Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ90_LEIIN

TriTrypDb:

LINF_210019400

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	245	247	PF00675	0.702
CLV_PCSK_KEX2_1	187	189	PF00082	0.482
CLV_PCSK_KEX2_1	245	247	PF00082	0.702
CLV_PCSK_KEX2_1	249	251	PF00082	0.694
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.482
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.590
CLV_PCSK_PC7_1	245	251	PF00082	0.635
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DEG_SPOP_SBC_1	166	170	PF00917	0.600
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.438
DOC_MAPK_HePTP_8	18	30	PF00069	0.448
DOC_MAPK_MEF2A_6	21	30	PF00069	0.445
DOC_MAPK_MEF2A_6	47	54	PF00069	0.471
DOC_PP2B_LxvP_1	24	27	PF13499	0.440
DOC_USP7_MATH_1	166	170	PF00917	0.783
DOC_USP7_MATH_1	99	103	PF00917	0.765
DOC_WW_Pin1_4	167	172	PF00397	0.730
DOC_WW_Pin1_4	216	221	PF00397	0.597
DOC_WW_Pin1_4	298	303	PF00397	0.503
LIG_14-3-3_CanoR_1	222	231	PF00244	0.644
LIG_14-3-3_CanoR_1	51	61	PF00244	0.424
LIG_14-3-3_CanoR_1	9	18	PF00244	0.660
LIG_CtBP_PxDLS_1	27	31	PF00389	0.524
LIG_FHA_1	11	17	PF00498	0.641
LIG_FHA_1	226	232	PF00498	0.657
LIG_FHA_1	237	243	PF00498	0.545
LIG_LIR_Nem_3	297	303	PF02991	0.588
LIG_NRBOX	146	152	PF00104	0.541
LIG_PDZ_Class_1	298	303	PF00595	0.503
LIG_SH2_STAT5	116	119	PF00017	0.518
LIG_SH2_STAT5	60	63	PF00017	0.398
LIG_TRAF2_1	287	290	PF00917	0.552
LIG_TRAF2_1	94	97	PF00917	0.603
LIG_TYR_ITIM	298	303	PF00017	0.579
MOD_CDC14_SPxK_1	219	222	PF00782	0.608
MOD_CDK_SPxK_1	216	222	PF00069	0.601
MOD_CK1_1	102	108	PF00069	0.722
MOD_CK1_1	152	158	PF00069	0.497
MOD_CK1_1	225	231	PF00069	0.597
MOD_CK2_1	284	290	PF00069	0.614
MOD_Cter_Amidation	247	250	PF01082	0.591
MOD_GlcNHglycan	159	162	PF01048	0.628
MOD_GlcNHglycan	176	179	PF01048	0.550
MOD_GlcNHglycan	204	207	PF01048	0.515
MOD_GlcNHglycan	70	73	PF01048	0.591
MOD_GSK3_1	166	173	PF00069	0.608
MOD_N-GLC_1	28	33	PF02516	0.486
MOD_N-GLC_2	110	112	PF02516	0.591
MOD_NEK2_1	28	33	PF00069	0.483
MOD_NEK2_1	68	73	PF00069	0.573
MOD_PIKK_1	170	176	PF00454	0.695
MOD_PKA_2	284	290	PF00069	0.547
MOD_Plk_1	117	123	PF00069	0.440
MOD_Plk_1	236	242	PF00069	0.683
MOD_Plk_1	28	34	PF00069	0.480
MOD_Plk_2-3	284	290	PF00069	0.571
MOD_Plk_4	28	34	PF00069	0.476
MOD_ProDKin_1	167	173	PF00069	0.728
MOD_ProDKin_1	216	222	PF00069	0.601
TRG_ENDOCYTIC_2	137	140	PF00928	0.429
TRG_ENDOCYTIC_2	295	298	PF00928	0.536
TRG_ENDOCYTIC_2	300	303	PF00928	0.537
TRG_ER_diArg_1	245	247	PF00400	0.708
TRG_ER_diArg_1	291	294	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P3	Leptomonas seymouri	36%	96%
A0A3Q8IL55	Leishmania donovani	99%	100%
A4HC50	Leishmania braziliensis	67%	99%
E9AV98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QC82	Leishmania major	91%	100%