LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
RF-1 domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HZC8_LEIIN
TriTrypDb:
LINF_210021200
Length:
583

Annotations

Annotations by Jardim et al.

Translation, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HZC8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZC8

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003747 translation release factor activity 5 11
GO:0005488 binding 1 11
GO:0008079 translation termination factor activity 4 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003824 catalytic activity 1 2
GO:0008168 methyltransferase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016741 transferase activity, transferring one-carbon groups 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 191 195 PF00656 0.493
CLV_C14_Caspase3-7 490 494 PF00656 0.448
CLV_NRD_NRD_1 117 119 PF00675 0.740
CLV_NRD_NRD_1 138 140 PF00675 0.559
CLV_NRD_NRD_1 249 251 PF00675 0.437
CLV_NRD_NRD_1 257 259 PF00675 0.432
CLV_NRD_NRD_1 338 340 PF00675 0.376
CLV_NRD_NRD_1 512 514 PF00675 0.248
CLV_NRD_NRD_1 88 90 PF00675 0.689
CLV_PCSK_FUR_1 254 258 PF00082 0.455
CLV_PCSK_KEX2_1 101 103 PF00082 0.730
CLV_PCSK_KEX2_1 256 258 PF00082 0.444
CLV_PCSK_KEX2_1 338 340 PF00082 0.376
CLV_PCSK_KEX2_1 449 451 PF00082 0.490
CLV_PCSK_KEX2_1 512 514 PF00082 0.248
CLV_PCSK_KEX2_1 88 90 PF00082 0.689
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.596
CLV_PCSK_PC1ET2_1 449 451 PF00082 0.490
CLV_PCSK_SKI1_1 162 166 PF00082 0.577
CLV_PCSK_SKI1_1 174 178 PF00082 0.585
CLV_PCSK_SKI1_1 200 204 PF00082 0.516
CLV_PCSK_SKI1_1 446 450 PF00082 0.583
CLV_PCSK_SKI1_1 495 499 PF00082 0.237
CLV_PCSK_SKI1_1 89 93 PF00082 0.644
DEG_APCC_DBOX_1 171 179 PF00400 0.413
DEG_Nend_UBRbox_3 1 3 PF02207 0.547
DEG_SPOP_SBC_1 226 230 PF00917 0.499
DEG_SPOP_SBC_1 60 64 PF00917 0.618
DOC_ANK_TNKS_1 458 465 PF00023 0.437
DOC_CYCLIN_RxL_1 507 519 PF00134 0.457
DOC_MAPK_gen_1 174 184 PF00069 0.414
DOC_MAPK_gen_1 254 264 PF00069 0.420
DOC_MAPK_MEF2A_6 256 264 PF00069 0.417
DOC_MAPK_RevD_3 124 140 PF00069 0.514
DOC_PP1_RVXF_1 510 517 PF00149 0.457
DOC_USP7_MATH_1 244 248 PF00917 0.510
DOC_USP7_MATH_1 394 398 PF00917 0.555
DOC_USP7_MATH_1 438 442 PF00917 0.363
DOC_USP7_MATH_1 458 462 PF00917 0.345
DOC_USP7_MATH_1 491 495 PF00917 0.448
DOC_USP7_MATH_1 58 62 PF00917 0.694
DOC_USP7_MATH_1 72 76 PF00917 0.724
DOC_USP7_MATH_1 79 83 PF00917 0.639
DOC_USP7_MATH_1 97 101 PF00917 0.543
DOC_USP7_UBL2_3 25 29 PF12436 0.498
DOC_WW_Pin1_4 423 428 PF00397 0.723
DOC_WW_Pin1_4 56 61 PF00397 0.634
DOC_WW_Pin1_4 62 67 PF00397 0.701
LIG_14-3-3_CanoR_1 200 209 PF00244 0.549
LIG_14-3-3_CanoR_1 273 283 PF00244 0.595
