LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZD4_LEIIN
TriTrypDb:
LINF_210021800
Length:
356

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 2
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZD4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZD4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.505
CLV_NRD_NRD_1 279 281 PF00675 0.528
CLV_NRD_NRD_1 93 95 PF00675 0.556
CLV_PCSK_KEX2_1 278 280 PF00082 0.515
CLV_PCSK_KEX2_1 93 95 PF00082 0.554
CLV_PCSK_PC7_1 89 95 PF00082 0.555
CLV_PCSK_SKI1_1 239 243 PF00082 0.652
DEG_APCC_DBOX_1 238 246 PF00400 0.613
DEG_Nend_Nbox_1 1 3 PF02207 0.555
DOC_ANK_TNKS_1 224 231 PF00023 0.492
DOC_CKS1_1 186 191 PF01111 0.616
DOC_CYCLIN_yCln2_LP_2 292 298 PF00134 0.616
DOC_MAPK_gen_1 212 221 PF00069 0.522
DOC_MAPK_gen_1 285 294 PF00069 0.605
DOC_PP2B_LxvP_1 292 295 PF13499 0.600
DOC_PP4_FxxP_1 221 224 PF00568 0.514
DOC_USP7_MATH_1 23 27 PF00917 0.581
DOC_USP7_MATH_1 296 300 PF00917 0.650
DOC_USP7_MATH_1 69 73 PF00917 0.619
DOC_USP7_UBL2_3 63 67 PF12436 0.514
DOC_WW_Pin1_4 122 127 PF00397 0.773
DOC_WW_Pin1_4 185 190 PF00397 0.645
DOC_WW_Pin1_4 67 72 PF00397 0.581
LIG_14-3-3_CanoR_1 148 154 PF00244 0.389
LIG_14-3-3_CanoR_1 32 40 PF00244 0.535
LIG_14-3-3_CanoR_1 324 331 PF00244 0.550
LIG_14-3-3_CanoR_1 89 93 PF00244 0.461
LIG_14-3-3_CanoR_1 94 102 PF00244 0.502
LIG_Actin_WH2_2 52 69 PF00022 0.505
LIG_BRCT_BRCA1_1 250 254 PF00533 0.600
LIG_deltaCOP1_diTrp_1 267 277 PF00928 0.425
LIG_FHA_1 257 263 PF00498 0.460
LIG_FHA_1 311 317 PF00498 0.530
LIG_FHA_1 73 79 PF00498 0.653
LIG_FHA_2 106 112 PF00498 0.626
LIG_FHA_2 139 145 PF00498 0.604
LIG_FHA_2 241 247 PF00498 0.683
LIG_FHA_2 332 338 PF00498 0.637
LIG_LIR_Apic_2 183 189 PF02991 0.552
LIG_LIR_Gen_1 251 262 PF02991 0.537
LIG_LIR_Gen_1 267 276 PF02991 0.477
LIG_LIR_Gen_1 37 48 PF02991 0.560
LIG_LIR_Nem_3 160 166 PF02991 0.482
LIG_LIR_Nem_3 251 257 PF02991 0.556
LIG_LIR_Nem_3 26 31 PF02991 0.560
LIG_LIR_Nem_3 37 43 PF02991 0.482
LIG_LIR_Nem_3 53 59 PF02991 0.321
LIG_MAD2 212 220 PF02301 0.494
LIG_Rb_LxCxE_1 193 203 PF01857 0.741
LIG_SH2_STAP1 149 153 PF00017 0.439
LIG_SH2_STAT5 112 115 PF00017 0.632
LIG_SH2_STAT5 54 57 PF00017 0.505
LIG_SH3_3 10 16 PF00018 0.678
LIG_SH3_3 263 269 PF00018 0.544
LIG_SH3_CIN85_PxpxPR_1 220 225 PF14604 0.385
LIG_TRAF2_1 178 181 PF00917 0.531
LIG_TRAF2_2 48 53 PF00917 0.508
MOD_CDC14_SPxK_1 125 128 PF00782 0.683
MOD_CDK_SPxK_1 122 128 PF00069 0.677
MOD_CDK_SPxK_1 185 191 PF00069 0.599
MOD_CK1_1 118 124 PF00069 0.744
MOD_CK1_1 72 78 PF00069 0.643
MOD_CK2_1 138 144 PF00069 0.577
MOD_GlcNHglycan 134 137 PF01048 0.685
MOD_GlcNHglycan 225 228 PF01048 0.627
MOD_GlcNHglycan 234 237 PF01048 0.630
MOD_GlcNHglycan 249 253 PF01048 0.606
MOD_GlcNHglycan 34 37 PF01048 0.541
MOD_GlcNHglycan 71 74 PF01048 0.615
MOD_GSK3_1 111 118 PF00069 0.638
MOD_GSK3_1 120 127 PF00069 0.746
MOD_GSK3_1 310 317 PF00069 0.454
MOD_GSK3_1 32 39 PF00069 0.557
MOD_GSK3_1 323 330 PF00069 0.452
MOD_GSK3_1 69 76 PF00069 0.559
MOD_GSK3_1 80 87 PF00069 0.454
MOD_N-GLC_1 314 319 PF02516 0.516
MOD_N-GLC_1 84 89 PF02516 0.473
MOD_NEK2_1 1 6 PF00069 0.538
MOD_NEK2_1 232 237 PF00069 0.693
MOD_NEK2_1 34 39 PF00069 0.586
MOD_NEK2_2 149 154 PF00069 0.454
MOD_NEK2_2 157 162 PF00069 0.516
MOD_NEK2_2 84 89 PF00069 0.449
MOD_PIKK_1 323 329 PF00454 0.612
MOD_PIKK_1 46 52 PF00454 0.545
MOD_PKA_1 93 99 PF00069 0.589
MOD_PKA_2 132 138 PF00069 0.676
MOD_PKA_2 323 329 PF00069 0.493
MOD_PKA_2 88 94 PF00069 0.486
MOD_Plk_1 157 163 PF00069 0.457
MOD_Plk_1 288 294 PF00069 0.714
MOD_Plk_1 296 302 PF00069 0.550
MOD_Plk_1 84 90 PF00069 0.447
MOD_Plk_4 1 7 PF00069 0.544
MOD_ProDKin_1 122 128 PF00069 0.776
MOD_ProDKin_1 185 191 PF00069 0.657
MOD_ProDKin_1 67 73 PF00069 0.595
MOD_SUMO_for_1 62 65 PF00179 0.512
MOD_SUMO_rev_2 58 64 PF00179 0.526
TRG_ENDOCYTIC_2 163 166 PF00928 0.443
TRG_ENDOCYTIC_2 54 57 PF00928 0.452
TRG_ER_diArg_1 210 213 PF00400 0.515
TRG_ER_diArg_1 277 280 PF00400 0.483
TRG_ER_diArg_1 92 94 PF00400 0.546
TRG_Pf-PMV_PEXEL_1 239 244 PF00026 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1F8 Leptomonas seymouri 51% 90%
A0A0S4IMV9 Bodo saltans 27% 100%
A0A1X0NHQ9 Trypanosomatidae 26% 100%
A0A3Q8IC12 Leishmania donovani 99% 100%
A0A3R7KKV6 Trypanosoma rangeli 26% 100%
A4HBZ4 Leishmania braziliensis 70% 100%
D0A150 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AVC1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QC59 Leishmania major 90% 100%
V5BHB3 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS