Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZC3_LEIIN

TriTrypDb:

LINF_210020700

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4HZC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.646
CLV_C14_Caspase3-7	399	403	PF00656	0.733
CLV_C14_Caspase3-7	421	425	PF00656	0.742
CLV_C14_Caspase3-7	486	490	PF00656	0.642
CLV_NRD_NRD_1	201	203	PF00675	0.666
CLV_NRD_NRD_1	205	207	PF00675	0.629
CLV_NRD_NRD_1	213	215	PF00675	0.571
CLV_NRD_NRD_1	97	99	PF00675	0.530
CLV_PCSK_KEX2_1	201	203	PF00082	0.666
CLV_PCSK_KEX2_1	205	207	PF00082	0.629
CLV_PCSK_KEX2_1	213	215	PF00082	0.571
CLV_PCSK_KEX2_1	97	99	PF00082	0.530
CLV_PCSK_PC7_1	201	207	PF00082	0.684
CLV_PCSK_SKI1_1	189	193	PF00082	0.530
DEG_APCC_DBOX_1	188	196	PF00400	0.522
DEG_APCC_DBOX_1	212	220	PF00400	0.697
DEG_APCC_DBOX_1	62	70	PF00400	0.530
DOC_CYCLIN_RxL_1	186	196	PF00134	0.526
DOC_CYCLIN_RxL_1	35	44	PF00134	0.316
DOC_CYCLIN_RxL_1	79	89	PF00134	0.541
DOC_USP7_MATH_1	149	153	PF00917	0.699
DOC_USP7_MATH_1	228	232	PF00917	0.804
DOC_USP7_MATH_1	279	283	PF00917	0.600
DOC_USP7_MATH_1	329	333	PF00917	0.605
DOC_USP7_MATH_1	431	435	PF00917	0.668
DOC_WW_Pin1_4	154	159	PF00397	0.671
DOC_WW_Pin1_4	233	238	PF00397	0.761
DOC_WW_Pin1_4	264	269	PF00397	0.722
DOC_WW_Pin1_4	351	356	PF00397	0.781
DOC_WW_Pin1_4	412	417	PF00397	0.796
LIG_14-3-3_CanoR_1	125	133	PF00244	0.595
LIG_14-3-3_CanoR_1	206	216	PF00244	0.661
LIG_14-3-3_CanoR_1	238	247	PF00244	0.748
LIG_14-3-3_CanoR_1	38	43	PF00244	0.316
LIG_14-3-3_CanoR_1	411	418	PF00244	0.710
LIG_14-3-3_CanoR_1	63	67	PF00244	0.530
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BIR_III_2	489	493	PF00653	0.706
LIG_EVH1_1	451	455	PF00568	0.744
LIG_FHA_1	42	48	PF00498	0.452
LIG_FHA_1	66	72	PF00498	0.452
LIG_FHA_2	419	425	PF00498	0.736
LIG_LIR_Apic_2	449	454	PF02991	0.758
LIG_LIR_Nem_3	424	429	PF02991	0.755
LIG_PDZ_Class_3	493	498	PF00595	0.673
LIG_PTB_Apo_2	87	94	PF02174	0.460
LIG_Rb_LxCxE_1	157	174	PF01857	0.586
LIG_SH2_NCK_1	326	330	PF00017	0.705
LIG_SH2_STAT3	369	372	PF00017	0.652
LIG_SH2_STAT5	369	372	PF00017	0.554
LIG_SH3_2	391	396	PF14604	0.625
LIG_SH3_2	452	457	PF14604	0.731
LIG_SH3_3	152	158	PF00018	0.623
LIG_SH3_3	244	250	PF00018	0.793
LIG_SH3_3	388	394	PF00018	0.623
LIG_SH3_3	414	420	PF00018	0.790
LIG_SH3_3	449	455	PF00018	0.650
LIG_SH3_5	322	326	PF00018	0.743
LIG_SUMO_SIM_par_1	2	10	PF11976	0.615
LIG_SUMO_SIM_par_1	38	44	PF11976	0.530
LIG_SUMO_SIM_par_1	67	72	PF11976	0.452
MOD_CDK_SPK_2	233	238	PF00069	0.742
MOD_CK1_1	142	148	PF00069	0.758
MOD_CK1_1	351	357	PF00069	0.734
MOD_CK1_1	41	47	PF00069	0.415
MOD_CK1_1	412	418	PF00069	0.702
MOD_CK1_1	419	425	PF00069	0.643
MOD_CK1_1	72	78	PF00069	0.333
MOD_CK2_1	380	386	PF00069	0.766
MOD_GlcNHglycan	141	144	PF01048	0.787
MOD_GlcNHglycan	147	150	PF01048	0.712
MOD_GlcNHglycan	151	154	PF01048	0.619
MOD_GlcNHglycan	21	24	PF01048	0.453
MOD_GlcNHglycan	223	226	PF01048	0.796
MOD_GlcNHglycan	229	233	PF01048	0.725
MOD_GlcNHglycan	240	243	PF01048	0.649
MOD_GlcNHglycan	327	330	PF01048	0.811
MOD_GlcNHglycan	333	336	PF01048	0.714
MOD_GlcNHglycan	380	383	PF01048	0.743
MOD_GlcNHglycan	397	401	PF01048	0.549
MOD_GlcNHglycan	421	424	PF01048	0.688
MOD_GlcNHglycan	432	436	PF01048	0.727
MOD_GlcNHglycan	93	96	PF01048	0.480
MOD_GSK3_1	120	127	PF00069	0.486
MOD_GSK3_1	145	152	PF00069	0.684
MOD_GSK3_1	208	215	PF00069	0.706
MOD_GSK3_1	325	332	PF00069	0.646
MOD_GSK3_1	367	374	PF00069	0.633
MOD_GSK3_1	380	387	PF00069	0.599
MOD_GSK3_1	405	412	PF00069	0.638
MOD_GSK3_1	65	72	PF00069	0.413
MOD_LATS_1	378	384	PF00433	0.827
MOD_N-GLC_1	77	82	PF02516	0.512
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	207	212	PF00069	0.611
MOD_NEK2_1	40	45	PF00069	0.444
MOD_NEK2_1	410	415	PF00069	0.607
MOD_NEK2_1	69	74	PF00069	0.431
MOD_NEK2_1	86	91	PF00069	0.466
MOD_NEK2_2	120	125	PF00069	0.678
MOD_NEK2_2	62	67	PF00069	0.530
MOD_NEK2_2	77	82	PF00069	0.342
MOD_PIKK_1	208	214	PF00454	0.708
MOD_PK_1	380	386	PF00069	0.753
MOD_PKA_2	124	130	PF00069	0.554
MOD_PKA_2	193	199	PF00069	0.555
MOD_PKA_2	212	218	PF00069	0.511
MOD_PKA_2	221	227	PF00069	0.608
MOD_PKA_2	301	307	PF00069	0.726
MOD_PKA_2	410	416	PF00069	0.658
MOD_PKA_2	62	68	PF00069	0.530
MOD_Plk_1	178	184	PF00069	0.566
MOD_Plk_1	329	335	PF00069	0.644
MOD_Plk_1	77	83	PF00069	0.410
MOD_Plk_4	1	7	PF00069	0.650
MOD_Plk_4	359	365	PF00069	0.695
MOD_ProDKin_1	154	160	PF00069	0.673
MOD_ProDKin_1	233	239	PF00069	0.761
MOD_ProDKin_1	264	270	PF00069	0.724
MOD_ProDKin_1	351	357	PF00069	0.780
MOD_ProDKin_1	412	418	PF00069	0.797
MOD_SUMO_rev_2	334	343	PF00179	0.605
TRG_ER_diArg_1	205	207	PF00400	0.667
TRG_ER_diArg_1	96	98	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWT1	Leishmania donovani	99%	100%
A4HBY1	Leishmania braziliensis	56%	97%
E9AVB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QC70	Leishmania major	85%	100%