LIG_14-3-3_CanoR_1 364 374 PF00244 0.367
LIG_14-3-3_CanoR_1 383 393 PF00244 0.583
LIG_14-3-3_CanoR_1 450 454 PF00244 0.447
LIG_Actin_WH2_2 178 195 PF00022 0.483
LIG_BIR_III_2 391 395 PF00653 0.557
LIG_BRCT_BRCA1_1 368 372 PF00533 0.485
LIG_CaM_IQ_9 154 169 PF13499 0.442
LIG_FHA_1 227 233 PF00498 0.551
LIG_FHA_1 39 45 PF00498 0.636
LIG_FHA_1 420 426 PF00498 0.554
LIG_FHA_1 556 562 PF00498 0.549
LIG_FHA_2 163 169 PF00498 0.558
LIG_GSK3_LRP6_1 56 62 PF00069 0.536
LIG_LIR_Gen_1 127 136 PF02991 0.417
LIG_LIR_Gen_1 228 238 PF02991 0.496
LIG_LIR_Gen_1 301 311 PF02991 0.403
LIG_LIR_Gen_1 348 356 PF02991 0.402
LIG_LIR_Gen_1 365 374 PF02991 0.381
LIG_LIR_Gen_1 45 55 PF02991 0.408
LIG_LIR_Gen_1 473 484 PF02991 0.539
LIG_LIR_Nem_3 127 133 PF02991 0.420
LIG_LIR_Nem_3 145 150 PF02991 0.408
LIG_LIR_Nem_3 228 234 PF02991 0.568
LIG_LIR_Nem_3 301 307 PF02991 0.411
LIG_LIR_Nem_3 348 353 PF02991 0.402
LIG_LIR_Nem_3 365 370 PF02991 0.432
LIG_LIR_Nem_3 473 479 PF02991 0.539
LIG_NRBOX 233 239 PF00104 0.466
LIG_Pex14_2 402 406 PF04695 0.346
LIG_SH2_CRK 350 354 PF00017 0.354
LIG_SH2_CRK 476 480 PF00017 0.539
LIG_SH2_PTP2 231 234 PF00017 0.423
LIG_SH2_PTP2 333 336 PF00017 0.497
LIG_SH2_STAP1 350 354 PF00017 0.375
LIG_SH2_STAP1 404 408 PF00017 0.420
LIG_SH2_STAP1 476 480 PF00017 0.562
LIG_SH2_STAP1 487 491 PF00017 0.515
LIG_SH2_STAT3 148 151 PF00017 0.431
LIG_SH2_STAT5 231 234 PF00017 0.533
LIG_SH2_STAT5 333 336 PF00017 0.438
LIG_SH2_STAT5 340 343 PF00017 0.389
LIG_SH2_STAT5 366 369 PF00017 0.549
LIG_SH2_STAT5 487 490 PF00017 0.451
LIG_SH3_3 52 58 PF00018 0.704
LIG_SUMO_SIM_anti_2 181 188 PF11976 0.414
LIG_SxIP_EBH_1 23 35 PF03271 0.495
LIG_TRAF2_1 295 298 PF00917 0.582
LIG_TRAF2_1 521 524 PF00917 0.504
LIG_TRAF2_1 544 547 PF00917 0.423
LIG_UBA3_1 26 35 PF00899 0.666
LIG_WRC_WIRS_1 353 358 PF05994 0.453
MOD_CK1_1 106 112 PF00069 0.615
MOD_CK1_1 170 176 PF00069 0.441
MOD_CK1_1 195 201 PF00069 0.486
MOD_CK1_1 269 275 PF00069 0.523
MOD_CK1_1 419 425 PF00069 0.624
MOD_CK1_1 429 435 PF00069 0.271
MOD_CK1_1 496 502 PF00069 0.485
MOD_CK1_1 59 65 PF00069 0.768
MOD_CK1_1 73 79 PF00069 0.674
MOD_CK1_1 82 88 PF00069 0.594
MOD_CK2_1 110 116 PF00069 0.572
MOD_CK2_1 149 155 PF00069 0.504
MOD_CK2_1 162 168 PF00069 0.514
MOD_CK2_1 496 502 PF00069 0.484
MOD_GlcNHglycan 105 108 PF01048 0.612
MOD_GlcNHglycan 276 279 PF01048 0.510
MOD_GlcNHglycan 284 287 PF01048 0.482
MOD_GlcNHglycan 377 380 PF01048 0.485
MOD_GlcNHglycan 396 399 PF01048 0.487
MOD_GlcNHglycan 418 421 PF01048 0.607
MOD_GlcNHglycan 428 431 PF01048 0.496
MOD_GlcNHglycan 434 437 PF01048 0.472
MOD_GlcNHglycan 440 443 PF01048 0.434
MOD_GlcNHglycan 460 463 PF01048 0.145
MOD_GlcNHglycan 495 498 PF01048 0.237
