_1	17	25	PF14671	0.338
DOC_CKS1_1	229	234	PF01111	0.598
DOC_MAPK_gen_1	55	64	PF00069	0.275
DOC_MAPK_MEF2A_6	55	64	PF00069	0.275
DOC_MAPK_NFAT4_5	55	63	PF00069	0.256
DOC_MAPK_RevD_3	90	105	PF00069	0.607
DOC_PP1_RVXF_1	79	86	PF00149	0.539
DOC_PP4_FxxP_1	227	230	PF00568	0.650
DOC_USP7_MATH_1	297	301	PF00917	0.712
DOC_USP7_MATH_1	306	310	PF00917	0.745
DOC_USP7_MATH_1	312	316	PF00917	0.769
DOC_USP7_MATH_1	32	36	PF00917	0.393
DOC_USP7_UBL2_3	178	182	PF12436	0.658
DOC_USP7_UBL2_3	218	222	PF12436	0.568
DOC_WW_Pin1_4	228	233	PF00397	0.592
DOC_WW_Pin1_4	24	29	PF00397	0.412
DOC_WW_Pin1_4	262	267	PF00397	0.727
LIG_14-3-3_CanoR_1	143	153	PF00244	0.664
LIG_14-3-3_CanoR_1	162	168	PF00244	0.647
LIG_14-3-3_CanoR_1	176	181	PF00244	0.566
LIG_14-3-3_CanoR_1	257	266	PF00244	0.728
LIG_14-3-3_CanoR_1	307	312	PF00244	0.671
LIG_14-3-3_CanoR_1	98	102	PF00244	0.590
LIG_Actin_WH2_2	83	100	PF00022	0.541
LIG_BRCT_BRCA1_1	10	14	PF00533	0.279
LIG_BRCT_BRCA1_1	187	191	PF00533	0.596
LIG_deltaCOP1_diTrp_1	183	191	PF00928	0.685
LIG_FHA_1	215	221	PF00498	0.574
LIG_FHA_1	4	10	PF00498	0.370
LIG_FHA_1	49	55	PF00498	0.358
LIG_FHA_2	343	349	PF00498	0.677
LIG_LIR_Gen_1	11	22	PF02991	0.370
LIG_LIR_Gen_1	188	197	PF02991	0.576
LIG_LIR_Nem_3	11	17	PF02991	0.305
LIG_LIR_Nem_3	188	194	PF02991	0.579
LIG_LIR_Nem_3	327	332	PF02991	0.713
LIG_SH2_CRK	80	84	PF00017	0.540
LIG_SH2_SRC	24	27	PF00017	0.347
LIG_SH2_STAT5	24	27	PF00017	0.406
LIG_SH2_STAT5	253	256	PF00017	0.742
LIG_SH2_STAT5	59	62	PF00017	0.484
LIG_SH2_STAT5	76	79	PF00017	0.226
LIG_SH3_3	15	21	PF00018	0.352
LIG_SH3_3	223	229	PF00018	0.594
LIG_SH3_3	291	297	PF00018	0.693
LIG_SH3_3	300	306	PF00018	0.680
LIG_SH3_3	59	65	PF00018	0.436
LIG_SUMO_SIM_par_1	60	66	PF11976	0.315
LIG_WW_1	21	24	PF00397	0.460
MOD_CDK_SPK_2	262	267	PF00069	0.705
MOD_CK1_1	127	133	PF00069	0.692
MOD_CK1_1	137	143	PF00069	0.663
MOD_CK1_1	144	150	PF00069	0.622
MOD_CK1_1	265	271	PF00069	0.791
MOD_CK1_1	320	326	PF00069	0.764
MOD_CK2_1	37	43	PF00069	0.440
MOD_GlcNHglycan	10	13	PF01048	0.312
MOD_GlcNHglycan	110	113	PF01048	0.417
MOD_GlcNHglycan	126	129	PF01048	0.512
MOD_GlcNHglycan	146	149	PF01048	0.402
MOD_GlcNHglycan	187	190	PF01048	0.416
MOD_GlcNHglycan	267	270	PF01048	0.565
MOD_GlcNHglycan	315	318	PF01048	0.549
MOD_GlcNHglycan	319	322	PF01048	0.556
MOD_GlcNHglycan	39	42	PF01048	0.632
MOD_GSK3_1	133	140	PF00069	0.689
MOD_GSK3_1	181	188	PF00069	0.627
MOD_GSK3_1	258	265	PF00069	0.741
MOD_GSK3_1	313	320	PF00069	0.749
MOD_GSK3_1	336	343	PF00069	0.702
MOD_GSK3_1	93	100	PF00069	0.568
MOD_LATS_1	174	180	PF00433	0.610
MOD_N-GLC_1	117	122	PF02516	0.448
MOD_N-GLC_1	133	138	PF02516	0.366
MOD_N-GLC_1	141	146	PF02516	0.583
MOD_N-GLC_1	214	219	PF02516	0.371
MOD_N-GLC_1	313	318	PF02516	0.491
MOD_NEK2_1	1	6	PF00069	0.547
MOD_NEK2_1	108	113	PF00069	0.581
MOD_NEK2_1	141	146	PF00069	0.641
MOD_NEK2_1	163	168	PF00069	0.663
MOD_NEK2_1	46	51	PF00069	0.447
MOD_NEK2_2	297	302	PF00069	0.703
MOD_PIKK_1	48	54	PF00454	0.423
MOD_PK_1	176	182	PF00069	0.602
MOD_PKA_1	181	187	PF00069	0.604
MOD_PKA_2	306	312	PF00069	0.729
MOD_PKA_2	97	103	PF00069	0.591
MOD_Plk_1	117	123	PF00069	0.649
MOD_Plk_1	46	52	PF00069	0.464
MOD_Plk_4	127	133	PF00069	0.647
MOD_Plk_4	181	187	PF00069	0.604
MOD_ProDKin_1	228	234	PF00069	0.595
MOD_ProDKin_1	24	30	PF00069	0.415
MOD_ProDKin_1	262	268	PF00069	0.726
MOD_SUMO_rev_2	280	285	PF00179	0.664
TRG_ENDOCYTIC_2	59	62	PF00928	0.509
TRG_ENDOCYTIC_2	80	83	PF00928	0.564
TRG_ER_diArg_1	171	173	PF00400	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA48	Leptomonas seymouri	49%	91%
A0A3S7WWN2	Leishmania donovani	99%	100%
A4HC52	Leishmania braziliensis	62%	100%
E9AVC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	96%
Q4QC57	Leishmania major	89%	100%