LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HZ71_LEIIN
TriTrypDb:
LINF_210012800 *
Length:
362

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HZ71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HZ71

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 236 238 PF00675 0.430
CLV_NRD_NRD_1 243 245 PF00675 0.429
CLV_NRD_NRD_1 280 282 PF00675 0.509
CLV_PCSK_FUR_1 234 238 PF00082 0.430
CLV_PCSK_KEX2_1 236 238 PF00082 0.430
CLV_PCSK_KEX2_1 280 282 PF00082 0.474
CLV_PCSK_SKI1_1 170 174 PF00082 0.384
CLV_PCSK_SKI1_1 197 201 PF00082 0.396
DEG_APCC_DBOX_1 22 30 PF00400 0.362
DEG_Nend_UBRbox_3 1 3 PF02207 0.437
DEG_SCF_FBW7_2 323 330 PF00400 0.568
DEG_SPOP_SBC_1 352 356 PF00917 0.573
DOC_CKS1_1 314 319 PF01111 0.555
DOC_CKS1_1 324 329 PF01111 0.500
DOC_CYCLIN_yCln2_LP_2 28 34 PF00134 0.369
DOC_MAPK_gen_1 150 158 PF00069 0.482
DOC_MAPK_MEF2A_6 178 187 PF00069 0.433
DOC_MAPK_MEF2A_6 221 229 PF00069 0.439
DOC_MAPK_MEF2A_6 23 32 PF00069 0.363
DOC_MAPK_MEF2A_6 40 47 PF00069 0.415
DOC_MAPK_NFAT4_5 23 31 PF00069 0.363
DOC_PP1_RVXF_1 150 156 PF00149 0.502
DOC_PP1_RVXF_1 168 174 PF00149 0.459
DOC_PP1_RVXF_1 195 202 PF00149 0.319
DOC_PP2B_LxvP_1 183 186 PF13499 0.518
DOC_PP2B_LxvP_1 28 31 PF13499 0.361
DOC_USP7_MATH_1 130 134 PF00917 0.479
DOC_USP7_MATH_1 21 25 PF00917 0.369
DOC_USP7_MATH_1 336 340 PF00917 0.478
DOC_USP7_MATH_1 352 356 PF00917 0.523
DOC_USP7_MATH_1 6 10 PF00917 0.421
DOC_USP7_UBL2_3 96 100 PF12436 0.420
DOC_WW_Pin1_4 1 6 PF00397 0.427
DOC_WW_Pin1_4 313 318 PF00397 0.663
DOC_WW_Pin1_4 323 328 PF00397 0.462
DOC_WW_Pin1_4 353 358 PF00397 0.591
DOC_WW_Pin1_4 59 64 PF00397 0.511
LIG_14-3-3_CanoR_1 23 27 PF00244 0.413
LIG_14-3-3_CanoR_1 55 59 PF00244 0.469
LIG_14-3-3_CanoR_1 70 80 PF00244 0.552
LIG_Actin_WH2_2 40 57 PF00022 0.417
LIG_AP2alpha_1 226 230 PF02296 0.335
LIG_BRCT_BRCA1_1 354 358 PF00533 0.515
LIG_BRCT_BRCA1_1 61 65 PF00533 0.421
LIG_Clathr_ClatBox_1 29 33 PF01394 0.408
LIG_deltaCOP1_diTrp_1 154 157 PF00928 0.317
LIG_deltaCOP1_diTrp_1 16 20 PF00928 0.451
LIG_EH_1 223 227 PF12763 0.389
LIG_EH1_1 249 257 PF00400 0.373
LIG_eIF4E_1 250 256 PF01652 0.389
LIG_FHA_1 117 123 PF00498 0.553
LIG_FHA_1 175 181 PF00498 0.499
LIG_FHA_1 187 193 PF00498 0.318
LIG_FHA_1 342 348 PF00498 0.523
LIG_FHA_1 73 79 PF00498 0.595
LIG_FHA_2 108 114 PF00498 0.492
LIG_GBD_Chelix_1 270 278 PF00786 0.462
LIG_LIR_Apic_2 16 21 PF02991 0.448
LIG_LIR_Gen_1 154 159 PF02991 0.358
LIG_LIR_Gen_1 216 225 PF02991 0.368
LIG_LIR_Gen_1 228 238 PF02991 0.286
LIG_LIR_Nem_3 113 117 PF02991 0.536
LIG_LIR_Nem_3 154 158 PF02991 0.345
LIG_LIR_Nem_3 216 220 PF02991 0.411
LIG_LIR_Nem_3 223 229 PF02991 0.378
LIG_LIR_Nem_3 326 331 PF02991 0.628
LIG_LIR_Nem_3 33 37 PF02991 0.483
LIG_Pex14_2 201 205 PF04695 0.283
LIG_Pex14_2 226 230 PF04695 0.322
LIG_SH2_STAT5 166 169 PF00017 0.354
LIG_SH2_STAT5 250 253 PF00017 0.405
LIG_SH2_STAT5 301 304 PF00017 0.612
LIG_SH2_STAT5 315 318 PF00017 0.601
LIG_SH2_STAT5 325 328 PF00017 0.653
LIG_SUMO_SIM_anti_2 24 31 PF11976 0.520
LIG_TRAF2_1 208 211 PF00917 0.343
LIG_TRAF2_1 83 86 PF00917 0.516
LIG_TRAF2_1 88 91 PF00917 0.494
LIG_UBA3_1 341 348 PF00899 0.502
MOD_CDK_SPxK_1 323 329 PF00069 0.538
MOD_CK1_1 262 268 PF00069 0.380
MOD_CK2_1 107 113 PF00069 0.540
MOD_CK2_1 205 211 PF00069 0.333
MOD_CK2_1 80 86 PF00069 0.530
MOD_Cter_Amidation 242 245 PF01082 0.420
MOD_GlcNHglycan 124 127 PF01048 0.458
MOD_GlcNHglycan 132 135 PF01048 0.436
MOD_GlcNHglycan 167 170 PF01048 0.372
MOD_GlcNHglycan 241 244 PF01048 0.311
MOD_GlcNHglycan 297 300 PF01048 0.500
MOD_GlcNHglycan 311 314 PF01048 0.536
MOD_GlcNHglycan 8 11 PF01048 0.614
MOD_GlcNHglycan 81 85 PF01048 0.610
MOD_GSK3_1 262 269 PF00069 0.422
MOD_GSK3_1 270 277 PF00069 0.474
MOD_GSK3_1 309 316 PF00069 0.635
MOD_GSK3_1 352 359 PF00069 0.715
MOD_GSK3_1 54 61 PF00069 0.441
MOD_N-GLC_1 122 127 PF02516 0.468
MOD_N-GLC_1 49 54 PF02516 0.387
MOD_NEK2_1 157 162 PF00069 0.341
MOD_NEK2_1 22 27 PF00069 0.426
MOD_NEK2_1 270 275 PF00069 0.457
MOD_NEK2_1 54 59 PF00069 0.588
MOD_NEK2_1 71 76 PF00069 0.495
MOD_PIKK_1 262 268 PF00454 0.453
MOD_PIKK_1 329 335 PF00454 0.523
MOD_PKA_2 22 28 PF00069 0.454
MOD_PKA_2 220 226 PF00069 0.383
MOD_PKA_2 259 265 PF00069 0.323
MOD_PKA_2 54 60 PF00069 0.530
MOD_Plk_1 49 55 PF00069 0.389
MOD_Plk_4 160 166 PF00069 0.522
MOD_Plk_4 22 28 PF00069 0.488
MOD_Plk_4 251 257 PF00069 0.339
MOD_ProDKin_1 1 7 PF00069 0.427
MOD_ProDKin_1 313 319 PF00069 0.661
MOD_ProDKin_1 323 329 PF00069 0.464
MOD_ProDKin_1 353 359 PF00069 0.591
MOD_ProDKin_1 59 65 PF00069 0.510
TRG_DiLeu_BaLyEn_6 67 72 PF01217 0.517
TRG_ENDOCYTIC_2 101 104 PF00928 0.469
TRG_ENDOCYTIC_2 114 117 PF00928 0.527
TRG_ENDOCYTIC_2 139 142 PF00928 0.606
TRG_ENDOCYTIC_2 325 328 PF00928 0.660
TRG_ER_diArg_1 150 153 PF00400 0.440
TRG_ER_diArg_1 233 236 PF00400 0.412
TRG_Pf-PMV_PEXEL_1 272 276 PF00026 0.468

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDD8 Leptomonas seymouri 63% 100%
A0A1X0NXM4 Trypanosomatidae 38% 100%
A0A3Q8IF37 Leishmania donovani 98% 100%
A0A3R7NME4 Trypanosoma rangeli 35% 100%
E9AIQ2 Leishmania braziliensis 77% 100%
E9AV38 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QCE3 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS