Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentatricopeptide repeat domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HZB3_LEIIN

TriTrypDb:

LINF_210008000

Length:

596

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.266
CLV_NRD_NRD_1	358	360	PF00675	0.434
CLV_NRD_NRD_1	398	400	PF00675	0.362
CLV_NRD_NRD_1	423	425	PF00675	0.376
CLV_NRD_NRD_1	47	49	PF00675	0.636
CLV_NRD_NRD_1	89	91	PF00675	0.693
CLV_PCSK_KEX2_1	108	110	PF00082	0.276
CLV_PCSK_KEX2_1	205	207	PF00082	0.408
CLV_PCSK_KEX2_1	398	400	PF00082	0.367
CLV_PCSK_KEX2_1	46	48	PF00082	0.635
CLV_PCSK_KEX2_1	89	91	PF00082	0.708
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.387
CLV_PCSK_SKI1_1	131	135	PF00082	0.404
CLV_PCSK_SKI1_1	14	18	PF00082	0.481
CLV_PCSK_SKI1_1	193	197	PF00082	0.350
CLV_PCSK_SKI1_1	205	209	PF00082	0.336
CLV_PCSK_SKI1_1	271	275	PF00082	0.363
CLV_PCSK_SKI1_1	294	298	PF00082	0.339
CLV_PCSK_SKI1_1	401	405	PF00082	0.469
CLV_PCSK_SKI1_1	424	428	PF00082	0.413
CLV_PCSK_SKI1_1	467	471	PF00082	0.417
DEG_APCC_DBOX_1	423	431	PF00400	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.396
DOC_CKS1_1	382	387	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.610
DOC_MAPK_gen_1	205	213	PF00069	0.416
DOC_MAPK_gen_1	398	407	PF00069	0.451
DOC_MAPK_gen_1	587	596	PF00069	0.506
DOC_MAPK_gen_1	9	19	PF00069	0.403
DOC_MAPK_MEF2A_6	12	21	PF00069	0.511
DOC_MAPK_MEF2A_6	318	327	PF00069	0.289
DOC_MAPK_MEF2A_6	511	520	PF00069	0.341
DOC_PP2B_LxvP_1	24	27	PF13499	0.612
DOC_PP2B_LxvP_1	67	70	PF13499	0.701
DOC_USP7_MATH_1	183	187	PF00917	0.368
DOC_USP7_MATH_1	238	242	PF00917	0.683
DOC_USP7_MATH_1	317	321	PF00917	0.274
DOC_USP7_MATH_1	562	566	PF00917	0.507
DOC_USP7_MATH_1	578	582	PF00917	0.331
DOC_WW_Pin1_4	162	167	PF00397	0.616
DOC_WW_Pin1_4	214	219	PF00397	0.478
DOC_WW_Pin1_4	246	251	PF00397	0.731
DOC_WW_Pin1_4	31	36	PF00397	0.686
DOC_WW_Pin1_4	381	386	PF00397	0.455
DOC_WW_Pin1_4	56	61	PF00397	0.711
LIG_14-3-3_CanoR_1	242	250	PF00244	0.542
LIG_14-3-3_CanoR_1	285	293	PF00244	0.453
LIG_14-3-3_CanoR_1	367	371	PF00244	0.469
LIG_14-3-3_CanoR_1	442	447	PF00244	0.274
LIG_14-3-3_CanoR_1	455	461	PF00244	0.274
LIG_14-3-3_CanoR_1	535	541	PF00244	0.429
LIG_14-3-3_CanoR_1	75	85	PF00244	0.670
LIG_Actin_WH2_2	164	179	PF00022	0.505
LIG_Actin_WH2_2	184	199	PF00022	0.364
LIG_Actin_WH2_2	257	273	PF00022	0.360
LIG_Actin_WH2_2	538	555	PF00022	0.486
