Guanylate cyclase

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Guanylate cyclase

Gene product:

serine/threonine protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4HZA0_LEIIN

TriTrypDb:

LINF_210006700

Length:

1711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Phosphorylation

Promastigote: 198

Expansion

Sequence features

A4HZA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZA0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006163	purine nucleotide metabolic process	5	7
GO:0006164	purine nucleotide biosynthetic process	6	7
GO:0006171	cAMP biosynthetic process	8	7
GO:0006182	cGMP biosynthetic process	8	6
GO:0006468	protein phosphorylation	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009117	nucleotide metabolic process	5	7
GO:0009150	purine ribonucleotide metabolic process	6	7
GO:0009152	purine ribonucleotide biosynthetic process	7	7
GO:0009165	nucleotide biosynthetic process	6	7
GO:0009187	cyclic nucleotide metabolic process	6	7
GO:0009190	cyclic nucleotide biosynthetic process	7	7
GO:0009259	ribonucleotide metabolic process	5	7
GO:0009260	ribonucleotide biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019693	ribose phosphate metabolic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046058	cAMP metabolic process	7	7
GO:0046068	cGMP metabolic process	7	6
GO:0046390	ribose phosphate biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0052652	cyclic purine nucleotide metabolic process	6	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0072521	purine-containing compound metabolic process	4	7
GO:0072522	purine-containing compound biosynthetic process	5	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901293	nucleoside phosphate biosynthetic process	5	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004383	guanylate cyclase activity	3	1
GO:0009975	cyclase activity	2	1
GO:0016829	lyase activity	2	1
GO:0016849	phosphorus-oxygen lyase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1397	1401	PF00656	0.810
CLV_C14_Caspase3-7	1679	1683	PF00656	0.598
CLV_C14_Caspase3-7	277	281	PF00656	0.746
CLV_C14_Caspase3-7	758	762	PF00656	0.814
CLV_C14_Caspase3-7	93	97	PF00656	0.685
CLV_NRD_NRD_1	1133	1135	PF00675	0.447
CLV_NRD_NRD_1	1221	1223	PF00675	0.466
CLV_NRD_NRD_1	154	156	PF00675	0.519
CLV_NRD_NRD_1	159	161	PF00675	0.499
CLV_NRD_NRD_1	1602	1604	PF00675	0.290
CLV_NRD_NRD_1	177	179	PF00675	0.572
CLV_NRD_NRD_1	190	192	PF00675	0.473
CLV_NRD_NRD_1	685	687	PF00675	0.435
CLV_NRD_NRD_1	737	739	PF00675	0.506
CLV_NRD_NRD_1	894	896	PF00675	0.532
CLV_NRD_NRD_1	925	927	PF00675	0.485
CLV_NRD_NRD_1	936	938	PF00675	0.499
CLV_PCSK_FUR_1	934	938	PF00082	0.495
CLV_PCSK_KEX2_1	1133	1135	PF00082	0.432
CLV_PCSK_KEX2_1	1221	1223	PF00082	0.471
CLV_PCSK_KEX2_1	154	156	PF00082	0.582
CLV_PCSK_KEX2_1	159	161	PF00082	0.588
CLV_PCSK_KEX2_1	1696	1698	PF00082	0.350
CLV_PCSK_KEX2_1	190	192	PF00082	0.547
CLV_PCSK_KEX2_1	585	587	PF00082	0.703
CLV_PCSK_KEX2_1	736	738	PF00082	0.502
CLV_PCSK_KEX2_1	780	782	PF00082	0.592
CLV_PCSK_KEX2_1	894	896	PF00082	0.532
CLV_PCSK_KEX2_1	925	927	PF00082	0.485
CLV_PCSK_KEX2_1	936	938	PF00082	0.499
CLV_PCSK_PC1ET2_1	1696	1698	PF00082	0.350
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.703
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.592
CLV_PCSK_PC7_1	155	161	PF00082	0.619
CLV_PCSK_PC7_1	581	587	PF00082	0.669
CLV_PCSK_SKI1_1	1006	1010	PF00082	0.488
CLV_PCSK_SKI1_1	1018	1022	PF00082	0.464
CLV_PCSK_SKI1_1	1042	1046	PF00082	0.508
CLV_PCSK_SKI1_1	1210	1214	PF00082	0.421
CLV_PCSK_SKI1_1	1555	1559	PF00082	0.399
CLV_PCSK_SKI1_1	1572	1576	PF00082	0.233
CLV_PCSK_SKI1_1	331	335	PF00082	0.661
CLV_PCSK_SKI1_1	367	371	PF00082	0.652
CLV_PCSK_SKI1_1	428	432	PF00082	0.547
CLV_PCSK_SKI1_1	444	448	PF00082	0.426
CLV_PCSK_SKI1_1	780	784	PF00082	0.594
CLV_PCSK_SKI1_1	929	933	PF00082	0.491
CLV_PCSK_SKI1_1	939	943	PF00082	0.494
CLV_Separin_Metazoa	364	368	PF03568	0.313
DEG_APCC_DBOX_1	1554	1562	PF00400	0.550
DEG_APCC_DBOX_1	693	701	PF00400	0.641
DEG_APCC_DBOX_1	76	84	PF00400	0.787
DEG_APCC_DBOX_1	928	936	PF00400	0.689
DEG_Nend_UBRbox_1	1	4	PF02207	0.735
DEG_SCF_FBW7_2	577	583	PF00400	0.469
DOC_CDC14_PxL_1	1196	1204	PF14671	0.788
DOC_CKS1_1	577	582	PF01111	0.476
DOC_CKS1_1	680	685	PF01111	0.684
DOC_CYCLIN_RxL_1	1476	1489	PF00134	0.598
DOC_CYCLIN_RxL_1	293	304	PF00134	0.676
DOC_CYCLIN_yCln2_LP_2	1260	1266	PF00134	0.815
DOC_MAPK_DCC_7	428	436	PF00069	0.349
DOC_MAPK_gen_1	1133	1140	PF00069	0.638
DOC_MAPK_gen_1	1572	1581	PF00069	0.512
DOC_MAPK_gen_1	178	185	PF00069	0.795
DOC_MAPK_gen_1	686	697	PF00069	0.708
DOC_MAPK_gen_1	925	932	PF00069	0.686
DOC_MAPK_MEF2A_6	1306	1313	PF00069	0.805
DOC_MAPK_MEF2A_6	1575	1583	PF00069	0.512
DOC_MAPK_MEF2A_6	428	436	PF00069	0.349
DOC_MAPK_MEF2A_6	705	714	PF00069	0.664
DOC_MAPK_MEF2A_6	73	82	PF00069	0.739
DOC_MAPK_MEF2A_6	925	932	PF00069	0.647
DOC_MAPK_MEF2A_6	982	990	PF00069	0.645
DOC_PP1_RVXF_1	300	306	PF00149	0.512
DOC_PP1_RVXF_1	685	692	PF00149	0.654
DOC_PP2B_LxvP_1	1086	1089	PF13499	0.699
DOC_PP2B_LxvP_1	1260	1263	PF13499	0.792
DOC_PP2B_LxvP_1	1483	1486	PF13499	0.512
DOC_PP2B_LxvP_1	3	6	PF13499	0.758
DOC_PP4_FxxP_1	257	260	PF00568	0.818
DOC_PP4_FxxP_1	495	498	PF00568	0.429
DOC_USP7_MATH_1	1077	1081	PF00917	0.807
DOC_USP7_MATH_1	1113	1117	PF00917	0.625
DOC_USP7_MATH_1	1254	1258	PF00917	0.830
DOC_USP7_MATH_1	1298	1302	PF00917	0.794
DOC_USP7_MATH_1	132	136	PF00917	0.715
DOC_USP7_MATH_1	1349	1353	PF00917	0.799
DOC_USP7_MATH_1	1358	1362	PF00917	0.770
DOC_USP7_MATH_1	1411	1415	PF00917	0.792
DOC_USP7_MATH_1	1484	1488	PF00917	0.512
DOC_USP7_MATH_1	149	153	PF00917	0.651
DOC_USP7_MATH_1	260	264	PF00917	0.807
DOC_USP7_MATH_1	272	276	PF00917	0.745
