Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ86_LEIIN

TriTrypDb:

LINF_210015200

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HZ86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ86

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0051087	protein-folding chaperone binding	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.683
CLV_C14_Caspase3-7	226	230	PF00656	0.638
CLV_NRD_NRD_1	132	134	PF00675	0.512
CLV_NRD_NRD_1	157	159	PF00675	0.320
CLV_NRD_NRD_1	186	188	PF00675	0.419
CLV_NRD_NRD_1	272	274	PF00675	0.349
CLV_NRD_NRD_1	285	287	PF00675	0.337
CLV_PCSK_KEX2_1	132	134	PF00082	0.513
CLV_PCSK_KEX2_1	157	159	PF00082	0.320
CLV_PCSK_KEX2_1	185	187	PF00082	0.412
CLV_PCSK_KEX2_1	272	274	PF00082	0.339
CLV_PCSK_KEX2_1	285	287	PF00082	0.363
CLV_PCSK_SKI1_1	157	161	PF00082	0.365
CLV_PCSK_SKI1_1	273	277	PF00082	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.444
DOC_ANK_TNKS_1	132	139	PF00023	0.613
DOC_MAPK_DCC_7	286	296	PF00069	0.599
DOC_PP4_FxxP_1	144	147	PF00568	0.598
DOC_USP7_MATH_1	110	114	PF00917	0.695
DOC_USP7_MATH_1	13	17	PF00917	0.532
DOC_USP7_MATH_1	147	151	PF00917	0.500
DOC_USP7_MATH_1	213	217	PF00917	0.686
DOC_USP7_MATH_1	25	29	PF00917	0.437
DOC_USP7_MATH_1	31	35	PF00917	0.447
DOC_USP7_UBL2_3	270	274	PF12436	0.592
DOC_WW_Pin1_4	21	26	PF00397	0.509
DOC_WW_Pin1_4	285	290	PF00397	0.585
DOC_WW_Pin1_4	36	41	PF00397	0.550
LIG_14-3-3_CanoR_1	97	106	PF00244	0.720
LIG_BRCT_BRCA1_1	149	153	PF00533	0.551
LIG_FHA_1	250	256	PF00498	0.549
LIG_FHA_1	282	288	PF00498	0.563
LIG_FHA_1	75	81	PF00498	0.329
LIG_FHA_2	170	176	PF00498	0.660
LIG_LIR_Apic_2	141	147	PF02991	0.616
LIG_LIR_Gen_1	150	159	PF02991	0.614
LIG_LIR_Nem_3	149	155	PF02991	0.558
LIG_LIR_Nem_3	39	45	PF02991	0.469
LIG_MLH1_MIPbox_1	149	153	PF16413	0.551
LIG_Rb_LxCxE_1	118	137	PF01857	0.611
LIG_SH2_NCK_1	20	24	PF00017	0.473
LIG_SH2_NCK_1	65	69	PF00017	0.328
LIG_SH2_SRC	63	66	PF00017	0.376
LIG_SH2_STAP1	65	69	PF00017	0.328
LIG_SH2_STAT3	59	62	PF00017	0.410
LIG_SH2_STAT5	155	158	PF00017	0.592
LIG_SH2_STAT5	173	176	PF00017	0.640
LIG_SH2_STAT5	63	66	PF00017	0.466
LIG_SH3_1	286	292	PF00018	0.601
LIG_SH3_3	286	292	PF00018	0.632
LIG_SH3_3	34	40	PF00018	0.465
LIG_SH3_3	7	13	PF00018	0.461
LIG_UBA3_1	44	51	PF00899	0.454
MOD_CDK_SPxxK_3	36	43	PF00069	0.474
MOD_CK1_1	100	106	PF00069	0.663
MOD_CK1_1	16	22	PF00069	0.452
MOD_CK1_1	30	36	PF00069	0.497
MOD_CK1_1	4	10	PF00069	0.469
MOD_CK1_1	46	52	PF00069	0.487
MOD_CK2_1	169	175	PF00069	0.533
MOD_GlcNHglycan	112	115	PF01048	0.494
MOD_GlcNHglycan	14	18	PF01048	0.678
MOD_GlcNHglycan	149	152	PF01048	0.337
MOD_GlcNHglycan	219	222	PF01048	0.481
MOD_GlcNHglycan	229	232	PF01048	0.427
MOD_GlcNHglycan	29	32	PF01048	0.684
MOD_GlcNHglycan	33	36	PF01048	0.704
MOD_GlcNHglycan	4	7	PF01048	0.751
MOD_GlcNHglycan	66	69	PF01048	0.376
MOD_GlcNHglycan	99	102	PF01048	0.488
MOD_GSK3_1	1	8	PF00069	0.481
MOD_GSK3_1	147	154	PF00069	0.638
MOD_GSK3_1	169	176	PF00069	0.564
MOD_GSK3_1	21	28	PF00069	0.499
MOD_GSK3_1	213	220	PF00069	0.745
MOD_GSK3_1	281	288	PF00069	0.563
MOD_GSK3_1	46	53	PF00069	0.420
MOD_GSK3_1	72	79	PF00069	0.436
MOD_N-GLC_1	208	213	PF02516	0.492
MOD_NEK2_1	1	6	PF00069	0.498
MOD_NEK2_1	29	34	PF00069	0.571
MOD_NEK2_1	44	49	PF00069	0.362
MOD_NEK2_1	72	77	PF00069	0.386
MOD_PIKK_1	249	255	PF00454	0.502
MOD_PIKK_1	46	52	PF00454	0.486
MOD_PKA_2	263	269	PF00069	0.651
MOD_Plk_1	190	196	PF00069	0.591
MOD_Plk_4	169	175	PF00069	0.558
MOD_Plk_4	190	196	PF00069	0.647
MOD_Plk_4	76	82	PF00069	0.376
MOD_ProDKin_1	21	27	PF00069	0.508
MOD_ProDKin_1	285	291	PF00069	0.584
MOD_ProDKin_1	36	42	PF00069	0.546
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.566
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.431
TRG_ER_diArg_1	156	158	PF00400	0.524
TRG_ER_diArg_1	184	187	PF00400	0.608
TRG_ER_diArg_1	285	287	PF00400	0.596
TRG_NES_CRM1_1	253	267	PF08389	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P829	Leptomonas seymouri	39%	100%
A0A1X0NYB3	Trypanosomatidae	31%	75%
A0A3Q8IB47	Leishmania donovani	99%	100%
A4HBT9	Leishmania braziliensis	70%	100%
E9AV61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QCC0	Leishmania major	89%	100%