LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZA6_LEIIN
TriTrypDb:
LINF_210007300
Length:
724

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005929 cilium 4 10
GO:0042995 cell projection 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0110165 cellular anatomical entity 1 10
GO:0120025 plasma membrane bounded cell projection 3 10

Expansion

Sequence features

A4HZA6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZA6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 118 122 PF00656 0.561
CLV_C14_Caspase3-7 154 158 PF00656 0.712
CLV_C14_Caspase3-7 235 239 PF00656 0.702
CLV_C14_Caspase3-7 520 524 PF00656 0.692
CLV_NRD_NRD_1 400 402 PF00675 0.520
CLV_NRD_NRD_1 456 458 PF00675 0.575
CLV_NRD_NRD_1 5 7 PF00675 0.575
CLV_NRD_NRD_1 596 598 PF00675 0.632
CLV_PCSK_KEX2_1 400 402 PF00082 0.520
CLV_PCSK_KEX2_1 456 458 PF00082 0.545
CLV_PCSK_KEX2_1 5 7 PF00082 0.536
CLV_PCSK_KEX2_1 596 598 PF00082 0.658
CLV_PCSK_SKI1_1 164 168 PF00082 0.553
CLV_PCSK_SKI1_1 261 265 PF00082 0.423
CLV_PCSK_SKI1_1 271 275 PF00082 0.474
CLV_PCSK_SKI1_1 308 312 PF00082 0.461
CLV_PCSK_SKI1_1 355 359 PF00082 0.410
CLV_PCSK_SKI1_1 511 515 PF00082 0.726
CLV_PCSK_SKI1_1 533 537 PF00082 0.643
CLV_PCSK_SKI1_1 575 579 PF00082 0.412
CLV_PCSK_SKI1_1 605 609 PF00082 0.544
CLV_PCSK_SKI1_1 95 99 PF00082 0.581
CLV_Separin_Metazoa 556 560 PF03568 0.404
DEG_ODPH_VHL_1 550 563 PF01847 0.459
DEG_SCF_FBW7_2 649 655 PF00400 0.531
DOC_CKS1_1 621 626 PF01111 0.456
DOC_CKS1_1 649 654 PF01111 0.527
DOC_CYCLIN_RxL_1 268 278 PF00134 0.550
DOC_CYCLIN_RxL_1 572 582 PF00134 0.507
DOC_CYCLIN_yCln2_LP_2 544 547 PF00134 0.539
DOC_CYCLIN_yCln2_LP_2 609 612 PF00134 0.560
DOC_MAPK_gen_1 400 410 PF00069 0.397
DOC_MAPK_gen_1 425 433 PF00069 0.482
DOC_MAPK_gen_1 5 11 PF00069 0.500
DOC_MAPK_gen_1 93 101 PF00069 0.516
DOC_MAPK_MEF2A_6 34 41 PF00069 0.329
DOC_MAPK_MEF2A_6 634 641 PF00069 0.471
DOC_MAPK_MEF2A_6 95 103 PF00069 0.561
DOC_PP1_RVXF_1 4 11 PF00149 0.550
DOC_PP2B_LxvP_1 274 277 PF13499 0.495
DOC_PP2B_LxvP_1 544 547 PF13499 0.539
DOC_PP2B_LxvP_1 608 611 PF13499 0.565
DOC_USP7_MATH_1 130 134 PF00917 0.608
DOC_USP7_MATH_1 136 140 PF00917 0.628
DOC_USP7_MATH_1 281 285 PF00917 0.503
DOC_USP7_MATH_1 338 342 PF00917 0.620
DOC_USP7_MATH_1 406 410 PF00917 0.489
DOC_USP7_MATH_1 446 450 PF00917 0.487
DOC_USP7_MATH_1 538 542 PF00917 0.656
DOC_USP7_MATH_1 601 605 PF00917 0.639
DOC_USP7_MATH_1 625 629 PF00917 0.549
DOC_USP7_MATH_1 76 80 PF00917 0.722
DOC_WW_Pin1_4 126 131 PF00397 0.667
DOC_WW_Pin1_4 156 161 PF00397 0.582