DOC_USP7_MATH_1	534	538	PF00917	0.327
DOC_USP7_MATH_1	674	678	PF00917	0.733
DOC_USP7_MATH_1	828	832	PF00917	0.803
DOC_USP7_MATH_1	980	984	PF00917	0.730
DOC_USP7_UBL2_3	1692	1696	PF12436	0.473
DOC_USP7_UBL2_3	411	415	PF12436	0.379
DOC_WD40_RPTOR_TOS_1	115	121	PF00400	0.648
DOC_WW_Pin1_4	1073	1078	PF00397	0.783
DOC_WW_Pin1_4	120	125	PF00397	0.760
DOC_WW_Pin1_4	1222	1227	PF00397	0.783
DOC_WW_Pin1_4	1232	1237	PF00397	0.728
DOC_WW_Pin1_4	1240	1245	PF00397	0.780
DOC_WW_Pin1_4	1255	1260	PF00397	0.770
DOC_WW_Pin1_4	1328	1333	PF00397	0.728
DOC_WW_Pin1_4	1345	1350	PF00397	0.784
DOC_WW_Pin1_4	1378	1383	PF00397	0.748
DOC_WW_Pin1_4	16	21	PF00397	0.785
DOC_WW_Pin1_4	1610	1615	PF00397	0.512
DOC_WW_Pin1_4	1622	1627	PF00397	0.512
DOC_WW_Pin1_4	1647	1652	PF00397	0.562
DOC_WW_Pin1_4	178	183	PF00397	0.796
DOC_WW_Pin1_4	243	248	PF00397	0.776
DOC_WW_Pin1_4	256	261	PF00397	0.586
DOC_WW_Pin1_4	372	377	PF00397	0.389
DOC_WW_Pin1_4	48	53	PF00397	0.814
DOC_WW_Pin1_4	519	524	PF00397	0.483
DOC_WW_Pin1_4	540	545	PF00397	0.394
DOC_WW_Pin1_4	576	581	PF00397	0.460
DOC_WW_Pin1_4	679	684	PF00397	0.724
DOC_WW_Pin1_4	763	768	PF00397	0.816
DOC_WW_Pin1_4	815	820	PF00397	0.804
DOC_WW_Pin1_4	99	104	PF00397	0.817
LIG_14-3-3_CanoR_1	1121	1131	PF00244	0.672
LIG_14-3-3_CanoR_1	133	140	PF00244	0.724
LIG_14-3-3_CanoR_1	1697	1704	PF00244	0.512
LIG_14-3-3_CanoR_1	238	247	PF00244	0.786
LIG_14-3-3_CanoR_1	252	258	PF00244	0.800
LIG_14-3-3_CanoR_1	302	306	PF00244	0.412
LIG_14-3-3_CanoR_1	499	509	PF00244	0.420
LIG_14-3-3_CanoR_1	690	694	PF00244	0.709
LIG_14-3-3_CanoR_1	807	814	PF00244	0.804
LIG_APCC_ABBA_1	1523	1528	PF00400	0.598
LIG_APCC_ABBA_1	226	231	PF00400	0.675
LIG_BRCT_BRCA1_1	1514	1518	PF00533	0.512
LIG_BRCT_BRCA1_1	215	219	PF00533	0.756
LIG_BRCT_BRCA1_1	222	226	PF00533	0.757
LIG_BRCT_BRCA1_1	710	714	PF00533	0.655
LIG_Clathr_ClatBox_1	1066	1070	PF01394	0.711
LIG_deltaCOP1_diTrp_1	1631	1639	PF00928	0.512
LIG_deltaCOP1_diTrp_1	407	416	PF00928	0.352
LIG_eIF4E_1	357	363	PF01652	0.466
LIG_eIF4E_1	666	672	PF01652	0.699
LIG_FHA_1	1005	1011	PF00498	0.736
LIG_FHA_1	1030	1036	PF00498	0.708
LIG_FHA_1	1180	1186	PF00498	0.818
LIG_FHA_1	1379	1385	PF00498	0.800
LIG_FHA_1	1397	1403	PF00498	0.591
LIG_FHA_1	1447	1453	PF00498	0.626
LIG_FHA_1	1506	1512	PF00498	0.530
LIG_FHA_1	1520	1526	PF00498	0.494
LIG_FHA_1	1547	1553	PF00498	0.507
LIG_FHA_1	1642	1648	PF00498	0.512
LIG_FHA_1	231	237	PF00498	0.766
LIG_FHA_1	302	308	PF00498	0.355
LIG_FHA_1	336	342	PF00498	0.452
LIG_FHA_1	378	384	PF00498	0.467
LIG_FHA_1	459	465	PF00498	0.387
LIG_FHA_1	483	489	PF00498	0.464
LIG_FHA_1	572	578	PF00498	0.465
LIG_FHA_1	632	638	PF00498	0.350
LIG_FHA_1	659	665	PF00498	0.483
LIG_FHA_1	690	696	PF00498	0.647
LIG_FHA_1	73	79	PF00498	0.731
LIG_FHA_1	897	903	PF00498	0.729
LIG_FHA_2	1088	1094	PF00498	0.749
LIG_FHA_2	1345	1351	PF00498	0.799
LIG_FHA_2	1395	1401	PF00498	0.806
