Phosphotransferase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphotransferase

Gene product:

hexokinase - putative

Species:

Leishmania infantum

UniProt:

A4HZB2_LEIIN

TriTrypDb:

LINF_210007900

Length:

471

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, Hexokinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005739	mitochondrion	5	2
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HZB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZB2

Function

Biological processes
Term	Name	Level	Count
GO:0001678	intracellular glucose homeostasis	4	17
GO:0005975	carbohydrate metabolic process	3	17
GO:0006082	organic acid metabolic process	3	17
GO:0006090	pyruvate metabolic process	7	17
GO:0006091	generation of precursor metabolites and energy	3	17
GO:0006096	glycolytic process	5	17
GO:0006139	nucleobase-containing compound metabolic process	3	17
GO:0006163	purine nucleotide metabolic process	5	17
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	17
GO:0006725	cellular aromatic compound metabolic process	3	17
GO:0006753	nucleoside phosphate metabolic process	4	17
GO:0006757	obsolete ATP generation from ADP	4	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009056	catabolic process	2	17
GO:0009117	nucleotide metabolic process	5	17
GO:0009132	nucleoside diphosphate metabolic process	5	17
GO:0009135	purine nucleoside diphosphate metabolic process	6	17
GO:0009141	nucleoside triphosphate metabolic process	5	17
GO:0009144	purine nucleoside triphosphate metabolic process	6	17
GO:0009150	purine ribonucleotide metabolic process	6	17
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	17
GO:0009185	ribonucleoside diphosphate metabolic process	6	17
GO:0009199	ribonucleoside triphosphate metabolic process	6	17
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	17
GO:0009259	ribonucleotide metabolic process	5	17
GO:0009987	cellular process	1	17
GO:0016052	carbohydrate catabolic process	4	17
GO:0016310	phosphorylation	5	17
GO:0019637	organophosphate metabolic process	3	17
GO:0019693	ribose phosphate metabolic process	4	17
GO:0019725	cellular homeostasis	2	17
GO:0019752	carboxylic acid metabolic process	5	17
GO:0032787	monocarboxylic acid metabolic process	6	17
GO:0033500	carbohydrate homeostasis	5	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0042592	homeostatic process	3	17
GO:0042593	glucose homeostasis	6	17
GO:0043436	oxoacid metabolic process	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044281	small molecule metabolic process	2	17
GO:0046031	ADP metabolic process	7	17
GO:0046034	ATP metabolic process	7	17
GO:0046483	heterocycle metabolic process	3	17
GO:0046939	obsolete nucleotide phosphorylation	6	17
GO:0048878	chemical homeostasis	4	17
GO:0055082	intracellular chemical homeostasis	3	17
GO:0055086	nucleobase-containing small molecule metabolic process	3	17
GO:0065007	biological regulation	1	17
GO:0065008	regulation of biological quality	2	17
GO:0071704	organic substance metabolic process	2	17
GO:0072521	purine-containing compound metabolic process	4	17
GO:1901135	carbohydrate derivative metabolic process	3	17
GO:1901360	organic cyclic compound metabolic process	3	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901575	organic substance catabolic process	3	17
GO:0005996	monosaccharide metabolic process	3	2
GO:0006006	glucose metabolic process	5	2
GO:0019318	hexose metabolic process	4	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0046835	carbohydrate phosphorylation	4	2
GO:0051156	glucose 6-phosphate metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004396	hexokinase activity	5	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0005536	glucose binding	4	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17
GO:0017076	purine nucleotide binding	4	17
GO:0019200	carbohydrate kinase activity	5	17
GO:0030246	carbohydrate binding	2	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0048029	monosaccharide binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0004340	glucokinase activity	6	2
GO:0008865	fructokinase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.391
CLV_C14_Caspase3-7	288	292	PF00656	0.349
CLV_NRD_NRD_1	200	202	PF00675	0.377
CLV_NRD_NRD_1	316	318	PF00675	0.292
CLV_PCSK_KEX2_1	152	154	PF00082	0.436
CLV_PCSK_KEX2_1	200	202	PF00082	0.327
CLV_PCSK_KEX2_1	316	318	PF00082	0.292
CLV_PCSK_KEX2_1	366	368	PF00082	0.413
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.436
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.436
CLV_PCSK_PC7_1	362	368	PF00082	0.413
CLV_PCSK_SKI1_1	120	124	PF00082	0.327
CLV_PCSK_SKI1_1	171	175	PF00082	0.315
CLV_PCSK_SKI1_1	23	27	PF00082	0.357
CLV_PCSK_SKI1_1	278	282	PF00082	0.308
CLV_PCSK_SKI1_1	28	32	PF00082	0.345
CLV_PCSK_SKI1_1	448	452	PF00082	0.377
CLV_PCSK_SKI1_1	46	50	PF00082	0.227
DEG_APCC_DBOX_1	27	35	PF00400	0.408
DEG_SCF_FBW7_2	293	298	PF00400	0.404
DOC_ANK_TNKS_1	329	336	PF00023	0.436
DOC_CDC14_PxL_1	400	408	PF14671	0.413
DOC_CYCLIN_RxL_1	167	178	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.413
DOC_MAPK_DCC_7	259	268	PF00069	0.373
DOC_MAPK_FxFP_2	160	163	PF00069	0.278
DOC_MAPK_gen_1	152	158	PF00069	0.436
DOC_MAPK_gen_1	200	208	PF00069	0.330
DOC_MAPK_gen_1	23	31	PF00069	0.420
DOC_MAPK_gen_1	276	285	PF00069	0.334
DOC_MAPK_gen_1	301	311	PF00069	0.349
DOC_MAPK_gen_1	316	322	PF00069	0.203
DOC_MAPK_gen_1	366	373	PF00069	0.355
DOC_MAPK_MEF2A_6	200	208	PF00069	0.282
DOC_MAPK_MEF2A_6	276	285	PF00069	0.404
DOC_PP4_FxxP_1	116	119	PF00568	0.278
DOC_PP4_FxxP_1	160	163	PF00568	0.278
DOC_USP7_MATH_1	254	258	PF00917	0.351
DOC_USP7_MATH_1	30	34	PF00917	0.327
DOC_USP7_MATH_1	341	345	PF00917	0.392
DOC_USP7_UBL2_3	167	171	PF12436	0.413
DOC_WW_Pin1_4	261	266	PF00397	0.308
DOC_WW_Pin1_4	291	296	PF00397	0.363
DOC_WW_Pin1_4	423	428	PF00397	0.334
LIG_14-3-3_CanoR_1	100	104	PF00244	0.327
LIG_14-3-3_CanoR_1	246	254	PF00244	0.399
LIG_14-3-3_CanoR_1	63	68	PF00244	0.402
LIG_Actin_WH2_2	187	202	PF00022	0.334
LIG_APCC_ABBA_1	283	288	PF00400	0.404
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_EH1_1	50	58	PF00400	0.334
LIG_FHA_1	181	187	PF00498	0.278
LIG_FHA_1	359	365	PF00498	0.327
LIG_FHA_1	408	414	PF00498	0.299
LIG_FHA_1	436	442	PF00498	0.366
LIG_FHA_2	282	288	PF00498	0.308
LIG_FHA_2	379	385	PF00498	0.439
LIG_GBD_Chelix_1	191	199	PF00786	0.308
LIG_LIR_Apic_2	113	119	PF02991	0.279
LIG_LIR_Apic_2	159	163	PF02991	0.278
LIG_LIR_Gen_1	128	138	PF02991	0.276
LIG_LIR_Gen_1	426	437	PF02991	0.346
LIG_LIR_Nem_3	128	134	PF02991	0.262
LIG_LIR_Nem_3	426	432	PF02991	0.288
LIG_LIR_Nem_3	83	89	PF02991	0.278
LIG_LIR_Nem_3	94	99	PF02991	0.278
LIG_OCRL_FandH_1	341	353	PF00620	0.413
LIG_PCNA_yPIPBox_3	213	222	PF02747	0.291
LIG_Pex14_1	177	181	PF04695	0.278
LIG_Pex14_2	158	162	PF04695	0.278
LIG_SH2_CRK	279	283	PF00017	0.317
LIG_SH2_STAP1	286	290	PF00017	0.327
LIG_SH2_STAP1	87	91	PF00017	0.278
LIG_SH2_STAT3	24	27	PF00017	0.492
LIG_SH2_STAT5	223	226	PF00017	0.332
LIG_SH2_STAT5	24	27	PF00017	0.492
LIG_SH2_STAT5	243	246	PF00017	0.110
LIG_SH2_STAT5	310	313	PF00017	0.278
LIG_SH2_STAT5	75	78	PF00017	0.286
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.291
LIG_SUMO_SIM_par_1	281	289	PF11976	0.404
LIG_SUMO_SIM_par_1	414	419	PF11976	0.278
LIG_UBA3_1	130	139	PF00899	0.308
LIG_UBA3_1	462	471	PF00899	0.484
LIG_WRC_WIRS_1	70	75	PF05994	0.378
MOD_CDK_SPxK_1	291	297	PF00069	0.377
MOD_CK1_1	248	254	PF00069	0.327
MOD_CK1_1	33	39	PF00069	0.345
MOD_CK2_1	14	20	PF00069	0.543
MOD_CK2_1	378	384	PF00069	0.413
MOD_CK2_1	418	424	PF00069	0.287
MOD_GlcNHglycan	120	123	PF01048	0.369
MOD_GlcNHglycan	247	250	PF01048	0.310
MOD_GlcNHglycan	256	259	PF01048	0.311
MOD_GlcNHglycan	306	309	PF01048	0.292
MOD_GlcNHglycan	454	458	PF01048	0.278
MOD_GSK3_1	175	182	PF00069	0.315
MOD_GSK3_1	374	381	PF00069	0.394
MOD_GSK3_1	436	443	PF00069	0.378
MOD_GSK3_1	69	76	PF00069	0.413
MOD_N-GLC_1	212	217	PF02516	0.278
MOD_N-GLC_2	240	242	PF02516	0.278
MOD_NEK2_1	156	161	PF00069	0.326
MOD_NEK2_1	195	200	PF00069	0.370
MOD_NEK2_1	405	410	PF00069	0.326
MOD_NEK2_1	441	446	PF00069	0.340
MOD_NEK2_1	91	96	PF00069	0.278
MOD_NEK2_1	99	104	PF00069	0.278
MOD_PIKK_1	33	39	PF00454	0.349
MOD_PIKK_1	407	413	PF00454	0.355
MOD_PKA_2	14	20	PF00069	0.535
MOD_PKA_2	245	251	PF00069	0.348
MOD_PKA_2	62	68	PF00069	0.278
MOD_PKA_2	99	105	PF00069	0.325
MOD_Plk_1	212	218	PF00069	0.278
MOD_Plk_2-3	16	22	PF00069	0.557
MOD_Plk_2-3	378	384	PF00069	0.347
MOD_Plk_4	215	221	PF00069	0.278
MOD_Plk_4	418	424	PF00069	0.290
MOD_Plk_4	436	442	PF00069	0.278
MOD_Plk_4	46	52	PF00069	0.352
MOD_Plk_4	69	75	PF00069	0.278
MOD_ProDKin_1	261	267	PF00069	0.308
MOD_ProDKin_1	291	297	PF00069	0.363
MOD_ProDKin_1	423	429	PF00069	0.334
MOD_SUMO_rev_2	109	117	PF00179	0.352
MOD_SUMO_rev_2	161	169	PF00179	0.327
TRG_DiLeu_BaEn_1	384	389	PF01217	0.389
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.378
TRG_ENDOCYTIC_2	86	89	PF00928	0.377
TRG_ER_diArg_1	199	201	PF00400	0.377
TRG_ER_diArg_1	316	318	PF00400	0.292
TRG_ER_diArg_1	389	392	PF00400	0.285
TRG_NES_CRM1_1	363	375	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.413
TRG_PTS2	1	12	PF00400	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0K0JFP3	Brugia malayi	34%	82%
A0A0N0P4X5	Leptomonas seymouri	84%	100%
A0A0S4IU04	Bodo saltans	54%	100%
A0A1X0NYR8	Trypanosomatidae	68%	100%
A0A3Q8IBX3	Leishmania donovani	100%	100%
A0A3S7WWB0	Leishmania donovani	100%	100%
A0A422NIL0	Trypanosoma rangeli	69%	100%
A4HBM3	Leishmania braziliensis	90%	100%
A4HZB1	Leishmania infantum	100%	100%
D0A1L5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A1L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AUZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AUZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O64390	Solanum tuberosum	36%	95%
P04806	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	97%
P04807	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	97%
P17709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	94%
P17712	Rattus norvegicus	32%	100%
P33284	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	97%
P35557	Homo sapiens	32%	100%
P50506	Schwanniomyces occidentalis	35%	99%
P50521	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P52792	Mus musculus	31%	100%
P80581	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	96%
P83776	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	97%
P93834	Arabidopsis thaliana	36%	94%
Q02155	Plasmodium falciparum	32%	96%
Q04409	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	94%
Q09756	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	97%
Q1WM15	Oryza sativa subsp. japonica	38%	100%
Q1WM16	Oryza sativa subsp. japonica	36%	100%
Q26609	Schistosoma mansoni	36%	100%
Q2KNB4	Oryza sativa subsp. japonica	35%	94%
Q2KNB5	Oryza sativa subsp. japonica	31%	93%
Q2KNB7	Oryza sativa subsp. japonica	36%	94%
Q2KNB9	Oryza sativa subsp. japonica	36%	95%
Q42525	Arabidopsis thaliana	36%	95%
Q4QCJ0	Leishmania major	98%	100%
Q4U3Y2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	32%	86%
Q4VT70	Leishmania major	99%	100%
Q56XE8	Arabidopsis thaliana	34%	94%
Q5W676	Oryza sativa subsp. japonica	37%	93%
Q6CUZ3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	98%
Q6Q8A5	Nicotiana tabacum	38%	94%
Q6Z398	Oryza sativa subsp. japonica	37%	93%
Q8LH82	Oryza sativa subsp. japonica	37%	95%
Q8LQ68	Oryza sativa subsp. japonica	36%	93%
Q92407	Aspergillus niger	33%	95%
Q969A8	Toxoplasma gondii	33%	100%
Q9FZG4	Arabidopsis thaliana	35%	96%
Q9LPS1	Arabidopsis thaliana	35%	95%
Q9NFT7	Drosophila melanogaster	32%	97%
Q9NFT9	Drosophila melanogaster	27%	100%
Q9SEK2	Nicotiana tabacum	37%	95%
Q9SEK3	Spinacia oleracea	38%	95%
Q9SQ76	Solanum tuberosum	36%	95%
Q9T071	Arabidopsis thaliana	26%	96%
V5BQ43	Trypanosoma cruzi	67%	100%