DOC_WW_Pin1_4 206 211 PF00397 0.788
DOC_WW_Pin1_4 521 526 PF00397 0.658
DOC_WW_Pin1_4 59 64 PF00397 0.556
DOC_WW_Pin1_4 620 625 PF00397 0.601
DOC_WW_Pin1_4 648 653 PF00397 0.525
DOC_WW_Pin1_4 72 77 PF00397 0.731
DOC_WW_Pin1_4 78 83 PF00397 0.725
LIG_14-3-3_CanoR_1 191 200 PF00244 0.564
LIG_14-3-3_CanoR_1 252 257 PF00244 0.474
LIG_14-3-3_CanoR_1 271 277 PF00244 0.561
LIG_14-3-3_CanoR_1 282 286 PF00244 0.489
LIG_14-3-3_CanoR_1 345 350 PF00244 0.475
LIG_14-3-3_CanoR_1 407 411 PF00244 0.517
LIG_14-3-3_CanoR_1 456 462 PF00244 0.538
LIG_14-3-3_CanoR_1 511 521 PF00244 0.766
LIG_14-3-3_CanoR_1 559 564 PF00244 0.548
LIG_14-3-3_CanoR_1 575 585 PF00244 0.465
LIG_14-3-3_CanoR_1 689 697 PF00244 0.568
LIG_14-3-3_CanoR_1 84 89 PF00244 0.711
LIG_Actin_WH2_2 419 434 PF00022 0.501
LIG_Actin_WH2_2 632 647 PF00022 0.519
LIG_Actin_WH2_2 676 691 PF00022 0.530
LIG_AP_GAE_1 361 367 PF02883 0.523
LIG_BIR_II_1 1 5 PF00653 0.640
LIG_BIR_III_2 157 161 PF00653 0.574
LIG_BIR_III_4 616 620 PF00653 0.657
LIG_BRCT_BRCA1_1 395 399 PF00533 0.509
LIG_BRCT_BRCA1_1 68 72 PF00533 0.649
LIG_Clathr_ClatBox_1 124 128 PF01394 0.697
LIG_deltaCOP1_diTrp_1 675 684 PF00928 0.473
LIG_FHA_1 161 167 PF00498 0.496
LIG_FHA_1 195 201 PF00498 0.646
LIG_FHA_1 324 330 PF00498 0.555
LIG_FHA_1 346 352 PF00498 0.555
LIG_FHA_1 50 56 PF00498 0.540
LIG_FHA_1 558 564 PF00498 0.418
LIG_FHA_1 59 65 PF00498 0.554
LIG_FHA_1 621 627 PF00498 0.617
LIG_FHA_1 717 723 PF00498 0.577
LIG_FHA_2 348 354 PF00498 0.510
LIG_FHA_2 412 418 PF00498 0.444
LIG_FHA_2 518 524 PF00498 0.709
LIG_GBD_Chelix_1 573 581 PF00786 0.541
LIG_HP1_1 525 529 PF01393 0.607
LIG_Integrin_RGD_1 236 238 PF01839 0.760
LIG_Integrin_RGD_1 290 292 PF01839 0.555
LIG_IRF3_LxIS_1 684 691 PF10401 0.506
LIG_LIR_Gen_1 170 179 PF02991 0.475
LIG_LIR_Gen_1 246 256 PF02991 0.519
LIG_LIR_Gen_1 471 480 PF02991 0.422
LIG_LIR_Gen_1 494 503 PF02991 0.546
LIG_LIR_Gen_1 540 550 PF02991 0.540
LIG_LIR_Gen_1 576 586 PF02991 0.464
LIG_LIR_Gen_1 635 644 PF02991 0.373
LIG_LIR_Gen_1 651 660 PF02991 0.485
LIG_LIR_Gen_1 675 685 PF02991 0.472
LIG_LIR_Nem_3 170 176 PF02991 0.460
LIG_LIR_Nem_3 246 251 PF02991 0.503
LIG_LIR_Nem_3 361 367 PF02991 0.446
LIG_LIR_Nem_3 471 477 PF02991 0.440
LIG_LIR_Nem_3 494 498 PF02991 0.524
LIG_LIR_Nem_3 540 545 PF02991 0.583
LIG_LIR_Nem_3 635 639 PF02991 0.374
LIG_LIR_Nem_3 651 656 PF02991 0.488
LIG_LIR_Nem_3 675 681 PF02991 0.451
LIG_LIR_Nem_3 703 708 PF02991 0.442
LIG_Pex14_2 342 346 PF04695 0.560
LIG_RPA_C_Fungi 389 401 PF08784 0.520
LIG_SH2_CRK 248 252 PF00017 0.524
LIG_SH2_CRK 474 478 PF00017 0.523
LIG_SH2_CRK 622 626 PF00017 0.641
LIG_SH2_GRB2like 314 317 PF00017 0.553
LIG_SH2_NCK_1 140 144 PF00017 0.546
LIG_SH2_SRC 304 307 PF00017 0.306
LIG_SH2_SRC 381 384 PF00017 0.525
LIG_SH2_STAP1 314 318 PF00017 0.505
LIG_SH2_STAP1 632 636 PF00017 0.417
LIG_SH2_STAT5 140 143 PF00017 0.369
LIG_SH2_STAT5 173 176 PF00017 0.503
LIG_SH2_STAT5 373 376 PF00017 0.516
LIG_SH2_STAT5 404 407 PF00017 0.451
LIG_SH2_STAT5 442 445 PF00017 0.504
LIG_SH2_STAT5 476 479 PF00017 0.519
LIG_SH2_STAT5 49 52 PF00017 0.554
LIG_SH2_STAT5 622 625 PF00017 0.564
LIG_SH3_3 163 169 PF00018 0.536
LIG_SH3_3 180 186 PF00018 0.517
LIG_SH3_3 618 624 PF00018 0.468
LIG_SH3_CIN85_PxpxPR_1 277 282 PF14604 0.400
LIG_Sin3_3 365 372 PF02671 0.501
LIG_SUMO_SIM_anti_2 348 353 PF11976 0.478
LIG_SUMO_SIM_anti_2 505 510 PF11976 0.691
LIG_SUMO_SIM_par_1 252 258 PF11976 0.476
LIG_SUMO_SIM_par_1 272 278 PF11976 0.281
LIG_SUMO_SIM_par_1 347 353 PF11976 0.459
LIG_SUMO_SIM_par_1 365 370 PF11976 0.317
LIG_SUMO_SIM_par_1 582 588 PF11976 0.445
LIG_SxIP_EBH_1 428 442 PF03271 0.259
LIG_TRFH_1 542 546 PF08558 0.551
LIG_TYR_ITIM 171 176 PF00017 0.461
MOD_CDK_SPxK_1 78 84 PF00069 0.736
MOD_CK1_1 139 145 PF00069 0.561
MOD_CK1_1 220 226 PF00069 0.811
MOD_CK1_1 323 329 PF00069 0.534
MOD_CK1_1 411 417 PF00069 0.443
MOD_CK1_1 576 582 PF00069 0.480
MOD_CK1_1 75 81 PF00069 0.770
MOD_CK2_1 252 258 PF00069 0.449
MOD_CK2_1 411 417 PF00069 0.449
MOD_CK2_1 446 452 PF00069 0.534
MOD_CK2_1 576 582 PF00069 0.416
MOD_Cter_Amidation 3 6 PF01082 0.573
MOD_GlcNHglycan 132 135 PF01048 0.579
MOD_GlcNHglycan 141 144 PF01048 0.572
MOD_GlcNHglycan 153 156 PF01048 0.668
MOD_GlcNHglycan 2 5 PF01048 0.582
MOD_GlcNHglycan 222 225 PF01048 0.721
MOD_GlcNHglycan 240 243 PF01048 0.428
MOD_GlcNHglycan 395 398 PF01048 0.434
MOD_GlcNHglycan 470 473 PF01048 0.487
MOD_GlcNHglycan 498 501 PF01048 0.481
MOD_GlcNHglycan 68 71 PF01048 0.643
MOD_GSK3_1 10 17 PF00069 0.473
MOD_GSK3_1 126 133 PF00069 0.622
MOD_GSK3_1 156 163 PF00069 0.523
MOD_GSK3_1 281 288 PF00069 0.591
MOD_GSK3_1 319 326 PF00069 0.492
MOD_GSK3_1 475 482 PF00069 0.453
MOD_GSK3_1 513 520 PF00069 0.699
MOD_GSK3_1 559 566 PF00069 0.549
MOD_GSK3_1 576 583 PF00069 0.438
MOD_GSK3_1 684 691 PF00069 0.545
MOD_GSK3_1 712 719 PF00069 0.532
MOD_GSK3_1 72 79 PF00069 0.771
MOD_N-GLC_1 457 462 PF02516 0.526
MOD_N-GLC_1 511 516 PF02516 0.683
MOD_N-GLC_1 700 705 PF02516 0.370
MOD_NEK2_1 10 15 PF00069 0.465
MOD_NEK2_1 151 156 PF00069 0.545
MOD_NEK2_1 285 290 PF00069 0.564
MOD_NEK2_1 367 372 PF00069 0.404
MOD_NEK2_1 41 46 PF00069 0.543
MOD_NEK2_1 431 436 PF00069 0.440
MOD_NEK2_1 513 518 PF00069 0.750
MOD_NEK2_1 573 578 PF00069 0.442
MOD_NEK2_1 58 63 PF00069 0.597
MOD_NEK2_1 684 689 PF00069 0.442
MOD_PIKK_1 285 291 PF00454 0.564
MOD_PIKK_1 323 329 PF00454 0.601
MOD_PIKK_1 514 520 PF00454 0.764
MOD_PK_1 320 326 PF00069 0.518
MOD_PK_1 432 438 PF00069 0.241
MOD_PK_1 457 463 PF00069 0.522
MOD_PK_1 559 565 PF00069 0.544
MOD_PKA_2 220 226 PF00069 0.788
MOD_PKA_2 232 238 PF00069 0.620
MOD_PKA_2 281 287 PF00069 0.592
MOD_PKA_2 393 399 PF00069 0.508
MOD_PKA_2 406 412 PF00069 0.541
MOD_PKA_2 431 437 PF00069 0.410
MOD_PKA_2 538 544 PF00069 0.638
MOD_PKA_2 688 694 PF00069 0.536
MOD_Plk_1 338 344 PF00069 0.627
MOD_Plk_1 457 463 PF00069 0.529
MOD_Plk_1 700 706 PF00069 0.455
MOD_Plk_2-3 113 119 PF00069 0.597
MOD_Plk_4 14 20 PF00069 0.527
MOD_Plk_4 178 184 PF00069 0.488
MOD_Plk_4 243 249 PF00069 0.531
MOD_Plk_4 314 320 PF00069 0.537
MOD_Plk_4 347 353 PF00069 0.512
MOD_Plk_4 457 463 PF00069 0.491
MOD_Plk_4 580 586 PF00069 0.525
MOD_Plk_4 627 633 PF00069 0.493
MOD_Plk_4 701 707 PF00069 0.485
MOD_Plk_4 718 724 PF00069 0.631
MOD_ProDKin_1 126 132 PF00069 0.667
MOD_ProDKin_1 156 162 PF00069 0.570
MOD_ProDKin_1 206 212 PF00069 0.787
MOD_ProDKin_1 521 527 PF00069 0.648
MOD_ProDKin_1 59 65 PF00069 0.553
MOD_ProDKin_1 620 626 PF00069 0.587
MOD_ProDKin_1 648 654 PF00069 0.527
MOD_ProDKin_1 72 78 PF00069 0.733
MOD_SUMO_for_1 50 53 PF00179 0.573
MOD_SUMO_rev_2 66 75 PF00179 0.722
TRG_DiLeu_BaEn_1 540 545 PF01217 0.609
TRG_DiLeu_BaEn_4 53 59 PF01217 0.549
TRG_DiLeu_BaLyEn_6 363 368 PF01217 0.389
TRG_DiLeu_BaLyEn_6 549 554 PF01217 0.356
TRG_ENDOCYTIC_2 173 176 PF00928 0.467
TRG_ENDOCYTIC_2 248 251 PF00928 0.478
TRG_ENDOCYTIC_2 295 298 PF00928 0.443
TRG_ENDOCYTIC_2 474 477 PF00928 0.483
TRG_ER_diArg_1 333 336 PF00400 0.696
TRG_ER_diArg_1 399 401 PF00400 0.481
TRG_ER_diArg_1 447 450 PF00400 0.562
TRG_ER_diArg_1 536 539 PF00400 0.658
TRG_NES_CRM1_1 661 676 PF08389 0.504
TRG_Pf-PMV_PEXEL_1 378 383 PF00026 0.412
TRG_Pf-PMV_PEXEL_1 519 523 PF00026 0.673
TRG_Pf-PMV_PEXEL_1 567 571 PF00026 0.527
TRG_Pf-PMV_PEXEL_1 575 580 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWM2 Leptomonas seymouri 57% 99%
A0A1X0NXC5 Trypanosomatidae 35% 97%
A0A3Q8IB10 Leishmania donovani 99% 100%
A4HBL8 Leishmania braziliensis 84% 100%
D0A1L2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AUY6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QCJ6 Leishmania major 95% 100%
V5BG13 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS