V-type proton ATPase subunit H

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase - putative

Species:

Leishmania infantum

UniProt:

A4HZD2_LEIIN

TriTrypDb:

LINF_210021600

Length:

483

Annotations

Annotations by Jardim et al.

ATP metabolism, ATP synthase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	5	12
GO:0032991	protein-containing complex	1	12
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	12
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	12
GO:0098796	membrane protein complex	2	12

Expansion

Sequence features

A4HZD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZD2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0016787	hydrolase activity	2	6
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	12
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	12
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	12
GO:0140657	ATP-dependent activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.370
CLV_C14_Caspase3-7	44	48	PF00656	0.343
CLV_NRD_NRD_1	178	180	PF00675	0.327
CLV_NRD_NRD_1	270	272	PF00675	0.361
CLV_NRD_NRD_1	333	335	PF00675	0.301
CLV_NRD_NRD_1	84	86	PF00675	0.234
CLV_PCSK_KEX2_1	178	180	PF00082	0.346
CLV_PCSK_KEX2_1	333	335	PF00082	0.301
CLV_PCSK_SKI1_1	146	150	PF00082	0.370
CLV_PCSK_SKI1_1	183	187	PF00082	0.340
CLV_PCSK_SKI1_1	435	439	PF00082	0.307
CLV_PCSK_SKI1_1	463	467	PF00082	0.310
DEG_APCC_DBOX_1	256	264	PF00400	0.301
DEG_ODPH_VHL_1	440	453	PF01847	0.370
DEG_SCF_FBW7_1	374	381	PF00400	0.358
DEG_SPOP_SBC_1	379	383	PF00917	0.421
DOC_CYCLIN_RxL_1	13	23	PF00134	0.448
DOC_CYCLIN_RxL_1	429	439	PF00134	0.421
DOC_MAPK_gen_1	178	187	PF00069	0.421
DOC_MAPK_gen_1	249	258	PF00069	0.303
DOC_MAPK_gen_1	384	393	PF00069	0.421
DOC_MAPK_gen_1	409	419	PF00069	0.448
DOC_MAPK_MEF2A_6	252	260	PF00069	0.302
DOC_MAPK_MEF2A_6	412	419	PF00069	0.421
DOC_MAPK_MEF2A_6	49	57	PF00069	0.315
DOC_MAPK_NFAT4_5	412	420	PF00069	0.332
DOC_MAPK_RevD_3	320	335	PF00069	0.296
DOC_PP1_RVXF_1	181	188	PF00149	0.379
DOC_USP7_UBL2_3	272	276	PF12436	0.448
DOC_WW_Pin1_4	298	303	PF00397	0.448
DOC_WW_Pin1_4	374	379	PF00397	0.317
LIG_14-3-3_CanoR_1	153	157	PF00244	0.421
LIG_14-3-3_CanoR_1	257	261	PF00244	0.406
LIG_14-3-3_CanoR_1	435	441	PF00244	0.414
LIG_AP2alpha_1	145	149	PF02296	0.370
LIG_BH_BH3_1	66	82	PF00452	0.421
LIG_BRCT_BRCA1_1	381	385	PF00533	0.336
LIG_BRCT_BRCA1_1	72	76	PF00533	0.370
LIG_BRCT_BRCA1_2	381	387	PF00533	0.386
LIG_Clathr_ClatBox_1	223	227	PF01394	0.386
LIG_DLG_GKlike_1	49	57	PF00625	0.421
LIG_eIF4E_1	228	234	PF01652	0.421
LIG_FHA_1	158	164	PF00498	0.374
LIG_FHA_1	198	204	PF00498	0.355
LIG_FHA_1	215	221	PF00498	0.180
LIG_FHA_1	23	29	PF00498	0.267
LIG_FHA_1	32	38	PF00498	0.307
LIG_FHA_1	41	47	PF00498	0.382
LIG_FHA_1	414	420	PF00498	0.322
LIG_FHA_1	467	473	PF00498	0.405
LIG_FHA_1	9	15	PF00498	0.387
LIG_FHA_2	62	68	PF00498	0.416
LIG_Integrin_RGD_1	93	95	PF01839	0.370
LIG_LIR_Gen_1	395	404	PF02991	0.361
LIG_LIR_Nem_3	142	148	PF02991	0.355
LIG_LIR_Nem_3	181	185	PF02991	0.398
LIG_LIR_Nem_3	225	231	PF02991	0.319
LIG_LIR_Nem_3	360	365	PF02991	0.317
LIG_LIR_Nem_3	375	379	PF02991	0.317
LIG_LIR_Nem_3	395	401	PF02991	0.361
LIG_LRP6_Inhibitor_1	21	27	PF00058	0.370
LIG_NRBOX	219	225	PF00104	0.421
LIG_NRBOX	259	265	PF00104	0.421
LIG_Pex14_1	222	226	PF04695	0.287
LIG_Pex14_2	145	149	PF04695	0.421
LIG_Pex14_2	182	186	PF04695	0.456
LIG_SH2_GRB2like	273	276	PF00017	0.358
LIG_SH2_STAP1	215	219	PF00017	0.301
LIG_SH2_STAP1	398	402	PF00017	0.386
LIG_SH2_STAP1	72	76	PF00017	0.408
LIG_SH2_STAT5	127	130	PF00017	0.390
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.486
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.408
LIG_SUMO_SIM_par_1	216	221	PF11976	0.358
LIG_SUMO_SIM_par_1	231	237	PF11976	0.358
LIG_TRAF2_1	281	284	PF00917	0.448
LIG_TYR_ITIM	213	218	PF00017	0.278
LIG_WRC_WIRS_1	223	228	PF05994	0.386
LIG_WRC_WIRS_1	306	311	PF05994	0.410
LIG_WRC_WIRS_1	359	364	PF05994	0.317
MOD_CK1_1	113	119	PF00069	0.419
MOD_CK1_1	190	196	PF00069	0.418
MOD_CK1_1	204	210	PF00069	0.350
MOD_CK1_1	329	335	PF00069	0.448
MOD_CK2_1	111	117	PF00069	0.419
MOD_CK2_1	278	284	PF00069	0.386
MOD_CK2_1	408	414	PF00069	0.382
MOD_CK2_1	61	67	PF00069	0.401
MOD_GlcNHglycan	206	209	PF01048	0.356
MOD_GlcNHglycan	370	373	PF01048	0.308
MOD_GlcNHglycan	4	7	PF01048	0.500
MOD_GSK3_1	111	118	PF00069	0.421
MOD_GSK3_1	157	164	PF00069	0.373
MOD_GSK3_1	197	204	PF00069	0.385
MOD_GSK3_1	214	221	PF00069	0.197
MOD_GSK3_1	374	381	PF00069	0.316
MOD_N-GLC_1	140	145	PF02516	0.442
MOD_NEK2_1	128	133	PF00069	0.333
MOD_NEK2_1	187	192	PF00069	0.313
MOD_NEK2_1	218	223	PF00069	0.343
MOD_NEK2_1	324	329	PF00069	0.301
MOD_NEK2_1	352	357	PF00069	0.525
MOD_NEK2_1	41	46	PF00069	0.313
MOD_NEK2_1	452	457	PF00069	0.418
MOD_NEK2_1	466	471	PF00069	0.409
MOD_NEK2_1	70	75	PF00069	0.350
MOD_PIKK_1	326	332	PF00454	0.386
MOD_PIKK_1	360	366	PF00454	0.421
MOD_PIKK_1	466	472	PF00454	0.421
MOD_PKA_2	152	158	PF00069	0.421
MOD_PKA_2	256	262	PF00069	0.413
MOD_PKA_2	408	414	PF00069	0.448
MOD_Plk_1	140	146	PF00069	0.389
MOD_Plk_1	22	28	PF00069	0.319
MOD_Plk_1	352	358	PF00069	0.427
MOD_Plk_1	413	419	PF00069	0.317
MOD_Plk_1	49	55	PF00069	0.414
MOD_Plk_4	103	109	PF00069	0.356
MOD_Plk_4	187	193	PF00069	0.441
MOD_Plk_4	214	220	PF00069	0.302
MOD_Plk_4	256	262	PF00069	0.375
MOD_Plk_4	311	317	PF00069	0.376
MOD_Plk_4	41	47	PF00069	0.287
MOD_ProDKin_1	298	304	PF00069	0.448
MOD_ProDKin_1	374	380	PF00069	0.317
MOD_SUMO_rev_2	268	274	PF00179	0.421
MOD_SUMO_rev_2	79	87	PF00179	0.234
TRG_DiLeu_BaEn_1	227	232	PF01217	0.426
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.386
TRG_ENDOCYTIC_2	215	218	PF00928	0.301
TRG_ENDOCYTIC_2	228	231	PF00928	0.301
TRG_ENDOCYTIC_2	398	401	PF00928	0.317
TRG_NES_CRM1_1	10	23	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	183	188	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIH3	Leptomonas seymouri	82%	100%
A0A0S4JQ71	Bodo saltans	43%	100%
A0A1X0NJ38	Trypanosomatidae	56%	100%
A0A3S5H7A0	Leishmania donovani	100%	100%
A0A422NSW7	Trypanosoma rangeli	54%	100%
A4HBZ2	Leishmania braziliensis	87%	100%
D0A152	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AVB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q22494	Caenorhabditis elegans	28%	100%
Q4QC61	Leishmania major	98%	100%
Q9U5N0	Manduca sexta	27%	100%
V5B1U1	Trypanosoma cruzi	50%	100%