LIG_eIF4E_1	287	293	PF01652	0.372
LIG_FHA_1	171	177	PF00498	0.441
LIG_FHA_1	198	204	PF00498	0.446
LIG_FHA_1	287	293	PF00498	0.454
LIG_FHA_1	317	323	PF00498	0.353
LIG_FHA_1	382	388	PF00498	0.384
LIG_FHA_1	407	413	PF00498	0.368
LIG_FHA_1	478	484	PF00498	0.281
LIG_FHA_1	80	86	PF00498	0.673
LIG_LIR_Gen_1	135	144	PF02991	0.320
LIG_LIR_Gen_1	151	162	PF02991	0.570
LIG_LIR_Gen_1	344	352	PF02991	0.395
LIG_LIR_Gen_1	443	450	PF02991	0.274
LIG_LIR_LC3C_4	184	189	PF02991	0.402
LIG_LIR_Nem_3	135	139	PF02991	0.313
LIG_LIR_Nem_3	278	282	PF02991	0.360
LIG_LIR_Nem_3	344	348	PF02991	0.374
LIG_LIR_Nem_3	443	449	PF02991	0.274
LIG_LIR_Nem_3	480	484	PF02991	0.276
LIG_LIR_Nem_3	505	510	PF02991	0.472
LIG_LIR_Nem_3	97	102	PF02991	0.357
LIG_LYPXL_yS_3	507	510	PF13949	0.351
LIG_MAD2	177	185	PF02301	0.510
LIG_MYND_3	518	522	PF01753	0.381
LIG_PDZ_Class_2	591	596	PF00595	0.470
LIG_Pex14_2	99	103	PF04695	0.389
LIG_PTB_Apo_2	97	104	PF02174	0.388
LIG_SH2_CRK	136	140	PF00017	0.340
LIG_SH2_CRK	4	8	PF00017	0.521
LIG_SH2_CRK	446	450	PF00017	0.289
LIG_SH2_GRB2like	4	7	PF00017	0.516
LIG_SH2_STAT3	351	354	PF00017	0.435
LIG_SH2_STAT5	102	105	PF00017	0.315
LIG_SH2_STAT5	138	141	PF00017	0.386
LIG_SH2_STAT5	282	285	PF00017	0.484
LIG_SH2_STAT5	287	290	PF00017	0.442
LIG_SH2_STAT5	351	354	PF00017	0.427
LIG_SH2_STAT5	368	371	PF00017	0.256
LIG_SH2_STAT5	374	377	PF00017	0.360
LIG_SH2_STAT5	4	7	PF00017	0.533
LIG_SH2_STAT5	500	503	PF00017	0.407
LIG_SH3_3	216	222	PF00018	0.552
LIG_SH3_3	24	30	PF00018	0.446
LIG_SUMO_SIM_anti_2	319	327	PF11976	0.306
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.287
LIG_SUMO_SIM_anti_2	565	570	PF11976	0.408
LIG_SUMO_SIM_par_1	186	192	PF11976	0.358
LIG_SUMO_SIM_par_1	264	269	PF11976	0.402
LIG_SUMO_SIM_par_1	305	312	PF11976	0.482
LIG_SUMO_SIM_par_1	403	409	PF11976	0.360
LIG_TRAF2_1	113	116	PF00917	0.433
LIG_TYR_ITIM	134	139	PF00017	0.369
LIG_TYR_ITIM	36	41	PF00017	0.668
LIG_UBA3_1	342	349	PF00899	0.355
LIG_WRC_WIRS_1	171	176	PF05994	0.469
LIG_WRC_WIRS_1	478	483	PF05994	0.350
MOD_CDC14_SPxK_1	217	220	PF00782	0.553
MOD_CDK_SPxK_1	214	220	PF00069	0.499
MOD_CDK_SPxK_1	56	62	PF00069	0.595
MOD_CK1_1	228	234	PF00069	0.791
MOD_CK1_1	246	252	PF00069	0.728
MOD_CK1_1	537	543	PF00069	0.439
MOD_CK1_1	79	85	PF00069	0.702
MOD_CK2_1	428	434	PF00069	0.485
MOD_GlcNHglycan	181	184	PF01048	0.406
MOD_GlcNHglycan	226	230	PF01048	0.802
