LeishMANIAdb
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Temperature dependent protein affecting M2 dsRNA replication-domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Temperature dependent protein affecting M2 dsRNA replication-domain-containing protein
Gene product:
Temperature dependent protein affecting M2 dsRNA replication - putative
Species:
Leishmania infantum
UniProt:
A4HZ83_LEIIN
TriTrypDb:
LINF_210014100 *
Length:
1048

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ83

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 13
GO:0009889 regulation of biosynthetic process 4 13
GO:0010468 regulation of gene expression 5 13
GO:0010556 regulation of macromolecule biosynthetic process 5 13
GO:0010608 post-transcriptional regulation of gene expression 6 13
GO:0019222 regulation of metabolic process 3 13
GO:0031323 regulation of cellular metabolic process 4 13
GO:0031326 regulation of cellular biosynthetic process 5 13
GO:0034248 regulation of amide metabolic process 5 13
GO:0050789 regulation of biological process 2 13
GO:0050794 regulation of cellular process 3 13
GO:0051171 regulation of nitrogen compound metabolic process 4 13
GO:0051246 regulation of protein metabolic process 5 13
GO:0060255 regulation of macromolecule metabolic process 4 13
GO:0065007 biological regulation 1 13
GO:0080090 regulation of primary metabolic process 4 13
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 13
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004518 nuclease activity 4 1
GO:0004519 endonuclease activity 5 1
GO:0004520 DNA endonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0017108 5'-flap endonuclease activity 7 1
GO:0048256 flap endonuclease activity 6 1
GO:0140097 catalytic activity, acting on DNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 776 780 PF00656 0.761
CLV_NRD_NRD_1 223 225 PF00675 0.607
CLV_NRD_NRD_1 983 985 PF00675 0.362
CLV_PCSK_KEX2_1 220 222 PF00082 0.610
CLV_PCSK_KEX2_1 542 544 PF00082 0.615
CLV_PCSK_KEX2_1 983 985 PF00082 0.362
CLV_PCSK_PC1ET2_1 220 222 PF00082 0.620
CLV_PCSK_PC1ET2_1 542 544 PF00082 0.617
CLV_PCSK_SKI1_1 1028 1032 PF00082 0.413
CLV_PCSK_SKI1_1 220 224 PF00082 0.606
CLV_PCSK_SKI1_1 431 435 PF00082 0.544
CLV_PCSK_SKI1_1 436 440 PF00082 0.570
CLV_PCSK_SKI1_1 542 546 PF00082 0.622
CLV_PCSK_SKI1_1 790 794 PF00082 0.443
CLV_PCSK_SKI1_1 900 904 PF00082 0.313
CLV_Separin_Metazoa 428 432 PF03568 0.386
CLV_Separin_Metazoa 817 821 PF03568 0.491
DEG_APCC_DBOX_1 506 514 PF00400 0.480
DEG_ODPH_VHL_1 207 218 PF01847 0.461
DEG_SCF_FBW7_1 481 487 PF00400 0.322
DEG_SPOP_SBC_1 778 782 PF00917 0.748
DOC_ANK_TNKS_1 94 101 PF00023 0.608
DOC_CKS1_1 481 486 PF01111 0.396
DOC_CYCLIN_RxL_1 217 227 PF00134 0.426
DOC_CYCLIN_yCln2_LP_2 607 613 PF00134 0.562
DOC_MAPK_DCC_7 290 299 PF00069 0.325
DOC_MAPK_MEF2A_6 239 248 PF00069 0.368
DOC_PP1_RVXF_1 447 454 PF00149 0.412
DOC_PP1_RVXF_1 635 641 PF00149 0.562
DOC_PP1_RVXF_1 788 794 PF00149 0.685
DOC_PP2B_LxvP_1 129 132 PF13499 0.604
DOC_PP2B_LxvP_1 401 404 PF13499 0.326
DOC_PP4_MxPP_1 155 158 PF00568 0.562
DOC_PP4_MxPP_1 395 398 PF00568 0.333
DOC_PP4_MxPP_1 40 43 PF00568 0.565
DOC_USP7_MATH_1 466 470 PF00917 0.347
DOC_USP7_MATH_1 484 488 PF00917 0.439
DOC_USP7_MATH_1 49 53 PF00917 0.477
DOC_USP7_MATH_1 7 11 PF00917 0.608
DOC_USP7_MATH_1 784 788 PF00917 0.666
DOC_USP7_MATH_2 316 322 PF00917 0.441
DOC_WW_Pin1_4 1006 1011 PF00397 0.630
DOC_WW_Pin1_4 312 317 PF00397 0.458
DOC_WW_Pin1_4 480 485 PF00397 0.363
DOC_WW_Pin1_4 522 527 PF00397 0.361
DOC_WW_Pin1_4 54 59 PF00397 0.613
DOC_WW_Pin1_4 665 670 PF00397 0.657
DOC_WW_Pin1_4 67 72 PF00397 0.543
DOC_WW_Pin1_4 704 709 PF00397 0.651
DOC_WW_Pin1_4 924 929 PF00397 0.545
DOC_WW_Pin1_4 957 962 PF00397 0.562
LIG_14-3-3_CanoR_1 224 229 PF00244 0.413
LIG_14-3-3_CanoR_1 361 370 PF00244 0.403
LIG_14-3-3_CanoR_1 790 799 PF00244 0.612
LIG_14-3-3_CanoR_1 814 821 PF00244 0.545
LIG_Actin_WH2_2 210 226 PF00022 0.430
LIG_Actin_WH2_2 653 668 PF00022 0.639
LIG_Actin_WH2_2 675 693 PF00022 0.634
LIG_Actin_WH2_2 968 985 PF00022 0.500
LIG_APCC_ABBA_1 402 407 PF00400 0.386
LIG_APCC_ABBA_1 929 934 PF00400 0.504
LIG_APCC_ABBAyCdc20_2 1028 1034 PF00400 0.617
LIG_BIR_III_2 200 204 PF00653 0.581
LIG_BIR_III_4 629 633 PF00653 0.562
LIG_BRCT_BRCA1_1 524 528 PF00533 0.340
LIG_BRCT_BRCA1_1 558 562 PF00533 0.362
LIG_BRCT_BRCA1_1 825 829 PF00533 0.577
LIG_Clathr_ClatBox_1 657 661 PF01394 0.557
LIG_FHA_1 1013 1019 PF00498 0.561
LIG_FHA_1 243 249 PF00498 0.352
LIG_FHA_1 262 268 PF00498 0.261
LIG_FHA_1 416 422 PF00498 0.423
LIG_FHA_1 472 478 PF00498 0.396
LIG_FHA_1 574 580 PF00498 0.416
LIG_FHA_1 792 798 PF00498 0.595
LIG_FHA_1 814 820 PF00498 0.475
LIG_FHA_1 832 838 PF00498 0.412
LIG_FHA_1 901 907 PF00498 0.535
LIG_FHA_1 925 931 PF00498 0.573
LIG_FHA_2 210 216 PF00498 0.431
LIG_FHA_2 335 341 PF00498 0.392
LIG_FHA_2 488 494 PF00498 0.447
LIG_FHA_2 828 834 PF00498 0.522
LIG_FHA_2 867 873 PF00498 0.522
LIG_FHA_2 958 964 PF00498 0.477
LIG_Integrin_RGD_1 204 206 PF01839 0.779
LIG_IRF3_LxIS_1 793 800 PF10401 0.596
LIG_LIR_Apic_2 496 501 PF02991 0.460
LIG_LIR_Apic_2 52 58 PF02991 0.610
LIG_LIR_Gen_1 212 222 PF02991 0.359
LIG_LIR_Gen_1 323 333 PF02991 0.367
LIG_LIR_Gen_1 448 458 PF02991 0.362
LIG_LIR_Gen_1 476 486 PF02991 0.339
LIG_LIR_Gen_1 487 495 PF02991 0.325
LIG_LIR_Gen_1 601 612 PF02991 0.560
LIG_LIR_Gen_1 720 730 PF02991 0.504
LIG_LIR_Gen_1 794 801 PF02991 0.527
LIG_LIR_Gen_1 921 931 PF02991 0.498
LIG_LIR_Gen_1 987 998 PF02991 0.570
LIG_LIR_Nem_3 212 217 PF02991 0.357
LIG_LIR_Nem_3 323 329 PF02991 0.347
LIG_LIR_Nem_3 432 437 PF02991 0.408
LIG_LIR_Nem_3 448 453 PF02991 0.274
LIG_LIR_Nem_3 476 481 PF02991 0.332
LIG_LIR_Nem_3 487 491 PF02991 0.346
LIG_LIR_Nem_3 520 524 PF02991 0.399
LIG_LIR_Nem_3 559 565 PF02991 0.320
LIG_LIR_Nem_3 569 575 PF02991 0.300
LIG_LIR_Nem_3 601 607 PF02991 0.557
LIG_LIR_Nem_3 720 726 PF02991 0.501
LIG_LIR_Nem_3 729 735 PF02991 0.494
LIG_LIR_Nem_3 794 799 PF02991 0.535
LIG_LIR_Nem_3 874 880 PF02991 0.564
LIG_LIR_Nem_3 969 975 PF02991 0.522
LIG_LIR_Nem_3 987 993 PF02991 0.444
LIG_NRBOX 938 944 PF00104 0.562
LIG_PCNA_PIPBox_1 210 219 PF02747 0.436
LIG_PCNA_PIPBox_1 584 593 PF02747 0.418
LIG_PCNA_yPIPBox_3 204 217 PF02747 0.492
LIG_PCNA_yPIPBox_3 973 986 PF02747 0.562
LIG_Pex14_1 640 644 PF04695 0.490
LIG_Pex14_1 877 881 PF04695 0.491
LIG_Pex14_2 571 575 PF04695 0.352
LIG_Pex14_2 732 736 PF04695 0.516
LIG_Pex14_2 911 915 PF04695 0.538
LIG_SH2_CRK 524 528 PF00017 0.327
LIG_SH2_NCK_1 524 528 PF00017 0.374
LIG_SH2_PTP2 946 949 PF00017 0.491
LIG_SH2_SRC 498 501 PF00017 0.456
LIG_SH2_STAP1 214 218 PF00017 0.405
LIG_SH2_STAP1 881 885 PF00017 0.491
LIG_SH2_STAT3 881 884 PF00017 0.562
LIG_SH2_STAT5 1044 1047 PF00017 0.647
LIG_SH2_STAT5 437 440 PF00017 0.423
LIG_SH2_STAT5 521 524 PF00017 0.325
LIG_SH2_STAT5 540 543 PF00017 0.323
LIG_SH2_STAT5 564 567 PF00017 0.313
LIG_SH2_STAT5 572 575 PF00017 0.315
LIG_SH2_STAT5 591 594 PF00017 0.481
LIG_SH2_STAT5 735 738 PF00017 0.555
LIG_SH2_STAT5 796 799 PF00017 0.502
LIG_SH2_STAT5 946 949 PF00017 0.471
LIG_SH2_STAT5 994 997 PF00017 0.487
LIG_SH2_STAT5 999 1002 PF00017 0.514
LIG_SH3_3 1004 1010 PF00018 0.626
LIG_SH3_3 115 121 PF00018 0.556
LIG_SH3_3 125 131 PF00018 0.522
LIG_SH3_3 135 141 PF00018 0.569
LIG_SH3_3 154 160 PF00018 0.629
LIG_SH3_3 190 196 PF00018 0.506
LIG_SH3_3 26 32 PF00018 0.597
LIG_SH3_3 369 375 PF00018 0.309
LIG_SH3_3 38 44 PF00018 0.513
LIG_SH3_3 55 61 PF00018 0.484
LIG_SH3_3 648 654 PF00018 0.596
LIG_SH3_3 697 703 PF00018 0.700
LIG_SH3_3 858 864 PF00018 0.494
LIG_SH3_3 925 931 PF00018 0.577
LIG_SH3_3 946 952 PF00018 0.562
LIG_SUMO_SIM_anti_2 655 662 PF11976 0.624
LIG_SUMO_SIM_par_1 244 249 PF11976 0.364
LIG_SUMO_SIM_par_1 655 662 PF11976 0.584
LIG_SUMO_SIM_par_1 685 693 PF11976 0.571
LIG_TRAF2_1 869 872 PF00917 0.567
LIG_TRAF2_1 960 963 PF00917 0.491
LIG_TYR_ITIM 522 527 PF00017 0.326
LIG_TYR_ITIM 944 949 PF00017 0.491
LIG_TYR_ITSM 792 799 PF00017 0.605
LIG_UBA3_1 15 23 PF00899 0.611
LIG_UBA3_1 278 284 PF00899 0.419
LIG_UBA3_1 618 627 PF00899 0.562
LIG_WRC_WIRS_1 228 233 PF05994 0.388
LIG_WRC_WIRS_1 727 732 PF05994 0.531
LIG_WW_1 951 954 PF00397 0.562
MOD_CDK_SPK_2 704 709 PF00069 0.676
MOD_CDK_SPxxK_3 957 964 PF00069 0.562
MOD_CK1_1 1005 1011 PF00069 0.594
MOD_CK1_1 242 248 PF00069 0.436
MOD_CK1_1 473 479 PF00069 0.385
MOD_CK1_1 487 493 PF00069 0.339
MOD_CK1_1 534 540 PF00069 0.390
MOD_CK1_1 689 695 PF00069 0.578
MOD_CK1_1 913 919 PF00069 0.503
MOD_CK2_1 1005 1011 PF00069 0.622
MOD_CK2_1 209 215 PF00069 0.442
MOD_CK2_1 312 318 PF00069 0.366
MOD_CK2_1 334 340 PF00069 0.421
MOD_CK2_1 473 479 PF00069 0.354
MOD_CK2_1 487 493 PF00069 0.353
MOD_CK2_1 866 872 PF00069 0.522
MOD_CK2_1 957 963 PF00069 0.483
MOD_CMANNOS 640 643 PF00535 0.309
MOD_Cter_Amidation 716 719 PF01082 0.352
MOD_GlcNHglycan 170 173 PF01048 0.785
MOD_GlcNHglycan 348 351 PF01048 0.633
MOD_GlcNHglycan 5 8 PF01048 0.775
MOD_GlcNHglycan 558 561 PF01048 0.553
MOD_GlcNHglycan 738 741 PF01048 0.515
MOD_GlcNHglycan 760 763 PF01048 0.580
MOD_GlcNHglycan 9 12 PF01048 0.753
MOD_GlcNHglycan 912 915 PF01048 0.339
MOD_GSK3_1 1002 1009 PF00069 0.576
MOD_GSK3_1 223 230 PF00069 0.408
MOD_GSK3_1 3 10 PF00069 0.555
MOD_GSK3_1 436 443 PF00069 0.363
MOD_GSK3_1 462 469 PF00069 0.377
MOD_GSK3_1 480 487 PF00069 0.315
MOD_GSK3_1 50 57 PF00069 0.617
MOD_GSK3_1 513 520 PF00069 0.373
MOD_GSK3_1 522 529 PF00069 0.300
MOD_GSK3_1 530 537 PF00069 0.348
MOD_GSK3_1 573 580 PF00069 0.394
MOD_GSK3_1 617 624 PF00069 0.516
MOD_GSK3_1 643 650 PF00069 0.583
MOD_GSK3_1 682 689 PF00069 0.639
MOD_GSK3_1 791 798 PF00069 0.612
MOD_GSK3_1 819 826 PF00069 0.518
MOD_GSK3_1 827 834 PF00069 0.488
MOD_GSK3_1 866 873 PF00069 0.567
MOD_LATS_1 515 521 PF00433 0.409
MOD_LATS_1 716 722 PF00433 0.538
MOD_N-GLC_1 556 561 PF02516 0.562
MOD_N-GLC_1 67 72 PF02516 0.837
MOD_N-GLC_1 704 709 PF02516 0.496
MOD_N-GLC_1 784 789 PF02516 0.502
MOD_N-GLC_1 895 900 PF02516 0.362
MOD_N-GLC_2 378 380 PF02516 0.569
MOD_NEK2_1 168 173 PF00069 0.589
MOD_NEK2_1 19 24 PF00069 0.573
MOD_NEK2_1 223 228 PF00069 0.409
MOD_NEK2_1 269 274 PF00069 0.341
MOD_NEK2_1 345 350 PF00069 0.421
MOD_NEK2_1 456 461 PF00069 0.359
MOD_NEK2_1 513 518 PF00069 0.369
MOD_NEK2_1 573 578 PF00069 0.418
MOD_NEK2_1 686 691 PF00069 0.578
MOD_NEK2_1 777 782 PF00069 0.787
MOD_NEK2_1 852 857 PF00069 0.481
MOD_NEK2_1 895 900 PF00069 0.552
MOD_NEK2_1 910 915 PF00069 0.341
MOD_NEK2_1 967 972 PF00069 0.548
MOD_NEK2_1 986 991 PF00069 0.363
MOD_NEK2_2 209 214 PF00069 0.459
MOD_PIKK_1 334 340 PF00454 0.463
MOD_PIKK_1 471 477 PF00454 0.419
MOD_PIKK_1 585 591 PF00454 0.352
MOD_PIKK_1 617 623 PF00454 0.507
MOD_PIKK_1 977 983 PF00454 0.562
MOD_PK_1 1002 1008 PF00069 0.608
MOD_PKA_1 224 230 PF00069 0.436
MOD_PKA_1 718 724 PF00069 0.512
MOD_PKA_2 223 229 PF00069 0.428
MOD_PKA_2 242 248 PF00069 0.411
MOD_PKA_2 813 819 PF00069 0.542
MOD_Plk_1 534 540 PF00069 0.431
MOD_Plk_1 682 688 PF00069 0.590
MOD_Plk_1 895 901 PF00069 0.562
MOD_Plk_1 916 922 PF00069 0.568
MOD_Plk_1 986 992 PF00069 0.562
MOD_Plk_2-3 670 676 PF00069 0.670
MOD_Plk_2-3 866 872 PF00069 0.424
MOD_Plk_4 1002 1008 PF00069 0.539
MOD_Plk_4 130 136 PF00069 0.611
MOD_Plk_4 209 215 PF00069 0.418
MOD_Plk_4 227 233 PF00069 0.266
MOD_Plk_4 277 283 PF00069 0.393
MOD_Plk_4 473 479 PF00069 0.421
MOD_Plk_4 534 540 PF00069 0.394
MOD_Plk_4 566 572 PF00069 0.291
MOD_Plk_4 643 649 PF00069 0.561
MOD_Plk_4 682 688 PF00069 0.610
MOD_Plk_4 690 696 PF00069 0.592
MOD_Plk_4 718 724 PF00069 0.503
MOD_ProDKin_1 1006 1012 PF00069 0.628
MOD_ProDKin_1 312 318 PF00069 0.452
MOD_ProDKin_1 480 486 PF00069 0.365
MOD_ProDKin_1 522 528 PF00069 0.362
MOD_ProDKin_1 54 60 PF00069 0.612
MOD_ProDKin_1 665 671 PF00069 0.654
MOD_ProDKin_1 67 73 PF00069 0.543
MOD_ProDKin_1 704 710 PF00069 0.649
MOD_ProDKin_1 924 930 PF00069 0.545
MOD_ProDKin_1 957 963 PF00069 0.562
MOD_SUMO_rev_2 406 411 PF00179 0.390
MOD_SUMO_rev_2 862 869 PF00179 0.424
MOD_SUMO_rev_2 963 972 PF00179 0.562
TRG_DiLeu_BaEn_1 603 608 PF01217 0.562
TRG_DiLeu_BaEn_1 963 968 PF01217 0.562
TRG_DiLeu_BaLyEn_6 218 223 PF01217 0.426
TRG_DiLeu_BaLyEn_6 653 658 PF01217 0.631
TRG_DiLeu_BaLyEn_6 925 930 PF01217 0.577
TRG_DiLeu_LyEn_5 963 968 PF01217 0.554
TRG_ENDOCYTIC_2 1044 1047 PF00928 0.641
TRG_ENDOCYTIC_2 214 217 PF00928 0.354
TRG_ENDOCYTIC_2 405 408 PF00928 0.332
TRG_ENDOCYTIC_2 478 481 PF00928 0.346
TRG_ENDOCYTIC_2 524 527 PF00928 0.327
TRG_ENDOCYTIC_2 572 575 PF00928 0.324
TRG_ENDOCYTIC_2 604 607 PF00928 0.520
TRG_ENDOCYTIC_2 796 799 PF00928 0.494
TRG_ENDOCYTIC_2 923 926 PF00928 0.542
TRG_ENDOCYTIC_2 946 949 PF00928 0.480
TRG_ER_diArg_1 95 98 PF00400 0.625
TRG_ER_diArg_1 964 967 PF00400 0.555
TRG_ER_diArg_1 982 984 PF00400 0.581
TRG_NES_CRM1_1 406 420 PF08389 0.437
TRG_Pf-PMV_PEXEL_1 361 366 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 900 904 PF00026 0.276

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9J9 Leptomonas seymouri 75% 77%
A0A1X0NZ14 Trypanosomatidae 47% 86%
A0A1X0P1K6 Trypanosomatidae 23% 100%
A0A3S7WWH1 Leishmania donovani 100% 76%
A0A422N7G4 Trypanosoma rangeli 43% 100%
A4HBS9 Leishmania braziliensis 92% 100%
D0A1F1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 86%
E9AV50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q38C92 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 46% 86%
Q4QCD1 Leishmania major 97% 100%
V5AYD9 Trypanosoma cruzi 43% 86%
V5BX20 Trypanosoma cruzi 22% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS