LeishMANIAdb
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Surface antigen-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania infantum
UniProt:
A4HZ93_LEIIN
TriTrypDb:
LINF_210019800
Length:
477

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 58, no: 12
NetGPI no yes: 0, no: 70
Cellular components
Term Name Level Count
GO:0005929 cilium 4 71
GO:0042995 cell projection 2 71
GO:0043226 organelle 2 71
GO:0043227 membrane-bounded organelle 3 71
GO:0110165 cellular anatomical entity 1 71
GO:0120025 plasma membrane bounded cell projection 3 71
GO:0016020 membrane 2 29
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

A4HZ93
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ93

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 447 451 PF00656 0.415
CLV_NRD_NRD_1 137 139 PF00675 0.445
CLV_NRD_NRD_1 43 45 PF00675 0.505
CLV_PCSK_SKI1_1 193 197 PF00082 0.494
CLV_PCSK_SKI1_1 44 48 PF00082 0.371
CLV_PCSK_SKI1_1 70 74 PF00082 0.228
DEG_Nend_UBRbox_4 1 3 PF02207 0.391
DOC_CYCLIN_yClb5_NLxxxL_5 121 127 PF00134 0.421
DOC_CYCLIN_yClb5_NLxxxL_5 142 151 PF00134 0.224
DOC_CYCLIN_yClb5_NLxxxL_5 166 175 PF00134 0.409
DOC_MAPK_gen_1 206 215 PF00069 0.281
DOC_MAPK_gen_1 229 239 PF00069 0.466
DOC_PP1_RVXF_1 300 306 PF00149 0.504
DOC_PP2B_LxvP_1 17 20 PF13499 0.582
DOC_USP7_MATH_1 253 257 PF00917 0.388
DOC_USP7_MATH_1 408 412 PF00917 0.373
DOC_USP7_MATH_1 458 462 PF00917 0.568
DOC_USP7_MATH_1 97 101 PF00917 0.496
DOC_WW_Pin1_4 89 94 PF00397 0.542
LIG_14-3-3_CanoR_1 206 211 PF00244 0.459
LIG_14-3-3_CanoR_1 232 238 PF00244 0.358
LIG_AP2alpha_1 46 50 PF02296 0.230
LIG_APCC_ABBA_1 379 384 PF00400 0.219
LIG_BRCT_BRCA1_1 100 104 PF00533 0.287
LIG_BRCT_BRCA1_1 106 110 PF00533 0.223
LIG_Clathr_ClatBox_1 285 289 PF01394 0.453
LIG_deltaCOP1_diTrp_1 227 230 PF00928 0.424
LIG_deltaCOP1_diTrp_1 299 305 PF00928 0.477
LIG_DLG_GKlike_1 206 213 PF00625 0.485
LIG_FHA_1 170 176 PF00498 0.263
LIG_FHA_1 210 216 PF00498 0.336
LIG_FHA_1 234 240 PF00498 0.359
LIG_FHA_1 267 273 PF00498 0.346
LIG_FHA_1 282 288 PF00498 0.322
LIG_FHA_1 291 297 PF00498 0.338
LIG_FHA_1 341 347 PF00498 0.333
LIG_FHA_1 354 360 PF00498 0.223
LIG_FHA_1 82 88 PF00498 0.446
LIG_FHA_2 402 408 PF00498 0.474
LIG_Integrin_isoDGR_2 119 121 PF01839 0.325
LIG_IRF3_LxIS_1 329 336 PF10401 0.446
LIG_LIR_Gen_1 251 258 PF02991 0.378
LIG_LIR_Gen_1 259 268 PF02991 0.364
LIG_LIR_Gen_1 299 306 PF02991 0.350
LIG_LIR_Gen_1 323 332 PF02991 0.303
LIG_LIR_Gen_1 397 408 PF02991 0.304
LIG_LIR_Gen_1 84 93 PF02991 0.495
LIG_LIR_Nem_3 130 134 PF02991 0.299
LIG_LIR_Nem_3 154 158 PF02991 0.413
LIG_LIR_Nem_3 259 263 PF02991 0.358
LIG_LIR_Nem_3 299 303 PF02991 0.301
LIG_LIR_Nem_3 328 332 PF02991 0.395
LIG_LIR_Nem_3 371 375 PF02991 0.458
LIG_LIR_Nem_3 397 403 PF02991 0.326
LIG_LIR_Nem_3 84 89 PF02991 0.503
LIG_NRBOX 281 287 PF00104 0.187
LIG_PCNA_TLS_4 44 51 PF02747 0.203
LIG_Pex14_1 396 400 PF04695 0.464
LIG_Pex14_2 288 292 PF04695 0.388
LIG_Pex14_2 46 50 PF04695 0.472
LIG_PTB_Apo_2 374 381 PF02174 0.220
LIG_PTB_Phospho_1 374 380 PF10480 0.227
LIG_SH2_NCK_1 35 39 PF00017 0.474
LIG_SH2_PTP2 400 403 PF00017 0.478
LIG_SH2_STAT5 165 168 PF00017 0.265
LIG_SH2_STAT5 35 38 PF00017 0.427
LIG_SH2_STAT5 380 383 PF00017 0.250
LIG_SH2_STAT5 400 403 PF00017 0.388
LIG_SUMO_SIM_anti_2 185 190 PF11976 0.404
LIG_SUMO_SIM_par_1 211 217 PF11976 0.342
LIG_SUMO_SIM_par_1 283 289 PF11976 0.315
LIG_SUMO_SIM_par_1 331 337 PF11976 0.409
LIG_TYR_ITIM 378 383 PF00017 0.429
LIG_UBA3_1 133 139 PF00899 0.249
MOD_CDC14_SPxK_1 92 95 PF00782 0.269
MOD_CDK_SPxK_1 89 95 PF00069 0.298
MOD_CK1_1 182 188 PF00069 0.356
MOD_CK1_1 209 215 PF00069 0.338
MOD_CK1_1 33 39 PF00069 0.425
MOD_CK1_1 336 342 PF00069 0.393
MOD_CK1_1 350 356 PF00069 0.358
MOD_CK1_1 434 440 PF00069 0.545
MOD_CK1_1 449 455 PF00069 0.567
MOD_CK1_1 459 465 PF00069 0.498
MOD_CK1_1 469 475 PF00069 0.542
MOD_CK2_1 157 163 PF00069 0.343
MOD_CK2_1 175 181 PF00069 0.365
MOD_CK2_1 253 259 PF00069 0.423
MOD_CK2_1 322 328 PF00069 0.211
MOD_CK2_1 401 407 PF00069 0.461
MOD_GlcNHglycan 100 103 PF01048 0.417
MOD_GlcNHglycan 123 126 PF01048 0.437
MOD_GlcNHglycan 147 150 PF01048 0.363
MOD_GlcNHglycan 154 158 PF01048 0.313
MOD_GlcNHglycan 220 223 PF01048 0.404
MOD_GlcNHglycan 243 247 PF01048 0.434
MOD_GlcNHglycan 32 35 PF01048 0.341
MOD_GlcNHglycan 324 327 PF01048 0.394
MOD_GlcNHglycan 340 343 PF01048 0.393
MOD_GlcNHglycan 364 367 PF01048 0.422
MOD_GlcNHglycan 457 461 PF01048 0.531
MOD_GlcNHglycan 81 84 PF01048 0.561
MOD_GSK3_1 123 130 PF00069 0.367
MOD_GSK3_1 141 148 PF00069 0.372
MOD_GSK3_1 153 160 PF00069 0.352
MOD_GSK3_1 171 178 PF00069 0.286
MOD_GSK3_1 214 221 PF00069 0.337
MOD_GSK3_1 262 269 PF00069 0.338
MOD_GSK3_1 277 284 PF00069 0.375
MOD_GSK3_1 288 295 PF00069 0.292
MOD_GSK3_1 316 323 PF00069 0.355
MOD_GSK3_1 336 343 PF00069 0.345
MOD_GSK3_1 346 353 PF00069 0.392
MOD_GSK3_1 426 433 PF00069 0.605
MOD_GSK3_1 452 459 PF00069 0.621
MOD_GSK3_1 469 476 PF00069 0.589
MOD_GSK3_1 77 84 PF00069 0.403
MOD_N-GLC_1 121 126 PF02516 0.373
MOD_N-GLC_1 145 150 PF02516 0.275
MOD_N-GLC_1 169 174 PF02516 0.308
MOD_N-GLC_1 394 399 PF02516 0.421
MOD_N-GLC_2 418 420 PF02516 0.474
MOD_N-GLC_2 65 67 PF02516 0.291
MOD_NEK2_1 104 109 PF00069 0.379
MOD_NEK2_1 110 115 PF00069 0.370
MOD_NEK2_1 123 128 PF00069 0.347
MOD_NEK2_1 147 152 PF00069 0.352
MOD_NEK2_1 164 169 PF00069 0.333
MOD_NEK2_1 171 176 PF00069 0.316
MOD_NEK2_1 196 201 PF00069 0.344
MOD_NEK2_1 220 225 PF00069 0.284
MOD_NEK2_1 244 249 PF00069 0.339
MOD_NEK2_1 281 286 PF00069 0.333
MOD_NEK2_1 288 293 PF00069 0.340
MOD_NEK2_1 316 321 PF00069 0.315
MOD_NEK2_1 340 345 PF00069 0.332
MOD_NEK2_1 347 352 PF00069 0.340
MOD_NEK2_1 364 369 PF00069 0.397
MOD_NEK2_1 394 399 PF00069 0.385
MOD_NEK2_1 468 473 PF00069 0.565
MOD_NEK2_1 50 55 PF00069 0.307
MOD_NEK2_2 157 162 PF00069 0.535
MOD_NEK2_2 179 184 PF00069 0.500
MOD_OFUCOSY 67 74 PF10250 0.352
MOD_PIKK_1 104 110 PF00454 0.491
MOD_PKA_2 218 224 PF00069 0.520
MOD_PKA_2 266 272 PF00069 0.491
MOD_Plk_1 104 110 PF00069 0.382
MOD_Plk_1 253 259 PF00069 0.379
MOD_Plk_1 288 294 PF00069 0.291
MOD_Plk_1 336 342 PF00069 0.364
MOD_Plk_1 449 455 PF00069 0.563
MOD_Plk_4 209 215 PF00069 0.393
MOD_Plk_4 233 239 PF00069 0.325
MOD_Plk_4 253 259 PF00069 0.357
MOD_Plk_4 277 283 PF00069 0.366
MOD_Plk_4 56 62 PF00069 0.397
MOD_ProDKin_1 89 95 PF00069 0.539
TRG_ENDOCYTIC_2 380 383 PF00928 0.353
TRG_ENDOCYTIC_2 400 403 PF00928 0.361
TRG_ER_diArg_1 23 26 PF00400 0.608
TRG_NLS_MonoExtC_3 137 143 PF00514 0.464
TRG_NLS_MonoExtN_4 135 142 PF00514 0.424
TRG_Pf-PMV_PEXEL_1 159 163 PF00026 0.186

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 27% 75%
A0A0N1I121 Leptomonas seymouri 28% 95%
A0A0N1I661 Leptomonas seymouri 34% 84%
A0A0N1I7S5 Leptomonas seymouri 33% 94%
A0A0N1II82 Leptomonas seymouri 34% 69%
A0A0S4ILC9 Bodo saltans 38% 86%
A0A0S4IN27 Bodo saltans 33% 88%
A0A0S4IQE4 Bodo saltans 31% 84%
A0A0S4IR61 Bodo saltans 32% 100%
A0A0S4ISU4 Bodo saltans 36% 72%
A0A0S4IU23 Bodo saltans 30% 81%
A0A0S4IU73 Bodo saltans 40% 96%
A0A0S4IV96 Bodo saltans 38% 79%
A0A0S4IVN7 Bodo saltans 39% 100%
A0A0S4IVQ8 Bodo saltans 38% 79%
A0A0S4IW93 Bodo saltans 30% 79%
A0A0S4IY44 Bodo saltans 29% 72%
A0A0S4IZC7 Bodo saltans 31% 100%
A0A0S4J014 Bodo saltans 34% 67%
A0A0S4J206 Bodo saltans 36% 78%
A0A0S4J2H8 Bodo saltans 28% 82%
A0A0S4J3T7 Bodo saltans 33% 100%
A0A0S4J5A0 Bodo saltans 35% 83%
A0A0S4J746 Bodo saltans 30% 68%
A0A0S4JAS1 Bodo saltans 36% 75%
A0A0S4JAW7 Bodo saltans 30% 94%
A0A0S4JB95 Bodo saltans 26% 79%
A0A0S4JD35 Bodo saltans 32% 80%
A0A0S4JDS1 Bodo saltans 27% 90%
A0A0S4JEK1 Bodo saltans 27% 100%
A0A0S4JEP2 Bodo saltans 27% 82%
A0A0S4JFC9 Bodo saltans 34% 99%
A0A0S4JL29 Bodo saltans 34% 94%
A0A0S4JQW3 Bodo saltans 26% 100%
A0A0S4JS12 Bodo saltans 29% 100%
A0A0S4JSB8 Bodo saltans 40% 86%
A0A0S4JVI0 Bodo saltans 28% 67%
A0A0S4KGV4 Bodo saltans 26% 88%
A0A0S4KH41 Bodo saltans 34% 69%
A0A0S4KJA7 Bodo saltans 29% 71%
A0A0S4KK37 Bodo saltans 30% 82%
A0A0S4KL26 Bodo saltans 26% 100%
A0A0S4KMV2 Bodo saltans 30% 100%
A0A3Q8IC27 Leishmania donovani 100% 100%
A0A3S5H6M3 Leishmania donovani 35% 70%
A0A3S5H6M4 Leishmania donovani 38% 73%
A0A3S7WS66 Leishmania donovani 38% 72%
A4HBX3 Leishmania braziliensis 64% 100%
A4HVB0 Leishmania infantum 36% 100%
D1GJ51 Leishmania infantum 34% 100%
E9AGG2 Leishmania infantum 34% 72%
E9AGG7 Leishmania infantum 32% 76%
E9AGG9 Leishmania infantum 37% 88%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 67%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 68%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
O02833 Papio hamadryas 23% 79%
O80809 Arabidopsis thaliana 28% 66%
O81765 Arabidopsis thaliana 24% 68%
P35858 Homo sapiens 27% 79%
P35859 Rattus norvegicus 20% 79%
P70389 Mus musculus 25% 79%
Q00874 Arabidopsis thaliana 28% 100%
Q1PEN0 Arabidopsis thaliana 24% 66%
Q3URE9 Mus musculus 21% 79%
Q4PSE6 Arabidopsis thaliana 28% 100%
Q4QC79 Leishmania major 92% 100%
Q4QGI0 Leishmania major 36% 100%
Q4QGI2 Leishmania major 35% 100%
Q4QGI4 Leishmania major 35% 100%
Q4QGI6 Leishmania major 32% 100%
Q4QGJ0 Leishmania major 33% 76%
Q4QGJ2 Leishmania major 32% 100%
Q4QGJ6 Leishmania major 31% 100%
Q4QGJ7 Leishmania major 31% 100%
Q4QGJ9 Leishmania major 34% 100%
Q4QGK0 Leishmania major 32% 100%
Q4QGK1 Leishmania major 32% 68%
Q4QGK2 Leishmania major 32% 100%
Q4QGK4 Leishmania major 33% 100%
Q4QGK8 Leishmania major 35% 100%
Q4QGL2 Leishmania major 35% 100%
Q4QGL4 Leishmania major 36% 100%
Q4QGL5 Leishmania major 29% 100%
Q4QGL8 Leishmania major 36% 78%
Q7L985 Homo sapiens 21% 79%
Q9LJW7 Arabidopsis thaliana 26% 67%
Q9SKK5 Arabidopsis thaliana 26% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS