Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZB7_LEIIN

TriTrypDb:

LINF_210008400

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HZB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.479
CLV_PCSK_KEX2_1	223	225	PF00082	0.473
CLV_PCSK_SKI1_1	63	67	PF00082	0.383
CLV_Separin_Metazoa	133	137	PF03568	0.371
DEG_SPOP_SBC_1	187	191	PF00917	0.600
DEG_SPOP_SBC_1	21	25	PF00917	0.646
DOC_MAPK_MEF2A_6	50	57	PF00069	0.695
DOC_USP7_MATH_1	188	192	PF00917	0.673
DOC_USP7_MATH_1	21	25	PF00917	0.701
DOC_USP7_MATH_1	28	32	PF00917	0.675
DOC_WW_Pin1_4	234	239	PF00397	0.725
DOC_WW_Pin1_4	3	8	PF00397	0.650
DOC_WW_Pin1_4	42	47	PF00397	0.628
DOC_WW_Pin1_4	65	70	PF00397	0.533
LIG_14-3-3_CanoR_1	223	228	PF00244	0.741
LIG_14-3-3_CanoR_1	38	43	PF00244	0.622
LIG_BRCT_BRCA1_1	43	47	PF00533	0.695
LIG_BRCT_BRCA1_1	60	64	PF00533	0.525
LIG_BRCT_BRCA1_2	60	66	PF00533	0.522
LIG_DLG_GKlike_1	223	231	PF00625	0.685
LIG_FHA_1	130	136	PF00498	0.420
LIG_FHA_1	168	174	PF00498	0.323
LIG_FHA_1	188	194	PF00498	0.748
LIG_FHA_1	80	86	PF00498	0.312
LIG_LIR_Gen_1	88	99	PF02991	0.326
LIG_LIR_Nem_3	170	175	PF02991	0.309
LIG_LIR_Nem_3	237	243	PF02991	0.668
LIG_LIR_Nem_3	61	67	PF02991	0.586
LIG_LIR_Nem_3	88	94	PF02991	0.345
LIG_LYPXL_yS_3	118	121	PF13949	0.371
LIG_Pex14_2	91	95	PF04695	0.340
LIG_PTB_Apo_2	72	79	PF02174	0.555
LIG_SH2_CRK	116	120	PF00017	0.388
LIG_SH2_CRK	179	183	PF00017	0.581
LIG_SH2_CRK	67	71	PF00017	0.573
LIG_SH2_NCK_1	227	231	PF00017	0.717
LIG_SH2_STAP1	100	104	PF00017	0.394
LIG_SH2_STAT5	131	134	PF00017	0.461
LIG_SH2_STAT5	67	70	PF00017	0.573
LIG_SH3_1	235	241	PF00018	0.658
LIG_SH3_3	235	241	PF00018	0.683
LIG_SH3_3	54	60	PF00018	0.678
LIG_SUMO_SIM_par_1	164	171	PF11976	0.340
LIG_UBA3_1	94	103	PF00899	0.434
LIG_WRC_WIRS_1	169	174	PF05994	0.340
MOD_CDK_SPxK_1	65	71	PF00069	0.530
MOD_CDK_SPxxK_3	3	10	PF00069	0.646
MOD_CK1_1	22	28	PF00069	0.719
MOD_CK2_1	37	43	PF00069	0.621
MOD_CMANNOS	8	11	PF00535	0.436
MOD_GlcNHglycan	157	160	PF01048	0.388
MOD_GlcNHglycan	190	193	PF01048	0.552
MOD_GlcNHglycan	196	199	PF01048	0.546
MOD_GlcNHglycan	218	221	PF01048	0.466
MOD_GlcNHglycan	26	29	PF01048	0.492
MOD_GlcNHglycan	3	6	PF01048	0.408
MOD_GlcNHglycan	60	63	PF01048	0.420
MOD_GSK3_1	145	152	PF00069	0.389
MOD_GSK3_1	19	26	PF00069	0.707
MOD_GSK3_1	209	216	PF00069	0.708
MOD_GSK3_1	37	44	PF00069	0.709
MOD_GSK3_1	79	86	PF00069	0.493
MOD_N-GLC_2	52	54	PF02516	0.388
MOD_NEK2_1	1	6	PF00069	0.718
MOD_NEK2_1	167	172	PF00069	0.336
MOD_NEK2_1	37	42	PF00069	0.689
MOD_PKA_1	223	229	PF00069	0.742
MOD_PKA_2	223	229	PF00069	0.740
MOD_PKA_2	37	43	PF00069	0.630
MOD_Plk_4	168	174	PF00069	0.430
MOD_Plk_4	94	100	PF00069	0.445
MOD_ProDKin_1	234	240	PF00069	0.727
MOD_ProDKin_1	3	9	PF00069	0.647
MOD_ProDKin_1	42	48	PF00069	0.627
MOD_ProDKin_1	65	71	PF00069	0.533
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.608
TRG_ENDOCYTIC_2	118	121	PF00928	0.371
TRG_ENDOCYTIC_2	179	182	PF00928	0.568
TRG_ENDOCYTIC_2	67	70	PF00928	0.634
TRG_ER_diArg_1	30	33	PF00400	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBS2	Leishmania donovani	100%	100%
A0A3R7KF63	Trypanosoma rangeli	34%	100%
A4HBM8	Leishmania braziliensis	73%	100%
E9AUZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCI5	Leishmania major	93%	100%