LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZC9_LEIIN
TriTrypDb:
LINF_210021300
Length:
358

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZC9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZC9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016491 oxidoreductase activity 2 3
GO:0051213 dioxygenase activity 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 206 208 PF00675 0.445
CLV_NRD_NRD_1 321 323 PF00675 0.533
CLV_PCSK_KEX2_1 321 323 PF00082 0.423
CLV_PCSK_SKI1_1 134 138 PF00082 0.384
CLV_PCSK_SKI1_1 172 176 PF00082 0.349
CLV_PCSK_SKI1_1 20 24 PF00082 0.484
CLV_PCSK_SKI1_1 5 9 PF00082 0.621
DEG_Nend_UBRbox_1 1 4 PF02207 0.544
DOC_CKS1_1 188 193 PF01111 0.351
DOC_MAPK_DCC_7 337 347 PF00069 0.371
DOC_MAPK_gen_1 169 178 PF00069 0.343
DOC_PP2B_LxvP_1 109 112 PF13499 0.559
DOC_PP2B_LxvP_1 151 154 PF13499 0.369
DOC_PP4_FxxP_1 160 163 PF00568 0.440
DOC_PP4_FxxP_1 37 40 PF00568 0.504
DOC_USP7_MATH_1 100 104 PF00917 0.399
DOC_USP7_MATH_1 154 158 PF00917 0.463
DOC_USP7_MATH_1 256 260 PF00917 0.367
DOC_WW_Pin1_4 181 186 PF00397 0.346
DOC_WW_Pin1_4 187 192 PF00397 0.336
DOC_WW_Pin1_4 231 236 PF00397 0.480
LIG_14-3-3_CanoR_1 195 203 PF00244 0.421
LIG_14-3-3_CanoR_1 207 211 PF00244 0.297
LIG_BRCT_BRCA1_1 156 160 PF00533 0.480
LIG_EH_1 254 258 PF12763 0.335
LIG_eIF4E_2 38 44 PF01652 0.368
LIG_FHA_1 115 121 PF00498 0.466
LIG_FHA_1 146 152 PF00498 0.447
LIG_FHA_1 16 22 PF00498 0.428
LIG_FHA_1 188 194 PF00498 0.351
LIG_FHA_1 23 29 PF00498 0.510
LIG_FHA_2 347 353 PF00498 0.601
LIG_FHA_2 79 85 PF00498 0.426
LIG_Integrin_RGD_1 221 223 PF01839 0.447
LIG_LIR_Apic_2 157 163 PF02991 0.433
LIG_LIR_Apic_2 35 41 PF02991 0.379
LIG_LIR_Gen_1 201 210 PF02991 0.364
LIG_LIR_Gen_1 50 60 PF02991 0.329
LIG_LIR_Nem_3 201 206 PF02991 0.370
LIG_LIR_Nem_3 234 239 PF02991 0.348
LIG_LIR_Nem_3 338 342 PF02991 0.430
LIG_LIR_Nem_3 50 55 PF02991 0.312
LIG_SH2_CRK 203 207 PF00017 0.370
LIG_SH2_CRK 38 42 PF00017 0.380
LIG_SH2_SRC 38 41 PF00017 0.410
LIG_SH2_STAT3 273 276 PF00017 0.454
LIG_SH2_STAT5 226 229 PF00017 0.366
LIG_SH2_STAT5 273 276 PF00017 0.333
LIG_SH2_STAT5 52 55 PF00017 0.309
LIG_SH3_3 26 32 PF00018 0.421
LIG_SH3_3 96 102 PF00018 0.444
LIG_SUMO_SIM_anti_2 171 177 PF11976 0.327
LIG_SUMO_SIM_anti_2 344 349 PF11976 0.409
LIG_SUMO_SIM_par_1 190 197 PF11976 0.473
LIG_WRC_WIRS_1 275 280 PF05994 0.343
MOD_CDK_SPxxK_3 231 238 PF00069 0.480
MOD_CK1_1 125 131 PF00069 0.421
MOD_CK1_1 196 202 PF00069 0.385
MOD_CK1_1 277 283 PF00069 0.345
MOD_CK2_1 102 108 PF00069 0.544
MOD_CK2_1 257 263 PF00069 0.362
MOD_CK2_1 328 334 PF00069 0.397
MOD_CK2_1 346 352 PF00069 0.572
MOD_CK2_1 78 84 PF00069 0.385
MOD_GlcNHglycan 104 107 PF01048 0.592
MOD_GlcNHglycan 124 127 PF01048 0.409
MOD_GlcNHglycan 259 262 PF01048 0.451
MOD_GlcNHglycan 309 312 PF01048 0.423
MOD_GSK3_1 125 132 PF00069 0.461
MOD_GSK3_1 141 148 PF00069 0.411
MOD_GSK3_1 239 246 PF00069 0.531
MOD_GSK3_1 267 274 PF00069 0.444
MOD_GSK3_1 346 353 PF00069 0.654
MOD_N-GLC_1 280 285 PF02516 0.335
MOD_NEK2_1 193 198 PF00069 0.422
MOD_NEK2_1 206 211 PF00069 0.300
MOD_NEK2_1 257 262 PF00069 0.359
MOD_NEK2_1 268 273 PF00069 0.309
MOD_NEK2_1 350 355 PF00069 0.559
MOD_NEK2_1 55 60 PF00069 0.478
MOD_NEK2_2 145 150 PF00069 0.309
MOD_PIKK_1 70 76 PF00454 0.470
MOD_PK_1 161 167 PF00069 0.323
MOD_PKA_2 168 174 PF00069 0.355
MOD_PKA_2 194 200 PF00069 0.398
MOD_PKA_2 206 212 PF00069 0.306
MOD_Plk_4 125 131 PF00069 0.397
MOD_Plk_4 161 167 PF00069 0.338
MOD_Plk_4 246 252 PF00069 0.544
MOD_Plk_4 268 274 PF00069 0.333
MOD_Plk_4 323 329 PF00069 0.467
MOD_ProDKin_1 181 187 PF00069 0.352
MOD_ProDKin_1 231 237 PF00069 0.476
MOD_SUMO_for_1 335 338 PF00179 0.520
MOD_SUMO_rev_2 351 356 PF00179 0.523
TRG_DiLeu_BaLyEn_6 188 193 PF01217 0.425
TRG_ENDOCYTIC_2 203 206 PF00928 0.389
TRG_ENDOCYTIC_2 52 55 PF00928 0.309
TRG_Pf-PMV_PEXEL_1 330 334 PF00026 0.523

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBK0 Leptomonas seymouri 83% 99%
A0A0S4JR98 Bodo saltans 51% 100%
A0A1X0NXW7 Trypanosomatidae 63% 100%
A0A3S7WWQ0 Leishmania donovani 100% 100%
A0A422NSQ3 Trypanosoma rangeli 60% 100%
D0A155 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9AIQ4 Leishmania braziliensis 87% 100%
E9AVB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QC64 Leishmania major 95% 100%
V5BRD2 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS