Putative vesicule-associated membrane protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicle-associated membrane protein - putative

Species:

Leishmania infantum

UniProt:

A4HZC6_LEIIN

TriTrypDb:

LINF_210021000

Length:

257

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, vesicule-associated membrane

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HZC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZC6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.514
CLV_NRD_NRD_1	98	100	PF00675	0.312
CLV_PCSK_KEX2_1	98	100	PF00082	0.312
CLV_PCSK_SKI1_1	113	117	PF00082	0.294
CLV_PCSK_SKI1_1	136	140	PF00082	0.289
CLV_PCSK_SKI1_1	219	223	PF00082	0.352
CLV_PCSK_SKI1_1	23	27	PF00082	0.261
CLV_PCSK_SKI1_1	245	249	PF00082	0.602
DOC_MAPK_gen_1	154	162	PF00069	0.461
DOC_MAPK_gen_1	68	76	PF00069	0.536
DOC_MAPK_MEF2A_6	154	162	PF00069	0.485
DOC_PP4_FxxP_1	116	119	PF00568	0.590
DOC_PP4_FxxP_1	131	134	PF00568	0.425
DOC_PP4_FxxP_1	37	40	PF00568	0.530
DOC_USP7_MATH_1	147	151	PF00917	0.641
DOC_WW_Pin1_4	26	31	PF00397	0.582
LIG_14-3-3_CanoR_1	50	54	PF00244	0.519
LIG_14-3-3_CanoR_1	57	64	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BIR_III_4	84	88	PF00653	0.497
LIG_CaM_IQ_9	197	212	PF13499	0.419
LIG_FHA_1	188	194	PF00498	0.429
LIG_FHA_1	27	33	PF00498	0.541
LIG_LIR_Apic_2	129	134	PF02991	0.505
LIG_LIR_Apic_2	34	40	PF02991	0.539
LIG_LIR_Gen_1	42	48	PF02991	0.483
LIG_LIR_Gen_1	58	66	PF02991	0.512
LIG_LIR_Gen_1	75	86	PF02991	0.474
LIG_LIR_Nem_3	42	47	PF02991	0.484
LIG_LIR_Nem_3	58	64	PF02991	0.506
LIG_PCNA_yPIPBox_3	124	136	PF02747	0.548
LIG_Pex14_2	112	116	PF04695	0.478
LIG_SH2_CRK	13	17	PF00017	0.454
LIG_SH2_CRK	88	92	PF00017	0.525
LIG_SH2_STAT5	234	237	PF00017	0.352
LIG_SH3_3	114	120	PF00018	0.595
LIG_SH3_3	27	33	PF00018	0.548
LIG_TRAF2_1	70	73	PF00917	0.650
LIG_WRC_WIRS_1	234	239	PF05994	0.398
MOD_CK1_1	49	55	PF00069	0.399
MOD_GlcNHglycan	143	146	PF01048	0.473
MOD_GlcNHglycan	149	152	PF01048	0.540
MOD_GlcNHglycan	253	256	PF01048	0.647
MOD_GlcNHglycan	51	54	PF01048	0.438
MOD_GlcNHglycan	58	61	PF01048	0.430
MOD_GSK3_1	246	253	PF00069	0.671
MOD_GSK3_1	31	38	PF00069	0.446
MOD_N-GLC_1	62	67	PF02516	0.440
MOD_NEK2_1	140	145	PF00069	0.520
MOD_NEK2_1	200	205	PF00069	0.262
MOD_NEK2_1	211	216	PF00069	0.296
MOD_NEK2_1	56	61	PF00069	0.358
MOD_NEK2_2	212	217	PF00069	0.293
MOD_PIKK_1	246	252	PF00454	0.608
MOD_PKA_2	201	207	PF00069	0.296
MOD_PKA_2	49	55	PF00069	0.384
MOD_PKA_2	56	62	PF00069	0.333
MOD_Plk_1	72	78	PF00069	0.485
MOD_ProDKin_1	26	32	PF00069	0.495
MOD_SUMO_for_1	70	73	PF00179	0.450
MOD_SUMO_rev_2	150	156	PF00179	0.273
MOD_SUMO_rev_2	163	168	PF00179	0.417
TRG_DiLeu_BaEn_4	7	13	PF01217	0.493
TRG_ENDOCYTIC_2	13	16	PF00928	0.310
TRG_ENDOCYTIC_2	234	237	PF00928	0.352
TRG_ENDOCYTIC_2	78	81	PF00928	0.336
TRG_ENDOCYTIC_2	88	91	PF00928	0.325
TRG_NES_CRM1_1	106	118	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P366	Leptomonas seymouri	79%	97%
A0A0S4JL59	Bodo saltans	45%	100%
A0A1X0NYJ8	Trypanosomatidae	57%	100%
A0A3Q8IE03	Leishmania donovani	100%	100%
A0A422NSS3	Trypanosoma rangeli	58%	100%
A4HBY4	Leishmania braziliensis	89%	100%
D0A159	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AVB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QC67	Leishmania major	96%	100%
V5BHA3	Trypanosoma cruzi	57%	100%