RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ88_LEIIN

TriTrypDb:

LINF_210015400

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ88

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	3
GO:0051537	2 iron, 2 sulfur cluster binding	4	3
GO:0051540	metal cluster binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.557
CLV_C14_Caspase3-7	223	227	PF00656	0.514
CLV_C14_Caspase3-7	615	619	PF00656	0.534
CLV_C14_Caspase3-7	77	81	PF00656	0.770
CLV_NRD_NRD_1	267	269	PF00675	0.457
CLV_NRD_NRD_1	577	579	PF00675	0.583
CLV_NRD_NRD_1	7	9	PF00675	0.558
CLV_PCSK_FUR_1	575	579	PF00082	0.546
CLV_PCSK_KEX2_1	266	268	PF00082	0.466
CLV_PCSK_KEX2_1	574	576	PF00082	0.546
CLV_PCSK_KEX2_1	577	579	PF00082	0.522
CLV_PCSK_KEX2_1	7	9	PF00082	0.558
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.597
CLV_PCSK_PC7_1	3	9	PF00082	0.566
CLV_PCSK_SKI1_1	191	195	PF00082	0.557
CLV_PCSK_SKI1_1	307	311	PF00082	0.465
CLV_PCSK_SKI1_1	47	51	PF00082	0.635
CLV_PCSK_SKI1_1	497	501	PF00082	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DEG_SPOP_SBC_1	98	102	PF00917	0.625
DOC_CKS1_1	19	24	PF01111	0.547
DOC_CYCLIN_RxL_1	494	502	PF00134	0.487
DOC_MAPK_gen_1	358	365	PF00069	0.462
DOC_MAPK_MEF2A_6	177	184	PF00069	0.515
DOC_MAPK_MEF2A_6	343	352	PF00069	0.315
DOC_PP1_RVXF_1	129	135	PF00149	0.598
DOC_SPAK_OSR1_1	360	364	PF12202	0.407
DOC_USP7_MATH_1	146	150	PF00917	0.698
DOC_USP7_MATH_1	222	226	PF00917	0.505
DOC_USP7_MATH_1	232	236	PF00917	0.707
DOC_USP7_MATH_1	302	306	PF00917	0.647
DOC_USP7_MATH_1	404	408	PF00917	0.692
DOC_USP7_MATH_1	412	416	PF00917	0.688
DOC_USP7_MATH_1	423	427	PF00917	0.673
DOC_USP7_MATH_1	462	466	PF00917	0.389
DOC_USP7_MATH_1	523	527	PF00917	0.577
DOC_USP7_MATH_1	557	561	PF00917	0.455
DOC_USP7_MATH_1	58	62	PF00917	0.554
DOC_USP7_MATH_1	612	616	PF00917	0.541
DOC_USP7_MATH_1	74	78	PF00917	0.723
DOC_USP7_MATH_1	99	103	PF00917	0.693
DOC_WW_Pin1_4	15	20	PF00397	0.634
DOC_WW_Pin1_4	166	171	PF00397	0.677
DOC_WW_Pin1_4	176	181	PF00397	0.547
DOC_WW_Pin1_4	33	38	PF00397	0.644
DOC_WW_Pin1_4	402	407	PF00397	0.599
DOC_WW_Pin1_4	419	424	PF00397	0.701
DOC_WW_Pin1_4	447	452	PF00397	0.457
DOC_WW_Pin1_4	460	465	PF00397	0.554
DOC_WW_Pin1_4	508	513	PF00397	0.532
DOC_WW_Pin1_4	526	531	PF00397	0.437
DOC_WW_Pin1_4	54	59	PF00397	0.790
DOC_WW_Pin1_4	662	667	PF00397	0.369
DOC_WW_Pin1_4	87	92	PF00397	0.734
LIG_14-3-3_CanoR_1	191	197	PF00244	0.509
LIG_14-3-3_CanoR_1	257	265	PF00244	0.601
LIG_14-3-3_CanoR_1	360	366	PF00244	0.534
LIG_14-3-3_CanoR_1	456	461	PF00244	0.466
LIG_14-3-3_CanoR_1	658	668	PF00244	0.418
LIG_Actin_WH2_2	178	196	PF00022	0.461
