PUA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HZ72_LEIIN

TriTrypDb:

LINF_210012900

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HZ72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ72

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.432
CLV_NRD_NRD_1	153	155	PF00675	0.549
CLV_NRD_NRD_1	174	176	PF00675	0.346
CLV_NRD_NRD_1	187	189	PF00675	0.375
CLV_NRD_NRD_1	307	309	PF00675	0.396
CLV_NRD_NRD_1	318	320	PF00675	0.361
CLV_NRD_NRD_1	371	373	PF00675	0.553
CLV_NRD_NRD_1	377	379	PF00675	0.567
CLV_PCSK_KEX2_1	187	189	PF00082	0.457
CLV_PCSK_KEX2_1	318	320	PF00082	0.408
CLV_PCSK_KEX2_1	362	364	PF00082	0.577
CLV_PCSK_KEX2_1	376	378	PF00082	0.573
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.577
CLV_PCSK_PC7_1	372	378	PF00082	0.402
CLV_PCSK_SKI1_1	154	158	PF00082	0.424
CLV_PCSK_SKI1_1	212	216	PF00082	0.491
CLV_PCSK_SKI1_1	362	366	PF00082	0.588
CLV_PCSK_SKI1_1	93	97	PF00082	0.285
DEG_APCC_DBOX_1	199	207	PF00400	0.332
DOC_CDC14_PxL_1	107	115	PF14671	0.324
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.378
DOC_MAPK_gen_1	175	182	PF00069	0.409
DOC_MAPK_gen_1	223	232	PF00069	0.454
DOC_MAPK_gen_1	296	306	PF00069	0.400
DOC_MAPK_gen_1	372	381	PF00069	0.417
DOC_MAPK_gen_1	69	78	PF00069	0.425
DOC_MAPK_MEF2A_6	93	102	PF00069	0.357
DOC_PP2B_LxvP_1	108	111	PF13499	0.391
DOC_PP2B_LxvP_1	195	198	PF13499	0.468
DOC_PP4_FxxP_1	207	210	PF00568	0.385
DOC_PP4_FxxP_1	53	56	PF00568	0.411
DOC_USP7_MATH_1	160	164	PF00917	0.512
DOC_USP7_MATH_1	317	321	PF00917	0.358
DOC_USP7_MATH_1	56	60	PF00917	0.545
DOC_USP7_UBL2_3	212	216	PF12436	0.454
DOC_USP7_UBL2_3	309	313	PF12436	0.323
DOC_USP7_UBL2_3	357	361	PF12436	0.601
DOC_USP7_UBL2_3	362	366	PF12436	0.588
DOC_WW_Pin1_4	233	238	PF00397	0.570
DOC_WW_Pin1_4	76	81	PF00397	0.330
LIG_14-3-3_CanoR_1	296	302	PF00244	0.462
LIG_BRCT_BRCA1_1	78	82	PF00533	0.318
LIG_CaM_IQ_9	3	19	PF13499	0.399
LIG_FHA_1	213	219	PF00498	0.313
LIG_FHA_2	63	69	PF00498	0.489
LIG_LIR_Apic_2	51	56	PF02991	0.420
LIG_LIR_Gen_1	168	173	PF02991	0.346
LIG_LIR_Nem_3	168	172	PF02991	0.341
LIG_LIR_Nem_3	181	186	PF02991	0.327
LIG_LIR_Nem_3	75	81	PF02991	0.400
LIG_PDZ_Class_2	376	381	PF00595	0.430
LIG_Pex14_2	78	82	PF04695	0.332
LIG_SH2_CRK	227	231	PF00017	0.385
LIG_SH2_GRB2like	227	230	PF00017	0.401
LIG_SH2_NCK_1	227	231	PF00017	0.385
LIG_SH2_NCK_1	257	261	PF00017	0.317
LIG_SH2_STAP1	213	217	PF00017	0.391
LIG_SH2_STAT5	251	254	PF00017	0.342
LIG_SH2_STAT5	264	267	PF00017	0.329
LIG_SH2_STAT5	329	332	PF00017	0.522
LIG_SH2_STAT5	5	8	PF00017	0.438
LIG_SH3_3	301	307	PF00018	0.351
LIG_SUMO_SIM_par_1	177	184	PF11976	0.364
LIG_UBA3_1	326	335	PF00899	0.561
LIG_WRC_WIRS_1	50	55	PF05994	0.514
MOD_CK1_1	233	239	PF00069	0.527
MOD_CK2_1	62	68	PF00069	0.431
MOD_GlcNHglycan	232	235	PF01048	0.519
MOD_GlcNHglycan	258	261	PF01048	0.310
MOD_GlcNHglycan	266	269	PF01048	0.340
MOD_GlcNHglycan	282	285	PF01048	0.375
MOD_GlcNHglycan	315	318	PF01048	0.484
MOD_GSK3_1	150	157	PF00069	0.433
MOD_GSK3_1	161	168	PF00069	0.337
MOD_GSK3_1	208	215	PF00069	0.380
MOD_GSK3_1	264	271	PF00069	0.371
MOD_GSK3_1	313	320	PF00069	0.469
MOD_N-GLC_1	160	165	PF02516	0.463
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	150	155	PF00069	0.426
MOD_NEK2_1	272	277	PF00069	0.397
MOD_PIKK_1	355	361	PF00454	0.518
MOD_PKA_1	154	160	PF00069	0.503
MOD_PKA_2	317	323	PF00069	0.470
MOD_PKA_2	7	13	PF00069	0.452
MOD_PKB_1	223	231	PF00069	0.436
MOD_Plk_2-3	62	68	PF00069	0.440
MOD_Plk_4	1	7	PF00069	0.517
MOD_Plk_4	49	55	PF00069	0.478
MOD_Plk_4	82	88	PF00069	0.416
MOD_ProDKin_1	233	239	PF00069	0.557
MOD_ProDKin_1	76	82	PF00069	0.326
MOD_SUMO_for_1	364	367	PF00179	0.584
TRG_DiLeu_BaEn_1	248	253	PF01217	0.364
TRG_ENDOCYTIC_2	227	230	PF00928	0.414
TRG_ER_diArg_1	186	188	PF00400	0.454
TRG_ER_diArg_1	222	225	PF00400	0.299
TRG_ER_diArg_1	376	378	PF00400	0.565
TRG_NLS_Bipartite_1	298	312	PF00514	0.337
TRG_NLS_MonoExtC_3	360	365	PF00514	0.590
TRG_NLS_MonoExtN_4	307	312	PF00514	0.413
TRG_NLS_MonoExtN_4	361	366	PF00514	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U9	Leptomonas seymouri	57%	77%
A0A0S4JCB2	Bodo saltans	43%	99%
A0A1X0NY04	Trypanosomatidae	45%	100%
A0A3Q8IAU3	Leishmania donovani	99%	100%
A0A3R7KMU3	Trypanosoma rangeli	48%	100%
A4HBR8	Leishmania braziliensis	83%	100%
D0A1G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AV39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCE2	Leishmania major	92%	100%
V5BIF1	Trypanosoma cruzi	46%	100%