LIG_FHA_2	464	470	PF00498	0.407
LIG_FHA_2	750	756	PF00498	0.738
LIG_FHA_2	811	817	PF00498	0.747
LIG_FHA_2	828	834	PF00498	0.807
LIG_LIR_Apic_2	1345	1349	PF02991	0.674
LIG_LIR_Apic_2	1613	1619	PF02991	0.512
LIG_LIR_Apic_2	255	260	PF02991	0.821
LIG_LIR_Apic_2	390	396	PF02991	0.427
LIG_LIR_Apic_2	493	498	PF02991	0.425
LIG_LIR_Gen_1	167	176	PF02991	0.805
LIG_LIR_Gen_1	184	194	PF02991	0.583
LIG_LIR_Gen_1	360	371	PF02991	0.427
LIG_LIR_Gen_1	44	54	PF02991	0.780
LIG_LIR_Gen_1	460	469	PF02991	0.362
LIG_LIR_Gen_1	506	516	PF02991	0.465
LIG_LIR_Gen_1	532	542	PF02991	0.392
LIG_LIR_Gen_1	813	822	PF02991	0.768
LIG_LIR_Gen_1	829	837	PF02991	0.718
LIG_LIR_Gen_1	90	95	PF02991	0.683
LIG_LIR_Nem_3	1462	1466	PF02991	0.494
LIG_LIR_Nem_3	167	171	PF02991	0.806
LIG_LIR_Nem_3	184	189	PF02991	0.581
LIG_LIR_Nem_3	304	308	PF02991	0.412
LIG_LIR_Nem_3	44	50	PF02991	0.782
LIG_LIR_Nem_3	441	445	PF02991	0.391
LIG_LIR_Nem_3	506	512	PF02991	0.395
LIG_LIR_Nem_3	532	538	PF02991	0.391
LIG_LIR_Nem_3	587	591	PF02991	0.429
LIG_LIR_Nem_3	615	621	PF02991	0.362
LIG_LIR_Nem_3	813	817	PF02991	0.767
LIG_LIR_Nem_3	829	835	PF02991	0.719
LIG_LIR_Nem_3	90	94	PF02991	0.683
LIG_MYND_1	1303	1307	PF01753	0.834
LIG_NRBOX	302	308	PF00104	0.408
LIG_PCNA_PIPBox_1	356	365	PF02747	0.466
LIG_PCNA_PIPBox_1	489	498	PF02747	0.415
LIG_PCNA_yPIPBox_3	1210	1224	PF02747	0.715
LIG_PCNA_yPIPBox_3	356	370	PF02747	0.425
LIG_PCNA_yPIPBox_3	489	499	PF02747	0.418
LIG_PDZ_Class_2	1706	1711	PF00595	0.579
LIG_Pex14_2	1009	1013	PF04695	0.652
LIG_Pex14_2	164	168	PF04695	0.808
LIG_Pex14_2	496	500	PF04695	0.445
LIG_Pex14_2	782	786	PF04695	0.744
LIG_PTB_Apo_2	1104	1111	PF02174	0.598
LIG_Rb_pABgroove_1	1043	1051	PF01858	0.691
LIG_SH2_CRK	1196	1200	PF00017	0.717
LIG_SH2_CRK	308	312	PF00017	0.491
LIG_SH2_CRK	393	397	PF00017	0.386
LIG_SH2_CRK	442	446	PF00017	0.414
LIG_SH2_GRB2like	519	522	PF00017	0.365
LIG_SH2_NCK_1	1098	1102	PF00017	0.655
LIG_SH2_NCK_1	1163	1167	PF00017	0.733
LIG_SH2_NCK_1	402	406	PF00017	0.331
LIG_SH2_NCK_1	483	487	PF00017	0.569
LIG_SH2_PTP2	1290	1293	PF00017	0.789
LIG_SH2_SRC	1290	1293	PF00017	0.789
LIG_SH2_SRC	1663	1666	PF00017	0.592
LIG_SH2_STAP1	1004	1008	PF00017	0.687
LIG_SH2_STAP1	1049	1053	PF00017	0.655
LIG_SH2_STAP1	1098	1102	PF00017	0.655
LIG_SH2_STAP1	1163	1167	PF00017	0.761
LIG_SH2_STAP1	832	836	PF00017	0.721
LIG_SH2_STAP1	897	901	PF00017	0.767
LIG_SH2_STAT3	1142	1145	PF00017	0.699
LIG_SH2_STAT5	1290	1293	PF00017	0.825
LIG_SH2_STAT5	1451	1454	PF00017	0.566
LIG_SH2_STAT5	1467	1470	PF00017	0.448
LIG_SH2_STAT5	1616	1619	PF00017	0.512
LIG_SH2_STAT5	462	465	PF00017	0.417
LIG_SH2_STAT5	519	522	PF00017	0.433
LIG_SH2_STAT5	545	548	PF00017	0.395
LIG_SH2_STAT5	623	626	PF00017	0.407
LIG_SH2_STAT5	657	660	PF00017	0.405
LIG_SH2_STAT5	666	669	PF00017	0.607
LIG_SH2_STAT5	70	73	PF00017	0.753
LIG_SH2_STAT5	708	711	PF00017	0.651
LIG_SH2_STAT5	720	723	PF00017	0.601
LIG_SH2_STAT5	913	916	PF00017	0.655
LIG_SH2_STAT5	987	990	PF00017	0.612
LIG_SH3_3	1034	1040	PF00018	0.690
LIG_SH3_3	1282	1288	PF00018	0.733
LIG_SH3_3	1301	1307	PF00018	0.836
LIG_SH3_3	1310	1316	PF00018	0.747
LIG_SH3_3	1348	1354	PF00018	0.827
LIG_SH3_3	1645	1651	PF00018	0.562
LIG_SH3_3	1669	1675	PF00018	0.512
LIG_SH3_3	520	526	PF00018	0.411
LIG_SH3_3	547	553	PF00018	0.344
LIG_SH3_3	771	777	PF00018	0.756
LIG_SH3_3	817	823	PF00018	0.765
LIG_SH3_3	831	837	PF00018	0.817
LIG_SH3_3	845	851	PF00018	0.679
LIG_SH3_CIN85_PxpxPR_1	1146	1151	PF14604	0.735
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.763
LIG_SUMO_SIM_anti_2	1498	1503	PF11976	0.550
LIG_SUMO_SIM_anti_2	1676	1682	PF11976	0.509
LIG_SUMO_SIM_anti_2	633	639	PF11976	0.398
LIG_SUMO_SIM_par_1	1064	1070	PF11976	0.674
LIG_SUMO_SIM_par_1	123	130	PF11976	0.739
LIG_SUMO_SIM_par_1	1268	1273	PF11976	0.817
LIG_SUMO_SIM_par_1	181	188	PF11976	0.702
LIG_SxIP_EBH_1	159	171	PF03271	0.809
LIG_TRAF2_1	126	129	PF00917	0.782
LIG_TRAF2_1	1334	1337	PF00917	0.732
LIG_TRAF2_1	20	23	PF00917	0.785
LIG_TRAF2_1	869	872	PF00917	0.750
LIG_TRFH_1	226	230	PF08558	0.801
LIG_TYR_ITIM	1161	1166	PF00017	0.733
LIG_TYR_ITIM	1194	1199	PF00017	0.744
LIG_TYR_ITIM	306	311	PF00017	0.423
LIG_TYR_ITIM	440	445	PF00017	0.356
LIG_TYR_ITIM	655	660	PF00017	0.423
LIG_TYR_ITSM	828	835	PF00017	0.718
LIG_UBA3_1	185	192	PF00899	0.743
LIG_UBA3_1	362	370	PF00899	0.474
LIG_UBA3_1	422	428	PF00899	0.345
LIG_UBA3_1	508	514	PF00899	0.414
LIG_UBA3_1	931	939	PF00899	0.693
LIG_WRC_WIRS_1	1580	1585	PF05994	0.598
LIG_WRC_WIRS_1	161	166	PF05994	0.806
LIG_WRC_WIRS_1	449	454	PF05994	0.412
MOD_CDC14_SPxK_1	1225	1228	PF00782	0.819
MOD_CDC14_SPxK_1	1625	1628	PF00782	0.598
MOD_CDC14_SPxK_1	246	249	PF00782	0.699
MOD_CDK_SPK_2	576	581	PF00069	0.451
MOD_CDK_SPxK_1	1073	1079	PF00069	0.752
MOD_CDK_SPxK_1	1222	1228	PF00069	0.799
MOD_CDK_SPxK_1	1622	1628	PF00069	0.598
MOD_CDK_SPxK_1	243	249	PF00069	0.694
MOD_CDK_SPxxK_3	679	686	PF00069	0.721
MOD_CK1_1	102	108	PF00069	0.811
MOD_CK1_1	1328	1334	PF00069	0.735
MOD_CK1_1	1394	1400	PF00069	0.761
MOD_CK1_1	1401	1407	PF00069	0.762
MOD_CK1_1	1435	1441	PF00069	0.693
MOD_CK1_1	1487	1493	PF00069	0.550
MOD_CK1_1	1695	1701	PF00069	0.598
MOD_CK1_1	181	187	PF00069	0.779
MOD_CK1_1	222	228	PF00069	0.760
MOD_CK1_1	255	261	PF00069	0.777
MOD_CK1_1	267	273	PF00069	0.816
MOD_CK1_1	275	281	PF00069	0.739
MOD_CK1_1	375	381	PF00069	0.404
MOD_CK1_1	45	51	PF00069	0.780
MOD_CK1_1	484	490	PF00069	0.494
MOD_CK1_1	630	636	PF00069	0.498
MOD_CK2_1	1087	1093	PF00069	0.764
MOD_CK2_1	1177	1183	PF00069	0.829
MOD_CK2_1	123	129	PF00069	0.743
MOD_CK2_1	1344	1350	PF00069	0.823
MOD_CK2_1	1487	1493	PF00069	0.516
MOD_CK2_1	1603	1609	PF00069	0.598
MOD_CK2_1	166	172	PF00069	0.806
MOD_CK2_1	333	339	PF00069	0.490
MOD_CK2_1	463	469	PF00069	0.427
MOD_CK2_1	50	56	PF00069	0.769
MOD_CK2_1	749	755	PF00069	0.735
MOD_CK2_1	757	763	PF00069	0.744
MOD_CK2_1	810	816	PF00069	0.793
MOD_CK2_1	827	833	PF00069	0.806
MOD_GlcNHglycan	1045	1048	PF01048	0.491
MOD_GlcNHglycan	1061	1064	PF01048	0.505
MOD_GlcNHglycan	1070	1074	PF01048	0.516
MOD_GlcNHglycan	1142	1145	PF01048	0.499
MOD_GlcNHglycan	1232	1235	PF01048	0.525
MOD_GlcNHglycan	1264	1267	PF01048	0.545
MOD_GlcNHglycan	1271	1275	PF01048	0.448
MOD_GlcNHglycan	1280	1283	PF01048	0.540
MOD_GlcNHglycan	1327	1330	PF01048	0.519
MOD_GlcNHglycan	134	137	PF01048	0.491
MOD_GlcNHglycan	1368	1371	PF01048	0.518
MOD_GlcNHglycan	1387	1390	PF01048	0.532
MOD_GlcNHglycan	1393	1396	PF01048	0.563
MOD_GlcNHglycan	1404	1407	PF01048	0.431
MOD_GlcNHglycan	1417	1420	PF01048	0.459
MOD_GlcNHglycan	147	150	PF01048	0.564
MOD_GlcNHglycan	1473	1476	PF01048	0.312
MOD_GlcNHglycan	1488	1492	PF01048	0.288
MOD_GlcNHglycan	1594	1597	PF01048	0.303
MOD_GlcNHglycan	1666	1669	PF01048	0.332
MOD_GlcNHglycan	1698	1701	PF01048	0.350
MOD_GlcNHglycan	215	218	PF01048	0.582
MOD_GlcNHglycan	222	225	PF01048	0.469
MOD_GlcNHglycan	241	244	PF01048	0.615
MOD_GlcNHglycan	276	280	PF01048	0.582
MOD_GlcNHglycan	335	338	PF01048	0.689
MOD_GlcNHglycan	44	47	PF01048	0.558
MOD_GlcNHglycan	455	458	PF01048	0.644
MOD_GlcNHglycan	52	55	PF01048	0.595
MOD_GlcNHglycan	526	529	PF01048	0.671
MOD_GlcNHglycan	556	559	PF01048	0.592
MOD_GlcNHglycan	602	605	PF01048	0.668
MOD_GlcNHglycan	66	69	PF01048	0.481
MOD_GlcNHglycan	917	920	PF01048	0.482
MOD_GlcNHglycan	945	948	PF01048	0.426
MOD_GSK3_1	1069	1076	PF00069	0.737
MOD_GSK3_1	1077	1084	PF00069	0.736
MOD_GSK3_1	1119	1126	PF00069	0.628
MOD_GSK3_1	1175	1182	PF00069	0.803
MOD_GSK3_1	1222	1229	PF00069	0.800
MOD_GSK3_1	1230	1237	PF00069	0.756
MOD_GSK3_1	1245	1252	PF00069	0.705
MOD_GSK3_1	1270	1277	PF00069	0.734
MOD_GSK3_1	1345	1352	PF00069	0.774
MOD_GSK3_1	1364	1371	PF00069	0.707
MOD_GSK3_1	1394	1401	PF00069	0.804
MOD_GSK3_1	1411	1418	PF00069	0.646
MOD_GSK3_1	1419	1426	PF00069	0.745
MOD_GSK3_1	1435	1442	PF00069	0.625
MOD_GSK3_1	1447	1454	PF00069	0.616
MOD_GSK3_1	145	152	PF00069	0.796
MOD_GSK3_1	1541	1548	PF00069	0.560
MOD_GSK3_1	1559	1566	PF00069	0.412
MOD_GSK3_1	160	167	PF00069	0.702
MOD_GSK3_1	1627	1634	PF00069	0.512
MOD_GSK3_1	1692	1699	PF00069	0.550
MOD_GSK3_1	181	188	PF00069	0.701
MOD_GSK3_1	239	246	PF00069	0.820
MOD_GSK3_1	252	259	PF00069	0.796
MOD_GSK3_1	260	267	PF00069	0.811
MOD_GSK3_1	275	282	PF00069	0.669
MOD_GSK3_1	323	330	PF00069	0.556
MOD_GSK3_1	331	338	PF00069	0.419
MOD_GSK3_1	344	351	PF00069	0.318
MOD_GSK3_1	448	455	PF00069	0.432
MOD_GSK3_1	463	470	PF00069	0.362
MOD_GSK3_1	499	506	PF00069	0.440
MOD_GSK3_1	515	522	PF00069	0.376
MOD_GSK3_1	534	541	PF00069	0.355
MOD_GSK3_1	569	576	PF00069	0.503
MOD_GSK3_1	627	634	PF00069	0.446
MOD_GSK3_1	699	706	PF00069	0.676
MOD_GSK3_1	806	813	PF00069	0.754
MOD_GSK3_1	877	884	PF00069	0.766
MOD_GSK3_1	95	102	PF00069	0.803
MOD_GSK3_1	998	1005	PF00069	0.658
MOD_N-GLC_1	1081	1086	PF02516	0.527
MOD_N-GLC_1	1402	1407	PF02516	0.569
MOD_N-GLC_1	1435	1440	PF02516	0.526
MOD_N-GLC_1	1446	1451	PF02516	0.457
MOD_N-GLC_1	1505	1510	PF02516	0.350
MOD_N-GLC_1	219	224	PF02516	0.561
MOD_N-GLC_1	416	421	PF02516	0.645
MOD_N-GLC_1	500	505	PF02516	0.620
MOD_N-GLC_1	554	559	PF02516	0.634
MOD_N-GLC_1	915	920	PF02516	0.454
MOD_N-GLC_2	193	195	PF02516	0.596
MOD_N-GLC_2	595	597	PF02516	0.623
MOD_NEK2_1	1069	1074	PF00069	0.724
MOD_NEK2_1	1081	1086	PF00069	0.757
MOD_NEK2_1	1140	1145	PF00069	0.705
MOD_NEK2_1	1177	1182	PF00069	0.782
MOD_NEK2_1	1249	1254	PF00069	0.837
MOD_NEK2_1	1276	1281	PF00069	0.743
MOD_NEK2_1	1391	1396	PF00069	0.792
MOD_NEK2_1	1423	1428	PF00069	0.736
MOD_NEK2_1	1452	1457	PF00069	0.571
MOD_NEK2_1	1531	1536	PF00069	0.512
MOD_NEK2_1	1592	1597	PF00069	0.517
MOD_NEK2_1	185	190	PF00069	0.753
MOD_NEK2_1	219	224	PF00069	0.745
MOD_NEK2_1	301	306	PF00069	0.542
MOD_NEK2_1	33	38	PF00069	0.811
MOD_NEK2_1	333	338	PF00069	0.497
MOD_NEK2_1	452	457	PF00069	0.444
MOD_NEK2_1	471	476	PF00069	0.438
MOD_NEK2_1	508	513	PF00069	0.401
MOD_NEK2_1	658	663	PF00069	0.576
MOD_NEK2_1	72	77	PF00069	0.753
MOD_NEK2_1	864	869	PF00069	0.789
MOD_NEK2_2	410	415	PF00069	0.434
MOD_NEK2_2	448	453	PF00069	0.387
MOD_PIKK_1	1087	1093	PF00454	0.675
MOD_PIKK_1	1177	1183	PF00454	0.829
MOD_PIKK_1	1242	1248	PF00454	0.701
MOD_PIKK_1	260	266	PF00454	0.809
MOD_PIKK_1	500	506	PF00454	0.382
MOD_PIKK_1	881	887	PF00454	0.681
MOD_PK_1	905	911	PF00069	0.689
MOD_PKA_1	154	160	PF00069	0.695
MOD_PKA_1	1603	1609	PF00069	0.598
MOD_PKA_1	1696	1702	PF00069	0.550
MOD_PKA_2	108	114	PF00069	0.740
MOD_PKA_2	1227	1233	PF00069	0.742
MOD_PKA_2	132	138	PF00069	0.701
MOD_PKA_2	1452	1458	PF00069	0.486
MOD_PKA_2	154	160	PF00069	0.765
MOD_PKA_2	1696	1702	PF00069	0.512
MOD_PKA_2	220	226	PF00069	0.735
MOD_PKA_2	301	307	PF00069	0.542
MOD_PKA_2	689	695	PF00069	0.660
MOD_PKA_2	806	812	PF00069	0.805
MOD_Plk_1	1077	1083	PF00069	0.808
MOD_Plk_1	1092	1098	PF00069	0.555
MOD_Plk_1	1298	1304	PF00069	0.752
MOD_Plk_1	1435	1441	PF00069	0.722
MOD_Plk_1	1505	1511	PF00069	0.525
MOD_Plk_1	230	236	PF00069	0.729
MOD_Plk_1	327	333	PF00069	0.423
MOD_Plk_1	33	39	PF00069	0.750
MOD_Plk_1	416	422	PF00069	0.481
MOD_Plk_1	500	506	PF00069	0.382
MOD_Plk_1	621	627	PF00069	0.388
MOD_Plk_1	698	704	PF00069	0.642
MOD_Plk_1	749	755	PF00069	0.719
MOD_Plk_1	864	870	PF00069	0.772
MOD_Plk_1	871	877	PF00069	0.727
MOD_Plk_1	897	903	PF00069	0.680
MOD_Plk_2-3	607	613	PF00069	0.461
MOD_Plk_2-3	755	761	PF00069	0.814
MOD_Plk_2-3	810	816	PF00069	0.802
MOD_Plk_4	1411	1417	PF00069	0.756
MOD_Plk_4	1447	1453	PF00069	0.654
MOD_Plk_4	1519	1525	PF00069	0.598
MOD_Plk_4	160	166	PF00069	0.808
MOD_Plk_4	181	187	PF00069	0.703
MOD_Plk_4	231	237	PF00069	0.800
MOD_Plk_4	301	307	PF00069	0.485
MOD_Plk_4	344	350	PF00069	0.485
MOD_Plk_4	388	394	PF00069	0.431
MOD_Plk_4	426	432	PF00069	0.353
MOD_Plk_4	458	464	PF00069	0.393
MOD_Plk_4	487	493	PF00069	0.466
MOD_Plk_4	503	509	PF00069	0.302
MOD_Plk_4	639	645	PF00069	0.504
MOD_Plk_4	749	755	PF00069	0.719
MOD_Plk_4	770	776	PF00069	0.763
MOD_Plk_4	897	903	PF00069	0.680
MOD_Plk_4	993	999	PF00069	0.742
MOD_ProDKin_1	1073	1079	PF00069	0.788
MOD_ProDKin_1	120	126	PF00069	0.755
MOD_ProDKin_1	1222	1228	PF00069	0.789
MOD_ProDKin_1	1232	1238	PF00069	0.730
MOD_ProDKin_1	1240	1246	PF00069	0.780
MOD_ProDKin_1	1255	1261	PF00069	0.768
MOD_ProDKin_1	1328	1334	PF00069	0.729
MOD_ProDKin_1	1345	1351	PF00069	0.782
MOD_ProDKin_1	1378	1384	PF00069	0.747
MOD_ProDKin_1	16	22	PF00069	0.786
MOD_ProDKin_1	1610	1616	PF00069	0.512
MOD_ProDKin_1	1622	1628	PF00069	0.512
MOD_ProDKin_1	1647	1653	PF00069	0.562
MOD_ProDKin_1	178	184	PF00069	0.794
MOD_ProDKin_1	243	249	PF00069	0.779
MOD_ProDKin_1	256	262	PF00069	0.584
MOD_ProDKin_1	372	378	PF00069	0.385
MOD_ProDKin_1	48	54	PF00069	0.814
MOD_ProDKin_1	519	525	PF00069	0.479
MOD_ProDKin_1	540	546	PF00069	0.389
MOD_ProDKin_1	576	582	PF00069	0.458
MOD_ProDKin_1	679	685	PF00069	0.722
MOD_ProDKin_1	763	769	PF00069	0.817
MOD_ProDKin_1	815	821	PF00069	0.805
MOD_ProDKin_1	99	105	PF00069	0.819
MOD_SUMO_for_1	1212	1215	PF00179	0.648
MOD_SUMO_rev_2	364	372	PF00179	0.486
MOD_SUMO_rev_2	568	574	PF00179	0.421
TRG_DiLeu_BaEn_1	1496	1501	PF01217	0.550
TRG_DiLeu_BaEn_1	910	915	PF01217	0.672
TRG_DiLeu_BaEn_4	120	126	PF01217	0.714
TRG_DiLeu_BaLyEn_6	1062	1067	PF01217	0.702
TRG_ENDOCYTIC_2	1163	1166	PF00928	0.708
TRG_ENDOCYTIC_2	1196	1199	PF00928	0.728
TRG_ENDOCYTIC_2	1467	1470	PF00928	0.512
TRG_ENDOCYTIC_2	308	311	PF00928	0.423
TRG_ENDOCYTIC_2	442	445	PF00928	0.456
TRG_ENDOCYTIC_2	449	452	PF00928	0.335
TRG_ENDOCYTIC_2	462	465	PF00928	0.331
TRG_ENDOCYTIC_2	657	660	PF00928	0.370
TRG_ENDOCYTIC_2	669	672	PF00928	0.615
TRG_ENDOCYTIC_2	832	835	PF00928	0.721
TRG_ENDOCYTIC_2	861	864	PF00928	0.807
TRG_ENDOCYTIC_2	987	990	PF00928	0.729
TRG_ER_diArg_1	1132	1134	PF00400	0.647
TRG_ER_diArg_1	1220	1222	PF00400	0.691
TRG_ER_diArg_1	159	161	PF00400	0.731
TRG_ER_diArg_1	189	191	PF00400	0.791
TRG_ER_diArg_1	735	738	PF00400	0.700
TRG_ER_diArg_1	893	895	PF00400	0.741
TRG_ER_diArg_1	925	927	PF00400	0.685
TRG_ER_diArg_1	934	937	PF00400	0.694
TRG_NES_CRM1_1	1025	1039	PF08389	0.650
TRG_NLS_MonoExtC_3	177	182	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	1079	1083	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	1192	1197	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I1	Leptomonas seymouri	50%	95%
A0A3S7WWE3	Leishmania donovani	98%	100%
D0A1K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AUY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCK2	Leishmania major	89%	100%