LIG_APCC_ABBA_1	561	566	PF00400	0.409
LIG_BIR_III_4	147	151	PF00653	0.610
LIG_Clathr_ClatBox_1	184	188	PF01394	0.469
LIG_FHA_1	153	159	PF00498	0.740
LIG_FHA_1	166	172	PF00498	0.519
LIG_FHA_1	177	183	PF00498	0.485
LIG_FHA_1	19	25	PF00498	0.587
LIG_FHA_1	260	266	PF00498	0.639
LIG_FHA_2	193	199	PF00498	0.486
LIG_FHA_2	299	305	PF00498	0.585
LIG_FHA_2	91	97	PF00498	0.697
LIG_Integrin_RGDW_4	642	645	PF00362	0.356
LIG_LIR_Apic_2	644	648	PF02991	0.366
LIG_LIR_Gen_1	118	124	PF02991	0.667
LIG_LIR_Gen_1	214	222	PF02991	0.468
LIG_LIR_Gen_1	308	317	PF02991	0.517
LIG_LIR_Gen_1	477	487	PF02991	0.432
LIG_LIR_Gen_1	550	561	PF02991	0.503
LIG_LIR_Nem_3	118	122	PF02991	0.674
LIG_LIR_Nem_3	214	220	PF02991	0.390
LIG_LIR_Nem_3	477	482	PF02991	0.494
LIG_LIR_Nem_3	550	556	PF02991	0.480
LIG_NRBOX	495	501	PF00104	0.420
LIG_Pex14_1	134	138	PF04695	0.551
LIG_SH2_CRK	479	483	PF00017	0.444
LIG_SH2_CRK	553	557	PF00017	0.501
LIG_SH3_2	666	671	PF14604	0.413
LIG_SH3_3	107	113	PF00018	0.577
LIG_SH3_3	16	22	PF00018	0.611
LIG_SH3_3	362	368	PF00018	0.368
LIG_SH3_3	426	432	PF00018	0.639
LIG_SH3_3	663	669	PF00018	0.377
LIG_SUMO_SIM_par_1	183	189	PF11976	0.460
LIG_TRAF2_1	195	198	PF00917	0.496
MOD_CDK_SPK_2	176	181	PF00069	0.519
MOD_CDK_SPK_2	526	531	PF00069	0.533
MOD_CDK_SPK_2	662	667	PF00069	0.369
MOD_CK1_1	140	146	PF00069	0.679
MOD_CK1_1	153	159	PF00069	0.670
MOD_CK1_1	176	182	PF00069	0.570
MOD_CK1_1	18	24	PF00069	0.655
MOD_CK1_1	183	189	PF00069	0.524
MOD_CK1_1	225	231	PF00069	0.656
MOD_CK1_1	233	239	PF00069	0.716
MOD_CK1_1	298	304	PF00069	0.627
MOD_CK1_1	366	372	PF00069	0.501
MOD_CK1_1	405	411	PF00069	0.713
MOD_CK1_1	526	532	PF00069	0.681
MOD_CK1_1	638	644	PF00069	0.390
MOD_CK1_1	649	655	PF00069	0.406
MOD_CK1_1	662	668	PF00069	0.316
MOD_CK1_1	90	96	PF00069	0.743
MOD_CK2_1	146	152	PF00069	0.693
MOD_CK2_1	192	198	PF00069	0.483
MOD_CK2_1	302	308	PF00069	0.557
MOD_CK2_1	90	96	PF00069	0.722
MOD_Cter_Amidation	575	578	PF01082	0.476
MOD_GlcNHglycan	101	104	PF01048	0.710
MOD_GlcNHglycan	142	145	PF01048	0.643
MOD_GlcNHglycan	147	151	PF01048	0.691
MOD_GlcNHglycan	152	155	PF01048	0.787
MOD_GlcNHglycan	229	232	PF01048	0.703
MOD_GlcNHglycan	28	31	PF01048	0.629
MOD_GlcNHglycan	414	417	PF01048	0.720
MOD_GlcNHglycan	425	428	PF01048	0.668
MOD_GlcNHglycan	460	463	PF01048	0.550
MOD_GlcNHglycan	501	504	PF01048	0.620
MOD_GlcNHglycan	508	511	PF01048	0.580
MOD_GSK3_1	136	143	PF00069	0.650
MOD_GSK3_1	14	21	PF00069	0.552
MOD_GSK3_1	146	153	PF00069	0.736
MOD_GSK3_1	171	178	PF00069	0.657
MOD_GSK3_1	192	199	PF00069	0.499
MOD_GSK3_1	211	218	PF00069	0.358
MOD_GSK3_1	222	229	PF00069	0.509
MOD_GSK3_1	232	239	PF00069	0.652
MOD_GSK3_1	257	264	PF00069	0.621
MOD_GSK3_1	298	305	PF00069	0.481
MOD_GSK3_1	327	334	PF00069	0.496
MOD_GSK3_1	400	407	PF00069	0.592
MOD_GSK3_1	408	415	PF00069	0.595
MOD_GSK3_1	419	426	PF00069	0.731
MOD_GSK3_1	437	444	PF00069	0.572
MOD_GSK3_1	456	463	PF00069	0.586
MOD_GSK3_1	504	511	PF00069	0.622
MOD_GSK3_1	54	61	PF00069	0.609
MOD_GSK3_1	85	92	PF00069	0.624
MOD_GSK3_1	99	106	PF00069	0.657
MOD_LATS_1	6	12	PF00433	0.546
MOD_N-GLC_1	150	155	PF02516	0.661
MOD_N-GLC_1	226	231	PF02516	0.708
MOD_N-GLC_1	331	336	PF02516	0.573
MOD_N-GLC_1	423	428	PF02516	0.472
MOD_N-GLC_1	438	443	PF02516	0.467
MOD_NEK2_1	171	176	PF00069	0.674
MOD_NEK2_1	361	366	PF00069	0.389
MOD_NEK2_1	499	504	PF00069	0.589
MOD_NEK2_1	541	546	PF00069	0.418
MOD_NEK2_1	59	64	PF00069	0.725
MOD_NEK2_1	620	625	PF00069	0.490
MOD_NEK2_1	636	641	PF00069	0.406
MOD_NEK2_2	248	253	PF00069	0.482
MOD_OFUCOSY	72	78	PF10250	0.463
MOD_PIKK_1	302	308	PF00454	0.484
MOD_PIKK_1	438	444	PF00454	0.512
MOD_PIKK_1	66	72	PF00454	0.565
MOD_PK_1	295	301	PF00069	0.426
MOD_PKA_2	2	8	PF00069	0.598
MOD_PKA_2	311	317	PF00069	0.565
MOD_PKA_2	332	338	PF00069	0.459
MOD_PKA_2	455	461	PF00069	0.470
MOD_PKA_2	659	665	PF00069	0.415
MOD_Plk_1	438	444	PF00069	0.508
MOD_Plk_1	557	563	PF00069	0.439
MOD_Plk_4	154	160	PF00069	0.672
MOD_Plk_4	180	186	PF00069	0.619
MOD_Plk_4	462	468	PF00069	0.527
MOD_ProDKin_1	15	21	PF00069	0.636
MOD_ProDKin_1	166	172	PF00069	0.676
MOD_ProDKin_1	176	182	PF00069	0.544
MOD_ProDKin_1	33	39	PF00069	0.645
MOD_ProDKin_1	402	408	PF00069	0.600
MOD_ProDKin_1	419	425	PF00069	0.696
MOD_ProDKin_1	447	453	PF00069	0.453
MOD_ProDKin_1	460	466	PF00069	0.541
MOD_ProDKin_1	508	514	PF00069	0.534
MOD_ProDKin_1	526	532	PF00069	0.430
MOD_ProDKin_1	54	60	PF00069	0.791
MOD_ProDKin_1	662	668	PF00069	0.371
MOD_ProDKin_1	87	93	PF00069	0.735
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.565
TRG_ENDOCYTIC_2	479	482	PF00928	0.436
TRG_ENDOCYTIC_2	553	556	PF00928	0.528
TRG_ER_diArg_1	265	268	PF00400	0.552
TRG_ER_diArg_1	482	485	PF00400	0.384
TRG_ER_diArg_1	575	578	PF00400	0.549
TRG_ER_diArg_1	655	658	PF00400	0.528
TRG_ER_diArg_1	7	9	PF00400	0.591
TRG_NLS_MonoExtC_3	573	578	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ9	Leptomonas seymouri	42%	100%
A0A1X0NXN9	Trypanosomatidae	32%	100%
A0A3S5H797	Leishmania donovani	99%	100%
A0A422NWI0	Trypanosoma rangeli	35%	100%
A4HBU1	Leishmania braziliensis	71%	100%
D0A1D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AV63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCB8	Leishmania major	91%	100%
V5BMW0	Trypanosoma cruzi	33%	100%