LeishMANIAdb
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Major vault protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Major vault protein-like protein
Gene product:
major vault protein-like protein
Species:
Leishmania infantum
UniProt:
A4HZA7_LEIIN
TriTrypDb:
LINF_210007400
Length:
959

Annotations

Annotations by Jardim et al.

Nuclear proteins, Major vault -like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 10
GO:0005737 cytoplasm 2 10
GO:0032991 protein-containing complex 1 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 10
GO:1990904 ribonucleoprotein complex 2 10

Expansion

Sequence features

A4HZA7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZA7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 282 286 PF00656 0.362
CLV_C14_Caspase3-7 369 373 PF00656 0.473
CLV_C14_Caspase3-7 510 514 PF00656 0.684
CLV_C14_Caspase3-7 712 716 PF00656 0.496
CLV_C14_Caspase3-7 74 78 PF00656 0.457
CLV_NRD_NRD_1 300 302 PF00675 0.448
CLV_NRD_NRD_1 402 404 PF00675 0.345
CLV_NRD_NRD_1 449 451 PF00675 0.237
CLV_NRD_NRD_1 853 855 PF00675 0.400
CLV_NRD_NRD_1 875 877 PF00675 0.398
CLV_PCSK_FUR_1 297 301 PF00082 0.363
CLV_PCSK_KEX2_1 299 301 PF00082 0.506
CLV_PCSK_KEX2_1 401 403 PF00082 0.327
CLV_PCSK_KEX2_1 449 451 PF00082 0.237
CLV_PCSK_KEX2_1 855 857 PF00082 0.425
CLV_PCSK_PC1ET2_1 855 857 PF00082 0.507
CLV_PCSK_PC7_1 397 403 PF00082 0.398
CLV_PCSK_SKI1_1 347 351 PF00082 0.357
CLV_PCSK_SKI1_1 403 407 PF00082 0.323
CLV_PCSK_SKI1_1 424 428 PF00082 0.265
CLV_PCSK_SKI1_1 449 453 PF00082 0.238
CLV_PCSK_SKI1_1 742 746 PF00082 0.419
CLV_PCSK_SKI1_1 776 780 PF00082 0.388
CLV_Separin_Metazoa 796 800 PF03568 0.379
CLV_Separin_Metazoa 851 855 PF03568 0.464
DEG_APCC_DBOX_1 793 801 PF00400 0.356
DOC_CKS1_1 177 182 PF01111 0.405
DOC_CKS1_1 701 706 PF01111 0.405
DOC_CYCLIN_RxL_1 446 454 PF00134 0.405
DOC_CYCLIN_yCln2_LP_2 28 34 PF00134 0.398
DOC_MAPK_gen_1 297 305 PF00069 0.438
DOC_MAPK_gen_1 401 407 PF00069 0.289
DOC_MAPK_gen_1 854 861 PF00069 0.391
DOC_MAPK_gen_1 909 918 PF00069 0.423
DOC_MAPK_HePTP_8 624 636 PF00069 0.498
DOC_MAPK_MEF2A_6 549 557 PF00069 0.172
DOC_MAPK_MEF2A_6 627 636 PF00069 0.498
DOC_MAPK_MEF2A_6 747 755 PF00069 0.406
DOC_MAPK_MEF2A_6 776 783 PF00069 0.356
DOC_MAPK_NFAT4_5 776 784 PF00069 0.360
DOC_PP1_RVXF_1 480 486 PF00149 0.353
DOC_PP4_FxxP_1 172 175 PF00568 0.480
DOC_PP4_FxxP_1 232 235 PF00568 0.294
DOC_PP4_FxxP_1 427 430 PF00568 0.465
DOC_PP4_FxxP_1 583 586 PF00568 0.422
DOC_PP4_FxxP_1 660 663 PF00568 0.385
DOC_USP7_MATH_1 106 110 PF00917 0.356
DOC_USP7_MATH_1 455 459 PF00917 0.437
DOC_USP7_MATH_1 470 474 PF00917 0.361
DOC_USP7_MATH_1 505 509 PF00917 0.637
DOC_USP7_MATH_1 672 676 PF00917 0.458
DOC_USP7_MATH_1 759 763 PF00917 0.458
DOC_USP7_MATH_1 810 814 PF00917 0.535
DOC_USP7_MATH_1 840 844 PF00917 0.492
DOC_USP7_MATH_2 704 710 PF00917 0.399
DOC_WW_Pin1_4 115 120 PF00397 0.452
DOC_WW_Pin1_4 129 134 PF00397 0.476
DOC_WW_Pin1_4 176 181 PF00397 0.515
DOC_WW_Pin1_4 193 198 PF00397 0.282
DOC_WW_Pin1_4 43 48 PF00397 0.474
DOC_WW_Pin1_4 588 593 PF00397 0.426
DOC_WW_Pin1_4 700 705 PF00397 0.405
DOC_WW_Pin1_4 832 837 PF00397 0.425
DOC_WW_Pin1_4 85 90 PF00397 0.474
DOC_WW_Pin1_4 925 930 PF00397 0.504
DOC_WW_Pin1_4 944 949 PF00397 0.570
LIG_14-3-3_CanoR_1 456 460 PF00244 0.420
LIG_14-3-3_CanoR_1 864 868 PF00244 0.391
LIG_14-3-3_CterR_2 957 959 PF00244 0.493
LIG_Actin_WH2_2 444 462 PF00022 0.405
LIG_BIR_II_1 1 5 PF00653 0.473
LIG_BIR_III_2 77 81 PF00653 0.376
LIG_BIR_III_2 833 837 PF00653 0.457
LIG_BRCT_BRCA1_1 514 518 PF00533 0.468
LIG_BRCT_BRCA1_1 715 719 PF00533 0.399
LIG_CtBP_PxDLS_1 592 596 PF00389 0.399
LIG_deltaCOP1_diTrp_1 475 485 PF00928 0.374
LIG_EVH1_2 54 58 PF00568 0.372
LIG_FHA_1 1 7 PF00498 0.605
LIG_FHA_1 177 183 PF00498 0.405
LIG_FHA_1 20 26 PF00498 0.322
LIG_FHA_1 236 242 PF00498 0.305
LIG_FHA_1 31 37 PF00498 0.368
LIG_FHA_1 320 326 PF00498 0.521
LIG_FHA_1 344 350 PF00498 0.435
LIG_FHA_1 418 424 PF00498 0.439
LIG_FHA_1 552 558 PF00498 0.425
LIG_FHA_1 579 585 PF00498 0.432
LIG_FHA_1 726 732 PF00498 0.465
LIG_FHA_1 793 799 PF00498 0.472
LIG_FHA_2 125 131 PF00498 0.457
LIG_FHA_2 136 142 PF00498 0.272
LIG_FHA_2 246 252 PF00498 0.473
LIG_FHA_2 33 39 PF00498 0.334
LIG_FHA_2 365 371 PF00498 0.415
LIG_FHA_2 372 378 PF00498 0.385
LIG_FHA_2 479 485 PF00498 0.556
LIG_FHA_2 659 665 PF00498 0.497
LIG_FHA_2 701 707 PF00498 0.399
LIG_FHA_2 725 731 PF00498 0.424
LIG_FHA_2 803 809 PF00498 0.365
LIG_FHA_2 846 852 PF00498 0.506
LIG_FHA_2 882 888 PF00498 0.415
LIG_LIR_Apic_2 101 106 PF02991 0.396
LIG_LIR_Apic_2 191 197 PF02991 0.520
LIG_LIR_Apic_2 425 430 PF02991 0.438
LIG_LIR_Apic_2 437 443 PF02991 0.406
LIG_LIR_Apic_2 581 586 PF02991 0.465
LIG_LIR_Apic_2 610 615 PF02991 0.460
LIG_LIR_Apic_2 657 663 PF02991 0.405
LIG_LIR_Gen_1 13 19 PF02991 0.332
LIG_LIR_Gen_1 204 215 PF02991 0.385
LIG_LIR_Gen_1 248 258 PF02991 0.439
LIG_LIR_Gen_1 308 317 PF02991 0.408
LIG_LIR_Gen_1 548 557 PF02991 0.229
LIG_LIR_Gen_1 56 65 PF02991 0.340
LIG_LIR_Gen_1 884 893 PF02991 0.437
LIG_LIR_Nem_3 117 123 PF02991 0.420
LIG_LIR_Nem_3 13 17 PF02991 0.327
LIG_LIR_Nem_3 204 210 PF02991 0.372
