Likely part of the mitochondrial MICOS complex, based on homology.. It is possible that this protein only has a single TM segment as the first can also be a transit signal.. Localization: Mitochondrial inner membrane (by homology)
Uncharacterized Protein, Uncharacterized
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 9 |
| NetGPI | no | yes: 0, no: 9 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0032991 | protein-containing complex | 1 | 10 |
| GO:0061617 | MICOS complex | 4 | 10 |
| GO:0098796 | membrane protein complex | 2 | 10 |
| GO:0098798 | mitochondrial protein-containing complex | 2 | 10 |
| GO:0098800 | inner mitochondrial membrane protein complex | 3 | 10 |
| GO:0005739 | mitochondrion | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 1 |
Related structures:
AlphaFold database: A4HZ74
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_PCSK_SKI1_1 | 27 | 31 | PF00082 | 0.524 |
| CLV_PCSK_SKI1_1 | 88 | 92 | PF00082 | 0.248 |
| DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.421 |
| DEG_SPOP_SBC_1 | 108 | 112 | PF00917 | 0.478 |
| DOC_USP7_MATH_1 | 108 | 112 | PF00917 | 0.541 |
| DOC_USP7_MATH_1 | 3 | 7 | PF00917 | 0.417 |
| DOC_USP7_UBL2_3 | 13 | 17 | PF12436 | 0.537 |
| LIG_BRCT_BRCA1_1 | 47 | 51 | PF00533 | 0.269 |
| LIG_FHA_1 | 85 | 91 | PF00498 | 0.292 |
| LIG_FHA_2 | 21 | 27 | PF00498 | 0.496 |
| LIG_LIR_Gen_1 | 33 | 44 | PF02991 | 0.282 |
| LIG_LIR_Nem_3 | 33 | 39 | PF02991 | 0.251 |
| LIG_SH2_STAT5 | 38 | 41 | PF00017 | 0.248 |
| LIG_SH2_STAT5 | 84 | 87 | PF00017 | 0.248 |
| LIG_SH2_STAT5 | 89 | 92 | PF00017 | 0.421 |
| LIG_SH3_3 | 102 | 108 | PF00018 | 0.499 |
| MOD_CK1_1 | 37 | 43 | PF00069 | 0.482 |
| MOD_CK1_1 | 6 | 12 | PF00069 | 0.510 |
| MOD_CK1_1 | 64 | 70 | PF00069 | 0.324 |
| MOD_GlcNHglycan | 101 | 104 | PF01048 | 0.648 |
| MOD_GSK3_1 | 30 | 37 | PF00069 | 0.371 |
| MOD_GSK3_1 | 69 | 76 | PF00069 | 0.330 |
| MOD_GSK3_1 | 80 | 87 | PF00069 | 0.264 |
| MOD_NEK2_1 | 19 | 24 | PF00069 | 0.634 |
| MOD_NEK2_1 | 30 | 35 | PF00069 | 0.356 |
| MOD_PIKK_1 | 30 | 36 | PF00454 | 0.437 |
| MOD_Plk_1 | 20 | 26 | PF00069 | 0.450 |
| MOD_Plk_1 | 3 | 9 | PF00069 | 0.418 |
| MOD_Plk_1 | 40 | 46 | PF00069 | 0.155 |
| MOD_Plk_4 | 20 | 26 | PF00069 | 0.607 |
| MOD_Plk_4 | 55 | 61 | PF00069 | 0.285 |
| MOD_Plk_4 | 80 | 86 | PF00069 | 0.248 |
| MOD_Plk_4 | 96 | 102 | PF00069 | 0.458 |
| MOD_SUMO_rev_2 | 83 | 90 | PF00179 | 0.282 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0S4IQE6 | Bodo saltans | 55% | 100% |
| A0A1X0NZ69 | Trypanosomatidae | 64% | 94% |
| A0A3Q8IB36 | Leishmania donovani | 100% | 100% |
| A0A422NHB5 | Trypanosoma rangeli | 59% | 97% |
| A4HBS0 | Leishmania braziliensis | 95% | 100% |
| D0A1G4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 67% | 98% |
| E9AV41 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 98% | 100% |
| Q4QCE0 | Leishmania major | 98% | 100% |