Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ79_LEIIN

TriTrypDb:

LINF_210013600

Length:

782

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HZ79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.769
CLV_C14_Caspase3-7	442	446	PF00656	0.656
CLV_C14_Caspase3-7	491	495	PF00656	0.695
CLV_C14_Caspase3-7	731	735	PF00656	0.538
CLV_NRD_NRD_1	236	238	PF00675	0.519
CLV_NRD_NRD_1	277	279	PF00675	0.594
CLV_NRD_NRD_1	374	376	PF00675	0.520
CLV_NRD_NRD_1	380	382	PF00675	0.474
CLV_NRD_NRD_1	503	505	PF00675	0.708
CLV_NRD_NRD_1	513	515	PF00675	0.646
CLV_NRD_NRD_1	517	519	PF00675	0.660
CLV_NRD_NRD_1	563	565	PF00675	0.554
CLV_NRD_NRD_1	567	569	PF00675	0.548
CLV_NRD_NRD_1	625	627	PF00675	0.666
CLV_NRD_NRD_1	96	98	PF00675	0.679
CLV_PCSK_FUR_1	501	505	PF00082	0.733
CLV_PCSK_FUR_1	511	515	PF00082	0.685
CLV_PCSK_FUR_1	94	98	PF00082	0.705
CLV_PCSK_KEX2_1	236	238	PF00082	0.519
CLV_PCSK_KEX2_1	277	279	PF00082	0.594
CLV_PCSK_KEX2_1	374	376	PF00082	0.520
CLV_PCSK_KEX2_1	380	382	PF00082	0.474
CLV_PCSK_KEX2_1	503	505	PF00082	0.723
CLV_PCSK_KEX2_1	513	515	PF00082	0.636
CLV_PCSK_KEX2_1	517	519	PF00082	0.642
CLV_PCSK_KEX2_1	563	565	PF00082	0.552
CLV_PCSK_KEX2_1	567	569	PF00082	0.551
CLV_PCSK_KEX2_1	625	627	PF00082	0.666
CLV_PCSK_KEX2_1	94	96	PF00082	0.659
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.734
CLV_PCSK_PC7_1	513	519	PF00082	0.687
CLV_PCSK_PC7_1	563	569	PF00082	0.659
CLV_PCSK_SKI1_1	215	219	PF00082	0.662
CLV_PCSK_SKI1_1	237	241	PF00082	0.500
CLV_PCSK_SKI1_1	278	282	PF00082	0.513
CLV_PCSK_SKI1_1	380	384	PF00082	0.530
CLV_PCSK_SKI1_1	563	567	PF00082	0.609
CLV_PCSK_SKI1_1	582	586	PF00082	0.719
CLV_PCSK_SKI1_1	764	768	PF00082	0.686
CLV_PCSK_SKI1_1	77	81	PF00082	0.512
DEG_APCC_DBOX_1	190	198	PF00400	0.620
DEG_APCC_DBOX_1	71	79	PF00400	0.549
DEG_APCC_DBOX_1	719	727	PF00400	0.663
DEG_ODPH_VHL_1	571	583	PF01847	0.523
DEG_SPOP_SBC_1	119	123	PF00917	0.695
DEG_SPOP_SBC_1	642	646	PF00917	0.693
DEG_SPOP_SBC_1	713	717	PF00917	0.680
DOC_CKS1_1	242	247	PF01111	0.514
DOC_CKS1_1	434	439	PF01111	0.473
DOC_CKS1_1	765	770	PF01111	0.678
DOC_CYCLIN_RxL_1	374	386	PF00134	0.532
DOC_CYCLIN_RxL_1	560	569	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.652
DOC_MAPK_gen_1	213	220	PF00069	0.589
DOC_MAPK_gen_1	380	387	PF00069	0.582
DOC_MAPK_gen_1	513	523	PF00069	0.703
DOC_MAPK_MEF2A_6	380	387	PF00069	0.533
DOC_MAPK_NFAT4_5	380	388	PF00069	0.541
DOC_PP1_RVXF_1	141	147	PF00149	0.615
DOC_PP1_RVXF_1	75	81	PF00149	0.509
DOC_PP2B_LxvP_1	360	363	PF13499	0.664
DOC_PP2B_LxvP_1	737	740	PF13499	0.702
DOC_USP7_MATH_1	149	153	PF00917	0.643
DOC_USP7_MATH_1	348	352	PF00917	0.713
DOC_USP7_MATH_1	57	61	PF00917	0.624
DOC_USP7_MATH_1	577	581	PF00917	0.601
DOC_USP7_MATH_1	642	646	PF00917	0.717
DOC_WW_Pin1_4	166	171	PF00397	0.641
DOC_WW_Pin1_4	172	177	PF00397	0.630
DOC_WW_Pin1_4	241	246	PF00397	0.511
DOC_WW_Pin1_4	298	303	PF00397	0.718
DOC_WW_Pin1_4	31	36	PF00397	0.644
DOC_WW_Pin1_4	405	410	PF00397	0.652
DOC_WW_Pin1_4	433	438	PF00397	0.475
DOC_WW_Pin1_4	53	58	PF00397	0.497
DOC_WW_Pin1_4	630	635	PF00397	0.719
DOC_WW_Pin1_4	764	769	PF00397	0.674
LIG_14-3-3_CanoR_1	213	220	PF00244	0.634
LIG_14-3-3_CanoR_1	303	313	PF00244	0.669
LIG_14-3-3_CanoR_1	354	363	PF00244	0.666
LIG_14-3-3_CanoR_1	439	447	PF00244	0.658
LIG_14-3-3_CanoR_1	555	565	PF00244	0.584
LIG_14-3-3_CanoR_1	567	573	PF00244	0.679
LIG_14-3-3_CanoR_1	602	608	PF00244	0.569
LIG_14-3-3_CanoR_1	625	635	PF00244	0.717
LIG_14-3-3_CanoR_1	97	107	PF00244	0.667
LIG_Actin_WH2_2	551	569	PF00022	0.662
LIG_Actin_WH2_2	58	74	PF00022	0.445
LIG_Actin_WH2_2	750	766	PF00022	0.616
LIG_BIR_III_2	247	251	PF00653	0.523
LIG_BIR_III_4	125	129	PF00653	0.677
LIG_BRCT_BRCA1_1	579	583	PF00533	0.721
LIG_Clathr_ClatBox_1	471	475	PF01394	0.654
LIG_CSL_BTD_1	322	325	PF09270	0.537
LIG_CtBP_PxDLS_1	672	676	PF00389	0.746
LIG_EVH1_2	324	328	PF00568	0.544
LIG_FHA_1	113	119	PF00498	0.722
LIG_FHA_1	331	337	PF00498	0.601
LIG_FHA_1	368	374	PF00498	0.505
LIG_FHA_1	425	431	PF00498	0.629
LIG_FHA_1	650	656	PF00498	0.773
LIG_FHA_1	66	72	PF00498	0.608
LIG_FHA_1	772	778	PF00498	0.700
LIG_FHA_2	242	248	PF00498	0.549
LIG_FHA_2	306	312	PF00498	0.633
LIG_FHA_2	440	446	PF00498	0.658
LIG_FHA_2	555	561	PF00498	0.665
LIG_FHA_2	652	658	PF00498	0.685
LIG_FHA_2	86	92	PF00498	0.576
LIG_LIR_Gen_1	113	120	PF02991	0.671
LIG_LIR_Gen_1	221	231	PF02991	0.595
LIG_LIR_Gen_1	271	280	PF02991	0.508
LIG_LIR_Gen_1	386	394	PF02991	0.637
LIG_LIR_Gen_1	46	54	PF02991	0.571
LIG_LIR_Nem_3	113	119	PF02991	0.672
LIG_LIR_Nem_3	221	227	PF02991	0.566
LIG_LIR_Nem_3	261	267	PF02991	0.543
LIG_LIR_Nem_3	271	275	PF02991	0.329
LIG_LIR_Nem_3	321	326	PF02991	0.641
LIG_LIR_Nem_3	386	390	PF02991	0.631
LIG_LIR_Nem_3	46	51	PF02991	0.503
LIG_LIR_Nem_3	559	565	PF02991	0.611
LIG_LIR_Nem_3	690	696	PF02991	0.642
LIG_NRBOX	580	586	PF00104	0.701
LIG_OCRL_FandH_1	386	398	PF00620	0.560
LIG_PCNA_PIPBox_1	751	760	PF02747	0.449
LIG_PCNA_yPIPBox_3	251	265	PF02747	0.490
LIG_Pex14_1	76	80	PF04695	0.451
LIG_Pex14_2	14	18	PF04695	0.551
LIG_Pex14_2	80	84	PF04695	0.466
LIG_PTAP_UEV_1	362	367	PF05743	0.512
LIG_PTB_Apo_2	78	85	PF02174	0.461
LIG_REV1ctd_RIR_1	11	21	PF16727	0.646
LIG_RPA_C_Fungi	272	284	PF08784	0.527
LIG_RPA_C_Fungi	370	382	PF08784	0.633
LIG_SH2_CRK	264	268	PF00017	0.527
LIG_SH2_CRK	279	283	PF00017	0.469
LIG_SH2_CRK	693	697	PF00017	0.684
LIG_SH2_NCK_1	116	120	PF00017	0.671
LIG_SH2_NCK_1	423	427	PF00017	0.637
LIG_SH2_PTP2	272	275	PF00017	0.509
LIG_SH2_SRC	423	426	PF00017	0.597
LIG_SH2_SRC	460	463	PF00017	0.631
LIG_SH2_STAP1	116	120	PF00017	0.671
LIG_SH2_STAP1	279	283	PF00017	0.545
LIG_SH2_STAP1	605	609	PF00017	0.524
LIG_SH2_STAT3	605	608	PF00017	0.628
LIG_SH2_STAT3	620	623	PF00017	0.661
LIG_SH2_STAT5	224	227	PF00017	0.505
LIG_SH2_STAT5	241	244	PF00017	0.506
LIG_SH2_STAT5	272	275	PF00017	0.509
LIG_SH2_STAT5	48	51	PF00017	0.582
LIG_SH2_STAT5	749	752	PF00017	0.623
LIG_SH2_STAT5	85	88	PF00017	0.506
LIG_SH3_3	158	164	PF00018	0.725
LIG_SH3_3	29	35	PF00018	0.704
LIG_SH3_3	360	366	PF00018	0.687
LIG_SH3_3	665	671	PF00018	0.690
LIG_SH3_3	705	711	PF00018	0.623
LIG_SH3_4	772	779	PF00018	0.626
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.702
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.472
LIG_SUMO_SIM_anti_2	614	619	PF11976	0.629
LIG_SUMO_SIM_par_1	265	271	PF11976	0.516
LIG_SUMO_SIM_par_1	60	66	PF11976	0.631
LIG_SUMO_SIM_par_1	671	677	PF11976	0.741
LIG_TRAF2_1	152	155	PF00917	0.631
LIG_TRAF2_1	249	252	PF00917	0.476
LIG_TRAF2_1	466	469	PF00917	0.652
LIG_TRAF2_1	728	731	PF00917	0.603
LIG_UBA3_1	257	265	PF00899	0.572
LIG_UBA3_1	753	760	PF00899	0.497
LIG_WRC_WIRS_1	38	43	PF05994	0.587
LIG_WRC_WIRS_1	48	53	PF05994	0.512
MOD_CDC14_SPxK_1	633	636	PF00782	0.755
MOD_CDK_SPK_2	298	303	PF00069	0.655
MOD_CDK_SPxK_1	433	439	PF00069	0.473
MOD_CDK_SPxK_1	630	636	PF00069	0.743
MOD_CK1_1	121	127	PF00069	0.642
MOD_CK1_1	295	301	PF00069	0.684
MOD_CK1_1	318	324	PF00069	0.682
MOD_CK1_1	367	373	PF00069	0.611
MOD_CK1_1	463	469	PF00069	0.688
MOD_CK1_1	538	544	PF00069	0.625
MOD_CK1_1	715	721	PF00069	0.608
MOD_CK2_1	121	127	PF00069	0.702
MOD_CK2_1	149	155	PF00069	0.602
MOD_CK2_1	246	252	PF00069	0.489
MOD_CK2_1	30	36	PF00069	0.685
MOD_CK2_1	305	311	PF00069	0.673
MOD_CK2_1	324	330	PF00069	0.371
MOD_CK2_1	463	469	PF00069	0.702
MOD_CK2_1	490	496	PF00069	0.786
MOD_CK2_1	523	529	PF00069	0.773
MOD_CK2_1	554	560	PF00069	0.582
MOD_CK2_1	98	104	PF00069	0.633
MOD_Cter_Amidation	501	504	PF01082	0.736
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.498
MOD_GlcNHglycan	172	175	PF01048	0.757
MOD_GlcNHglycan	176	179	PF01048	0.686
MOD_GlcNHglycan	294	297	PF01048	0.710
MOD_GlcNHglycan	320	323	PF01048	0.683
MOD_GlcNHglycan	350	353	PF01048	0.709
MOD_GlcNHglycan	356	359	PF01048	0.735
MOD_GlcNHglycan	366	369	PF01048	0.682
MOD_GlcNHglycan	465	468	PF01048	0.662
MOD_GlcNHglycan	525	528	PF01048	0.757
MOD_GlcNHglycan	529	534	PF01048	0.727
MOD_GlcNHglycan	537	540	PF01048	0.598
MOD_GlcNHglycan	59	62	PF01048	0.627
MOD_GlcNHglycan	699	702	PF01048	0.666
MOD_GlcNHglycan	717	720	PF01048	0.430
MOD_GSK3_1	166	173	PF00069	0.646
MOD_GSK3_1	185	192	PF00069	0.426
MOD_GSK3_1	27	34	PF00069	0.774
MOD_GSK3_1	53	60	PF00069	0.603
MOD_GSK3_1	534	541	PF00069	0.632
MOD_GSK3_1	554	561	PF00069	0.552
MOD_GSK3_1	626	633	PF00069	0.656
MOD_GSK3_1	651	658	PF00069	0.738
MOD_N-GLC_1	330	335	PF02516	0.655
MOD_NEK2_1	258	263	PF00069	0.564
MOD_NEK2_1	292	297	PF00069	0.713
MOD_NEK2_1	383	388	PF00069	0.590
MOD_NEK2_1	535	540	PF00069	0.637
MOD_NEK2_1	558	563	PF00069	0.583
MOD_NEK2_1	566	571	PF00069	0.655
MOD_NEK2_2	577	582	PF00069	0.603
MOD_PIKK_1	258	264	PF00454	0.603
MOD_PIKK_1	521	527	PF00454	0.784
MOD_PIKK_1	619	625	PF00454	0.664
MOD_PIKK_1	772	778	PF00454	0.767
MOD_PKA_2	198	204	PF00069	0.697
MOD_PKA_2	554	560	PF00069	0.525
MOD_PKA_2	566	572	PF00069	0.637
MOD_PKA_2	603	609	PF00069	0.590
MOD_Plk_1	112	118	PF00069	0.752
MOD_Plk_1	132	138	PF00069	0.732
MOD_Plk_1	330	336	PF00069	0.595
MOD_Plk_1	460	466	PF00069	0.623
MOD_Plk_1	477	483	PF00069	0.602
MOD_Plk_1	495	501	PF00069	0.667
MOD_Plk_1	65	71	PF00069	0.559
MOD_Plk_2-3	651	657	PF00069	0.759
MOD_Plk_4	185	191	PF00069	0.684
MOD_Plk_4	37	43	PF00069	0.562
MOD_Plk_4	399	405	PF00069	0.680
MOD_Plk_4	449	455	PF00069	0.512
MOD_Plk_4	47	53	PF00069	0.524
MOD_Plk_4	477	483	PF00069	0.599
MOD_Plk_4	85	91	PF00069	0.586
MOD_ProDKin_1	166	172	PF00069	0.643
MOD_ProDKin_1	241	247	PF00069	0.515
MOD_ProDKin_1	298	304	PF00069	0.715
MOD_ProDKin_1	31	37	PF00069	0.635
MOD_ProDKin_1	405	411	PF00069	0.650
MOD_ProDKin_1	433	439	PF00069	0.473
MOD_ProDKin_1	53	59	PF00069	0.491
MOD_ProDKin_1	630	636	PF00069	0.723
MOD_ProDKin_1	764	770	PF00069	0.678
MOD_SUMO_rev_2	124	134	PF00179	0.787
MOD_SUMO_rev_2	651	661	PF00179	0.648
MOD_SUMO_rev_2	724	733	PF00179	0.493
TRG_DiLeu_BaEn_1	399	404	PF01217	0.704
TRG_DiLeu_BaEn_1	66	71	PF01217	0.551
TRG_DiLeu_BaEn_2	578	584	PF01217	0.671
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.597
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.489
TRG_DiLeu_BaLyEn_6	561	566	PF01217	0.630
TRG_ENDOCYTIC_2	116	119	PF00928	0.673
TRG_ENDOCYTIC_2	224	227	PF00928	0.505
TRG_ENDOCYTIC_2	264	267	PF00928	0.524
TRG_ENDOCYTIC_2	272	275	PF00928	0.410
TRG_ENDOCYTIC_2	279	282	PF00928	0.448
TRG_ENDOCYTIC_2	423	426	PF00928	0.504
TRG_ENDOCYTIC_2	48	51	PF00928	0.582
TRG_ENDOCYTIC_2	693	696	PF00928	0.677
TRG_ER_diArg_1	235	237	PF00400	0.495
TRG_ER_diArg_1	277	279	PF00400	0.594
TRG_ER_diArg_1	373	375	PF00400	0.520
TRG_ER_diArg_1	379	381	PF00400	0.474
TRG_ER_diArg_1	512	514	PF00400	0.690
TRG_ER_diArg_1	516	518	PF00400	0.702
TRG_ER_diArg_1	562	564	PF00400	0.537
TRG_ER_diArg_1	566	568	PF00400	0.552
TRG_ER_diArg_1	94	97	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	582	586	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ90	Leptomonas seymouri	57%	72%
A0A3R7K7W4	Trypanosoma rangeli	30%	83%
A0A3S7WWF2	Leishmania donovani	99%	100%
A4HBS5	Leishmania braziliensis	80%	100%
D0A1F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
E9AV46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QCD5	Leishmania major	93%	100%
V5DEN0	Trypanosoma cruzi	30%	83%