Phosphotransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphotransferase

Gene product:

hexokinase - putative

Species:

Leishmania infantum

UniProt:

A4HZB1_LEIIN

TriTrypDb:

LINF_210007800

Length:

471

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, Hexokinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	17

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Expansion

Sequence features

A4HZB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZB1

Function

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Biological processes
Term	Name	Level	Count
GO:0001678	intracellular glucose homeostasis	4	17
GO:0005975	carbohydrate metabolic process	3	17
GO:0005996	monosaccharide metabolic process	3	2
GO:0006006	glucose metabolic process	5	2
GO:0006082	organic acid metabolic process	3	17
GO:0006090	pyruvate metabolic process	7	17
GO:0006091	generation of precursor metabolites and energy	3	17
GO:0006096	glycolytic process	5	17
GO:0006139	nucleobase-containing compound metabolic process	3	17
GO:0006163	purine nucleotide metabolic process	5	17

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004340	glucokinase activity	6	2
GO:0004396	hexokinase activity	5	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0005536	glucose binding	4	17
GO:0008865	fructokinase activity	6	2
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.430
CLV_C14_Caspase3-7	288	292	PF00656	0.404
CLV_NRD_NRD_1	200	202	PF00675	0.430
CLV_NRD_NRD_1	316	318	PF00675	0.349
CLV_PCSK_KEX2_1	152	154	PF00082	0.481
CLV_PCSK_KEX2_1	200	202	PF00082	0.382
CLV_PCSK_KEX2_1	316	318	PF00082	0.349
CLV_PCSK_KEX2_1	366	368	PF00082	0.463
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.481
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.481

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0K0JFP3	Brugia malayi	34%	82%
A0A0N0P4X5	Leptomonas seymouri	84%	100%
A0A0S4IU04	Bodo saltans	55%	100%
A0A1X0NYR8	Trypanosomatidae	68%	100%
A0A3Q8IBX3	Leishmania donovani	100%	100%
A0A3S7WWB0	Leishmania donovani	100%	100%
A0A422NIL0	Trypanosoma rangeli	69%	100%
A4HBM3	Leishmania braziliensis	90%	100%
A4HZB2	Leishmania infantum	100%	100%
D0A1L5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%

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