Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZD0_LEIIN

TriTrypDb:

LINF_210021400

Length:

161

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.558
CLV_NRD_NRD_1	93	95	PF00675	0.640
CLV_PCSK_KEX2_1	10	12	PF00082	0.558
CLV_PCSK_KEX2_1	92	94	PF00082	0.645
CLV_PCSK_SKI1_1	102	106	PF00082	0.654
CLV_PCSK_SKI1_1	117	121	PF00082	0.492
DEG_APCC_DBOX_1	131	139	PF00400	0.354
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
LIG_14-3-3_CanoR_1	21	30	PF00244	0.618
LIG_14-3-3_CanoR_1	5	9	PF00244	0.748
LIG_14-3-3_CanoR_1	58	64	PF00244	0.422
LIG_APCC_ABBA_1	118	123	PF00400	0.427
LIG_APCC_ABBAyCdc20_2	117	123	PF00400	0.417
LIG_BRCT_BRCA1_1	150	154	PF00533	0.452
LIG_FHA_2	138	144	PF00498	0.456
LIG_FHA_2	94	100	PF00498	0.392
LIG_GBD_Chelix_1	34	42	PF00786	0.393
LIG_LIR_Gen_1	151	158	PF02991	0.390
LIG_LIR_Gen_1	45	52	PF02991	0.520
LIG_LIR_Nem_3	143	149	PF02991	0.388
LIG_LIR_Nem_3	151	157	PF02991	0.349
LIG_LIR_Nem_3	45	50	PF02991	0.520
LIG_WRC_WIRS_1	105	110	PF05994	0.378
MOD_CK1_1	133	139	PF00069	0.464
MOD_CK2_1	104	110	PF00069	0.417
MOD_CK2_1	137	143	PF00069	0.424
MOD_Cter_Amidation	114	117	PF01082	0.704
MOD_GlcNHglycan	134	138	PF01048	0.639
MOD_GlcNHglycan	150	153	PF01048	0.597
MOD_GlcNHglycan	87	90	PF01048	0.641
MOD_GSK3_1	121	128	PF00069	0.467
MOD_GSK3_1	133	140	PF00069	0.421
MOD_GSK3_1	21	28	PF00069	0.735
MOD_NEK2_1	42	47	PF00069	0.433
MOD_NEK2_2	142	147	PF00069	0.412
MOD_OFUCOSY	18	25	PF10250	0.426
MOD_PK_1	125	131	PF00069	0.421
MOD_PKA_1	10	16	PF00069	0.625
MOD_PKA_1	93	99	PF00069	0.418
MOD_PKA_2	4	10	PF00069	0.721
MOD_PKA_2	93	99	PF00069	0.413
MOD_PKB_1	19	27	PF00069	0.694
MOD_Plk_1	142	148	PF00069	0.412
MOD_Plk_4	104	110	PF00069	0.437
MOD_Plk_4	125	131	PF00069	0.405
MOD_Plk_4	4	10	PF00069	0.707
MOD_Plk_4	42	48	PF00069	0.516
MOD_Plk_4	59	65	PF00069	0.358
MOD_SUMO_rev_2	110	118	PF00179	0.469
TRG_DiLeu_BaEn_1	114	119	PF01217	0.400
TRG_ER_diArg_1	19	22	PF00400	0.749
TRG_ER_diArg_1	9	11	PF00400	0.748
TRG_ER_diArg_1	91	94	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR8	Leptomonas seymouri	61%	100%
A0A0S4JJA7	Bodo saltans	46%	100%
A0A1X0NXY8	Trypanosomatidae	39%	100%
A0A3R7KIY1	Trypanosoma rangeli	44%	100%
A0A3S7WWM3	Leishmania donovani	100%	100%
A4HBY8	Leishmania braziliensis	67%	100%
D0A154	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QC63	Leishmania major	91%	100%