Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain/Protein tyrosine kinase - putative

Species:

Leishmania infantum

UniProt:

A4HZ84_LEIIN

TriTrypDb:

LINF_210014200

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HZ84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ84

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006914	autophagy	3	5
GO:0008152	metabolic process	1	6
GO:0009056	catabolic process	2	5
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044248	cellular catabolic process	3	5
GO:0061919	process utilizing autophagic mechanism	2	5
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0006996	organelle organization	4	1
GO:0007033	vacuole organization	5	1
GO:0016043	cellular component organization	3	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0046777	protein autophosphorylation	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1905037	autophagosome organization	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.589
CLV_NRD_NRD_1	216	218	PF00675	0.407
CLV_PCSK_KEX2_1	214	216	PF00082	0.407
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.407
CLV_PCSK_SKI1_1	137	141	PF00082	0.371
CLV_PCSK_SKI1_1	200	204	PF00082	0.407
CLV_PCSK_SKI1_1	221	225	PF00082	0.362
CLV_PCSK_SKI1_1	303	307	PF00082	0.504
CLV_PCSK_SKI1_1	551	555	PF00082	0.696
CLV_PCSK_SKI1_1	610	614	PF00082	0.516
CLV_Separin_Metazoa	324	328	PF03568	0.407
CLV_Separin_Metazoa	342	346	PF03568	0.407
DEG_Nend_UBRbox_2	1	3	PF02207	0.838
DEG_SCF_FBW7_2	60	67	PF00400	0.773
DEG_SPOP_SBC_1	157	161	PF00917	0.421
DEG_SPOP_SBC_1	489	493	PF00917	0.827
DEG_SPOP_SBC_1	561	565	PF00917	0.748
DEG_SPOP_SBC_1	738	742	PF00917	0.655
DEG_SPOP_SBC_1	94	98	PF00917	0.804
DOC_CKS1_1	293	298	PF01111	0.407
DOC_CKS1_1	61	66	PF01111	0.780
DOC_CYCLIN_RxL_1	607	616	PF00134	0.509
DOC_MAPK_DCC_7	392	402	PF00069	0.657
DOC_MAPK_gen_1	166	174	PF00069	0.415
DOC_MAPK_gen_1	221	230	PF00069	0.407
DOC_MAPK_JIP1_4	224	230	PF00069	0.407
DOC_MAPK_MEF2A_6	166	174	PF00069	0.407
DOC_PP2B_LxvP_1	139	142	PF13499	0.504
DOC_PP2B_LxvP_1	775	778	PF13499	0.801
DOC_PP4_FxxP_1	402	405	PF00568	0.581
DOC_PP4_FxxP_1	575	578	PF00568	0.754
DOC_PP4_FxxP_1	99	102	PF00568	0.815
DOC_USP7_MATH_1	262	266	PF00917	0.350
DOC_USP7_MATH_1	405	409	PF00917	0.714
DOC_USP7_MATH_1	485	489	PF00917	0.828
DOC_USP7_MATH_1	509	513	PF00917	0.744
DOC_USP7_MATH_1	521	525	PF00917	0.618
DOC_USP7_MATH_1	589	593	PF00917	0.660
DOC_USP7_MATH_1	645	649	PF00917	0.649
DOC_USP7_MATH_1	738	742	PF00917	0.685
DOC_USP7_MATH_1	750	754	PF00917	0.718
DOC_USP7_MATH_1	88	92	PF00917	0.708
DOC_USP7_MATH_1	94	98	PF00917	0.746
DOC_WW_Pin1_4	104	109	PF00397	0.655
DOC_WW_Pin1_4	283	288	PF00397	0.449
DOC_WW_Pin1_4	292	297	PF00397	0.356
DOC_WW_Pin1_4	423	428	PF00397	0.749
DOC_WW_Pin1_4	557	562	PF00397	0.809
DOC_WW_Pin1_4	60	65	PF00397	0.679
LIG_14-3-3_CanoR_1	200	205	PF00244	0.407
LIG_14-3-3_CanoR_1	368	374	PF00244	0.369
LIG_14-3-3_CanoR_1	377	381	PF00244	0.315
LIG_14-3-3_CanoR_1	385	389	PF00244	0.265
LIG_14-3-3_CanoR_1	610	615	PF00244	0.510
LIG_APCC_ABBAyCdc20_2	216	222	PF00400	0.407
LIG_BRCT_BRCA1_1	167	171	PF00533	0.504
LIG_BRCT_BRCA1_1	285	289	PF00533	0.407
LIG_BRCT_BRCA1_1	95	99	PF00533	0.807
LIG_EVH1_2	398	402	PF00568	0.552
LIG_FHA_1	201	207	PF00498	0.407
LIG_FHA_1	237	243	PF00498	0.370
LIG_FHA_1	399	405	PF00498	0.625
LIG_FHA_1	561	567	PF00498	0.801
LIG_FHA_1	585	591	PF00498	0.583
LIG_FHA_1	681	687	PF00498	0.526
LIG_FHA_2	229	235	PF00498	0.504
LIG_FHA_2	268	274	PF00498	0.467
LIG_FHA_2	368	374	PF00498	0.407
LIG_FHA_2	705	711	PF00498	0.644
LIG_FHA_2	738	744	PF00498	0.760
LIG_GBD_Chelix_1	614	622	PF00786	0.600
LIG_LIR_Apic_2	295	301	PF02991	0.407
LIG_LIR_Apic_2	401	405	PF02991	0.575
LIG_LIR_Apic_2	573	578	PF02991	0.778
LIG_LIR_Apic_2	96	102	PF02991	0.811
LIG_LIR_Gen_1	133	142	PF02991	0.504
LIG_LIR_Gen_1	168	177	PF02991	0.407
LIG_LIR_Gen_1	524	533	PF02991	0.767
LIG_LIR_Gen_1	592	601	PF02991	0.631
LIG_LIR_Nem_3	133	138	PF02991	0.504
LIG_LIR_Nem_3	168	174	PF02991	0.407
LIG_LIR_Nem_3	283	288	PF02991	0.504
LIG_LIR_Nem_3	346	351	PF02991	0.407
LIG_LIR_Nem_3	524	529	PF02991	0.783
LIG_LIR_Nem_3	592	596	PF02991	0.634
LIG_MAD2	217	225	PF02301	0.407
LIG_MYND_1	395	399	PF01753	0.653
LIG_PDZ_Class_2	784	789	PF00595	0.499
LIG_Pex14_2	285	289	PF04695	0.504
LIG_PTB_Apo_2	540	547	PF02174	0.614
LIG_PTB_Phospho_1	540	546	PF10480	0.612
LIG_Rb_pABgroove_1	112	120	PF01858	0.504
LIG_SH2_CRK	39	43	PF00017	0.493
LIG_SH2_CRK	546	550	PF00017	0.703
LIG_SH2_NCK_1	24	28	PF00017	0.489
LIG_SH2_PTP2	13	16	PF00017	0.664
LIG_SH2_SRC	598	601	PF00017	0.533
LIG_SH2_STAP1	118	122	PF00017	0.504
LIG_SH2_STAP1	626	630	PF00017	0.623
LIG_SH2_STAP1	682	686	PF00017	0.518
LIG_SH2_STAT3	600	603	PF00017	0.557
LIG_SH2_STAT5	13	16	PF00017	0.621
LIG_SH2_STAT5	177	180	PF00017	0.434
LIG_SH2_STAT5	546	549	PF00017	0.711
LIG_SH2_STAT5	598	601	PF00017	0.533
LIG_SH2_STAT5	617	620	PF00017	0.568
LIG_SH2_STAT5	629	632	PF00017	0.457
LIG_SH2_STAT5	635	638	PF00017	0.401
LIG_SH2_STAT5	682	685	PF00017	0.472
LIG_SH3_1	392	398	PF00018	0.659
LIG_SH3_1	546	552	PF00018	0.802
LIG_SH3_2	464	469	PF14604	0.759
LIG_SH3_3	135	141	PF00018	0.504
LIG_SH3_3	390	396	PF00018	0.666
LIG_SH3_3	449	455	PF00018	0.830
LIG_SH3_3	461	467	PF00018	0.685
LIG_SH3_3	481	487	PF00018	0.810
LIG_SH3_3	505	511	PF00018	0.791
LIG_SH3_3	546	552	PF00018	0.689
LIG_SH3_3	58	64	PF00018	0.675
LIG_SH3_3	724	730	PF00018	0.815
LIG_SH3_3	775	781	PF00018	0.792
LIG_SH3_3	99	105	PF00018	0.737
LIG_Sin3_3	226	233	PF02671	0.504
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.407
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.629
LIG_SUMO_SIM_par_1	319	324	PF11976	0.407
LIG_TRAF2_1	726	729	PF00917	0.689
LIG_TRFH_1	575	579	PF08558	0.755
LIG_TYR_ITIM	37	42	PF00017	0.581
LIG_TYR_ITIM	596	601	PF00017	0.631
LIG_UBA3_1	210	214	PF00899	0.504
LIG_WRC_WIRS_1	590	595	PF05994	0.642
LIG_WW_2	395	398	PF00397	0.644
LIG_WW_3	140	144	PF00397	0.504
MOD_CDC14_SPxK_1	300	303	PF00782	0.407
MOD_CDK_SPxK_1	297	303	PF00069	0.407
MOD_CK1_1	158	164	PF00069	0.378
MOD_CK1_1	165	171	PF00069	0.495
MOD_CK1_1	436	442	PF00069	0.810
MOD_CK1_1	488	494	PF00069	0.827
MOD_CK1_1	560	566	PF00069	0.722
MOD_CK1_1	568	574	PF00069	0.517
MOD_CK1_1	70	76	PF00069	0.647
MOD_CK1_1	705	711	PF00069	0.732
MOD_CK1_1	736	742	PF00069	0.720
MOD_CK1_1	753	759	PF00069	0.640
MOD_CK1_1	95	101	PF00069	0.808
MOD_CK2_1	158	164	PF00069	0.504
MOD_CK2_1	267	273	PF00069	0.467
MOD_CK2_1	480	486	PF00069	0.746
MOD_CK2_1	705	711	PF00069	0.782
MOD_CK2_1	723	729	PF00069	0.660
MOD_CK2_1	737	743	PF00069	0.691
MOD_GlcNHglycan	145	149	PF01048	0.511
MOD_GlcNHglycan	231	234	PF01048	0.504
MOD_GlcNHglycan	262	265	PF01048	0.434
MOD_GlcNHglycan	316	319	PF01048	0.407
MOD_GlcNHglycan	433	436	PF01048	0.830
MOD_GlcNHglycan	45	48	PF01048	0.530
MOD_GlcNHglycan	486	490	PF01048	0.675
MOD_GlcNHglycan	567	570	PF01048	0.715
MOD_GlcNHglycan	692	695	PF01048	0.659
MOD_GlcNHglycan	7	10	PF01048	0.804
MOD_GlcNHglycan	704	707	PF01048	0.562
MOD_GlcNHglycan	748	751	PF01048	0.654
MOD_GlcNHglycan	90	93	PF01048	0.769
MOD_GSK3_1	100	107	PF00069	0.596
MOD_GSK3_1	155	162	PF00069	0.324
MOD_GSK3_1	288	295	PF00069	0.444
MOD_GSK3_1	334	341	PF00069	0.415
MOD_GSK3_1	429	436	PF00069	0.755
MOD_GSK3_1	485	492	PF00069	0.753
MOD_GSK3_1	557	564	PF00069	0.700
MOD_GSK3_1	63	70	PF00069	0.679
MOD_GSK3_1	636	643	PF00069	0.586
MOD_GSK3_1	733	740	PF00069	0.654
MOD_GSK3_1	746	753	PF00069	0.649
MOD_GSK3_1	88	95	PF00069	0.765
MOD_N-GLC_2	647	649	PF02516	0.700
MOD_NEK2_1	156	161	PF00069	0.352
MOD_NEK2_1	228	233	PF00069	0.350
MOD_NEK2_1	326	331	PF00069	0.365
MOD_NEK2_1	384	389	PF00069	0.382
MOD_NEK2_1	636	641	PF00069	0.660
MOD_NEK2_1	702	707	PF00069	0.630
MOD_NEK2_1	746	751	PF00069	0.701
MOD_NEK2_2	209	214	PF00069	0.407
MOD_PIKK_1	334	340	PF00454	0.407
MOD_PIKK_1	433	439	PF00454	0.813
MOD_PIKK_1	499	505	PF00454	0.709
MOD_PIKK_1	67	73	PF00454	0.757
MOD_PK_1	480	486	PF00069	0.831
MOD_PKA_2	165	171	PF00069	0.407
MOD_PKA_2	326	332	PF00069	0.367
MOD_PKA_2	367	373	PF00069	0.370
MOD_PKA_2	376	382	PF00069	0.318
MOD_PKA_2	384	390	PF00069	0.274
MOD_PKA_2	515	521	PF00069	0.817
MOD_PKA_2	640	646	PF00069	0.691
MOD_Plk_4	384	390	PF00069	0.504
MOD_Plk_4	45	51	PF00069	0.540
MOD_Plk_4	610	616	PF00069	0.505
MOD_ProDKin_1	104	110	PF00069	0.642
MOD_ProDKin_1	283	289	PF00069	0.449
MOD_ProDKin_1	292	298	PF00069	0.356
MOD_ProDKin_1	423	429	PF00069	0.748
MOD_ProDKin_1	557	563	PF00069	0.808
MOD_ProDKin_1	60	66	PF00069	0.684
MOD_SUMO_for_1	333	336	PF00179	0.504
MOD_SUMO_rev_2	77	84	PF00179	0.826
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.815
TRG_ENDOCYTIC_2	13	16	PF00928	0.664
TRG_ENDOCYTIC_2	39	42	PF00928	0.575
TRG_ENDOCYTIC_2	598	601	PF00928	0.630
TRG_ER_diArg_1	215	217	PF00400	0.407
TRG_ER_diArg_1	697	700	PF00400	0.588
TRG_NLS_MonoCore_2	213	218	PF00514	0.407
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGM5	Leptomonas seymouri	44%	74%
A0A3S7WWM5	Leishmania donovani	100%	80%
E9AV51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCD0	Leishmania major	93%	100%