MOD_GlcNHglycan 72 75 PF01048 0.627
MOD_GlcNHglycan 81 84 PF01048 0.556
MOD_GlcNHglycan 93 96 PF01048 0.565
MOD_GSK3_1 106 113 PF00069 0.624
MOD_GSK3_1 163 170 PF00069 0.571
MOD_GSK3_1 200 207 PF00069 0.607
MOD_GSK3_1 221 228 PF00069 0.595
MOD_GSK3_1 262 269 PF00069 0.413
MOD_GSK3_1 362 369 PF00069 0.428
MOD_GSK3_1 419 426 PF00069 0.602
MOD_GSK3_1 454 461 PF00069 0.485
MOD_GSK3_1 56 63 PF00069 0.712
MOD_GSK3_1 70 77 PF00069 0.595
MOD_N-GLC_1 103 108 PF02516 0.745
MOD_N-GLC_1 269 274 PF02516 0.495
MOD_N-GLC_1 38 43 PF02516 0.617
MOD_N-GLC_1 468 473 PF02516 0.232
MOD_N-GLC_1 516 521 PF02516 0.291
MOD_NEK2_1 103 108 PF00069 0.721
MOD_NEK2_1 192 197 PF00069 0.569
MOD_NEK2_1 202 207 PF00069 0.461
MOD_NEK2_1 262 267 PF00069 0.427
MOD_NEK2_1 274 279 PF00069 0.468
MOD_NEK2_1 4 9 PF00069 0.533
MOD_NEK2_1 406 411 PF00069 0.410
MOD_NEK2_1 431 436 PF00069 0.362
MOD_NEK2_1 516 521 PF00069 0.518
MOD_NEK2_1 91 96 PF00069 0.657
MOD_PIKK_1 200 206 PF00454 0.632
MOD_PIKK_1 293 299 PF00454 0.518
MOD_PIKK_1 4 10 PF00454 0.546
MOD_PIKK_1 470 476 PF00454 0.437
MOD_PK_1 449 455 PF00069 0.494
MOD_PKA_1 449 455 PF00069 0.494
MOD_PKA_2 192 198 PF00069 0.493
MOD_PKA_2 411 417 PF00069 0.483
MOD_PKA_2 449 455 PF00069 0.433
MOD_PKA_2 458 464 PF00069 0.441
MOD_Plk_1 167 173 PF00069 0.445
MOD_Plk_1 269 275 PF00069 0.566
MOD_Plk_1 516 522 PF00069 0.491
MOD_Plk_4 227 233 PF00069 0.433
MOD_ProDKin_1 423 429 PF00069 0.711
MOD_ProDKin_1 56 62 PF00069 0.637
MOD_SUMO_for_1 176 179 PF00179 0.422
MOD_SUMO_for_1 209 212 PF00179 0.623
MOD_SUMO_for_1 278 281 PF00179 0.528
MOD_SUMO_for_1 521 524 PF00179 0.497
MOD_SUMO_rev_2 155 164 PF00179 0.512
TRG_AP2beta_CARGO_1 127 137 PF09066 0.417
TRG_DiLeu_BaEn_1 524 529 PF01217 0.573
TRG_DiLeu_BaLyEn_6 257 262 PF01217 0.416
TRG_ENDOCYTIC_2 147 150 PF00928 0.566
TRG_ENDOCYTIC_2 231 234 PF00928 0.563
TRG_ENDOCYTIC_2 333 336 PF00928 0.408
TRG_ENDOCYTIC_2 350 353 PF00928 0.239
TRG_ENDOCYTIC_2 476 479 PF00928 0.539
TRG_ER_diArg_1 136 139 PF00400 0.517
TRG_ER_diArg_1 254 257 PF00400 0.438
TRG_ER_diArg_1 337 339 PF00400 0.366
TRG_ER_diArg_1 512 514 PF00400 0.482
TRG_ER_diArg_1 87 89 PF00400 0.675
TRG_Pf-PMV_PEXEL_1 200 204 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P368 Leptomonas seymouri 61% 89%
A0A0S4JFA6 Bodo saltans 36% 88%
A0A1X0NXZ0 Trypanosomatidae 44% 82%
A0A3Q8IB76 Leishmania donovani 99% 100%
A0A422NSQ1 Trypanosoma rangeli 44% 89%
A4HBY7 Leishmania braziliensis 81% 100%
D0A156 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 92%
E9AVB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QC65 Leishmania major 92% 100%
V5BLU1 Trypanosoma cruzi 44% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS