Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ96_LEIIN

TriTrypDb:

LINF_210020100

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.618
CLV_C14_Caspase3-7	236	240	PF00656	0.501
CLV_NRD_NRD_1	147	149	PF00675	0.769
CLV_NRD_NRD_1	165	167	PF00675	0.351
CLV_NRD_NRD_1	226	228	PF00675	0.516
CLV_PCSK_FUR_1	145	149	PF00082	0.613
CLV_PCSK_KEX2_1	147	149	PF00082	0.665
CLV_PCSK_KEX2_1	165	167	PF00082	0.345
CLV_PCSK_KEX2_1	226	228	PF00082	0.516
CLV_PCSK_KEX2_1	63	65	PF00082	0.766
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.766
CLV_PCSK_SKI1_1	16	20	PF00082	0.519
CLV_PCSK_SKI1_1	166	170	PF00082	0.523
CLV_PCSK_SKI1_1	226	230	PF00082	0.527
DEG_APCC_DBOX_1	15	23	PF00400	0.593
DEG_SPOP_SBC_1	107	111	PF00917	0.503
DEG_SPOP_SBC_1	93	97	PF00917	0.617
DOC_CYCLIN_RxL_1	163	171	PF00134	0.507
DOC_MAPK_DCC_7	11	20	PF00069	0.522
DOC_MAPK_gen_1	226	233	PF00069	0.526
DOC_MAPK_MEF2A_6	226	233	PF00069	0.526
DOC_USP7_MATH_1	106	110	PF00917	0.555
DOC_USP7_MATH_1	146	150	PF00917	0.668
DOC_USP7_MATH_1	283	287	PF00917	0.541
DOC_USP7_MATH_1	47	51	PF00917	0.573
DOC_USP7_MATH_1	94	98	PF00917	0.655
DOC_WW_Pin1_4	132	137	PF00397	0.615
LIG_14-3-3_CanoR_1	11	19	PF00244	0.545
LIG_14-3-3_CanoR_1	145	151	PF00244	0.648
LIG_14-3-3_CanoR_1	46	52	PF00244	0.664
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BRCT_BRCA1_1	34	38	PF00533	0.524
LIG_FHA_1	228	234	PF00498	0.570
LIG_FHA_1	257	263	PF00498	0.681
LIG_FHA_1	32	38	PF00498	0.586
LIG_FHA_1	52	58	PF00498	0.616
LIG_FHA_2	232	238	PF00498	0.524
LIG_FHA_2	94	100	PF00498	0.545
LIG_LIR_Nem_3	179	185	PF02991	0.468
LIG_LIR_Nem_3	286	291	PF02991	0.498
LIG_NRBOX	224	230	PF00104	0.523
LIG_SH2_CRK	182	186	PF00017	0.465
LIG_SH2_STAT3	250	253	PF00017	0.540
LIG_SH2_STAT5	209	212	PF00017	0.510
LIG_SH2_STAT5	250	253	PF00017	0.568
LIG_SH3_3	128	134	PF00018	0.737
LIG_SH3_3	264	270	PF00018	0.619
LIG_TRAF2_1	234	237	PF00917	0.529
LIG_TRAF2_1	97	100	PF00917	0.518
MOD_CK1_1	109	115	PF00069	0.744
MOD_CK1_1	27	33	PF00069	0.613
MOD_CK1_1	50	56	PF00069	0.610
MOD_CK1_1	66	72	PF00069	0.520
MOD_CK2_1	231	237	PF00069	0.527
MOD_CK2_1	93	99	PF00069	0.627
MOD_GlcNHglycan	153	156	PF01048	0.532
MOD_GlcNHglycan	182	185	PF01048	0.408
MOD_GlcNHglycan	26	29	PF01048	0.572
MOD_GlcNHglycan	77	80	PF01048	0.587
MOD_GSK3_1	106	113	PF00069	0.751
MOD_GSK3_1	146	153	PF00069	0.636
MOD_GSK3_1	203	210	PF00069	0.521
MOD_GSK3_1	227	234	PF00069	0.553
MOD_GSK3_1	27	34	PF00069	0.575
MOD_GSK3_1	47	54	PF00069	0.468
MOD_GSK3_1	71	78	PF00069	0.626
MOD_N-GLC_2	21	23	PF02516	0.564
MOD_NEK2_1	168	173	PF00069	0.632
MOD_NEK2_1	202	207	PF00069	0.512
MOD_NEK2_1	57	62	PF00069	0.562
MOD_NEK2_1	83	88	PF00069	0.593
MOD_PK_1	85	91	PF00069	0.571
MOD_PKA_1	63	69	PF00069	0.680
MOD_PKA_2	10	16	PF00069	0.556
MOD_PKA_2	146	152	PF00069	0.649
MOD_PKA_2	207	213	PF00069	0.515
MOD_PKA_2	63	69	PF00069	0.730
MOD_Plk_1	178	184	PF00069	0.464
MOD_ProDKin_1	132	138	PF00069	0.619
MOD_SUMO_for_1	176	179	PF00179	0.508
TRG_DiLeu_BaEn_1	224	229	PF01217	0.520
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.556
TRG_DiLeu_LyEn_5	224	229	PF01217	0.520
TRG_ENDOCYTIC_2	182	185	PF00928	0.497
TRG_ENDOCYTIC_2	186	189	PF00928	0.483
TRG_ENDOCYTIC_2	209	212	PF00928	0.510
TRG_ER_diArg_1	145	148	PF00400	0.665
TRG_ER_diArg_1	164	166	PF00400	0.340
TRG_ER_diArg_1	225	227	PF00400	0.525
TRG_NLS_MonoCore_2	60	65	PF00514	0.615
TRG_NLS_MonoExtN_4	61	66	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWL4	Leishmania donovani	99%	100%
A4HBX6	Leishmania braziliensis	78%	100%
E9AVA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QC76	Leishmania major	92%	100%