Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZA8_LEIIN

TriTrypDb:

LINF_210007500

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.643
CLV_NRD_NRD_1	141	143	PF00675	0.480
CLV_NRD_NRD_1	221	223	PF00675	0.465
CLV_NRD_NRD_1	245	247	PF00675	0.500
CLV_NRD_NRD_1	304	306	PF00675	0.433
CLV_NRD_NRD_1	376	378	PF00675	0.431
CLV_NRD_NRD_1	389	391	PF00675	0.392
CLV_PCSK_KEX2_1	141	143	PF00082	0.480
CLV_PCSK_KEX2_1	221	223	PF00082	0.469
CLV_PCSK_KEX2_1	245	247	PF00082	0.500
CLV_PCSK_KEX2_1	304	306	PF00082	0.460
CLV_PCSK_KEX2_1	376	378	PF00082	0.434
CLV_PCSK_KEX2_1	389	391	PF00082	0.404
CLV_PCSK_SKI1_1	179	183	PF00082	0.392
CLV_PCSK_SKI1_1	314	318	PF00082	0.447
CLV_PCSK_SKI1_1	384	388	PF00082	0.400
CLV_PCSK_SKI1_1	456	460	PF00082	0.519
DEG_APCC_DBOX_1	389	397	PF00400	0.542
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DOC_CYCLIN_RxL_1	374	385	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.443
DOC_MAPK_DCC_7	221	229	PF00069	0.476
DOC_MAPK_gen_1	139	147	PF00069	0.365
DOC_MAPK_gen_1	221	229	PF00069	0.476
DOC_MAPK_gen_1	245	253	PF00069	0.442
DOC_MAPK_gen_1	304	312	PF00069	0.471
DOC_MAPK_gen_1	376	383	PF00069	0.476
DOC_MAPK_gen_1	389	395	PF00069	0.513
DOC_MAPK_gen_1	453	461	PF00069	0.474
DOC_MAPK_MEF2A_6	139	147	PF00069	0.292
DOC_MAPK_MEF2A_6	179	186	PF00069	0.418
DOC_MAPK_MEF2A_6	222	231	PF00069	0.460
DOC_MAPK_MEF2A_6	246	255	PF00069	0.407
DOC_MAPK_MEF2A_6	26	33	PF00069	0.384
DOC_MAPK_MEF2A_6	376	383	PF00069	0.443
DOC_MAPK_MEF2A_6	70	77	PF00069	0.337
DOC_MAPK_NFAT4_5	376	384	PF00069	0.448
DOC_USP7_MATH_1	439	443	PF00917	0.693
DOC_USP7_MATH_1	60	64	PF00917	0.434
DOC_WW_Pin1_4	278	283	PF00397	0.621
DOC_WW_Pin1_4	437	442	PF00397	0.759
LIG_14-3-3_CanoR_1	376	380	PF00244	0.443
LIG_14-3-3_CanoR_1	460	464	PF00244	0.602
LIG_Actin_WH2_2	296	313	PF00022	0.309
LIG_BIR_III_2	249	253	PF00653	0.438
LIG_Clathr_ClatBox_1	407	411	PF01394	0.451
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.457
LIG_deltaCOP1_diTrp_1	483	488	PF00928	0.486
LIG_EVH1_1	431	435	PF00568	0.620
LIG_FHA_1	138	144	PF00498	0.420
LIG_FHA_1	191	197	PF00498	0.421
LIG_FHA_1	199	205	PF00498	0.438
LIG_FHA_1	232	238	PF00498	0.521
LIG_FHA_1	351	357	PF00498	0.362
LIG_FHA_1	453	459	PF00498	0.486
LIG_FHA_1	7	13	PF00498	0.670
LIG_FHA_2	380	386	PF00498	0.487
LIG_FHA_2	89	95	PF00498	0.480
LIG_GBD_Chelix_1	379	387	PF00786	0.447
LIG_GBD_Chelix_1	400	408	PF00786	0.371
LIG_LIR_Apic_2	363	369	PF02991	0.380
LIG_LIR_Gen_1	483	494	PF02991	0.432
LIG_LIR_Nem_3	483	489	PF02991	0.431
LIG_LYPXL_SIV_4	338	346	PF13949	0.405
LIG_NRBOX	382	388	PF00104	0.411
LIG_NRBOX	399	405	PF00104	0.427
LIG_NRBOX	73	79	PF00104	0.441
LIG_PCNA_yPIPBox_3	389	399	PF02747	0.459
LIG_SH2_STAT3	150	153	PF00017	0.381
LIG_SH2_STAT5	352	355	PF00017	0.452
LIG_SH2_STAT5	366	369	PF00017	0.354
LIG_SH2_STAT5	505	508	PF00017	0.505
LIG_SH3_3	123	129	PF00018	0.443
LIG_SH3_3	155	161	PF00018	0.437
LIG_SH3_3	262	268	PF00018	0.393
LIG_SH3_3	429	435	PF00018	0.674
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.270
LIG_SUMO_SIM_anti_2	394	400	PF11976	0.378
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.372
LIG_SUMO_SIM_anti_2	69	76	PF11976	0.408
LIG_SUMO_SIM_par_1	167	173	PF11976	0.298
LIG_SUMO_SIM_par_1	182	187	PF11976	0.462
LIG_SUMO_SIM_par_1	227	235	PF11976	0.456
LIG_SUMO_SIM_par_1	405	412	PF11976	0.439
LIG_SUMO_SIM_par_1	73	79	PF11976	0.407
LIG_TRAF2_1	85	88	PF00917	0.337
LIG_TYR_ITIM	81	86	PF00017	0.332
MOD_CK1_1	190	196	PF00069	0.427
MOD_CK1_1	476	482	PF00069	0.531
MOD_CK2_1	29	35	PF00069	0.533
MOD_CK2_1	379	385	PF00069	0.462
MOD_GlcNHglycan	189	192	PF01048	0.286
MOD_GlcNHglycan	241	244	PF01048	0.431
MOD_GlcNHglycan	411	414	PF01048	0.525
MOD_GlcNHglycan	420	423	PF01048	0.644
MOD_GlcNHglycan	441	444	PF01048	0.622
MOD_GlcNHglycan	475	478	PF01048	0.567
MOD_GlcNHglycan	499	502	PF01048	0.454
MOD_GlcNHglycan	52	55	PF01048	0.568
MOD_GlcNHglycan	56	59	PF01048	0.555
MOD_GSK3_1	133	140	PF00069	0.577
MOD_GSK3_1	274	281	PF00069	0.531
MOD_GSK3_1	375	382	PF00069	0.381
MOD_GSK3_1	437	444	PF00069	0.720
MOD_GSK3_1	50	57	PF00069	0.622
MOD_NEK2_1	231	236	PF00069	0.498
MOD_NEK2_1	370	375	PF00069	0.461
MOD_NEK2_1	379	384	PF00069	0.369
MOD_NEK2_1	402	407	PF00069	0.449
MOD_NEK2_1	459	464	PF00069	0.625
MOD_NEK2_2	216	221	PF00069	0.485
MOD_PIKK_1	111	117	PF00454	0.501
MOD_PIKK_1	21	27	PF00454	0.659
MOD_PKA_2	133	139	PF00069	0.510
MOD_PKA_2	375	381	PF00069	0.452
MOD_PKA_2	452	458	PF00069	0.500
MOD_PKA_2	459	465	PF00069	0.429
MOD_Plk_1	232	238	PF00069	0.408
MOD_Plk_1	482	488	PF00069	0.528
MOD_Plk_1	87	93	PF00069	0.453
MOD_Plk_2-3	274	280	PF00069	0.532
MOD_Plk_2-3	88	94	PF00069	0.482
MOD_Plk_4	153	159	PF00069	0.441
MOD_Plk_4	232	238	PF00069	0.564
MOD_Plk_4	29	35	PF00069	0.530
MOD_Plk_4	402	408	PF00069	0.461
MOD_ProDKin_1	278	284	PF00069	0.604
MOD_ProDKin_1	437	443	PF00069	0.760
MOD_SUMO_for_1	92	95	PF00179	0.442
TRG_DiLeu_BaEn_1	394	399	PF01217	0.383
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.463
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.413
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.345
TRG_ENDOCYTIC_2	83	86	PF00928	0.380
TRG_ER_diArg_1	131	134	PF00400	0.441
TRG_ER_diArg_1	141	143	PF00400	0.392
TRG_ER_diArg_1	220	222	PF00400	0.514
TRG_ER_diArg_1	244	246	PF00400	0.488
TRG_ER_diArg_1	303	305	PF00400	0.429
TRG_ER_diArg_1	388	390	PF00400	0.431
TRG_ER_diArg_1	40	43	PF00400	0.470
TRG_NES_CRM1_1	397	411	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I200	Leptomonas seymouri	45%	90%
A0A0S4IXJ4	Bodo saltans	25%	100%
A0A3R7KNI1	Trypanosoma rangeli	30%	89%
A0A3S5H793	Leishmania donovani	100%	100%
A4HBM0	Leishmania braziliensis	78%	100%
E9AUY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCJ4	Leishmania major	94%	100%
V5DGY6	Trypanosoma cruzi	30%	100%