MOD_GlcNHglycan	251	254	PF01048	0.730
MOD_GlcNHglycan	43	46	PF01048	0.723
MOD_GlcNHglycan	430	433	PF01048	0.536
MOD_GlcNHglycan	471	474	PF01048	0.432
MOD_GlcNHglycan	81	85	PF01048	0.667
MOD_GSK3_1	179	186	PF00069	0.431
MOD_GSK3_1	224	231	PF00069	0.748
MOD_GSK3_1	244	251	PF00069	0.655
MOD_GSK3_1	296	303	PF00069	0.479
MOD_GSK3_1	362	369	PF00069	0.501
MOD_GSK3_1	451	458	PF00069	0.308
MOD_GSK3_1	465	472	PF00069	0.251
MOD_GSK3_1	547	554	PF00069	0.417
MOD_GSK3_1	76	83	PF00069	0.565
MOD_N-GLC_1	51	56	PF02516	0.579
MOD_NEK2_1	243	248	PF00069	0.630
MOD_NEK2_1	41	46	PF00069	0.721
MOD_NEK2_1	469	474	PF00069	0.339
MOD_NEK2_2	403	408	PF00069	0.355
MOD_PIKK_1	277	283	PF00454	0.479
MOD_PIKK_1	328	334	PF00454	0.454
MOD_PIKK_1	534	540	PF00454	0.479
MOD_PKA_1	89	95	PF00069	0.469
MOD_PKA_2	233	239	PF00069	0.633
MOD_PKA_2	366	372	PF00069	0.499
MOD_PKA_2	456	462	PF00069	0.368
MOD_PKA_2	534	540	PF00069	0.336
MOD_PKA_2	89	95	PF00069	0.560
MOD_Plk_1	502	508	PF00069	0.337
MOD_Plk_1	80	86	PF00069	0.631
MOD_Plk_4	170	176	PF00069	0.409
MOD_Plk_4	183	189	PF00069	0.358
MOD_Plk_4	456	462	PF00069	0.393
MOD_Plk_4	547	553	PF00069	0.379
MOD_Plk_4	89	95	PF00069	0.443
MOD_ProDKin_1	162	168	PF00069	0.614
MOD_ProDKin_1	214	220	PF00069	0.499
MOD_ProDKin_1	246	252	PF00069	0.731
MOD_ProDKin_1	31	37	PF00069	0.688
MOD_ProDKin_1	381	387	PF00069	0.452
MOD_ProDKin_1	56	62	PF00069	0.712
MOD_SUMO_rev_2	23	33	PF00179	0.453
MOD_SUMO_rev_2	422	427	PF00179	0.416
TRG_DiLeu_BaEn_1	321	326	PF01217	0.341
TRG_DiLeu_BaEn_2	114	120	PF01217	0.500
TRG_DiLeu_BaEn_4	422	428	PF01217	0.421
TRG_ENDOCYTIC_2	136	139	PF00928	0.348
TRG_ENDOCYTIC_2	38	41	PF00928	0.701
TRG_ENDOCYTIC_2	4	7	PF00928	0.484
TRG_ENDOCYTIC_2	446	449	PF00928	0.289
TRG_ENDOCYTIC_2	466	469	PF00928	0.145
TRG_ENDOCYTIC_2	507	510	PF00928	0.351
TRG_ER_diArg_1	46	48	PF00400	0.635
TRG_ER_diArg_1	579	582	PF00400	0.438
TRG_ER_diArg_1	88	90	PF00400	0.572
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C5	Leptomonas seymouri	69%	78%
A0A0S4J3H1	Bodo saltans	40%	100%
A0A1X0NYY0	Trypanosomatidae	52%	96%
A0A3S7WWD8	Leishmania donovani	100%	100%
A0A422NII4	Trypanosoma rangeli	50%	100%
A4HBM4	Leishmania braziliensis	88%	100%
D0A1L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AUZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QCI9	Leishmania major	96%	100%
V5BG17	Trypanosoma cruzi	52%	100%