LIG_LIR_Nem_3 248 253 PF02991 0.403
LIG_LIR_Nem_3 254 258 PF02991 0.302
LIG_LIR_Nem_3 308 313 PF02991 0.407
LIG_LIR_Nem_3 33 37 PF02991 0.230
LIG_LIR_Nem_3 548 553 PF02991 0.340
LIG_LIR_Nem_3 56 61 PF02991 0.336
LIG_LIR_Nem_3 588 593 PF02991 0.439
LIG_LIR_Nem_3 641 645 PF02991 0.500
LIG_LIR_Nem_3 884 889 PF02991 0.436
LIG_Pex14_1 103 107 PF04695 0.382
LIG_Pex14_2 427 431 PF04695 0.465
LIG_Rb_pABgroove_1 560 568 PF01858 0.385
LIG_SH2_CRK 310 314 PF00017 0.281
LIG_SH2_CRK 395 399 PF00017 0.400
LIG_SH2_CRK 550 554 PF00017 0.384
LIG_SH2_CRK 82 86 PF00017 0.353
LIG_SH2_NCK_1 368 372 PF00017 0.480
LIG_SH2_PTP2 194 197 PF00017 0.430
LIG_SH2_PTP2 390 393 PF00017 0.399
LIG_SH2_SRC 14 17 PF00017 0.272
LIG_SH2_SRC 262 265 PF00017 0.380
LIG_SH2_SRC 276 279 PF00017 0.265
LIG_SH2_SRC 37 40 PF00017 0.450
LIG_SH2_SRC 390 393 PF00017 0.385
LIG_SH2_STAP1 395 399 PF00017 0.400
LIG_SH2_STAP1 886 890 PF00017 0.506
LIG_SH2_STAT5 14 17 PF00017 0.267
LIG_SH2_STAT5 178 181 PF00017 0.411
LIG_SH2_STAT5 194 197 PF00017 0.372
LIG_SH2_STAT5 202 205 PF00017 0.305
LIG_SH2_STAT5 245 248 PF00017 0.443
LIG_SH2_STAT5 276 279 PF00017 0.398
LIG_SH2_STAT5 288 291 PF00017 0.435
LIG_SH2_STAT5 310 313 PF00017 0.250
LIG_SH2_STAT5 34 37 PF00017 0.227
LIG_SH2_STAT5 368 371 PF00017 0.434
LIG_SH2_STAT5 390 393 PF00017 0.411
LIG_SH2_STAT5 414 417 PF00017 0.406
LIG_SH2_STAT5 447 450 PF00017 0.471
LIG_SH2_STAT5 612 615 PF00017 0.492
LIG_SH2_STAT5 725 728 PF00017 0.428
LIG_SH2_STAT5 82 85 PF00017 0.422
LIG_SH3_3 118 124 PF00018 0.353
LIG_SH3_3 125 131 PF00018 0.399
LIG_SH3_3 150 156 PF00018 0.405
LIG_SH3_3 192 198 PF00018 0.530
LIG_SH3_3 310 316 PF00018 0.374
LIG_SH3_3 381 387 PF00018 0.438
LIG_SH3_3 48 54 PF00018 0.397
LIG_SH3_3 573 579 PF00018 0.502
LIG_SH3_3 58 64 PF00018 0.314
LIG_SH3_3 597 603 PF00018 0.461
LIG_SH3_3 947 953 PF00018 0.660
LIG_SUMO_SIM_anti_2 24 30 PF11976 0.342
LIG_SUMO_SIM_anti_2 847 854 PF11976 0.466
LIG_SUMO_SIM_par_1 591 596 PF11976 0.440
LIG_SUMO_SIM_par_1 620 626 PF11976 0.420
LIG_SUMO_SIM_par_1 727 733 PF11976 0.435
LIG_TRAF2_1 165 168 PF00917 0.364
LIG_TRAF2_1 473 476 PF00917 0.485
LIG_TRFH_1 120 124 PF08558 0.345
LIG_TRFH_1 337 341 PF08558 0.381
LIG_TYR_ITSM 306 313 PF00017 0.391
LIG_TYR_ITSM 882 889 PF00017 0.473
LIG_UBA3_1 932 938 PF00899 0.464
LIG_WRC_WIRS_1 247 252 PF05994 0.357
LIG_WW_1 392 395 PF00397 0.310
LIG_WW_1 79 82 PF00397 0.344
LIG_WW_3 539 543 PF00397 0.381
MOD_CDK_SPK_2 176 181 PF00069 0.237
MOD_CDK_SPxK_1 832 838 PF00069 0.400
MOD_CK1_1 188 194 PF00069 0.314
MOD_CK1_1 2 8 PF00069 0.396
MOD_CK1_1 504 510 PF00069 0.617
MOD_CK1_1 511 517 PF00069 0.599
MOD_CK1_1 644 650 PF00069 0.229
MOD_CK1_1 709 715 PF00069 0.270
MOD_CK1_1 762 768 PF00069 0.502
MOD_CK1_1 88 94 PF00069 0.583
MOD_CK1_1 892 898 PF00069 0.373
MOD_CK2_1 124 130 PF00069 0.423
MOD_CK2_1 135 141 PF00069 0.205
MOD_CK2_1 245 251 PF00069 0.405
MOD_CK2_1 352 358 PF00069 0.357
MOD_CK2_1 364 370 PF00069 0.232
MOD_CK2_1 371 377 PF00069 0.226
MOD_CK2_1 462 468 PF00069 0.402
MOD_CK2_1 470 476 PF00069 0.380
MOD_CK2_1 478 484 PF00069 0.411
MOD_CK2_1 504 510 PF00069 0.717
MOD_CK2_1 700 706 PF00069 0.446
MOD_CK2_1 802 808 PF00069 0.383
MOD_CK2_1 845 851 PF00069 0.502
MOD_CK2_1 876 882 PF00069 0.395
MOD_Cter_Amidation 297 300 PF01082 0.367
MOD_GlcNHglycan 203 206 PF01048 0.375
MOD_GlcNHglycan 463 467 PF01048 0.594
MOD_GlcNHglycan 503 506 PF01048 0.656
MOD_GlcNHglycan 507 510 PF01048 0.545
MOD_GlcNHglycan 595 598 PF01048 0.258
MOD_GlcNHglycan 646 650 PF01048 0.200
MOD_GlcNHglycan 678 681 PF01048 0.306
MOD_GlcNHglycan 820 823 PF01048 0.496
MOD_GSK3_1 137 144 PF00069 0.373
MOD_GSK3_1 276 283 PF00069 0.353
MOD_GSK3_1 343 350 PF00069 0.333
MOD_GSK3_1 455 462 PF00069 0.298
MOD_GSK3_1 501 508 PF00069 0.628
MOD_GSK3_1 53 60 PF00069 0.491
MOD_GSK3_1 541 548 PF00069 0.396
MOD_GSK3_1 566 573 PF00069 0.242
MOD_GSK3_1 641 648 PF00069 0.272
MOD_GSK3_1 672 679 PF00069 0.366
MOD_GSK3_1 709 716 PF00069 0.291
MOD_GSK3_1 80 87 PF00069 0.365
MOD_GSK3_1 921 928 PF00069 0.518
MOD_N-GLC_1 691 696 PF02516 0.223
MOD_N-GLC_2 21 23 PF02516 0.376
MOD_NEK2_1 305 310 PF00069 0.471
MOD_NEK2_1 487 492 PF00069 0.540
MOD_NEK2_1 565 570 PF00069 0.251
MOD_NEK2_1 593 598 PF00069 0.295
MOD_NEK2_1 658 663 PF00069 0.315
MOD_NEK2_1 717 722 PF00069 0.270
MOD_NEK2_1 724 729 PF00069 0.264
MOD_NEK2_1 745 750 PF00069 0.403
MOD_NEK2_1 818 823 PF00069 0.479
MOD_NEK2_1 84 89 PF00069 0.439
MOD_NEK2_2 292 297 PF00069 0.350
MOD_NEK2_2 371 376 PF00069 0.296
MOD_NEK2_2 455 460 PF00069 0.321
MOD_PIKK_1 305 311 PF00454 0.436
MOD_PIKK_1 53 59 PF00454 0.392
MOD_PK_1 422 428 PF00069 0.172
MOD_PKA_1 876 882 PF00069 0.367
MOD_PKA_2 455 461 PF00069 0.272
MOD_PKA_2 541 547 PF00069 0.401
MOD_PKA_2 863 869 PF00069 0.472
MOD_Plk_1 470 476 PF00069 0.486
MOD_Plk_1 691 697 PF00069 0.223
MOD_Plk_1 802 808 PF00069 0.417
MOD_Plk_2-3 141 147 PF00069 0.237
MOD_Plk_2-3 641 647 PF00069 0.390
MOD_Plk_2-3 730 736 PF00069 0.209
MOD_Plk_4 2 8 PF00069 0.502
MOD_Plk_4 24 30 PF00069 0.348
MOD_Plk_4 251 257 PF00069 0.318
MOD_Plk_4 284 290 PF00069 0.463
MOD_Plk_4 32 38 PF00069 0.398
MOD_Plk_4 333 339 PF00069 0.377
MOD_Plk_4 558 564 PF00069 0.371
MOD_Plk_4 578 584 PF00069 0.123
MOD_Plk_4 607 613 PF00069 0.275
MOD_Plk_4 692 698 PF00069 0.220
MOD_Plk_4 706 712 PF00069 0.209
MOD_Plk_4 80 86 PF00069 0.366
MOD_Plk_4 894 900 PF00069 0.503
MOD_ProDKin_1 115 121 PF00069 0.449
MOD_ProDKin_1 129 135 PF00069 0.473
MOD_ProDKin_1 176 182 PF00069 0.391
MOD_ProDKin_1 193 199 PF00069 0.279
MOD_ProDKin_1 43 49 PF00069 0.475
MOD_ProDKin_1 588 594 PF00069 0.267
MOD_ProDKin_1 700 706 PF00069 0.237
MOD_ProDKin_1 832 838 PF00069 0.427
MOD_ProDKin_1 85 91 PF00069 0.471
MOD_ProDKin_1 925 931 PF00069 0.504
MOD_ProDKin_1 944 950 PF00069 0.567
MOD_SUMO_for_1 788 791 PF00179 0.458
MOD_SUMO_rev_2 772 778 PF00179 0.377
TRG_DiLeu_BaEn_1 24 29 PF01217 0.307
TRG_DiLeu_BaEn_1 356 361 PF01217 0.321
TRG_DiLeu_BaEn_1 558 563 PF01217 0.321
TRG_DiLeu_BaEn_2 250 256 PF01217 0.274
TRG_DiLeu_BaLyEn_6 118 123 PF01217 0.410
TRG_DiLeu_BaLyEn_6 132 137 PF01217 0.441
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.229
TRG_ENDOCYTIC_2 14 17 PF00928 0.322
TRG_ENDOCYTIC_2 207 210 PF00928 0.466
TRG_ENDOCYTIC_2 258 261 PF00928 0.319
TRG_ENDOCYTIC_2 310 313 PF00928 0.259
TRG_ENDOCYTIC_2 395 398 PF00928 0.436
TRG_ENDOCYTIC_2 550 553 PF00928 0.413
TRG_ENDOCYTIC_2 82 85 PF00928 0.430
TRG_ENDOCYTIC_2 886 889 PF00928 0.480
TRG_ER_diArg_1 296 299 PF00400 0.464
TRG_ER_diArg_1 401 403 PF00400 0.386
TRG_ER_diArg_1 448 450 PF00400 0.321
TRG_ER_diArg_1 631 634 PF00400 0.321
TRG_ER_diArg_1 853 856 PF00400 0.474
TRG_NES_CRM1_1 184 199 PF08389 0.326
TRG_NES_CRM1_1 907 919 PF08389 0.569
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 449 454 PF00026 0.284
TRG_Pf-PMV_PEXEL_1 876 880 PF00026 0.471
TRG_Pf-PMV_PEXEL_1 911 915 PF00026 0.425

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Z8 Leptomonas seymouri 32% 100%
A0A0N1PCB5 Leptomonas seymouri 63% 96%
A0A0S4ISQ0 Bodo saltans 30% 100%
A0A0S4JL46 Bodo saltans 30% 100%
A0A1X0NXD4 Trypanosomatidae 44% 100%
A0A1X0P8P2 Trypanosomatidae 28% 100%
A0A3Q8IKW2 Leishmania donovani 100% 100%
A0A3S7XAQ4 Leishmania donovani 31% 100%
A0A422NLE5 Trypanosoma rangeli 30% 100%
A4HP51 Leishmania braziliensis 32% 90%
A4IDF8 Leishmania infantum 31% 90%
D0A1L3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ASV9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 90%
E9AUY7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
P54659 Dictyostelium discoideum 32% 100%
Q4Q1N7 Leishmania major 32% 90%
Q4QCJ5 Leishmania major 96% 100%
Q5ZMI4 Gallus gallus 32% 100%
V5B0K2 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS