Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/RING-H2 zinc finger/Zinc finger - C3HC4 type (RING finger) containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZC7_LEIIN

TriTrypDb:

LINF_210021100

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HZC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZC7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0005488	binding	1	2
GO:0005515	protein binding	2	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0097602	cullin family protein binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.548
CLV_PCSK_KEX2_1	128	130	PF00082	0.548
CLV_PCSK_SKI1_1	190	194	PF00082	0.676
CLV_PCSK_SKI1_1	236	240	PF00082	0.342
CLV_PCSK_SKI1_1	257	261	PF00082	0.461
DOC_CDC14_PxL_1	69	77	PF14671	0.608
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.597
DOC_USP7_MATH_1	10	14	PF00917	0.577
DOC_USP7_MATH_1	122	126	PF00917	0.657
DOC_USP7_MATH_1	192	196	PF00917	0.633
DOC_USP7_MATH_1	199	203	PF00917	0.611
DOC_USP7_MATH_1	216	220	PF00917	0.730
DOC_USP7_MATH_1	57	61	PF00917	0.613
DOC_USP7_MATH_2	102	108	PF00917	0.530
DOC_WW_Pin1_4	115	120	PF00397	0.576
DOC_WW_Pin1_4	136	141	PF00397	0.663
DOC_WW_Pin1_4	194	199	PF00397	0.709
DOC_WW_Pin1_4	204	209	PF00397	0.552
DOC_WW_Pin1_4	268	273	PF00397	0.391
DOC_WW_Pin1_4	80	85	PF00397	0.635
DOC_WW_Pin1_4	98	103	PF00397	0.465
LIG_14-3-3_CanoR_1	159	163	PF00244	0.627
LIG_14-3-3_CanoR_1	257	262	PF00244	0.369
LIG_FHA_1	106	112	PF00498	0.482
LIG_FHA_1	158	164	PF00498	0.559
LIG_FHA_1	221	227	PF00498	0.552
LIG_FHA_1	27	33	PF00498	0.608
LIG_FHA_2	238	244	PF00498	0.369
LIG_LIR_Gen_1	107	116	PF02991	0.501
LIG_LIR_Nem_3	107	112	PF02991	0.474
LIG_LIR_Nem_3	50	55	PF02991	0.710
LIG_NRBOX	74	80	PF00104	0.580
LIG_Pex14_2	2	6	PF04695	0.555
LIG_SH2_CRK	264	268	PF00017	0.284
LIG_SH2_STAT5	245	248	PF00017	0.304
LIG_SH3_3	108	114	PF00018	0.476
LIG_SH3_3	137	143	PF00018	0.618
LIG_SH3_3	206	212	PF00018	0.616
LIG_SH3_3	96	102	PF00018	0.588
LIG_SUMO_SIM_par_1	74	83	PF11976	0.626
LIG_TRAF2_1	101	104	PF00917	0.551
LIG_WRC_WIRS_1	106	111	PF05994	0.466
MOD_CK1_1	118	124	PF00069	0.670
MOD_CK1_1	169	175	PF00069	0.605
MOD_CK1_1	181	187	PF00069	0.575
MOD_CK1_1	202	208	PF00069	0.594
MOD_CK1_1	220	226	PF00069	0.591
MOD_CK1_1	80	86	PF00069	0.636
MOD_CK2_1	124	130	PF00069	0.772
MOD_CK2_1	162	168	PF00069	0.574
MOD_CK2_1	237	243	PF00069	0.369
MOD_CK2_1	98	104	PF00069	0.517
MOD_GlcNHglycan	12	15	PF01048	0.567
MOD_GlcNHglycan	164	167	PF01048	0.656
MOD_GlcNHglycan	168	171	PF01048	0.636
MOD_GlcNHglycan	175	178	PF01048	0.659
MOD_GlcNHglycan	3	6	PF01048	0.655
MOD_GlcNHglycan	52	55	PF01048	0.560
MOD_GlcNHglycan	59	62	PF01048	0.545
MOD_GlcNHglycan	8	11	PF01048	0.580
MOD_GSK3_1	1	8	PF00069	0.744
MOD_GSK3_1	10	17	PF00069	0.552
MOD_GSK3_1	114	121	PF00069	0.597
MOD_GSK3_1	124	131	PF00069	0.667
MOD_GSK3_1	158	165	PF00069	0.690
MOD_GSK3_1	169	176	PF00069	0.575
MOD_GSK3_1	178	185	PF00069	0.508
MOD_GSK3_1	190	197	PF00069	0.637
MOD_GSK3_1	199	206	PF00069	0.592
MOD_GSK3_1	216	223	PF00069	0.609
MOD_GSK3_1	57	64	PF00069	0.604
MOD_GSK3_1	79	86	PF00069	0.590
MOD_N-GLC_1	14	19	PF02516	0.578
MOD_NEK2_1	157	162	PF00069	0.707
MOD_NEK2_1	250	255	PF00069	0.319
MOD_NEK2_1	79	84	PF00069	0.556
MOD_PIKK_1	192	198	PF00454	0.636
MOD_PIKK_1	199	205	PF00454	0.626
MOD_PKA_1	128	134	PF00069	0.550
MOD_PKA_2	128	134	PF00069	0.621
MOD_PKA_2	158	164	PF00069	0.700
MOD_Plk_2-3	237	243	PF00069	0.369
MOD_Plk_4	158	164	PF00069	0.569
MOD_Plk_4	26	32	PF00069	0.607
MOD_ProDKin_1	115	121	PF00069	0.579
MOD_ProDKin_1	136	142	PF00069	0.659
MOD_ProDKin_1	194	200	PF00069	0.711
MOD_ProDKin_1	204	210	PF00069	0.554
MOD_ProDKin_1	268	274	PF00069	0.395
MOD_ProDKin_1	80	86	PF00069	0.636
MOD_ProDKin_1	98	104	PF00069	0.463
MOD_SUMO_rev_2	233	241	PF00179	0.463
TRG_Pf-PMV_PEXEL_1	224	229	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K6	Leptomonas seymouri	37%	95%
A0A3S7WWM2	Leishmania donovani	99%	100%
A4HBY6	Leishmania braziliensis	72%	100%
E9AVB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QC66	Leishmania major	88%	99%